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September 2024
Case

Myeloma Investment Fund

By: Kyle Myers and Scott Sawaya

This case explores a critical decision facing the Myeloma Investment Fund (MIF) as it evaluates two investment opportunities aimed at accelerating a cure for multiple myeloma.

The MIF, a venture philanthropy fund, must choose between two distinct paths. One... View Details

Keywords: Venture Philanthropy; Biomedical Research; Investing For Impact; Innovation ＆ Entrepreneurship; Venture Capital; Science-Based Business; Philanthropy and Charitable Giving; Decision Making; Health Care and Treatment; Biotechnology Industry; Pharmaceutical Industry

September 9, 2024
Article

Ten Questions for a Winning Climate-transition Business Strategy

By: George Serafeim

The move to a low-carbon economy will create opportunities for innovation and growth. To make the most of them, leaders must understand the challenges they could face along the way. View Details

Keywords: Technology; Organizational Transformations; Business Model Innovation; Innovation and Invention; Climate Change; Transformation; Leadership; Business Strategy; Environmental Sustainability; Change Management; Entrepreneurship

September–October 2024
Article

Where Data-Driven Decision-Making Can Go Wrong

By: Michael Luca and Amy C. Edmondson

When considering internal data or the results of a study, often business leaders either take the evidence presented as gospel or dismiss it altogether. Both approaches are misguided. What leaders need to do instead is conduct rigorous discussions that assess any... View Details

Keywords: Information; Analytics and Data Science; Analysis; Decision Making

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August 2024
Case

Iogen: Decarbonizing Hard-to-Abate Sectors

By: George Serafeim, Charlotte Foody and John Mulliken

Brian Foody, CEO of Iogen Corporation, was an early leader in advanced biofuels, developing a range of technologies to transform agricultural waste into transportation fuel. With $100 million in revenue and 350 patents across various biofuel technologies, Iogen was... View Details

Keywords: Technology; Biofuel; Market Attractiveness; Decarbonization; Technological Innovation; Climate Change; Energy; Environmental Sustainability; Transformation; Market Entry and Exit; Strategy; Energy Industry; United States; United Kingdom

August 2024 (Revised November 2024)
Case

Commonwealth Fusion Systems: Born at Scale

By: Joshua Lev Krieger, Jim Matheson, Kyle Myers, Gunnar Trumbull and Richard Vietor

This case study chronicles the journey of Commonwealth Fusion Systems (CFS) on its ambitious mission to commercialize fusion energy and become the world’s leading provider of fusion power plants. Emerging from a “special arrangement” with MIT's Plasma Science and... View Details

Keywords: Nuclear Energy; Innovation; Entrepreneurship; Entrepreneurial Finance; Energy Generation; Commercialization; Science-Based Business; Technological Innovation; Market Entry and Exit; Energy Industry

July 2024
Case

ZEISS: Commercializing Science

By: Maria P. Roche, Carlota Moniz and Daniela Beyersdorfer

Karl Lamprecht, President and CEO of the ZEISS AG Group, mused on how far ZEISS had come in 175 years of being a pioneer in optics, and how the course he had charted since taking the helm of the company could keep it on track. In his role, he oversaw the four core... View Details

June 2024
Simulation

Vehicle Lifecycle Emissions Calculator

By: Mike Toffel, Shirley Lu and George Serafeim

This Vehicle Lifecycle Emissions Calculator calculates the greenhouse gas emissions over the lifespan of internal combustion engine (ICEs) vehicles, battery electric vehicles (BEVs), and plug-in hybrid electric vehicles (PHEV), including those associated with their... View Details

Keywords: Decarbonization; Environment; Carbon Accounting; Carbon; Carbon Abatement; Electric Vehicles; Automobiles; Environmental Accounting; Environmental Management; Environmental Sustainability; Strategy; Technological Innovation; Supply Chain; Business and Stakeholder Relations; Climate Change; Transportation; Transportation Industry; Auto Industry; Battery Industry

June 2024
Case

Arete Research on Unity Software

By: Joseph Pacelli and Tonia Labruyere

Richard Kramer had founded Arete Research, an independent financial research provider, in 2000 after a successful career as a sell-side analyst at Goldman Sachs. He reflects on his team's coverage of Unity Software, a U.S.-based mobile games software company, that... View Details

Keywords: Analysis; Initial Public Offering; Analytics and Data Science; Applications and Software; Mobile and Wireless Technology; Valuation; Value Creation; Mergers and Acquisitions; Business Model; Reports; Financial Services Industry; Video Game Industry; United Kingdom; United States

June 2024 (Revised December 2024)
Case

Climate Governance at Linde plc (A)

By: Lynn S. Paine, Suraj Srinivasan, Emilie Billaud and Vincent Dessain

In July 2023, the Linde plc board of directors' sustainability committee convened in London to review the company's environmental performance, with a focus on decarbonization and clean energy. Linde was the world's largest industrial gas supplier, with a workforce of... View Details

Keywords: Climate Change; Environmental Sustainability; Green Technology; Multinational Firms and Management; Corporate Accountability; Corporate Disclosure; Corporate Governance; Governing and Advisory Boards; Compensation and Benefits; Innovation Strategy; Leading Change; Goals and Objectives; Business and Shareholder Relations; Chemical Industry; United States; Germany; Europe; North America; London

June 2024
Supplement

Climate Governance at Linde plc (B)

By: Lynn S. Paine, Suraj Srinivasan, Emilie Billaud and Vincent Dessain

In July 2023, the Linde plc board of directors' sustainability committee convened in London to review the company's environmental performance, with a focus on decarbonization and clean energy. Linde was the world's largest industrial gas supplier, with a workforce of... View Details

