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      • Faculty Publications  (907)

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      • June 2023
      • Case

      Verve Therapeutics: Taking DNA Editing to Heart

      By: Shikhar Ghosh and Shweta Bagai
      Verve Therapeutics, a public biotech company based in Boston, created a novel approach to addressing cardiovascular disease (CVD) - a leading cause of deaths globally. The company's approach was a single shot treatment to permanently lower cholesterol, thus reducing... View Details
      Keywords: AI; Genetic Engineering; Medicine; Health Care and Treatment; Genetics; Innovation Strategy; Business and Stakeholder Relations; Medical Specialties; Innovation and Invention; Entrepreneurship; Biotechnology Industry
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      Ghosh, Shikhar, and Shweta Bagai. "Verve Therapeutics: Taking DNA Editing to Heart." Harvard Business School Case 823-113, June 2023.
      • May 2023 (Revised June 2023)
      • Supplement

      Novartis (B): Reimagining Medicine

      By: Ramon Casadesus-Masanell, Claudio Feser, Karolin Frankenberger and David Redaschi
      This case unfolds around the first-ever approved personalized cancer treatment, how Novartis wrapped it into a new business model design, and how Novartis scaled it. Novartis — one of the largest pharmaceutical companies in the world — is, among other ventures,... View Details
      Keywords: Health Care and Treatment; Business Model; Production; Business Strategy; Pharmaceutical Industry
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      Casadesus-Masanell, Ramon, Claudio Feser, Karolin Frankenberger, and David Redaschi. "Novartis (B): Reimagining Medicine." Harvard Business School Supplement 723-444, May 2023. (Revised June 2023.)
      • April 2023 (Revised April 2024)
      • Teaching Note

      Netflix's Culture: Binge or Cringe?

      By: Hubert Joly, Leonard A. Schlesinger, James Barnett and Stacy Straaberg
      Teaching Note for HBS Case No. 522-096. View Details
      Keywords: Compensation and Benefits; Employees; Recruitment; Resignation and Termination; Retention; Selection and Staffing; Innovation and Management; Innovation Strategy; Leadership Style; Business or Company Management; Management Style; Media; Business Processes; Organizational Culture; Organizational Structure; Performance Expectations; Performance Productivity; Creativity; Business Strategy; Entertainment and Recreation Industry; Media and Broadcasting Industry; Motion Pictures and Video Industry; Video Game Industry; North America; California; Canada; Europe; Middle East; Africa; Asia; Latin America
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      Joly, Hubert, Leonard A. Schlesinger, James Barnett, and Stacy Straaberg. "Netflix's Culture: Binge or Cringe?" Harvard Business School Teaching Note 523-004, April 2023. (Revised April 2024.)
      • April 2023 (Revised September 2023)
      • Case

      Apple's iPhone Revolution: Pioneering the Circular Economy

      By: George Serafeim
      When asked to identify an example of a circular economy business model that has generated billions in revenues for a company, ChatGPT, the famous chatbot that in 2022 rocked the world with its ability to perform a variety of tasks, immediately identified and... View Details
      Keywords: Iphone; Smartphone; Waste Management; Recycling; Innovation; Product Upgrade; Product Life Cycle; Sustainability; Climate Impact; Digital; Business Model Innovation; Climate Change; Information Technology; Business Model; Electronics Industry; Information Technology Industry
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      Serafeim, George. "Apple's iPhone Revolution: Pioneering the Circular Economy." Harvard Business School Case 123-089, April 2023. (Revised September 2023.)
      • April 2023 (Revised February 2024)
      • Case

      AI Wars

      By: Andy Wu, Matt Higgins, Miaomiao Zhang and Hang Jiang
      In February 2024, the world was looking to Google to see what the search giant and long-time putative technical leader in artificial intelligence (AI) would do to compete in the massively hyped technology of generative AI. Over a year ago, OpenAI released ChatGPT, a... View Details
      Keywords: AI; Artificial Intelligence; AI and Machine Learning; Technology Adoption; Competitive Strategy; Technological Innovation
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      Wu, Andy, Matt Higgins, Miaomiao Zhang, and Hang Jiang. "AI Wars." Harvard Business School Case 723-434, April 2023. (Revised February 2024.)
      • April 2023 (Revised September 2023)
      • Case

      Levels: The Remote, Asynchronous, Deep Work Management System

      By: Joseph B. Fuller and George Gonzalez
      Levels is a highly innovative startup in the health care space. They intend to revolutionize health by linking behavior—eating, exercise, sleeping, etc.—to changes in metabolism. They believe metabolic health can be managed through careful monitoring of changes in... View Details
      Keywords: Applications and Software; Business Startups; Organizational Culture; Management Style; Technology Industry; United States
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      Fuller, Joseph B., and George Gonzalez. "Levels: The Remote, Asynchronous, Deep Work Management System." Harvard Business School Case 323-069, April 2023. (Revised September 2023.)
      • April 2023
      • Article

