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- All HBS Web
(300)
- News (58)
- Research (196)
- Multimedia (6)
- Faculty Publications (123)
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- November 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Safe and Cheap Diagnostics | Note on the Development of Ultrasound Scanning (through 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Safe and Cheap Diagnostics | Note on the Development of Ultrasound Scanning (through 2000)." Harvard Business School Technical Note 321-054, November 2020. (Revised May 2021.)
- March 2020
- Article
Diagnosing Missing Always at Random in Multivariate Data
By: Iavor I. Bojinov, Natesh S. Pillai and Donald B. Rubin
Models for analyzing multivariate data sets with missing values require strong, often assessable, assumptions. The most common of these is that the mechanism that created the missing data is ignorable—a twofold assumption dependent on the mode of inference. The first... View Details
Keywords: Missing Data; Diagnostic Tools; Sensitivity Analysis; Hypothesis Testing; Missing At Random; Row Exchangeability; Analytics and Data Science; Mathematical Methods
Bojinov, Iavor I., Natesh S. Pillai, and Donald B. Rubin. "Diagnosing Missing Always at Random in Multivariate Data." Biometrika 107, no. 1 (March 2020): 246–253.
- 2022
- Article
Nonparametric Subset Scanning for Detection of Heteroscedasticity
By: Charles R. Doss and Edward McFowland III
We propose Heteroscedastic Subset Scan (HSS), a novel method for identifying covariates that are responsible for violations of the homoscedasticity assumption in regression settings. Viewing the problem as one of anomalous pattern detection, we use subset scanning... View Details
Doss, Charles R., and Edward McFowland III. "Nonparametric Subset Scanning for Detection of Heteroscedasticity." Journal of Computational and Graphical Statistics 31, no. 3 (2022): 813–823.
- September 2013 (Revised August 2014)
- Case
Claritas Genomics
By: Robert F. Higgins and Matthew Preble
Claritas Genomics was formed in January 2013 when BCH spun out its Genetics Diagnostic Lab into a fully commercial entity. Claritas offered over 100 genomic tests to detect a range of conditions, including autism and intellectual disabilities, and was developing new... View Details
Keywords: Boston Children's Hospital; Genetic Engineering; Genetically Modified; Genetics Diagnostics; Health Care Industry; Healthcare IT; Healthcare Technology; Healthcare Ventures; Biomedical Research; Patrice Milos; Genomics; Genomic Testing; Life Technologies; Health Care and Treatment; Information Technology; Information Management; Genetics; Biotechnology Industry; Information Technology Industry; Health Industry; Boston; Massachusetts; United States
Higgins, Robert F., and Matthew Preble. "Claritas Genomics." Harvard Business School Case 814-032, September 2013. (Revised August 2014.)
- June 2005 (Revised March 2017)
- Teaching Note
Siebel Systems: Organizing for the Customer
By: Robert Simons
Teaching Note to (103-014). The Siebel Systems case describes the unusual accountability and organizing choices made by managers of a successful, rapidly growing software development company. The case is set in 2002, but details the critical decisions made by founder... View Details
- November 2014
- Teaching Note
Claritas Genomics
By: Robert F. Higgins and Matthew G. Preble
Dr. Patrice Milos is the first CEO of Claritas Genomics (Claritas) and she faces a number of challenges in scaling the young company. Claritas was formed around a lab spun out from Boston Children's Hospital (BCH) which had performed genomic tests for the hospital. Now... View Details
- June 2014 (Revised March 2017)
- Teaching Note
Agero: Enhancing Capabilities for Customers
By: Robert Simons and Natalie Kindred
This is the teaching note for Agero: Enhancing Capabilities for Customers (HBS No. 113-001) View Details
- December 2002
- Background Note
Simulation of Prices, Rates and Cash Flows (B)
Considers more advanced issues required for complete cash flow simulation, including residual diagnostics (to determine whether a process has been identified correctly), simulation of nonmarket risk variables, and real options. View Details
Shimko, David C. "Simulation of Prices, Rates and Cash Flows (B)." Harvard Business School Background Note 203-057, December 2002.
- 04 May 2007
- What Do You Think?