May 2024
Teaching Note

Vineyard Wind Starts Spinning (A): Overcoming Onshore Challenges to Offshore Wind

By: Rosabeth Moss Kanter and Jacob A. Small

Teaching Note for HBS Case No. 324-113. To activate the first wind turbines in the ocean off Martha’s Vineyard eventually supplying clean energy to 400,000 households, Vineyard Wind’s leaders had to navigate the permitting process, numerous delays, and objections from... View Details

Keywords: Joint Ventures; Renewable Energy; Corporate Social Responsibility and Impact; Business and Stakeholder Relations; Environmental Sustainability; Energy Industry; Massachusetts; Martha's Vineyard; New Bedford

May 2024
Case

Pernod Ricard: Uncorking Digital Transformation

By: Iavor Bojinov, Edward McFowland III, François Candelon, Nikolina Jonsson and Emer Moloney

This case study explores the opportunities and challenges of the digital transformation journey of French wine and spirits company Pernod Ricard. As part of the transformation, the company launched four key digital programs (KDPs) aimed at using data and artificial... View Details

Keywords: Business Organization; Business Divisions; Talent and Talent Management; Global Strategy; AI and Machine Learning; Analytics and Data Science; Digital Transformation; Digital Strategy; Advertising; Sales; Organizational Culture; Product Development; Decision Making; Technology Adoption; Alignment; Expansion; Food and Beverage Industry; France; Europe

April 2024
Supplement

Recycle & Re-Match: The Future of Soccer Turfs

By: George Serafeim

April 2024 (Revised August 2024)
Case

The Engine

By: Joshua Lev Krieger, Jim Matheson, Fiona Murray and Nicholas Christman

The Engine, a venture capital firm founded by MIT to fill a gap in the technology funding landscape by commercializing breakthrough science and technology. Led by managing partner and CEO Katie Rae, the Engine's unique approach involved an unusually longer fund life,... View Details

Keywords: Growth and Development Strategy; Mission and Purpose; Venture Capital; Business Startups; Entrepreneurial Finance; Financial Services Industry

April 2024 (Revised November 2024)
Case

Moderna: Pioneering a People Platform to Accelerate Science Innovation

By: Tatiana Sandino, Emil Dy and Samuel Grad

Moderna was founded in 2010 to explore how messenger ribonucleic acid (mRNA) could be used to create breakthrough medicines by encoding instructions for the body to create antibodies. When Stéphane Bancel (HBS 2000) took over in 2011, he bet on the potential of this... View Details

Keywords: Disruptive Innovation; Talent and Talent Management; Selection and Staffing; AI and Machine Learning; Digital Strategy; Innovation and Management; Leadership Development; Management Practices and Processes; Management Systems; Organizational Culture; Performance Evaluation; Alignment; Employee Relationship Management; Science-Based Business; Expansion; Pharmaceutical Industry; Biotechnology Industry; United States

March 2024 (Revised July 2025)
Supplement

Miracle Therapeutics (B)

By: Satish Tadikonda, William Marks and Wendi Yajnik

Supplements the (A) case. Following on the negotiations detailed in the Miracle Therapeutics (A) case, Beth Sharp and Jennifer Brilliant from Miracle Therapeutics face new challenges with their company's funding and intellectual property (IP) after several missteps.... View Details

Keywords: Business Startups; Financing and Loans; Intellectual Property; Problems and Challenges; Business or Company Management

March 2024
Case

Biomanufacturing Decentralization by Stämm

By: Paul A. Gompers, Jenyfeer Martínez Buitrago and Mariana Cal

In Buenos Aires, Argentina, cousins Llamazares and D’Alvia founded Stämm, a startup based on the idea of decentralizing biomanufacturing processes and downsizing biotech facilities. After raising its seed and series A rounds, and while finalizing its series B round in... View Details

Keywords: Business Model; Business Startups; Entrepreneurship; Venture Capital; Selection and Staffing; Technological Innovation; Science-Based Business; Business Strategy; Commercialization; Growth and Development Strategy; Product Launch; Research and Development; Biotechnology Industry; Latin America; South America; Argentina; Buenos Aires

March 2024
Case

From 'BIG' Ideas to Sustainable Impact at ICL Group (A)

By: Linda A. Hill and Lydia Begag

In the summer of 2023, Eduard (“Eddie”) Croitoru, Vice President (VP) of ICL Group (“ICL”) Corporate Initiatives, was reflecting on ICL’s internal ideation program, the Business Innovation for Growth (BIG) Accelerator. When Raviv Zoller became the CEO of ICL in 2018,... View Details

March 2024 (Revised April 2024)
Supplement

From 'BIG' Ideas to Sustainable Impact at ICL Group (B)

By: Linda A. Hill and Lydia Begag

In August 2023, Raviv Zoller, CEO of ICL Group, discussed his upcoming business trip to St. Louis with Eduard Croitoru, VP of ICL Corporate Initiatives, to commemorate the construction of ICL's new $400 million advanced manufacturing facility. In preparation for the... View Details

March 2024 (Revised April 2024)
Case

Out of Hand Theater: Monetizing Creativity

By: Christina Wallace, Henry McGee, Rohit Deshpandé and Max Hancock

Ariel Fristoe co-founded the Out of Hand Theater ensemble (OOH) in Atlanta in 2001. OOH began as a traditional theater nonprofit, which Ariel and her colleagues ran on a shoestring budget. But over the years, the group transformed: First, around 2010, OOH pivoted to... View Details

Keywords: Business Transformation; Theatre-company; Arts Marketing; Transformation; Theater Entertainment; Social Marketing; Business Model; Entertainment and Recreation Industry; Atlanta

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