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      • March 2021
      • Supplement

      Facebook's Libra (B): The Privatization of Money?

      By: Marco Di Maggio, Ethan Rouen, George Serafeim and Amy Klopfenstein
      This case addresses the events that took place following the conclusion of the case “Facebook’s Libra (A): The Privatization of Money?” In October 2019, several months after the conclusion of the A case, multiple members of the Libra Association announced that they... View Details
      Keywords: Blockchain; Cryptocurrency; Accounting; Economics; Money; Governance; Governing and Advisory Boards; Policy; Governance Controls; Innovation and Invention; Innovation Strategy; Technological Innovation; Disruptive Innovation; Information Technology; Digital Platforms; Information Infrastructure; Technology Industry; Europe; Switzerland; United States; California
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      Di Maggio, Marco, Ethan Rouen, George Serafeim, and Amy Klopfenstein. "Facebook's Libra (B): The Privatization of Money?" Harvard Business School Supplement 121-055, March 2021.
      • February 2021 (Revised June 2023)
      • Case

      Henry Ford: Changing the World

      By: Robert Simons and Max Saffer
      This case traces the rise of Henry Ford from a small farm in Michigan to the controlling shareholder of the Ford Motor Company. The case describes how Ford, as young man, acquired engineering skills and the risks he took as he built and marketed one of the first... View Details
      Keywords: Technology; Entrepreneurship; Personal Characteristics; Business Startups; Management; Success; Values and Beliefs; Technological Innovation; Personal Development and Career; Auto Industry; United States; Michigan
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      Simons, Robert, and Max Saffer. "Henry Ford: Changing the World." Harvard Business School Case 121-063, February 2021. (Revised June 2023.)
      • February 2021
      • Case

      Digital Manufacturing at Amgen

      By: Shane Greenstein, Kyle R. Myers and Sarah Mehta
      This case discusses efforts made by biotechnology (biotech) company Amgen to introduce digital technologies into its manufacturing processes. Doing so is complicated by the fact that the process for manufacturing biologics—or therapeutics made from living cells—is... View Details
      Keywords: Digital Technologies; Change; Change Management; Decision Making; Cost vs Benefits; Decisions; Information; Analytics and Data Science; Innovation and Invention; Innovation and Management; Innovation Leadership; Innovation Strategy; Technological Innovation; Jobs and Positions; Knowledge; Leadership; Organizational Culture; Science; Strategy; Information Technology; Technology Adoption; Biotechnology Industry; Pharmaceutical Industry; United States; California; Puerto Rico; Rhode Island
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      Greenstein, Shane, Kyle R. Myers, and Sarah Mehta. "Digital Manufacturing at Amgen." Harvard Business School Case 621-008, February 2021.
      • February 2021
      • Article

      Do Household Wealth Shocks Affect Productivity? Evidence from Innovative Workers During the Great Recession

      By: S. Bernstein, T. McQuade and R. Townsend
      We investigate how the deterioration of household balance sheets affects worker productivity, and, in turn, economic downturns. Specifically, we compare the output of innovative workers who experienced differential declines in housing wealth during the financial crisis... View Details
      Keywords: Great Recession; Household; Financial Condition; System Shocks; Employees; Performance Productivity
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      Bernstein, S., T. McQuade, and R. Townsend. "Do Household Wealth Shocks Affect Productivity? Evidence from Innovative Workers During the Great Recession." Journal of Finance 76, no. 1 (February 2021): 57–111.
      • Article

      Variety of Innovation in Global Value Chains

      By: Giulio Buciuni and Gary P. Pisano
      This article analyzes how the geography and organization of pre- and production stages in Global Value Chains (GVC) contribute to lead firms' innovation development. A novel approach in GVC studies is introduced based on transaction cost economics (TCE) and the... View Details
      Keywords: GVC; Global Value Chains; Manufacturing; Production; Global Range; Innovation and Invention
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      Buciuni, Giulio, and Gary P. Pisano. "Variety of Innovation in Global Value Chains." Art. 101167. Journal of World Business 56, no. 2 (February 2021).
      • January 2021 (Revised August 2021)
      • Case

      ByteDance: TikTok and the Trials of Going Viral

      By: William C. Kirby and John P. McHugh
      In 2020, TikTok became the most valuable start-up ever. The short-form, video-sharing social media platform emerged as the crown jewel of the Chinese technology firm ByteDance, realizing 850 million monthly users and an estimated worth of $180 billion. However, a... View Details
      Keywords: China; Technology; Startup; Start-up; International Strategy; Global Strategy And Leadership; Innovation; Political Risk; Regulations; Trump; Foreign Policy; Foreign Investment; Chinese Internet Market; Global Strategy; Crisis Management; Risk and Uncertainty; Entrepreneurship; Globalized Economies and Regions; Government Legislation; Innovation and Management; Governing Rules, Regulations, and Reforms; Internet and the Web; Social Media; Technology Industry; China; United States
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      Kirby, William C., and John P. McHugh. "ByteDance: TikTok and the Trials of Going Viral." Harvard Business School Case 321-110, January 2021. (Revised August 2021.)
      • Article