How Do Managers Think?
of the "ease with which relevant examples come to mind"). In his words, the diagnostic process is even "compromised by positive or negative feelings we have toward another person." Putting it bluntly, research has... View Details
Keywords: by Jim Heskett
- January 2017
- Case
Danaher Corporation, 2007–2017
By: John R. Wells and Gabriel Ellsworth
On July 2, 2016, Danaher Corporation completed the spinoff of Fortive Corporation. The previous day, Danaher’s stock price had reached an all-time high. In 2015, Danaher had decided to split off its test and measurement, fuel and fleet management, and automation... View Details
Keywords: Danaher; Fortive; Larry Culp; Beckman Coulter; Pall; Life Sciences; Diagnostics; Environmental Operations; Water Management; Dental; Testing; Measurement; Fuel; Fleet Management; Automation; Toolmaking; Tools; Disease Management; Continuous Improvement; Toyota Production System; Divestiture; Spinoffs; Spin-off; Networks; Acquisition; Mergers and Acquisitions; Business Conglomerates; Business Divisions; Business Subsidiaries; Business Units; Business Growth and Maturation; Business Model; For-Profit Firms; Joint Ventures; Restructuring; Engineering; Chemicals; Construction; Machinery and Machining; Profit; Revenue; Globalized Firms and Management; Multinational Firms and Management; Health; Health Care and Treatment; Health Disorders; Medical Specialties; Business History; Job Cuts and Outsourcing; Business or Company Management; Growth and Development Strategy; Management Analysis, Tools, and Techniques; Management Practices and Processes; Management Succession; Management Systems; Resource Allocation; Market Entry and Exit; Measurement and Metrics; Logistics; Business Processes; Organizational Change and Adaptation; Public Ownership; Problems and Challenges; Science; Genetics; Natural Environment; Wastes and Waste Processing; Science-Based Business; Opportunities; Strategy; Adaptation; Business Strategy; Competition; Competitive Strategy; Competitive Advantage; Consolidation; Corporate Strategy; Diversification; Expansion; Technology; Software; Technology Networks; Technology Platform; Value; Valuation; Aerospace Industry; Auto Industry; Biotechnology Industry; Chemical Industry; Computer Industry; Construction Industry; Consumer Products Industry; Distribution Industry; Electronics Industry; Food and Beverage Industry; Health Industry; Industrial Products Industry; Information Technology Industry; Manufacturing Industry; Medical Devices and Supplies Industry; Pharmaceutical Industry; Retail Industry; Rubber Industry; Semiconductor Industry; Shipping Industry; Technology Industry; Telecommunications Industry; Utilities Industry; United States; District of Columbia
Wells, John R., and Gabriel Ellsworth. "Danaher Corporation, 2007–2017." Harvard Business School Case 717-464, January 2017.
- 2021
- Working Paper
Real Credit Cycles
By: Pedro Bordalo, Nicola Gennaioli, Andrei Shleifer and Stephen J. Terry
We incorporate diagnostic expectations, a psychologically founded model of overreaction to news, into a workhorse business cycle model with heterogeneous firms and risky debt. A realistic degree of diagnosticity, estimated from the forecast errors of managers of U.S.... View Details
Bordalo, Pedro, Nicola Gennaioli, Andrei Shleifer, and Stephen J. Terry. "Real Credit Cycles." NBER Working Paper Series, No. 28416, January 2021.
- April 1989 (Revised October 2005)
- Case
James Burke: A Career in American Business (A)
By: Richard S. Tedlow and Wendy Smith
Presents an historical overview of the professional career of James E. Burke, chairman and CEO of Johnson & Johnson. Examines the corporation's handling of three major occurrences--the Tylenol poisonings in 1982 and 1986 and the acquisition and subsequent sale of... View Details
Keywords: Business History; Marketing Strategy; Ethics; Personal Development and Career; Crisis Management; Consumer Products Industry; Health Industry; United States
Tedlow, Richard S., and Wendy Smith. "James Burke: A Career in American Business (A)." Harvard Business School Case 389-177, April 1989. (Revised October 2005.)
