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    • All HBS Web  (169)
      • Faculty Publications  (25)

      Substance Use DisorderRemove Substance Use Disorder →

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      • July 2024
      • Case

      “In That Crucible, You Find Innovation”: Public Safety Transformation in Albuquerque

      By: Hise O. Gibson and Antonio Manuel Oftelie
      “In That Crucible, You Find Innovation”: Public Safety Transformation in Albuquerque" centers on Mayor Tim Keller’s leadership during the social justice protests in 2020 and his efforts to reinvent Albuquerque’s public safety model. Faced with both a federal consent... View Details
      Keywords: Change Management; Government Administration; Leading Change; Safety; Social Issues; Governing Rules, Regulations, and Reforms; Ethics; Public Administration Industry; New Mexico
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      Gibson, Hise O., and Antonio Manuel Oftelie. "“In That Crucible, You Find Innovation”: Public Safety Transformation in Albuquerque." Harvard Business School Case 625-026, July 2024.
      • April 2024
      • Article

      A Machine Learning Algorithm Predicting Risk of Dilating VUR among Infants with Hydronephrosis Using UTD Classification

      By: Hsin-Hsiao Scott Wang, Michael Lingzhi Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow and Caleb Nelson
      Backgrounds: Urinary Tract Dilation (UTD) classification has been designed to be a more objective grading system to evaluate antenatal and post-natal UTD. Due to unclear association between UTD classifications to specific anomalies such as vesico-ureteral reflux (VUR),... View Details
      Keywords: Health Disorders; Health Testing and Trials; AI and Machine Learning; Health Industry
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      Wang, Hsin-Hsiao Scott, Michael Lingzhi Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow, and Caleb Nelson. "A Machine Learning Algorithm Predicting Risk of Dilating VUR among Infants with Hydronephrosis Using UTD Classification." Journal of Pediatric Urology 20, no. 2 (April 2024): 271–278.
      • February 2024
      • Case

      Compass Pathways: Pioneering Psychedelic Treatment

      By: Tiona Zuzul, Kisha Lashley and Gamze Yucaoglu
      This case follows Compass Pathways, a pioneering company developing treatment for depression based on psilocybin, the compound found in ‘magic mushrooms.’ Psilocybin was a federally illegal substance in the U.S., and a “Schedule I” drug, defined as a drug “with no... View Details
      Keywords: Commercialization; Corporate Strategy; Competitive Strategy; Product Launch; Health Testing and Trials; Research and Development; Laws and Statutes; Pharmaceutical Industry; Europe; United States; United Kingdom
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      Zuzul, Tiona, Kisha Lashley, and Gamze Yucaoglu. "Compass Pathways: Pioneering Psychedelic Treatment." Harvard Business School Case 724-412, February 2024.
      • January 2024 (Revised April 2024)
      • Case

      Target Malaria: Editing Mosquitoes through Gene Drives

      By: Shikhar Ghosh and Shweta Bagai
      Target Malaria, a non-profit research consortium, is exploring the application of CRISPR-Cas9 gene editing technology to combat malaria in Sub-Saharan Africa. Its approach uses gene drives, a revolutionary tool, to suppress the population of malaria-carrying... View Details
      Keywords: Health Disorders; Technological Innovation; Nonprofit Organizations; Business Strategy; Genetics; Ethics; Governing Rules, Regulations, and Reforms; United States; United Kingdom; Burkina Faso; Africa
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      Ghosh, Shikhar, and Shweta Bagai. "Target Malaria: Editing Mosquitoes through Gene Drives." Harvard Business School Case 824-068, January 2024. (Revised April 2024.)
      • January 19, 2024
      • Article

      Value-Based Health Care Can Transform the Treatment of Patients with Substance Use Disorder

      By: Robert S. Kaplan and Sarah E. Wakeman
      U.S. overdose deaths currently exceed 100,000 per year. New facilities, known as bridge clinics, are broadening access to high-quality care by offering outpatient substance use disorder (SUD) treatment with few access barriers. But many of the critical services offered... View Details
      Keywords: Health Care and Treatment; Cost; Adoption
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      Kaplan, Robert S., and Sarah E. Wakeman. "Value-Based Health Care Can Transform the Treatment of Patients with Substance Use Disorder." Health Affairs Forefront (January 19, 2024).
      • January 2024
      • Article

