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- Faculty Publications (176)
Show Results For
- All HBS Web
(625)
- People (1)
- News (210)
- Research (303)
- Events (3)
- Multimedia (10)
- Faculty Publications (176)
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- October 2016 (Revised September 2017)
- Case
The CRISPR-Cas9 Quarrel
By: Richard G. Hamermesh and Matthew G. Preble
In mid-2016, the Broad Institute and the University of California, Berkeley were in the middle of a contentious patent dispute over which entity controlled a breakthrough gene editing technology called CRISPR-Cas9. With CRISPR-Cas9, scientists might soon be able to... View Details
Keywords: CRISPR; Broad Institute; University Of California Berkeley; Intellectual Property; Patents; Law; Lawsuits and Litigation; Science; Genetics; Entrepreneurship; Biotechnology Industry; United States
Hamermesh, Richard G., and Matthew G. Preble. "The CRISPR-Cas9 Quarrel." Harvard Business School Case 817-020, October 2016. (Revised September 2017.)
- November 2024
- Supplement
AlphaGo (C): Birth of a New Intelligence
By: Shikhar Ghosh and Shweta Bagai
This case, the final of a three-part series, explores DeepMind's pivotal transition from mastering games to solving real-world scientific challenges. In December 2020, DeepMind's AI system AlphaFold 2 achieved a breakthrough by solving protein folding—a 50-year-old... View Details
Keywords: Autonomy; Deep Learning; Drug Discovery; Healthcare Innovation; Neural Networks; Scientific Research; Technology Startup; AI and Machine Learning; Technological Innovation; Research and Development; Business Model; Business Strategy; Open Source Distribution; Technology Industry; United States
Ghosh, Shikhar, and Shweta Bagai. "AlphaGo (C): Birth of a New Intelligence." Harvard Business School Supplement 825-075, November 2024.
- February 2016
- Teaching Note
Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired
By: Rosabeth M. Kanter, Tessa Natanay Hamilton and Ai-Ling Jamila Malone
Following a successful military career as an Army Nurse, achieving rank as Major General, becoming the first female Acting Surgeon General of the Army, and the 22nd Chief of the Army Nurse Corps, Pollock developed a vested interest in improving the lives of the... View Details
Keywords: Health
- Article
Fast Generalized Subset Scan for Anomalous Pattern Detection
By: Edward McFowland III, Skyler Speakman and Daniel B. Neill
We propose Fast Generalized Subset Scan (FGSS), a new method for detecting anomalous patterns in general categorical data sets. We frame the pattern detection problem as a search over subsets of data records and attributes, maximizing a nonparametric scan statistic... View Details
Keywords: Pattern Detection; Anomaly Detection; Knowledge Discovery; Bayesian Networks; Scan Statistics; Analytics and Data Science
McFowland III, Edward, Skyler Speakman, and Daniel B. Neill. "Fast Generalized Subset Scan for Anomalous Pattern Detection." Art. 12. Journal of Machine Learning Research 14 (2013): 1533–1561.
- April 2011
- Article
Improving Cancer Care Through Public Reporting Of Meaningful Quality Measures
By: Tracy E. Spinks, Ronald Walters, Thomas W. Feeley, Heidi Wied Albright, Victoria S. Jordan, John Bingham and Thomas W. Burke
Historically, quality measures for cancer have followed a different route than overall quality measures in the health care system. Many specialized cancer treatment centers were exempt from standard reporting on quality measures because of the complexity of cancer.... View Details
Keywords: Cancer; Quality Metrics; Public Reporting; Affordable Care Act; Quality; Health; Health Industry; North and Central America
Spinks, Tracy E., Ronald Walters, Thomas W. Feeley, Heidi Wied Albright, Victoria S. Jordan, John Bingham, and Thomas W. Burke. "Improving Cancer Care Through Public Reporting Of Meaningful Quality Measures." Health Affairs 30, no. 4 (April 2011): 664–672. (doi: 10.1377/hlthaff.2011.0089.)
- 2022
- Working Paper
TalkToModel: Explaining Machine Learning Models with Interactive Natural Language Conversations
By: Dylan Slack, Satyapriya Krishna, Himabindu Lakkaraju and Sameer Singh
Practitioners increasingly use machine learning (ML) models, yet they have become more complex and harder to understand. To address this issue, researchers have proposed techniques to explain model predictions. However, practitioners struggle to use explainability... View Details
Slack, Dylan, Satyapriya Krishna, Himabindu Lakkaraju, and Sameer Singh. "TalkToModel: Explaining Machine Learning Models with Interactive Natural Language Conversations." Working Paper, 2022.
- August 2018
- Article
The Effect of Graphic Warnings on Sugary-Drink Purchasing
By: Grant Donnelly, Laura Y. Zatz, Daniel Svirsky and Leslie John
Governments have proposed text warning labels to decrease consumption of sugary drinks – a contributor to chronic diseases like diabetes. However, they may be less effective than more evocative, graphic warning labels. We field-tested the effectiveness of graphic... View Details
Keywords: Policy Making; Preferences; Food; Health; Policy; Information; Labels; Consumer Behavior; Decision Making; Performance Effectiveness
Donnelly, Grant, Laura Y. Zatz, Daniel Svirsky, and Leslie John. "The Effect of Graphic Warnings on Sugary-Drink Purchasing." Psychological Science 29, no. 8 (August 2018): 1321–1333.