- January 2011 (Revised March 2011)
- Case
Predictive Biosciences
By: Thomas R. Eisenmann, Jeffrey J. Bussgang and David Kiron
A small cancer diagnostics start-up is deciding whether to acquire a laboratory to make and sell its bladder cancer test or build its own manufacturing and sales team. View Details
Keywords: Mergers and Acquisitions; Factories, Labs, and Plants; Business Startups; Entrepreneurship; Health Testing and Trials; Growth and Development Strategy; Product Development; Biotechnology Industry
Eisenmann, Thomas R., Jeffrey J. Bussgang, and David Kiron. "Predictive Biosciences." Harvard Business School Case 811-015, January 2011. (Revised March 2011.)
- September 1997
- Case
Radiology Management Sciences
Radiology Management Sciences (RMS) analyzes diagnostic imaging claims to help HMOs and insurers control utilization. As industry changes threaten RMS's profitability, the company's founders contemplate two alternative business models. View Details
Corts, Kenneth S., and Grady M. Clouse. "Radiology Management Sciences." Harvard Business School Case 798-009, September 1997.
- January 2006 (Revised April 2007)
- Case
General Electric Healthcare, 2006
By: Tarun Khanna and Elizabeth Raabe
In January 2006, Joe Hogan, head of General Electric (GE) Healthcare Technologies, prepared to step into William Castell's shoes as CEO of GE Healthcare, the world's leading manufacturer of diagnostic imaging equipment. In 2004, former CEO Jeff Immelt acquired Amersham... View Details
Keywords: Corporate Entrepreneurship; Cost vs Benefits; Growth and Development Strategy; Mergers and Acquisitions; Machinery and Machining; Global Range; Multinational Firms and Management; Product Design; Technological Innovation; Expansion; Value Creation; Business Subsidiaries; Health Industry; Medical Devices and Supplies Industry
Khanna, Tarun, and Elizabeth Raabe. "General Electric Healthcare, 2006." Harvard Business School Case 706-478, January 2006. (Revised April 2007.)
- September 2014
- Case
Radiometer, 2013
By: John R. Wells and Galen Danskin
In 2013, Radiometer continued to lead the world in blood gas analysis equipment and accessories, selling direct and through distributors to hospital central laboratories, point-of-care locations, and non-hospital medical locations. Founded in 1935 and based in Denmark,... View Details
Keywords: Medical Devices; Medical Equipment ＆ Devices; Mergers ＆ Acquisitions; Strategic Analysis; Strategic Change; Family Business; Strategy; Mergers and Acquisitions; Medical Devices and Supplies Industry; Denmark; United States
Wells, John R., and Galen Danskin. "Radiometer, 2013." Harvard Business School Case 715-410, September 2014.
- Research Summary
Customer-Centric Marketing Strategy
By: Rohit Deshpande
Rohit Deshpandé's research program focuses on Customer-Centricity. A stream of projects examines the interaction between corporate and national culture as they influence the development and implementation of global marketing strategies in high performance firms. This... View Details
- April 1993 (Revised November 1994)
- Case
Chiron Corp.
Pablo Valenzuela, vice president of R&D at Chiron Corp., faces several choices for how to allocate scarce resources across several promising projects. These choices will determine Chiron's position in several emerging biotechnology and diagnostic markets, including... View Details
Keywords: Health Testing and Trials; Research and Development; Failure; Business Strategy; Joint Ventures; Strategic Planning; Opportunities; Product Development; Biotechnology Industry; California
Wheelwright, Steven C. "Chiron Corp." Harvard Business School Case 693-052, April 1993. (Revised November 1994.)
- October 2012
- Supplement
Aqua Bounty Courseware
By: Lucy White and Steve Burn-Murdoch
Valuation of a pre-revenue biotech company at IPO using probability trees and real option techniques. Company is based in Massachusetts and lists in London on AIM. Products are genetically-modified fast-growing salmon for fish farmers and disease-prevention drugs and... View Details
- October 2023 (Revised June 2024)
- Case
Revvity: A Symbol of Change
By: Satish Tadikonda and William Marks
After selling the PerkinElmer name and several ancillary business units, Prahlad Singh (CEO) and his team at the newly christened Revvity faced a challenge on how best to capitalize on the opportunities ahead for the business and emerge as winners within the Life... View Details
Tadikonda, Satish, and William Marks. "Revvity: A Symbol of Change." Harvard Business School Case 824-071, October 2023. (Revised June 2024.)