      A Cost Model for a Low Threshold Clinic Treating Opioid Use Disorder

      By: Sarah E. Wakeman, Elizabeth Powell, Syed Shehab, Grace Herman, Laura Kehoe and Robert S. Kaplan
      The US fee-for-service payment system under-reimburses clinics offering access to comprehensive treatments for opioid use disorder (OUD). The funding shortfall limits a clinic’s ability to expand and improve access, especially for socially marginalized patients with... View Details
      Keywords: Health Care and Treatment; Cost; Equality and Inequality; Health Industry
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      Wakeman, Sarah E., Elizabeth Powell, Syed Shehab, Grace Herman, Laura Kehoe, and Robert S. Kaplan. "A Cost Model for a Low Threshold Clinic Treating Opioid Use Disorder." Journal of Behavioral Health Services & Research 51, no. 1 (January 2024): 22–30.
      • January 2024
      • Article

      Subset Scanning for Multi-Trait Analysis Using GWAS Summary Statistics

      By: Rui Cao, Evan Olawsky, Edward McFowland III, Erin Marcotte, Logan Spector and Tianzhong Yang
      Multi-trait analysis has been shown to have greater statistical power than single-trait analysis. Most of the existing multi-trait analysis methods only work with a limited number of traits and usually prioritize high statistical power over identifying relevant traits,... View Details
      Keywords: Mathematical Methods; Health Disorders
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      Cao, Rui, Evan Olawsky, Edward McFowland III, Erin Marcotte, Logan Spector, and Tianzhong Yang. "Subset Scanning for Multi-Trait Analysis Using GWAS Summary Statistics." Bioinformatics 40, no. 1 (January 2024).
      • September 2023
      • Article

      The Health Costs of Dirty Energy: Evidence from the Capacity Market in Colombia

      By: Achyuta Adhvaryu, Theresa Molina, Anant Nyshadham, Jorge Tamayo and Nicholas Torres
      The health effects of “dirty” (fossil fuel driven) energy production are difficult to measure accurately due to the endogeneity of fuel choice. We exploit an electricity policy in Colombia that generates a price-based trigger for the use of thermal energy sources.... View Details
      Keywords: Pollution; Health Disorders; Energy Industry; Colombia
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      Adhvaryu, Achyuta, Theresa Molina, Anant Nyshadham, Jorge Tamayo, and Nicholas Torres. "The Health Costs of Dirty Energy: Evidence from the Capacity Market in Colombia." Art. 103116. Journal of Development Economics 164 (September 2023).
      • Summer 2023
      • Article

      Do Policies to Increase Access to Treatment for Opioid Use Disorder Work?

      By: Eric Barrette, Leemore S. Dafny and Karen Shen
      Even among commercially insured individuals, opioid use disorder is undertreated in the United States: nearly half receive no treatment within six months of a new diagnosis. Using a difference-in-differences specification exploiting the extension of insurance parity... View Details
      Keywords: Opioid Treatment; Medication-assisted Treatment; Substance Use Disorder; Private Insurance; Insurance; Health Care and Treatment
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      Barrette, Eric, Leemore S. Dafny, and Karen Shen. "Do Policies to Increase Access to Treatment for Opioid Use Disorder Work?" American Journal of Health Economics 9, no. 3 (Summer 2023): 297–330.
      • March 2021 (Revised January 2023)
      • Case

      The Trouble with TCE

      By: Vincent Pons, Rafael Di Tella and Galit Goldstein
      Trichloroethylene, or TCE, was a chemical used by tens of thousands of businesses in the United States. It was an affordable tool for many. Yet, TCE had been associated with important health risks, including cancer and autoimmune disease. TCE potentially posed other... View Details
      Keywords: Trichloroethylene; Toxicity; Lobbying; Chemicals; Health Disorders; Governing Rules, Regulations, and Reforms; Policy; Ethics; Business and Government Relations; Chemical Industry; United States
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      Pons, Vincent, Rafael Di Tella, and Galit Goldstein. "The Trouble with TCE." Harvard Business School Case 721-031, March 2021. (Revised January 2023.)
      • August 2020
      • Article

      Contextual Determinants of Parental Reflective Functioning: Children with Autism versus Their Typically Developing Siblings