- December 2012 (Revised November 2014)
- Case
W.R. Grace & Co.: Dealing with Asbestos Torts
By: Stuart C. Gilson and Sarah L. Abbott
A manufacturer of building products and specialty chemicals, W. R. Grace & Co. filed for Chapter 11 bankruptcy in 2001 in response to a flood of lawsuits alleging that its products contained asbestos, and had caused hundreds of thousands of people to contract... View Details
Keywords: Bankruptcy Reorganization; Business Failures; Environmental Regulations; Class Action Lawsuits; Natural Environment; Valuation; Health Disorders; Capital Structure; Restructuring; Lawsuits and Litigation; Chemicals; Crisis Management; Insolvency and Bankruptcy; Legal Liability; Construction Industry; Chemical Industry; United States
Gilson, Stuart C., and Sarah L. Abbott. "W.R. Grace & Co.: Dealing with Asbestos Torts." Harvard Business School Case 213-046, December 2012. (Revised November 2014.)
- January–February 2022
- Article
Mobilizing the U.S. Military’s TRICARE Program for Value-Based Care: A Report From the Defense Health Board
By: Robert S. Kaplan, Paul R. Schaettle, Vivian S. Lee, Michael D. Parkinson, Gregory H. Gorman and Michael-Anne Browne
The U.S. Military Health System spends about $50 billion annually through its TRICARE health plans to provide care to 9.6 million active duty service members, retirees, and their families. TRICARE, historically, has used the predominant U.S. fee-for-service payment... View Details
Kaplan, Robert S., Paul R. Schaettle, Vivian S. Lee, Michael D. Parkinson, Gregory H. Gorman, and Michael-Anne Browne. "Mobilizing the U.S. Military’s TRICARE Program for Value-Based Care: A Report From the Defense Health Board." Military Medicine 187, nos. 1-2 (January–February 2022): 12–16.
- Winter 2019
- Article
Value-based Health Care: Lessons for the Anesthesiologist
By: J.A. Martin, B.L. Potter, T.F. Flanagan and T.W. Feeley
At one point or another in our life, we all become consumers of the health care industry. Indeed, health care affects everyone and encompasses a diverse set of services from childbirth, to illness prevention, to the management of chronic disease and end-of-life care.... View Details
Keywords: Value-based Health Care; Anesthesiologists; Health Care and Treatment; Value; Cost Management; Problems and Challenges; Health Industry; United States
Martin, J.A., B.L. Potter, T.F. Flanagan, and T.W. Feeley. "Value-based Health Care: Lessons for the Anesthesiologist." International Anesthesiology Clinics 57, no. 1 (Winter 2019): 63–80.
- November 2011 (Revised August 2012)
- Case
Healthymagination at GE Healthcare Systems
By: Vineet Kumar and V. Kasturi Rangan
Jeff Immelt, the CEO of GE, introduced a new innovation strategy named "healthymagination" in 2009. With cost, quality, and access as its three pillars, healthymagination ensures a strong focus for new product introduction efforts all around GE. But will this focus... View Details
Keywords: Innovation and Invention; Product Marketing; Marketing Strategy; Medical Devices and Supplies Industry; Health Industry
Kumar, Vineet, and V. Kasturi Rangan. "Healthymagination at GE Healthcare Systems." Harvard Business School Case 512-039, November 2011. (Revised August 2012.)
- September 2020
- Case
Enabling Teamwork at the Cleveland Clinic
By: Amy C. Edmondson and Michaela J. Kerrissey
This case examines efforts to foster teamwork within and across work units in the Cleveland Clinic, a large, distributed healthcare delivery organization. With a long history of valuing teamwork since its founding in 1921, the Clinic had taken dramatic steps to further... View Details
Keywords: Teamwork; Teaming; Health Care; Health Care and Treatment; Groups and Teams; Health Industry; United States
Edmondson, Amy C., and Michaela J. Kerrissey. "Enabling Teamwork at the Cleveland Clinic." Harvard Business School Case 621-040, September 2020.
- November 2009 (Revised January 2011)
- Case
International AIDS Vaccine Initiative
By: Allen S. Grossman and Cathy Ross
Dedicated to accelerating the development of a safe, effective, accessible, preventive HIV vaccine, the International AIDS Vaccine Initiative (IAVI) pioneered ways of addressing the inadequate incentive structures that prevented progress toward vaccines for AIDS and... View Details
Keywords: Developing Countries and Economies; Globalized Firms and Management; Health Care and Treatment; Health Disorders; Business and Government Relations; Partners and Partnerships; Research and Development; Social Enterprise; Health Industry
Grossman, Allen S., and Cathy Ross. "International AIDS Vaccine Initiative." Harvard Business School Case 310-015, November 2009. (Revised January 2011.)
