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  • All HBS Web  (5,476)
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    • News  (1,387)
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    • Multimedia  (58)
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  • July 2025
  • Case

The Future in Sight: LumineticsCore and the First Autonomous AI for Diagnostics

By: Michael Lingzhi Li and Tinglong Dai
After two decades of research, Dr. Michael Abramoff successfully launched LumineticsCore—the first autonomous AI system authorized by the FDA to diagnose diabetic retinopathy without physician oversight. The case traces his journey across algorithm design, clinical... View Details
Keywords: Healthcare; AI; Regulation; Medical Technology; Health Care and Treatment; AI and Machine Learning; Medical Specialties; Health Industry; Technology Industry; United States
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Li, Michael Lingzhi, and Tinglong Dai. "The Future in Sight: LumineticsCore and the First Autonomous AI for Diagnostics." Harvard Business School Case 626-019, July 2025.
  • Forthcoming
  • Article

Sending a Message: An Empirical Assessment of Responses to Punitive and Non-punitive Compliance Messaging Strategies

By: Jodi L. Short, Michael W. Toffel, Elizabeth A. Keenan and Melissa Ouellet
Regulators operate in an increasingly hostile political environment. The U.S. Supreme Court is ramping up efforts to curtail the authority of administrative agencies. The second election of Donald Trump to the presidency has unleashed a torrent of anti-regulatory... View Details
Keywords: Field Experiment; Compliance; Compliance Programs; Compliance Policies; Regulatory Enforcement; Environmental Regulation; Environmental Policy; Government Experimentation; Governance Compliance; Government Administration; Governing Rules, Regulations, and Reforms; Business and Government Relations; Construction Industry; Public Administration Industry; California; United States
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Short, Jodi L., Michael W. Toffel, Elizabeth A. Keenan, and Melissa Ouellet. "Sending a Message: An Empirical Assessment of Responses to Punitive and Non-punitive Compliance Messaging Strategies." Ecology Law Quarterly (forthcoming).
  • October 2014 (Revised June 2016)
  • Case

Barclays Bank, 2008

By: Lucy White, Steve Burn-Murdoch and Jerome Lenhardt
In the midst of the financial crisis, Barclays (the world's 4th largest bank by assets) is forced by UK regulators to raise more capital. Should it take up the UK government's offer to invest, or take funding from investors from the Middle East? Students may price the... View Details
Keywords: Government And Business; Option Contract; Corporate Finance; Bank Capital; Bank Regulation; Finance; Banking Industry; Europe; North and Central America
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White, Lucy, Steve Burn-Murdoch, and Jerome Lenhardt. "Barclays Bank, 2008." Harvard Business School Case 215-027, October 2014. (Revised June 2016.)
  • 2016
  • Article

The Mirroring Hypothesis: Theory, Evidence, and Exceptions

By: Lyra J. Colfer and Carliss Y. Baldwin
The mirroring hypothesis predicts that organizational ties within a project, firm, or group of firms (e.g., communication, collocation, employment) will correspond to the technical dependencies in the work being performed. This article presents a unified picture of... View Details
Keywords: Modularity; Mirroring Hypothesis; Organization Design; Conway's Law; Knowledge Boundaries; Relational Contracts; Open Source Software; Organizational Design; Organizational Structure; Boundaries; Knowledge Management; Applications and Software
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Colfer, Lyra J., and Carliss Y. Baldwin. "The Mirroring Hypothesis: Theory, Evidence, and Exceptions." Industrial and Corporate Change 25, no. 5 (2016): 709–738. (Lead Article.)
  • 04 Jun 2019
  • Working Paper Summaries

Political Influence and Merger Antitrust Reviews

Keywords: by Mihir N. Mehta, Suraj Srinivasan, and Wanli Zhao
  • May 2014
  • Supplement

Barclays Bank, 2008 - courseware

By: Lucy White
In the midst of the financial crisis, Barclays (the world's 4th largest bank by assets) is forced by UK regulators to raise more capital. Should it take up the UK government's offer to invest, or take funding from investors from the Middle East? Students may price the... View Details
Keywords: Government And Business; Option Contract; Corporate Finance; Bank Capital; Bank Regulation; Finance; Banking Industry; Europe; North and Central America
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White, Lucy. "Barclays Bank, 2008 - courseware." Harvard Business School Spreadsheet Supplement 214-707, May 2014.
  • October 2021
  • Article

Can Self-Regulation Save Digital Platforms?