      By: Yael Enav, Dana Erhard-Weiss, Amit Goldenberg, Marguerite Knudston, Antonio Y. Hardan and James J. Gross
      In this study, we examined parental reflective functioning using the Parental Developmental Interview when parents were talking about their interactions with their child with autism versus the child’s typically developing siblings. Our sample included 30 parents who... View Details
      Keywords: Autism Spectrum Disorders; Family Functioning And Support; Parents; Reflective Functioning; Siblings; Health Disorders; Family and Family Relationships
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      Enav, Yael, Dana Erhard-Weiss, Amit Goldenberg, Marguerite Knudston, Antonio Y. Hardan, and James J. Gross. "Contextual Determinants of Parental Reflective Functioning: Children with Autism versus Their Typically Developing Siblings." Autism 24, no. 6 (August 2020).
      • Article

      Treatment Of Opioid Use Disorder Among Commercially Insured U.S. Adults, 2008–17

      By: Karen Shen, Eric Barrette and Leemore S. Dafny
      There is abundant literature on efforts to reduce opioid prescriptions and misuse, but comparatively little on the treatment provided to people with opioid use disorder (OUD). Using claims data representing 12–15 million nonelderly adults covered through commercial... View Details
      Keywords: Opioid Treatment; Medication-assisted Treatment; Substance Use Disorder; Private Insurance; Health Disorders; Health Care and Treatment; Insurance; United States
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      Shen, Karen, Eric Barrette, and Leemore S. Dafny. "Treatment Of Opioid Use Disorder Among Commercially Insured U.S. Adults, 2008–17." Health Affairs 39, no. 6 (June 2020): 993–1001.
      • March 2020 (Revised June 2023)
      • Case

      EyeControl: Inspiring Communication

      By: Paul A. Gompers and Danielle Golan
      Eye-controlled communication device startup EyeControl was founded in Tel Aviv, Israel in 2016 by cofounders with a shared personal connection to locked-in syndrome—a neurological disorder that left sufferers cognitively sound, yet paralyzed, with the exception of eye... View Details
      Keywords: Health Disorders; Communication Technology; Business Startups; Expansion; Finance; Decision Making; Social Enterprise; Medical Devices and Supplies Industry
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      Gompers, Paul A., and Danielle Golan. "EyeControl: Inspiring Communication." Harvard Business School Case 820-078, March 2020. (Revised June 2023.)
      • Article

      TDABC Cost Analysis of Ocular Disorders in an Ophthalmology Emergency Department versus Urgent Care: Clinical Experience at Massachusetts Eye and Ear

      By: Robert S. Kaplan, Jonathan Chou, Mahek Shah, Amy Watts, Matthew Gardiner, Joan Miller and John I. Lowenstein
      Purpose  To perform a cost analysis comparison for managing common ocular disorders in an eye emergency department (ED) versus an urgent care setting using a time-driven activity-based cost model (TDABC) to assist physicians and staff in appropriate allocation of... View Details
      Keywords: Time-driven Activity-based Cost Model; Emergency Room; Urgent Care Clinic; Cost; Analysis; Activity Based Costing and Management; Health Care and Treatment
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      Kaplan, Robert S., Jonathan Chou, Mahek Shah, Amy Watts, Matthew Gardiner, Joan Miller, and John I. Lowenstein. "TDABC Cost Analysis of Ocular Disorders in an Ophthalmology Emergency Department versus Urgent Care: Clinical Experience at Massachusetts Eye and Ear." Journal of Academic Ophthalmology 10 (2018).
      • 2017
      • Chapter

      High Stakes Negotiation: Indian Gaming and Tribal/State Compacts

      By: Gavin Clarkson and James K. Sebenius
      Although Indian tribes and the surrounding states were often bitter enemies throughout much of the history of the United States, recently tribes and states have been able to work cooperatively in a number of areas. In some instances, Congress has mandated such... View Details
      Keywords: Indian Gaming; Negotiation; Regulation; Tribal Sovereignty; Sovereign Finance; Negotiation Participants; Relationships; Cooperation; Connecticut
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      Clarkson, Gavin, and James K. Sebenius. "High Stakes Negotiation: Indian Gaming and Tribal/State Compacts." Chap. 8 in American Indian Business: Principles and Practices, edited by Deanna M. Kennedy, Charles Harrington, Amy Klemm Verbos, Daniel Stewart, Joseph Gladstone, and Gavin Clarkson, 130–161. Seattle: University of Washington Press, 2017.
      • Article