- December 2006 (Revised August 2008)
- Case
Pervasis Therapeutics, Inc.
By: Robert F. Higgins and Virginia Fuller
In May 2005, Steve Bollinger was about to become president and chief operating officer of Pervasis Therapeutics, a small cell therapy start-up in Cambridge, Mass. If proven successful, Pervasis' product, Vascugel, could change the way vascular disease is treated and... View Details
Keywords: Business Startups; Venture Capital; Financial Strategy; Governing Rules, Regulations, and Reforms; Health Care and Treatment; Health Testing and Trials; Health Industry; Cambridge
Higgins, Robert F., and Virginia Fuller. "Pervasis Therapeutics, Inc." Harvard Business School Case 807-026, December 2006. (Revised August 2008.)
- March 2023 (Revised June 2025)
- Case
Close Concerns: Diabetes Research and Advocacy
By: Regina E. Herzlinger and Brian L. Walker
Diagnosed with diabetes at the age of 18, Kelly Close understood the importance of balancing consistency and iteration. This principle had also informed her professional work, which started with a rapid promotion from financial analyst at Goldman Sachs to an analyst... View Details
Keywords: Diabetes; Health; Health Care; Health Care And Treatment; Health Care Outcomes; Health Care Industry; Knowledge Dissemination; Outcome or Result; Equality and Inequality; Business Model; Entrepreneurship
Herzlinger, Regina E., and Brian L. Walker. "Close Concerns: Diabetes Research and Advocacy." Harvard Business School Case 323-047, March 2023. (Revised June 2025.)
- June 2002 (Revised November 2005)
- Case
Life, Death, and Property Rights: The Pharmaceutical Industry Faces AIDS in Africa
By: Debora L. Spar
In the final years of the 20th century, the world was hit by a plague of epidemic proportions--AIDS, a life-threatening disease that remained stubbornly immune to any cure or vaccine. In the developed nations of the West, AIDS was slowly brought under control through a... View Details
Keywords: Patents; Health Pandemics; Corporate Social Responsibility and Impact; Pharmaceutical Industry; Africa
Spar, Debora L., and Nick Bartlett. "Life, Death, and Property Rights: The Pharmaceutical Industry Faces AIDS in Africa." Harvard Business School Case 702-049, June 2002. (Revised November 2005.)
- May 2023 (Revised June 2023)
- Supplement
Novartis (C): Reimagining Medicine
By: Ramon Casadesus-Masanell, Claudio Feser, Karolin Frankenberger and David Redaschi
This case unfolds around the first-ever approved personalized cancer treatment, how Novartis wrapped it into a new business model design, and how Novartis scaled it. Novartis — one of the largest pharmaceutical companies in the world — is, among other ventures,... View Details
Keywords: Health Testing and Trials; Health Care and Treatment; Business Model; Problems and Challenges; Pharmaceutical Industry; Switzerland
Casadesus-Masanell, Ramon, Claudio Feser, Karolin Frankenberger, and David Redaschi. "Novartis (C): Reimagining Medicine." Harvard Business School Supplement 723-445, May 2023. (Revised June 2023.)
- 03 Apr 2009
- Working Paper Summaries
Applying the Care Delivery Value Chain: HIV/AIDS Care in Resource Poor Settings
- October 2012 (Revised October 2013)
- Case
Rock Health
By: Robert F. Higgins and Ian McKown Cornell
Rock Health was a San Francisco–based nonprofit organization offering accelerator services to spur innovation at the intersection of healthcare and technology. The company was the creation of Halle Tecco (HBS '11) and her HBS classmate Nate Gross (HBS '11), who met... View Details
Keywords: Innovation; Incubation; Healthcare Technology; Startups; Entrepreneurship; Innovation and Management; Health Care and Treatment; Business Startups; Health Industry; San Francisco; California; United States
Higgins, Robert F., and Ian McKown Cornell. "Rock Health." Harvard Business School Case 813-035, October 2012. (Revised October 2013.)
- July 2021 (Revised July 2022)
- Case
Brigham & Women's Hospital: Using Patient Reported Outcomes to Improve Breast Cancer Care
By: Robert S. Kaplan, Navraj S. Nagra and Syed S. Shehab
Dr. Andrea Pusic, breast cancer reconstruction surgeon, wants to extend outcomes measurement beyond traditional surgical metrics of infections, complications, and survival rates. The case describes her development of a new mobile phone app, which collects patients’... View Details
Keywords: Health Care and Treatment; Outcome or Result; Cost Management; Activity Based Costing and Management; Mobile and Wireless Technology; Health Testing and Trials; Surveys; Health Industry; Boston
Kaplan, Robert S., Navraj S. Nagra, and Syed S. Shehab. "Brigham & Women's Hospital: Using Patient Reported Outcomes to Improve Breast Cancer Care." Harvard Business School Case 122-010, July 2021. (Revised July 2022.)