      Healthy Buildings in 2070

      By: John D. Macomber and Joseph G. Allen
      Fifty years seems a very long time in the future for most industries. Not so in buildings and real estate; built structures routinely last decades if not hundreds of years, as long as they are economically competitive. Any discussion of the 50-year future has to... View Details
      Keywords: Health & Wellness; Real Estate; Architectural Innovation; Public Health; Health; Buildings and Facilities; Well-being
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      Macomber, John D., and Joseph G. Allen. "Healthy Buildings in 2070." The Bridge 50, no. S (Winter 2020): 11–14. (Special 50th Anniversary Issue edited by Ronald M. Latanision.)
      • 2020
      • Working Paper

      Short-Termism, Shareholder Payouts, and Investment in the EU

      By: Jesse M. Fried and Charles C.Y. Wang
      Investor-driven “short-termism” is said to harm EU public firms' ability to invest for the long term, prompting calls for the EU to better insulate managers from shareholder pressure. But the evidence offered—in the form of rising levels of repurchases and dividends—is... View Details
      Keywords: Short-termism; Quarterly Capitalism; EU; Dividends; Equity Issuances; Equity Compensastion; Capital Flows; Capital Distribution; R&D; Innovation; Investment; Corporate Governance; Investment Return; Acquisition; European Union
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      Fried, Jesse M., and Charles C.Y. Wang. "Short-Termism, Shareholder Payouts, and Investment in the EU." Harvard Business School Working Paper, No. 21-054, October 2020.
      • September 2020
      • Case

      Chip and Joanna Gaines' Magnolia Network

      By: Anita Elberse and Julia McNicholas
      Chip and Joanna Gaines, who have shot to fame as stars of the hit television show Fixer Upper, are preparing to launch their own television network. It is April 2019, a year since the home-renovation show Fixer Upper’s fifth season on cable channel HGTV ended, and more... View Details
      Keywords: Entertainment; Television; Superstars; Innovation; Creative Industries; Talent; General Management; Celebrities; Television Entertainment; Entrepreneurship; Joint Ventures; Innovation and Invention; Marketing; Strategy; Entertainment and Recreation Industry; Entertainment and Recreation Industry
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      Elberse, Anita, and Julia McNicholas. "Chip and Joanna Gaines' Magnolia Network." Harvard Business School Case 521-044, September 2020.
      • 2024
      • Working Paper

      Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances

      By: Amar Bhidé and Srikant M. Datar
      In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works, 2) the foundational advances and discoveries, 3) the... View Details
      Keywords: Immunotherapy; Health Care and Treatment; Innovation and Invention; Research and Development; Governing Rules, Regulations, and Reforms
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      Bhidé, Amar, and Srikant M. Datar. "Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 21-035, August 2020. (Revised May 2024.)
      • September 2020
      • Article

      Regulatory Sandboxes: A Cure for mHealth Pilotitis?

      By: Abhishek Bhatia, Rahul Matthan, Tarun Khanna and Satchit Balsari
      Mobile health (mHealth) and related digital health interventions in the past decade have not always scaled globally as anticipated earlier despite large investments by governments and philanthropic foundations. The implementation of digital health tools has suffered... View Details
      Keywords: COVID-19; mHealth; Digital Health; Design Thinking; Regulation; Intervention; Regulatory Sandbox; Health Care and Treatment; Technological Innovation; Design; Governing Rules, Regulations, and Reforms; India
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      Bhatia, Abhishek, Rahul Matthan, Tarun Khanna, and Satchit Balsari. "Regulatory Sandboxes: A Cure for mHealth Pilotitis?" Journal of Medical Internet Research 22, no. 9 (September 2020).
      • 2020
      • Working Paper

      Updating the Balanced Scorecard for Triple Bottom Line Strategies

      By: Robert S. Kaplan and David McMillan
      Many companies are now attempting to achieve triple bottom line performance on financial, environmental, and societal metrics. Successful strategies for such performance, however, generally require new relationships among multiple players in multiple sectors across a... View Details
      Keywords: Balanced Scorecard; Adaptation; Environmental Sustainability; Social Issues; Performance; Strategy
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      Kaplan, Robert S., and David McMillan. "Updating the Balanced Scorecard for Triple Bottom Line Strategies." Harvard Business School Working Paper, No. 21-028, August 2020.
      • Article

