Publications

October 2007 (Revised July 2013)
Case

Vertex Pharmaceuticals and the Cystic Fibrosis Foundation: Venture Philanthropy Funding for Biotech

By: Robert F. Higgins, Sophie LaMontagne and Brent Kazan

In 2001, Vertex Pharmaceuticals Incorporated acquired the San Diego-based biotech company, Aurora Biosciences. The combination of Vertex's and Aurora's technologies would improve the flow of novel drug candidates into development. However, several questions related to... View Details

Keywords: Philanthropy; Philanthropy Funding; Innovation; Funding Model; Venture Capital; Partners and Partnerships; Financing and Loans; Investment Funds; Acquisition; Philanthropy and Charitable Giving; Biotechnology Industry; Pharmaceutical Industry; San Diego

2024
Working Paper

Residential Battery Storage - Reshaping The Way We Do Electricity

By: Christian Kaps and Serguei Netessine

In this paper, we aim to understand when private households invest in behind-the-meter battery storage next to rooftop solar and how those batteries impact households, the electricity market, and emissions. We answer three main research questions: 1) When do customers... View Details

Keywords: Solar Power; Energy Storage; Technology And Innovation Management; Energy; Energy Policy; Renewable Energy; Technological Innovation; Innovation and Management; Energy Industry

Article

Lessons From Hollywood: A New Approach To Funding R&D

By: Gary P. Pisano and Andrew W. Lo

Companies find it increasingly difficult to justify long-term, risky R&D investments—particularly in science-based fields such as biotechnology, advanced materials, and energy. We argue in this article that the traditional venture model has limits for such investments... View Details

Keywords: Financial Innovation; Financial Strategy; Project Management; R＆D; Start-up; Innovation Strategy; Business Model; Research and Development; Financial Management; Risk Management; Strategy

Find at Harvard

September 2017 (Revised February 2023)
Case

Intermountain Healthcare: Pursuing Precision Medicine

By: Richard G. Hamermesh, Kathy E. Giusti, Robert S. Huckman and Julia Kelley

Headquartered in Salt Lake City, Intermountain Healthcare operates 23 hospitals and hundreds of clinics in Utah and Idaho and provides insurance to approximately 850,000 patients through its insurance arm, SelectHealth. In 2013, Intermountain, known for its commitment... View Details

Keywords: Precision Medicine; Healthcare; Innovation; Cancer; Cancer Research; Health Care; Technology; Health Care and Treatment; Innovation Leadership; Disruptive Innovation; Entrepreneurship; Decision Choices and Conditions; Health Industry; Insurance Industry; Utah; United States; North America

2024
Working Paper

Catalysts for Climate Solutions: Corporate Responses to Venture Capital Financing of Climate-tech Startups

By: Shirley Lu, George Serafeim and Simon Xu

We study whether incumbent firms increase their product focus on climate solutions in response to venture capital (VC) financing of climate-tech startups. Using large language models to measure a firm's focus on climate solutions, we find that incumbents in similar... View Details

Keywords: Climate Change; Climate Finance; Innovation; Technology; Entrepreneurship; Venture Capital; Private Equity; Environment; Sustainability

01 Jun 2023
News

Buy Big, Sell Small

brands and SKUs,” she says. Shruti, who graduated at the top of her class at the Indian Institute of Technology and had experience in consulting and impact investing, came to HBS to gain the skills to launch an India-based impact View Details

Keywords: Deborah Blagg; retail; supply chain management; entrepreneurship; leadership; innovation; Miscellaneous Store Retailers; Retail Trade

December 2017
Case

International Institute of Tropical Agriculture

By: Jose B. Alvarez and Sarah Mehta

It is July 2017, and Dr. Nteranya Sanginga, the director general of the Nigeria-based International Institute of Tropical Agriculture (IITA), is making progress toward two of his primary strategic objectives for the nonprofit research Institute: 1) to scale the impact... View Details

Keywords: Scaling Technologies; Youth Unemployment; Innovation In Nonprofits; Agribusiness; Plant-Based Agribusiness; Cash Flow; Labor; Employment; Commercialization; Problems and Challenges; Agriculture and Agribusiness Industry; Africa; Nigeria

2021
Working Paper

Accounting for Product Impact in the Airlines Industry

By: George Serafeim and Katie Trinh

We apply the product impact measurement framework of the Impact-Weighted Accounts Initiative (IWAI) in two competitor companies within the airlines industry. We design a monetization methodology that allows us to calculate monetary impact estimates of fare... View Details

June 2023
Case

Block: Creating an Ecosystem of Ecosystems

By: Lauren Cohen, Richard Ryffel, Grace Headinger and Ruoshi Qi

At Investor Day 2022, Block announced a new vision for its businesses: creating an ecosystem of ecosystems. Outside the norm for many public growth companies, Block had recently acquired a variety of new business streams in the creator economy and Bitcoin despite a... View Details