      The Real Exchange Rate, Innovation and Productivity

      By: Laura Alfaro, Alejandro Cuñat, Harald Fadinger and Yanping Liu
      We evaluate manufacturing firms' responses to changes in the real exchange rate (RER) using detailed firm-level data for a large set of countries for the period 2001-2010. We uncover the following stylized facts about regional variation of manufacturing firms'... View Details
      Keywords: Real Exchange Rate; Firm Level Data; Innovation; Productivity; Exporting; Importing; Credit Constraints; Currency Exchange Rate; Innovation and Invention; Performance Productivity
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      Alfaro, Laura, Alejandro Cuñat, Harald Fadinger, and Yanping Liu. "The Real Exchange Rate, Innovation and Productivity." Journal of the European Economic Association 21, no. 2 (April 2023): 637–689.
      • March 2023
      • Case

      Mirakl: Growing The Marketplace Economy

      By: Antonio Moreno, Santiago Gallino and Emilie Billaud
      Mirakl provided the technology and seller network required for companies like Macy's, Best Buy, Walmart, Siemens, or Carrefour to simply design, launch, and administer a marketplace that included products from third-party sellers. What began as a basic business idea in... View Details
      Keywords: Business Growth and Maturation; Business Startups; Transformation; Technological Innovation; Growth and Development Strategy; Internet and the Web; Technology Adoption; Sales; Information Technology Industry; Retail Industry; Web Services Industry; Europe; France; Paris; United States
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      Moreno, Antonio, Santiago Gallino, and Emilie Billaud. "Mirakl: Growing The Marketplace Economy." Harvard Business School Case 623-054, March 2023.
      • March 2023 (Revised June 2025)
      • Case

      Close Concerns: Diabetes Research and Advocacy

      By: Regina E. Herzlinger and Brian L. Walker
      This case describes the Exit considerations of Kelly Close, HBS MBA, and founder of the primary distributor of diabetes newsletters. It is part of the fourth module in the Innovating in Health Care HBS MBA course, which contains cases of other health care firms that... View Details
      Keywords: Diabetes; Health; Health Care; Health Care And Treatment; Health Care Outcomes; Health Care Industry; Knowledge Dissemination; Outcome or Result; Equality and Inequality; Business Model; Entrepreneurship
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      Herzlinger, Regina E., and Brian L. Walker. "Close Concerns: Diabetes Research and Advocacy." Harvard Business School Case 323-047, March 2023. (Revised June 2025.)
      • March 2023
      • Case

      Woven Planet - Designing Software for the Car of the Future

      By: Gary P. Pisano and Catherine Piner
      Founded in 2021, Woven Planet Holdings—a subsidiary of Toyota Motor Corporation—was developing Arene, an automotive software platform consisting of an operating system, development and simulation tools, and a cloud-based service that could store and analyze vehicle... View Details
      Keywords: Technology; Automated Driving; Innovation; Organizational Culture; Applications and Software; Safety; Product Launch; Product; Auto Industry; Technology Industry
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      Pisano, Gary P., and Catherine Piner. "Woven Planet - Designing Software for the Car of the Future." Harvard Business School Case 623-064, March 2023.
      • March 2023 (Revised May 2025)
      • Case

      On (A)

      By: Ramon Casadesus-Masanell, Karolin Frankenberger and Sascha Mader
      Founded in 2010, in just one decade, the Swiss company On had established itself as a main player in global sports footwear and apparel. Based on an unconventional strategy which one of the founders labeled as “obsessively distinct,” On grew its sales with a compound... View Details
      Keywords: Brands and Branding; Business Growth and Maturation; Business Model; Business Startups; Business Strategy; Competitive Advantage; Competitive Strategy; Corporate Strategy; Customer Focus and Relationships; Customer Satisfaction; Digital Marketing; Disruptive Innovation; Distribution Channels; Entrepreneurship; Environmental Sustainability; Global Strategy; Initial Public Offering; Innovation and Invention; Innovation Strategy; Market Entry and Exit; Marketing Strategy; Product Design; Product Development; Product Marketing; Social Media; Strategy; Supply Chain Management; Technological Innovation; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Europe; Switzerland; Germany; United States
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      Casadesus-Masanell, Ramon, Karolin Frankenberger, and Sascha Mader. "On (A)." Harvard Business School Case 723-430, March 2023. (Revised May 2025.)
      • February 2023 (Revised February 2025)
      • Case

