Publications

March 2024
Supplement

Miracle Therapeutics (B)

By: Satish Tadikonda, William Marks and Wendi Yajnik

Supplements the (A) case. Following on the negotiations detailed in the Miracle Therapeutics (A) case, Beth Sharp and Jennifer Brilliant from Miracle Therapeutics face new challenges with their company's funding and intellectual property (IP) after several missteps.... View Details

Keywords: Business Startups; Financing and Loans; Intellectual Property; Problems and Challenges; Business or Company Management

September 2019
Case

Nimbus Therapeutics

By: Peter Barrett, Karim Lakhani and Julia Kelley

This case focuses on Nimbus Therapeutics, a biotechnology startup based in Cambridge, Massachusetts, as its leadership team tries to determine the company’s long-term strategy. The startup’s founders structured Nimbus as a limited liability company, which has given it... View Details

Keywords: Business Startups; Organizational Structure; Strategy; Biotechnology Industry

August 2024
Case

Sky Therapeutics: Innovating in Digital Therapeutics

By: Satish Tadikonda, Olivia Reszczynski and William Marks

Shad Faraz and Alex Youssef were intrigued by the opportunities in the relatively new area of Digital Therapeutics. Despite initial successes, early entrants had struggled with reimbursement and revenue-predictability challenges. However, venture investors still... View Details

Keywords: Business Startups; Entrepreneurship; Mission and Purpose; Health Care and Treatment; Technological Innovation; Business Strategy; Health Industry; Technology Industry

August 2023 (Revised August 2023)
Case

Sky Therapeutics: Innovating in Digital Therapeutics

By: Satish Tadikonda, Olivia Reszczynski and William Marks

Shad Faraz and Alex Youssef were intrigued by the opportunities in the relatively new area of Digital Therapeutics. Despite initial successes, early entrants had struggled with reimbursement and revenue-predictability challenges. However, venture investors still... View Details

Keywords: Business Startups; Entrepreneurship; Mission and Purpose; Health Industry; Technology Industry

September 2014
Case

Pfizer's Centers for Therapeutic Innovation (CTI)

By: Gary Pisano, James Weber and Kait Szydlowski

In 2010, Pfizer established four small research units in New York, Boston, San Francisco, and San Diego located close to several premier Academic Medical Centers (AMCs), or hospitals with adjoining medical schools. The goal of these units was to redesign collaboration... View Details

Keywords: Drug Development; Academic Collaboration; Research And Development; Innovation; Translational Research; Management; Operations; Problems and Challenges; Research; Science; Information Technology; Strategy; Biotechnology Industry; Pharmaceutical Industry; North and Central America; Europe; Asia

November 2016
Case

Anthony Starks at InSiL Therapeutics (A)

By: Gary Pisano and Vicki Sato

When Bruce Wayne hired Anthony Starks, he thought he had hit a home run by getting the most brilliant and passionate scientist-leader in the field to be his CSO. But a few months in, Wayne and Starks begin to clash over crucial forward-looking decisions about the... View Details

Keywords: Biotech; Silicon; Managing Innovation; Management Challenges; Managing People; Managing Organization; R＆D; R＆D Project Management; Platform; Venture Capital; Drug Discovery; management; Biotechnology Industry; California

13 Feb 2023
News

Alumnus Gift Will Nurture Basic, Therapeutic Science

Swiss biotech executive, entrepreneur, and philanthropist Ernesto Bertarelli (MBA 1993) has pledged $75 million to advance basic scientific discovery, therapeutic science, and a culture of entrepreneurship at Harvard Medical School. The... View Details

23 Apr 2019
Video

X-Cor Therapeutics Final Pitch New Venture Competition 2019 Alumni Track

November 2016 (Revised December 2016)
Supplement

Anthony Starks at InSiL Therapeutics (B)

By: Vicki Sato and Gary Pisano

This case accompanies the (A) case from Anthony Starks's perspective. View Details

Keywords: Biotech; Management Challenges; R＆D; R＆D Project Management; Management; Biotechnology Industry; California

25 Mar 2016
Video

Duke Rohlen, Spirox & Advanced Cardiac Therapeutics

15 Jul 2020
Video

The HBS Health Minute: Translating Science into Therapeutics

31 Jan 2020
Video

Blavatnik Fellow Jayon Wang Propelling X-COR Therapeutics Forward

August 2023
Case

Constellation Pharmaceuticals: Corporate Development at a Novel Therapeutic Company

By: Satish Tadikonda and Brad Prosek

Constellation Pharmaceuticals was a company focused on epigenetic therapies for cancer patients. Despite a promising start and an early deal with a leading biopharma company, the company weathered twin setbacks in the end of a major research collaboration and the... View Details

Keywords: Mergers and Acquisitions; Health Care and Treatment; Organizational Change and Adaptation; Research and Development; Business Strategy; Partners and Partnerships; Goals and Objectives; Pharmaceutical Industry; United States

03 Nov 2017
HBS Seminar

Jason Gardner, PhD, Magenta Therapeutics (CEO, President and Cofounder)

12 PM – 1 PM EDT, 26 May 2021
Virtual Programming

Perspectives in Health: On Biotechnology Capital Strategy and the Future of Therapeutics

HBS Professor Amitabh Chandra will lead a discussion with Katrine Bosley to discuss the explosion of new ideas, capital in Life Sciences and the implications this has on the next generation of therapeutics. This hour-long discussion will include a Q&A for participants... View Details

May 2021
Case

The SMA Foundation: Steering Therapeutic Research and Development in a Rare Disease

By: Amitabh Chandra, Spencer Lee-Rey and Caroline Marra

This case explores incentives for rare disease drug development by chronicling the role of the Spinal Muscular Atrophy (SMA) Foundation in forming strategic partnerships with the scientific research community and pharmaceutical developers to transform the trajectory... View Details

Keywords: Innovation and Invention; Strategy; Business or Company Management; Society; Health; Public Administration Industry; Health Industry; United States

1983
Article

Level of Functioning and Length of Time in Treatment Variables Influencing Patient's Therapeutic Experience in Group Psychotherapy

By: Timothy Butler and Adelaide Fhuriman

Keywords: Health; Groups and Teams; Health Care and Treatment

Find at Harvard

February 2019 (Revised May 2019)
Case

Hot Chicken Takeover

By: William R. Kerr, Manjari Raman and Olivia Hull

By December 2018, entrepreneur Joe DeLoss’s fried chicken company, Hot Chicken Takeover, has opened three restaurants in Columbus, Ohio, using an unconventional employment model that helps people with criminal records get back on their feet. DeLoss is proud of the... View Details

September 2012
Supplement

Intraoperative Radiotherapy for Breast Cancer (B)

By: Willy Shih

The intraoperative radiotherapy (IORT) business at Carl Zeiss Meditec had struggled with growth since the time of the (A) case. Though the unit had grown revenues in excess of 50% and had exceeded its EBIT target, it faced several key strategic choices. Should it... View Details

Keywords: Radiotherapy; Breast Cancer; Brachytherapy; Therapeutic Radiation; Oncology; Oncology Treatment Systems; Elekta AB; Varian Medical Systems; Xoft; Electronic Brachytherapy; Intraoperative Radiotherapy; Disruptive Innovation; Health Care and Treatment; Entrepreneurship; Technological Innovation; Growth and Development Strategy; Health Industry; Germany