2021
Working Paper

Accounting for Product Impact in the Interactive Media and Services Industry

By: DG Park, George Serafeim and Katie Trinh

We apply the product impact measurement framework of the Impact-Weighted Accounts Initiative (IWAI) in two competitor companies within the interactive media and services industry. We design a monetization methodology that allows us to calculate monetary impact... View Details

01 Jun 2024
News

Quantum Leap

“This is the first new kind of computer in 75 years,” says John Levy (MBA 1979), CEO of the quantum computing startup SEEQC. “And we’re building it on a chip!” Strolling through his company’s design and testing facility in Elmsford, New York, Levy looks less like a... View Details

Keywords: Alexander Gelfand; photographed by Chris Sorensen; quantum computing; innovation; leadership; Computer and Electronic Product Manufacturing; Manufacturing

2021
Working Paper

Accounting for Product Impact in the Telecommunications Industry

By: George Serafeim and Katie Trinh

We apply the product impact measurement framework of the Impact-Weighted Accounts Initiative (IWAI) in two competitor companies within the telecommunications industry. We design a monetization methodology that allows us to calculate monetary impact estimates of network... View Details

2024
Working Paper

The Financial Anatomy of Climate Solutions: A Large Language Model Approach to Company Classification and Analysis

By: Shirley Lu and George Serafeim

Leveraging advancements in large language models (LLM), we study the financial characteristics of firms offering climate solutions-products and services aimed at fostering a transition to a low-carbon economy. We use a new measure that applies LLM to 10-K Item 1... View Details

Keywords: Climate; Climate Finance; Innovation; Technology; Financial Statement Analysis; AI and Machine Learning; Climate Change; Environmental Sustainability; Analysis; Financial Statements

17 Sep 2016
News

Keeping an Ear Out for Disruption

Keywords: disruptive innovation; currency exchange; management; leadership; technology; Securities, Commodities, and Other Financial Investments; Securities, Commodities, and Other Financial Investments

February 2015 (Revised November 2015)
Supplement

Building an Integrated Biopharma Company: Crucell (B)

By: Richard G. Hamermesh, Marianne Van Der Steen and Susan Harmeling

The Crucell (B) case updates events at Crucell since 2009. In September, 2009, Johnson & Johnson acquired 18% of Crucell for $400 million. This investment was part of a business development deal. Subsequently, in 2012, Johnson & Johnson acquired Crucell for $2.8... View Details

Keywords: Biotechnology; Biopharmacy Company; Licensing Agreements In Biopharmacy; Licensing; Human Cell-line Technology; Vaccine; Healthcare Innovation; Global Health; Entrepreneurship; Health Care and Treatment; Acquisition; Innovation and Invention; Biotechnology Industry; Pharmaceutical Industry

01 Dec 2022
News

Flying High

Subramanian and Pelet, on the runway with Aero (Courtesy Uma Subramanian) Subramanian and Pelet, on the runway with Aero (Courtesy Uma Subramanian) When Uma Subramanian (MBA 2008) joined Aero Technologies as CEO in March 2019, the company was “just a kernel of an... View Details

Keywords: April White; aviation; airlines; entrepreneurship; leadership; innovation; Air Transportation; Transportation

February 2014 (Revised August 2016)
Case

Strava

By: Joseph B. Lassiter III, William A. Sahlman and Sid Misra

Strava is a new fast-growing social network for the avid cyclist and runner. The Strava case traces the entrepreneurial journey of two serial entrepreneurs who have been co-founders in a prior venture, and who have co-founded Strava 3 years ago. The protagonists must... View Details

February 2022
Case

Cleveland Clinic Abu Dhabi

By: Linda A. Hill and Emily Tedards

In 2006, the Cleveland Clinic and Mubadala Investment Company partnered with a bold ambition to deliver world class healthcare in the United Arab Emirates. In 2015, after nearly a decade of planning and construction, Cleveland Clinic Abu Dhabi opened its doors. By... View Details

Keywords: Organizational Behavior; Culture; Alignment; Organizational Effectiveness; Purpose; Impact; Leadership Development; Diversity; Collaboration; Co-creation; Learning Organizations; Empowerment; Teams; Team Dynamics; Teamwork; Team Effectiveness; Trust; Talent; Talent Development And Retention; Psychological Safety; Organizational Evolution; Coaching; Board; Analytics; Innovation; Data; Data Visualization; Digital Technology; Digital; Customer Experience; Experimentation; Change Management; Data-driven Decision-making; Debates; Ecosystem; Partnership; Telemedicine; Sustainability; Global Organizations; Local; Hospital; Healthcare; United Arab Emirates; Health Care and Treatment; Partners and Partnerships; Globalization; Quality; Organizational Culture; Mission and Purpose; Innovation and Management; Information Technology; Joint Ventures; Leadership; Performance Effectiveness; Abu Dhabi; United Arab Emirates

March 2020
Article

Synergistic Value in Vertically Integrated Power-to-Gas Energy Systems

By: Gunther Glenk and Stefan Reichelstein

In vertically integrated energy systems, integration frequently entails operational gains that must be traded off against the requisite cost of capacity investments. In the context of the model analyzed in this study, the operational gains are subject to inherent... View Details