By: Michael A. Cusumano, Annabelle Gawer and David B. Yoffie
This article explores some of the critical challenges facing self-regulation and the regulatory environment for digital platforms. We examine several historical examples of firms and industries that attempted self-regulation before the Internet. All dealt with similar... View Details
Keywords: Self-regulation; Government Regulation; Digital Platforms; Governing Rules, Regulations, and Reforms
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Cusumano, Michael A., Annabelle Gawer, and David B. Yoffie. "Can Self-Regulation Save Digital Platforms?" Industrial and Corporate Change 30, no. 5 (October 2021): 1259–1285.
  • 1980
  • Book

Environmental Politics and the Coal Coalition

By: Richard Vietor
Keywords: Environmental Regulation; Coal Mining; Industrial Policy; United States; United States
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Vietor, Richard. Environmental Politics and the Coal Coalition. Texas A&M University Press, 1980.
  • September 2015
  • Technical Note

The On-Demand Economy

By: Cynthia A. Montgomery, James Weber and Elizabeth Anne Watkins
This note describes the emerging on-demand economy, also referred to as the sharing economy. The note highlights several companies including Uber and Airbnb that exemplify this new mode of competition, a model that threatens to disrupt traditional firms. Uber provides... View Details
Keywords: Regulation; Reform; Disruption; Disruptive Innovation; Strategy; Technological Innovation; Labor; Employment; Working Conditions; Human Capital; Rights; Organizational Design; Social and Collaborative Networks; Service Industry
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Montgomery, Cynthia A., James Weber, and Elizabeth Anne Watkins. "The On-Demand Economy." Harvard Business School Technical Note 716-405, September 2015.
  • September 2013
  • Case

Homestrings, Inc.: Diaspora-Based Financing and the Crowd Funding of Development

By: William R. Kerr and Alexis Brownell
Homestrings is an online investment platform for overseas diasporas to link financially with their home countries. The founder believes crowd-funding can become a pillar for development, but U.S. regulatory hurdles and resources constraints are substantial. The company... View Details
Keywords: Diasporas; Investments; Regulations; Africa; Crowd-funding; Development Finance; Entrepreneurship; Business Growth and Maturation; Financial Services Industry; Africa; United States
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Kerr, William R., and Alexis Brownell. "Homestrings, Inc.: Diaspora-Based Financing and the Crowd Funding of Development." Harvard Business School Case 814-031, September 2013.
  • March 2019
  • Article

Antitrust as Speech Control

By: Hillary Greene and Dennis Yao
Antitrust law, at times, dictates who, when, and about what people can and cannot speak. It would seem then that the First Amendment might have something to say about those constraints. And it does, though perhaps less directly and to a lesser degree than one might... View Details
Keywords: Antitrust Law; First Amendment; Spoken Communication; Laws and Statutes
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Greene, Hillary, and Dennis Yao. "Antitrust as Speech Control." William & Mary Law Review 60, no. 4 (March 2019): 1215–1267.
  • January 2021 (Revised August 2021)
  • Case

ByteDance: TikTok and the Trials of Going Viral

By: William C. Kirby and John P. McHugh
In 2020, TikTok became the most valuable start-up ever. The short-form, video-sharing social media platform emerged as the crown jewel of the Chinese technology firm ByteDance, realizing 850 million monthly users and an estimated worth of $180 billion. However, a... View Details
Keywords: China; Technology; Startup; Start-up; International Strategy; Global Strategy And Leadership; Innovation; Political Risk; Regulations; Trump; Foreign Policy; Foreign Investment; Chinese Internet Market; Global Strategy; Crisis Management; Risk and Uncertainty; Entrepreneurship; Globalized Economies and Regions; Government Legislation; Innovation and Management; Governing Rules, Regulations, and Reforms; Internet and the Web; Social Media; Technology Industry; China; United States
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Kirby, William C., and John P. McHugh. "ByteDance: TikTok and the Trials of Going Viral." Harvard Business School Case 321-110, January 2021. (Revised August 2021.)
  • 2019
  • Working Paper

Golden Opportunity? Voluntary Sustainability Standards for Artisanal and Small-scale Gold Mining and the United Nations Sustainable Development Goals

By: Kristin Sippl
While much is known about voluntary sustainability standards' contributions to certain issues in certain sectors, less is known about their contributions to the realization of the United Nations Sustainable Development Goals (SDGs). This paper helps balance the... View Details
Keywords: Sustainability Standards; Gold; Certification; Eco-labeling; International Law; Extractive Industries; Fair Trade; United Nations; Sustainable Development; Environmental Sustainability; Standards; Adoption; Governance; Global Range; Luxury; Mining Industry
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Sippl, Kristin. "Golden Opportunity? Voluntary Sustainability Standards for Artisanal Mining and the United Nations Sustainable Development Goals." Harvard Business School Working Paper, No. 19-024, September 2018. (Revised April 2019. Revise and Resubmit.)
  • November 2012 (Revised January 2013)
  • Case

Companion Diagnostics: Uncertainties for Approval and Reimbursement

By: Richard G. Hamermesh, Norman C. Selby and Phillip Andrews
The FDA approvals of novel therapeutics were seen as signs in the personalized medicine community of real progress in the growth of personalized medicine. The FDA's approval of such drugs, along with companion diagnostics, suggested a shift in thinking and regulatory... View Details
Keywords: Models Of Reimbursement; Personalized Medicine; Regulation; Healthcare Reform; Health Care and Treatment; Health Industry; United States
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Hamermesh, Richard G., Norman C. Selby, and Phillip Andrews. "Companion Diagnostics: Uncertainties for Approval and Reimbursement." Harvard Business School Case 813-037, November 2012. (Revised January 2013.)
  • January 2022
  • Article

