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August 2025
Background Note

A Managerial Perspective on Clinical Trials

By: Arthur A. Daemmrich, Satish Tadikonda and William Marks

This note describes the history and regulation of clinical trials, managerial challenges related to pharmaceutical product testing, and current debates regarding prescription drug safety. Since clinical testing takes between five and seven years, and consumes up to 70... View Details

Keywords: Governing Rules, Regulations, and Reforms; Health Testing and Trials; Product Development; Safety; Biotechnology Industry; Pharmaceutical Industry

2025
Book

Concise Business Guide to Climate Change: What Managers, Executives, and Students Need to Know

By: J. Gunnar Trumbull

Understanding the ground rules of climate change for business.

Climate has changed the game for businesses around the world. With climate-related disasters costing billions in damages and public pressure rising, over a hundred nations joined... View Details

Keywords: Climate Change; Environmental Sustainability; Corporate Social Responsibility and Impact; Business or Company Management; Governing Rules, Regulations, and Reforms

June 2025
Case

Assessing the Offers for Seven & i Holdings

By: Benjamin C. Esty, Nobuo Sato and Akiko Kanno

In the fall of 2024, the board of Seven and i Holdings Company (7&i, the parent company of 7-Eleven convenience stores in the US, Japan, and other countries) received multiple offers to buy the company. Two successive (and unsolicited) offers came from Alimentation... View Details

Keywords: Corporate Governance; Valuation; Value Creation; Bids and Bidding; Financial Strategy; Negotiation Offer; Mergers and Acquisitions; Corporate Finance; Business Conglomerates; Leveraged Buyouts; Governing Rules, Regulations, and Reforms; Retail Industry; Food and Beverage Industry; Japan; Canada

June 2025
Case

Crossing Borders, Dividing Politics: U.S. Immigration Policy and Political Polarization

By: Marco Tabellini and Alexis Lefort

This case explores the history and political dynamics of U.S. immigration policy, focusing on its evolution from the 18th century to 2025. It traces key legislative milestones, such as the 1965 Immigration and Nationality Act, DACA, and the 2025 Laken Riley Act,... View Details

Keywords: Immigration; National Security; Government Legislation; United States

June 2025
Article

Unregulated Emotional Risks of AI Wellness Apps

By: Julian De Freitas and Glenn Cohen

We propose that AI-driven wellness apps powered by large language models can foster extreme emotional attachments and dependencies akin to human relationships—posing risks like ambiguous loss and dysfunctional dependence—that challenge current regulatory frameworks and... View Details

Keywords: AI and Machine Learning; Well-being; Emotions; Governing Rules, Regulations, and Reforms

June 2025
Article

Who Benefits from Online Gig Economy Platforms?

By: Christopher T. Stanton and Catherine Thomas

Online labor platforms for short-term, remote work have many more job seekers than available jobs. Despite their relative abundance, workers capture a substantial share of the surplus from transactions. We draw this conclusion from demand estimates that imply workers'... View Details

Keywords: Gig Economy; Knowledge Workers; Online Platforms; Job Search; Governing Rules, Regulations, and Reforms; Wages; Demand and Consumers

May 2025 (Revised June 2025)
Background Note

Social Enterprise in Latin America

By: Brian L. Trelstad and Karina Souza

This research note provides an overview of the social enterprise ecosystem in Latin America, exploring current dynamics across key markets, including country-specific insights on Brazil, Mexico, Argentina, Colombia, Chile, and Central America. In a region characterized... View Details

May 2025
Case

A Decade of Corporate Governance Reform in Japan (2013-2023)

By: Charles C.Y. Wang and Akiko Kanno

Keywords: Corporate Governance; Japan

May 2025
Teaching Note

From oneworld to a New World? LATAM’s High-Stakes Alliance Dilemma

By: Juan Alcacer and Valentina Tarzijan

As global alliances evolve and regulatory barriers mount, LATAM Airlines must reassess the strategic logic of partnerships. In 2019, Delta Air Lines proposed a $1.9 billion investment and deeper cooperation via a Joint Business Agreement, prompting LATAM to evaluate... View Details

Keywords: Partners and Partnerships; Governing Rules, Regulations, and Reforms; Competitive Strategy; Decision Choices and Conditions; Air Transportation Industry; Latin America; North America

2025
Chapter

Institutional Entrepreneurship and Climate Change

By: Ann-Kristin Bergquist and Geoffrey Jones

This chapter explores when and why private regulatory governance systems became the primary form of global environmental governance. The chapter explores two different historical paths in such private regulation and how they came about. The first path involved... View Details

Keywords: Institutional Entrepreneurship; Environment; Climate Change; Governing Rules, Regulations, and Reforms; Environmental Regulation; Standards; Corporate Social Responsibility and Impact

April 2025 (Revised June 2025)
Case

Governing Sustainability in a Shifting Context (A)

By: Lynn S. Paine and Will Hurwitz

In early 2025, boards of directors had to rethink corporate responsibility and sustainability efforts amid rapidly-shifting social, legal, regulatory, and economic forces. While just a few years earlier, calls to address racial justice and climate change reached into... View Details