      Doing Business in Nairobi, Kenya

      By: Archie L. Jones, Leonard A. Schlesinger, Pippa Tubman Armerding and Kuria Kamau
      This case examines the challenges and opportunities of doing business in Nairobi, Kenya. It highlights Kenya's economic transformation in the decades leading up to 2024 in the context of its history, culture, and politics. The case gives an overview of some of the main... View Details
      Keywords: Business History; Business and Government Relations; Technological Innovation; Foreign Direct Investment; Economic Growth; Financial Crisis; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Kenya; Nairobi; Africa
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      Jones, Archie L., Leonard A. Schlesinger, Pippa Tubman Armerding, and Kuria Kamau. "Doing Business in Nairobi, Kenya." Harvard Business School Case 323-086, February 2023. (Revised February 2025.)
      • February 2023
      • Supplement

      Astyanax Kanakakis at norbloc: A Founder's Experience with the DIFC Fintech Hive

      By: Linda A. Hill and Lydia Begag
      norbloc was founded in 2016 in Stockholm, Sweden, by Astyanax Kanakakis and his co-founders, Vitalii Demianets and Sam Saatchi. Kanakakis and Demianets got to work to address a key gap in the industry: Know Your Customer (KYC) data sharing. As the first distributed KYC... View Details
      Keywords: Organizational Change and Adaptation; Organizational Design; Organizational Culture; Organizational Structure; Organizations; Leadership; Leadership Development; Leadership Style; Collaborative Innovation and Invention; Digital Transformation; Digital Strategy; Digital Platforms; Technology Adoption; Technological Innovation; Corporate Entrepreneurship; Business and Government Relations; Business Startups; Financial Services Industry; Technology Industry; Banking Industry; Information Technology Industry; Sweden; Europe; Singapore; London; United Arab Emirates; Dubai; Middle East; Athens; Greece
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      Hill, Linda A., and Lydia Begag. "Astyanax Kanakakis at norbloc: A Founder's Experience with the DIFC Fintech Hive." Harvard Business School Supplement 423-066, February 2023.
      • February 22, 2023
      • Article

      How to Seed Organic Marketing in a Video-First World

      By: Ayelet Israeli, Leonard A. Schlesinger and Matt Higgins
      Early direct-to-consumer (DTC) companies relied on plentiful capital and low-cost digital marketing to power growth. But as this sector has matured, capital is more constrained, social media is more cluttered, and customer acquisition costs are rising. DTC companies... View Details
      Keywords: Online Business; Ecommerce; E-commerce; E-Commerce Strategy; Omnichannel Retail; Omnichannel Retailing; Influencer Marketing; Consumer; Organic Growth; Video Advertising; Promotion; Celebrities; Online Advertising; Online Channel; Online Communities; Online Community; Go To Market Strategy; Platform; Media; Media Content; Digital; Digital Culture; Digital Influencers; Direct To Consumer Marketing; Direct-to-consumer; Innovation & Entrepreneurship; Innovation; Sales; Digital Platforms; Digital Marketing; Digital Strategy; Consumer Behavior; Internet and the Web; Advertising; Business Model; Growth Management; Marketing; Marketing Strategy; Marketing Channels; Marketing Communications; Communication Strategy; Innovation Strategy; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry; United States; North America
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      Israeli, Ayelet, Leonard A. Schlesinger, and Matt Higgins. "How to Seed Organic Marketing in a Video-First World." Harvard Business Review (website) (February 22, 2023).
      • December 2022
      • Case

      To Feed the Planet: Juan Luciano at ADM

      By: Joshua D. Margolis, David E. Bell, Damien McLoughlin, Stacy Straaberg and James Weber
      In December 2022, Juan Luciano, Chairman and CEO of agribusiness and nutrition giant ADM, considered the next phase of the historic company’s future. Beginning in 2011 when he joined as COO and moving into his tenure as CEO in 2015, Luciano led a transformation of ADM... View Details
      Keywords: Agriculture; Leadership; Agribusiness; Acquisition; Business Units; Customer Focus and Relationships; Customer Value and Value Chain; Forecasting and Prediction; Capital; Cash; Cost of Capital; Cost Management; Profit; Food; Global Range; Innovation Strategy; Leadership Development; Leadership Style; Leading Change; Growth and Development Strategy; Risk Management; Organizational Culture; Organizational Structure; Strategic Planning; Risk and Uncertainty; Adaptation; Business Strategy; Corporate Strategy; Vertical Integration; Value Creation; Transformation; Agriculture and Agribusiness Industry; Energy Industry; United States; Chicago
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      Margolis, Joshua D., David E. Bell, Damien McLoughlin, Stacy Straaberg, and James Weber. "To Feed the Planet: Juan Luciano at ADM." Harvard Business School Case 423-060, December 2022.
      • December 2022
      • Technical Note