      Active World Model Learning with Progress Curiosity

      By: Kuno Kim, Megumi Sano, Julian De Freitas, Nick Haber and Daniel Yamins
      World models are self-supervised predictive models of how the world evolves. Humans learn world models by curiously exploring their environment, in the process acquiring compact abstractions of high bandwidth sensory inputs, the ability to plan across long temporal... View Details
      Keywords: World Models; Mathematical Methods
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      Kim, Kuno, Megumi Sano, Julian De Freitas, Nick Haber, and Daniel Yamins. "Active World Model Learning with Progress Curiosity." Proceedings of the International Conference on Machine Learning (ICML) 37th (2020).
      • 2024
      • Working Paper

      Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances

      By: Amar Bhidé, Srikant Datar and Katherine Stebbins
      This case history describes the development of three generations of cephalosporins – antibiotics that have significantly reduced hospital infections. Specifically, we chronicle how: 1) Early (pre-cephalosporin) antibiotics were developed in the first half of the 20th... View Details
      Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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      Bhidé, Amar, Srikant Datar, and Katherine Stebbins. "Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-133, July 2020. (Revised May 2024.)
      • 2024
      • Working Paper

      Prozac—Controversial Blockbuster: Case Histories of Transformational Advances

      By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
      This case history describes the development of Prozac, a blockbuster drug that transformed the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we chronicle the: 1) prior treatments for depression and the research that... View Details
      Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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      Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Prozac—Controversial Blockbuster: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-135, July 2020. (Revised May 2024.)
      • 2024
      • Working Paper

      Tamoxifen—Reducing Breast Cancer Risks: Case Histories of Transformational Advances

      By: Amar Bhidé, Srikant Datar and Katherine Stebbins
      We describe the development of tamoxifen, considered a “gold standard” treatment for millions of breast cancer patients. Specifically, we describe breast cancer treatments before tamoxifen’s development; the initial development of tamoxifen from 1960 to 1973;... View Details
      Keywords: Health Care and Treatment; Technological Innovation; Innovation and Invention; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Governing Rules, Regulations, and Reforms
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      Bhidé, Amar, Srikant Datar, and Katherine Stebbins. "Tamoxifen—Reducing Breast Cancer Risks: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-134, July 2020. (Revised May 2024.)
      • June 2020 (Revised February 2021)
      • Case

      Accounting for Leases at American Airlines (A)

      By: Jonas Heese, Gerardo Pérez Cavazos and Julia Kelley
      In March 2020, as coronavirus reduced demand for air travel, an analyst was forecasting American Airlines’ (American’s) first quarter financial results. To develop a forecast, she needed to familiarize herself with Accounting Standards Update (ASU) 2016-02, “Leases... View Details
      Keywords: Accounting; Financial Reporting; Financial Statements; Finance; Governance; Corporate Accountability; Corporate Governance; Governing Rules, Regulations, and Reforms; Governing and Advisory Boards; Leasing; Accounting Industry; Air Transportation Industry; North and Central America; United States
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      Heese, Jonas, Gerardo Pérez Cavazos, and Julia Kelley. "Accounting for Leases at American Airlines (A)." Harvard Business School Case 120-069, June 2020. (Revised February 2021.)
      • March 2020 (Revised June 2022)
      • Case

      GreenLight Fund

      By: Brian Trelstad, Julia Kelley and Mel Martin
      As Tara Noland, the Executive Director (ED) of GreenLight Cincinnati, reflected on her first few years on the job. Noland had delivered on what she had been hired to do in the city: work with leading philanthropists and nonprofit executives to use data and evidence to... View Details
      Keywords: Philanthropy; Venture Philanthropy; Replication; Philanthropy and Charitable Giving; Venture Capital; Social Issues; Decision Making; Analytics and Data Science; Cincinnati
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      Trelstad, Brian, Julia Kelley, and Mel Martin. "GreenLight Fund." Harvard Business School Case 320-053, March 2020. (Revised June 2022.)
      • March 2020
      • Article

      A Revolution in Economics? It's Just Getting Started...

      By: Shawn A. Cole, William Pariente and Anja Sautmann
      We have each experienced thrills and pain while supporting the mission of the Abdul Latif Jameel Poverty Action Lab, which facilitated many of the experiments described in the 2019 Nobel Prize citation. J-PAL in many ways seeks to fulfill what Angrist and Pischke... View Details
      Keywords: Randomized Control Trials; Economics; Research; Innovation and Invention
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      Cole, Shawn A., William Pariente, and Anja Sautmann. "A Revolution in Economics? It's Just Getting Started..." Art. 104849. World Development 127 (March 2020).
      • 2020
      • Book

      Experimentation Works: The Surprising Power of Business Experiments

      By: Stefan Thomke
      Don’t fly blind. See how the power of experiments works for you. When it comes to improving customer experiences, trying out new business models, or developing new products, even the most experienced managers often get it wrong. They discover that intuition,... View Details
      Keywords: Experimentation; Experiments; Market Research; Innovation and Invention; Innovation and Management; Customers; Research
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      Thomke, Stefan. Experimentation Works: The Surprising Power of Business Experiments. Boston, MA: Harvard Business Review Press, 2020.
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