April 8, 2025
Article

Creating Workplaces Free of Forever Chemicals

By: Joseph G. Allen, Heather A. Henrikson and Michael W. Toffel

Forever chemicals are toxic and widely used in buildings and yet they remain on the rise globally with little regulation to control them. In the United States, for example, Environmental Protection Agency (EPA) regulations currently cover only forever chemicals in... View Details

Keywords: Occupational Health; Safety Regulations; Regulation; Working Conditions; Governing Rules, Regulations, and Reforms; Safety; Health

March 2025
Case

Intuit: Lobbying to Save TurboTax

By: Joseph L. Badaracco and Tom Quinn

Intuit’s TurboTax software held a dominant market position in the online tax preparation market. Many politicians over the years had proposed changes that would have harmed Intuit’s business—notably, allowing the Internal Revenue Service to develop a government-owned... View Details

Keywords: Lobbying; Fairness; Moral Sensibility; Government Legislation; Taxation; Business and Government Relations; Business and Stakeholder Relations; Reputation; Civil Society or Community; Public Opinion; Governing Rules, Regulations, and Reforms; Rank and Position; Power and Influence; Technology Industry; United States; Europe

2025
Working Paper

Blockchain-Induced Supply Chain Transparency and Firm Performance: The Role of Capacity Utilization

By: ShinWoo Lee Lee, Jedson Pinto, Daniel Rabetti and Gil Sadka

This study empirically investigates how blockchain adoption affects firm profitability. Employing a quasi-experimental design triggered by regulatory changes across the United States, we provide novel empirical evidence to recent theory, proposing that blockchain... View Details

Keywords: Blockchain; Supply Chain; Technology Adoption; Profit; Governing Rules, Regulations, and Reforms; United States

February 2025
Case

Abiomed: A Change of Heart

By: Satish Tadikonda, Faith Robertson and William Marks

After acquiring Impella CardioSystems AG in May 2005, Abiomed Inc., a company focused on cardiac care, ran into a dilemma. Its Impella 2.5 device was approved for use in the European Union, but CEO Michael Minogue had seemingly bet the company's future on the ability... View Details

Keywords: Mergers and Acquisitions; Governing Rules, Regulations, and Reforms; Health Care and Treatment; Business and Government Relations; Medical Devices and Supplies Industry; European Union; United States

February 2025
Case

Abiomed: Clinical Trials and Tribulations

By: Satish Tadikonda, Faith Robertson and William Marks

After receiving 510(k) clearance for the Impella 2.5 device, Abiomed had proceeded to conduct a premarket approval (PMA) process as well to prove clinical superiority, earn greater protection, and extend commercial runway. However, in the middle of the clinical trial... View Details

Keywords: Corporate Disclosure; Governing Rules, Regulations, and Reforms; Health Testing and Trials; Product Launch; Medical Devices and Supplies Industry

2025
Working Paper

Blockchain Adoption and Audit Quality

By: Mei Luo, Daniel Rabetti and Shuangchen Yu

This study examines the impact of blockchain adoption in the corporate setting. Specifically, we provide comprehensive empirical support to recent theory (Cao, Cong, and Young, 2024) proposing that blockchain adoption positively affects endogenous audit quality and... View Details

Keywords: Blockchain; Accounting Audits; Technology Adoption; Financial Reporting; Governing Rules, Regulations, and Reforms; China

February 2025
Article

Disclosure, Humanizing, and Contextual Vulnerability of Generative AI Chatbots

By: Julian De Freitas and I. Glenn Cohen

In the wake of recent advancements in generative AI, regulatory bodies are trying to keep pace. One key decision is whether to require app makers to disclose the use of generative AI-powered chatbots in their products. We suggest that some generative AI-based chatbots... View Details

Keywords: AI and Machine Learning; Governing Rules, Regulations, and Reforms; Applications and Software; Well-being

January 2025 (Revised April 2025)
Case

Doing Business in Cairo: Navigating a Path to Economic Resilience

By: A. Zelleke and Ahmed Dahawy

Egypt has long been a pivotal force in the Middle East and North Africa. Located at a crossroads of global trade routes, the country was a strategic partner for numerous regional and global powers. However, a substantial currency devaluation in 2016 brought many... View Details

Keywords: Business; Developing Countries and Economies; Economic Slowdown and Stagnation; Inflation and Deflation; Macroeconomics; Cross-Cultural and Cross-Border Issues; Globalized Economies and Regions; International Relations; Emerging Markets; Risk and Uncertainty; Culture; Economy; Country; Currency; Investment; Governing Rules, Regulations, and Reforms; Egypt

January 2025
Teaching Note

Vytal: Packaging-as-a-Service

By: George Serafeim, Michael W. Toffel and Stacy Straaberg

Teaching Note for HBS Case No. 124-007. The Germany-based startup Vytal operated the largest digital-native reusable packaging-as-a-service network globally, having raised nearly €15 million, established a large network of restaurant partners, and prevented the use of... View Details

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