      Risks and Opportunities from the Transition to a Low Carbon Economy: A Business Analysis Framework

      By: George Serafeim
      The transition to a low carbon economy introduces many risks and opportunities for businesses. Risks emerge from regulatory actions, such as carbon taxes and cap and trade systems, technological innovation that develop alternatives for customers making existing... View Details
      Keywords: Risk Assessment; Opportunities; Environmental Sustainability; Carbon Footprint; Risk Management; Competitive Dynamics; Business Analysis; Climate Change; Accounting; Finance; Valuation; Business and Shareholder Relations; Technological Innovation; Transition; Product Positioning; Renewable Energy; Analysis
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      Serafeim, George. "Risks and Opportunities from the Transition to a Low Carbon Economy: A Business Analysis Framework." Harvard Business School Technical Note 123-014, December 2022.
      • December 2022 (Revised January 2023)
      • Case

      Cann: High Hopes for Cannabis Infused Beverages

      By: Ayelet Israeli and Anne V. Wilson
      Founded in 2018 by Jake Bullock and Luke Anderson, Cann sold “social tonics,” or cannabis-infused beverages. By 2022, the company had several notable celebrity investors and talent partners, had sold over 10 million beverages to consumers, was distributing in six... View Details
      Keywords: Stigma; Product Innovation; Product Introduction; Product Differentiation; New Products; New Product Marketing; New Product Management; Brand Management; Branding; Packaging; Positioning; Growth Strategy And Execution; Growth; Cannabis Industry; Purpose; Purpose Brands; LGBTQ; Direct-to-consumer; DTC; Regulations; Channels Of Distribution; Product Development; Product Marketing; Product Positioning; Product; Innovation and Invention; Brands and Branding; Marketing; Marketing Communications; Marketing Channels; Advertising; Advertising Campaigns; Digital Marketing; Market Entry and Exit; Governing Rules, Regulations, and Reforms; Consumer Products Industry; Consumer Products Industry; United States; Canada; North America
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      Israeli, Ayelet, and Anne V. Wilson. "Cann: High Hopes for Cannabis Infused Beverages." Harvard Business School Case 523-074, December 2022. (Revised January 2023.)
      • December 2022
      • Article

      I Don't 'Recall': The Decision to Delay Innovation Launch to Avoid Costly Product Failure

      By: Byungyeon Kim, Oded Koenigsberg and Elie Ofek
      Innovations embody novel features or cutting-edge components aimed at delivering desired customer benefits. Oftentimes, however, we observe the need to recall new products shortly after their introduction. Indeed, a firm may rush an innovation to market in an attempt... View Details
      Keywords: Innovation Management; Innovation And Strategy; Product Development Strategy; Product Introduction; Quality Control; Product Recalls; Game Theory; Market Timing; Innovation Strategy; Product Launch; Product Development
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      Kim, Byungyeon, Oded Koenigsberg, and Elie Ofek. "I Don't 'Recall': The Decision to Delay Innovation Launch to Avoid Costly Product Failure." Management Science 68, no. 12 (December 2022): 8889–8908.
      • Article

      Innovations in Retail Operations: Thirty Years of Lessons from Production and Operations Management

      By: Marshall Fisher and Ananth Raman
      We review papers published in Production and Operations Management (POM) during its thirty-year history that deal with retail operations issues with an empirical approach. The papers span a range of issues, from traditional ones like forecasting and inventory... View Details
      Keywords: RFID; Innovation and Invention; Technology Adoption; Operations; E-commerce; Strategy; Retail Industry
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      Fisher, Marshall, and Ananth Raman. "Innovations in Retail Operations: Thirty Years of Lessons from Production and Operations Management." Special Issue on The 30th Anniversary Issue of Production and Operations Management edited by Subodha Kumar and Christopher S. Tang. Production and Operations Management 31, no. 12 (December 1, 2022): 4452–4461.
      • 2022
      • Working Paper

      Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation

      By: Amitabh Chandra, Jennifer Kao, Kathleen Miller and Ariel D. Stern
      Regulators of new products confront a tradeoff between speeding a new product to market and collecting additional product quality information. The FDA’s Breakthrough Therapy Designation (BTD) provides an opportunity to understand if a regulator can use new policy to... View Details
      Keywords: Research and Development; Governing Rules, Regulations, and Reforms; Product Development
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      Chandra, Amitabh, Jennifer Kao, Kathleen Miller, and Ariel D. Stern. "Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation." NBER Working Paper Series, No. 30712, December 2022.
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