Pushed into a Crowd: Repositioning Costs, Resources, and Competition in the RTE Cereal Industry

By: Young Hou and Dennis Yao
This paper exploits a natural experiment involving self-regulation in the ready-to-eat (RTE) breakfast cereal industry to evaluate the performance impact of product repositioning. It then examines how a product's brand equity value declines with repositioning distance... View Details
Keywords: Positioning; Resources; Brand Equity; Competitive Dynamics; Non-market Strategy; Regulation; Repositioning; Product Positioning; Performance Evaluation; Brands and Branding; Competitive Strategy; Consumer Products Industry
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Hou, Young, and Dennis Yao. "Pushed into a Crowd: Repositioning Costs, Resources, and Competition in the RTE Cereal Industry." Strategic Management Journal 43, no. 1 (January 2022): 3–29.
  • November 2012 (Revised September 2013)
  • Case

Barclays Bank, 2008

By: Lucy White, Steve Burn-Murdoch and Jerome Lenhardt
In the midst of the financial crisis, Barclays (the world's 4th largest bank by assets) is forced by UK regulators to raise more capital. Should it take up the UK government's offer to invest, or take funding from investors from the Middle East? Students may price the... View Details
Keywords: Government And Business; Option Contract; Corporate Finance; Bank Capital; Bank Regulation; Finance; Banking Industry; Europe; North and Central America
Citation
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White, Lucy, Steve Burn-Murdoch, and Jerome Lenhardt. "Barclays Bank, 2008." Harvard Business School Case 213-073, November 2012. (Revised September 2013.)
  • September 2014 (Revised November 2014)
  • Case

Marketing Marijuana in Colorado

By: John A. Quelch and David Lane
Colorado's 2014 legalization of marijuana for adult recreational (not just medical) use created a new market that entrepreneurs rushed to enter, channeled by regulations that aimed to minimize marijuana's access to minors while not stifling the emergent new industry.... View Details
Keywords: Public Health; Regulation; Marijuana; Plant-Based Agribusiness; Public Sector; Entrepreneurship; Health Care and Treatment; Agriculture and Agribusiness Industry; Agriculture and Agribusiness Industry; Colorado
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Quelch, John A., and David Lane. "Marketing Marijuana in Colorado." Harvard Business School Case 515-009, September 2014. (Revised November 2014.)
  • 08 May 2020
  • Working Paper Summaries

Corporate Environmental Impact: Measurement, Data and Information

Keywords: by George Serafeim, DG Park, David Freiberg, and T. Robert Zochowski
  • October 2023
  • Article

Improving Regulatory Effectiveness Through Better Targeting: Evidence from OSHA

By: Matthew S. Johnson, David I. Levine and Michael W. Toffel
We study how a regulator can best target inspections. Our case study is a U.S. Occupational Safety and Health Administration (OSHA) program that randomly allocated some inspections. On average, each inspection averted 2.4 serious injuries (9%) over the next five years.... View Details
Keywords: Safety Regulations; Regulations; Regulatory Enforcement; Machine Learning Models; Safety; Operations; Service Operations; Production; Forecasting and Prediction; Decisions; United States
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Johnson, Matthew S., David I. Levine, and Michael W. Toffel. "Improving Regulatory Effectiveness Through Better Targeting: Evidence from OSHA." American Economic Journal: Applied Economics 15, no. 4 (October 2023): 30–67. (Profiled in the Regulatory Review.)
  • January 2022
  • Article

Global Behaviors, Perceptions, and the Emergence of Social Norms at the Onset of the COVID-19 Pandemic

By: Lukas Hensel, Marc Witte, Stefano Caria, Thiemo Fetzer, Stefano Fiorin, Friedrich M. Goetz, Margarita Gomez, Johannes Haushofer, Andriy Ivchenko, Gordon T. Kraft-Todd, Elena Reutskaja, Christopher Roth, Erez Yoeli and Jon M. Jachimowicz
We conducted a large-scale survey covering 58 countries and over 100,000 respondents between late March and early April 2020 to study beliefs and attitudes towards citizens' and governments' responses at the onset of the COVID-19 pandemic. Most respondents reported... View Details
Keywords: COVID-19; Government Regulation; Social Norms; Health Pandemics; Governing Rules, Regulations, and Reforms; Behavior; Perception; Global Range; Surveys
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Hensel, Lukas, Marc Witte, Stefano Caria, Thiemo Fetzer, Stefano Fiorin, Friedrich M. Goetz, Margarita Gomez, Johannes Haushofer, Andriy Ivchenko, Gordon T. Kraft-Todd, Elena Reutskaja, Christopher Roth, Erez Yoeli, and Jon M. Jachimowicz. "Global Behaviors, Perceptions, and the Emergence of Social Norms at the Onset of the COVID-19 Pandemic." Journal of Economic Behavior & Organization 193 (January 2022): 473–496.
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