      Neurodiversity as a Competitive Advantage

      By: Robert D. Austin and Gary P. Pisano
      Many people with neurological conditions such as autism spectrum disorder and dyslexia have extraordinary skills, including those in pattern recognition, memory, and mathematics. Yet they often struggle to fit the profiles sought by employers. A growing number of... View Details
      Keywords: Competitive Advantage; Diversity; Competency and Skills
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      Austin, Robert D., and Gary P. Pisano. "Neurodiversity as a Competitive Advantage." Harvard Business Review 95, no. 3 (May–June 2017): 96–103.
      • October 2016
      • Case

      Addicaid: Scaling a Digital Platform for Addiction Wellness and Recovery

      By: Robert S. Huckman and Sarah Mehta
      In 2013, Sam Frons founded Addicaid—a mobile application (app) that allowed people in addiction recovery to track their progress, check in with counselors, and connect with others in recovery programs. The app was grounded in cognitive behavioral therapy and used the... View Details
      Keywords: Digital Health Interventions; Substance Use Disorder; Addiction Treatment; Addiction Recovery; Scale; Innovation; Health; Health Disorders; Health Industry; New York (city, NY)
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      Huckman, Robert S., and Sarah Mehta. "Addicaid: Scaling a Digital Platform for Addiction Wellness and Recovery." Harvard Business School Case 617-018, October 2016.
      • Article

      Time-driven Activity-based Costing of Multivessel Coronary Artery Bypass Grafting across National Boundaries to Identify Improvement Opportunities: Study Protocol

      By: F. Erhun, B. Mistry, T. Platcheck, A. Milstein, V.G. Narayanan and R. S. Kaplan
      Coronary artery bypass graft (CABG) surgery is a common treatment for coronary artery disease—a disease that affects over 10% of US adults and is a major cause of morbidity and mortality. In 2005, the mean cost for a CABG procedure among Medicare beneficiaries in the... View Details
      Keywords: Activity Based Costing and Management; Health Disorders; Health Care and Treatment; United States; India
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      Erhun, F., B. Mistry, T. Platcheck, A. Milstein, V.G. Narayanan, and R. S. Kaplan. "Time-driven Activity-based Costing of Multivessel Coronary Artery Bypass Grafting across National Boundaries to Identify Improvement Opportunities: Study Protocol." BMJ Open 5, no. 8 (2015).
      • Article

      Patterns of Failure after Involved Field Radiation Therapy for Pediatric and Young Adult Hodgkin Lymphoma

      By: Minh-Phuong Huynh-Le, Amanda J. Walker, Scott Duke Kominers, Ido Paz-Priel, Moody D. Wharam and Stephanie A. Terezakis
      Involved field radiation therapy (IFRT) is integral in curative therapy for Hodgkin lymphoma (HL), although primarily used in patients with intermediate/high‐risk HL. We present failure patterns and clinical outcomes in a cohort of pediatric and young adult patients... View Details
      Keywords: Hematology/oncology; Hodgkin Lymphoma; Involved Field Radiation Therapy; Health Disorders; Health Care and Treatment
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      Huynh-Le, Minh-Phuong, Amanda J. Walker, Scott Duke Kominers, Ido Paz-Priel, Moody D. Wharam, and Stephanie A. Terezakis. "Patterns of Failure after Involved Field Radiation Therapy for Pediatric and Young Adult Hodgkin Lymphoma." Pediatric Blood & Cancer 61, no. 7 (July 2014).
      • January 2014
      • Teaching Note

      Dr. Benjamin Hooks and Children's Health Forum

      By: Rosabeth Moss Kanter and Ai-Ling Malone
      The case includes law, business, and public health perspectives on an African American leader's social entrepreneurship and leadership in other social movements. Later in his life, Dr. Benjamin Hooks championed the eradication of lead poisoning. Prior to that Hooks... View Details
      Keywords: Leading Change; Health Disorders; Social Entrepreneurship; Personal Development and Career; Social Issues; United States
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      Kanter, Rosabeth Moss, and Ai-Ling Malone. "Dr. Benjamin Hooks and Children's Health Forum." Harvard Business School Teaching Note 314-092, January 2014.
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