Isolation - Publications - Faculty & Research

September 15, 2021
Article

Improving Deconvolution Methods in Biology Through Open Innovation Competitions: An Application to the Connectivity Map

By: Andrea Blasco, Ted Natoli, Michael G. Endres, Rinat A. Sergeev, Steven Randazzo, Jin Hyun Paik, N.J. Maximilian Macaluso, Rajiv Narayan, Xiaodong Lu, David Peck, Karim R. Lakhani and Aravind Subramanian

A recurring problem in biomedical research is how to isolate signals of distinct populations (cell types, tissues, and genes) from composite measures obtained by a single analyte or sensor. Existing computational deconvolution approaches work well in many specific... View Details

Keywords: Deconvolution; Methods; Open Innovation Competition; Genomics; Research; Innovation and Invention

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2021
Working Paper

rTSR: Properties, Determinants, and Consequences of Benchmark Choice

By: Paul Ma, Jee-Eun Shin and Charles C.Y. Wang

We develop a measurement-error framework for assessing the quality of relative-performance metrics designed to filter out the systematic component of performance and analyze relative total shareholder return (rTSR)—the predominant metric market participants use to... View Details

Keywords: Relative TSR; Relative Performance Evaluation; Systematic Risk; Board Of Directors; Compensation Consultants; Style Effects; Executive Compensation; Performance Evaluation; Corporate Governance

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2009
Book

Let Me Explain: Eugene G. Fubini's Life in Defense of America

By: David G. Fubini

There is no necessary relationship between fame and power, and great influence is often wielded in willful obscurity. So it was with the irascible, indomitable Eugene Fubini. A physics prodigy who fled Italy when the fascists came to power, his searing intelligence and... View Details

Keywords: Biography; Personal Development and Career; National Security; United States

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February 2017
Article

Resident Networks and Corporate Connections: Evidence from World War II Internment Camps

By: Lauren Cohen, Umit Gurun and Christopher J. Malloy

We demonstrate that simply by using the ethnic makeup surrounding a firm’s location, we can predict, on average, which trade links are valuable for firms. Using customs and port authority data on the international shipments of all U.S. publicly traded firms, we show... View Details

Keywords: Information Networks; Trade Links; Firm Behavior; Networks; Geographic Location; Ethnicity; Organizations; Trade

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26 Apr 2012
Working Paper Summaries

What Makes a Critic Tick? Connected Authors and the Determinants of Book Reviews

Keywords: by Loretti I. Dobrescu, Michael Luca & Alberto Motta; Information; Publishing

2006
Case

Strategies for Preventing a Knowledge-Loss Crisis

When employees leave an organization, they depart with more than what they know; they also leave with critical knowledge about who they know. Thus, the departure of key people can significantly affect the relationship structure and consequent functioning of an... View Details

Keywords: Analytics; Networks; Knowledge Management; Resignation and Termination

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20 Mar 2008
Working Paper Summaries

Sell Side School Ties

Keywords: by Lauren H. Cohen, Andrea Frazzini & Christopher J. Malloy; Financial Services

2020
Working Paper

How Competition Affects Contributions to Open Source Platforms: Evidence from OpenStreetMap and Google Maps

By: Abhishek Nagaraj and Henning Piezunka

Open source platforms often face competition from commercial alternatives and yet we lack an understanding of whether and how commercial competition affects contributions to open source platforms. We study how contributions to OpenStreetMap, a widely-used open source... View Details

Keywords: Open Source Platforms; Contributions; Competitive Entry; Impact; Multi-Sided Platforms; Competition

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We present evidence that high concentration in mortgage lending reduces the sensitivity of mortgage rates and refinancing activity to mortgage-backed security (MBS) yields. We isolate the direct effect of concentration and rule out alternative explanations in two ways.... View Details

Web

Faculty & Research

isolate the direct effects of tariff changes across product categories and trading partners. Our analysis reveals rapid pricing responses, though their magnitude remains modest relative to the announced tariff rates and varies by country... View Details

06 Jan 2015
Working Paper Summaries

Henry A. Kissinger as Negotiator: Background and Key Accomplishments

Keywords: by James Sebenius & Laurence A. Green

24 Jan 2024
Op-Ed

Why Boeing’s Problems with the 737 MAX Began More Than 25 Years Ago

in design and production with its newest jumbo jet, the 787 Dreamliner. Such frequent, repeated crises point to a deeper issue than isolated engineering mishaps. The underlying cause of these issues is a leadership failure that has... View Details

Keywords: by Bill George; Air Transportation; Transportation; Aerospace

21 Jan 2014
First Look

First Look: January 21

Publications August 2013 Journal of Economic Behavior & Organization Awards Unbundled: Evidence from a Natural Field Experiment By: Ashraf, Nava, Oriana Bandiera, and Scott Lee Abstract—Organizations often use non-monetary awards to incentivize performance. Awards... View Details

Keywords: Sean Silverthorne

31 Mar 2010
Working Paper Summaries

When Open Architecture Beats Closed: The Entrepreneurial Use of Architectural Knowledge

Keywords: by Carliss Y. Baldwin

17 Jan 2008
Working Paper Summaries

Competition in Modular Clusters

Keywords: by Carliss Y. Baldwin & C. Jason Woodard; Consulting; Communications; Telecommunications; Pharmaceutical

Research Summary

Research

Professor Karmarkar's research in consumer behavior develops theory-driven frameworks “from the brain up”. In particular, using a combination of consumer psychology, behavioral economics, and insights from neuroscience, she investigates the factors that consciously... View Details

Do Networks Help People To Manage Poverty?

Social support networks can provide much-needed emotional, material, and financial help for people living in poverty, yet little is known about how social capital is created and augmented within such networks. Further, these networks can be eroded by sustained... View Details

December 2013
Case

Bruce Allyn: Negotiating with the KGB (A)

By: James K. Sebenius

Isolated by the KGB in Moscow, Harvard graduate student Bruce Allyn faces high-pressure negotiation tactics to recruit him for the Soviet spy agency. At the tense height of the Cold War, with CIA agents systematically being exposed and executed in Russia, Allyn was... View Details