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July 2024
Case

ZEISS: Commercializing Science

By: Maria P. Roche, Carlota Moniz and Daniela Beyersdorfer

Karl Lamprecht, President and CEO of the ZEISS AG Group, mused on how far ZEISS had come in 175 years of being a pioneer in optics, and how the course he had charted since taking the helm of the company could keep it on track. In his role, he oversaw the four core... View Details

2023
Working Paper

Coordinated R&D Programs and the Creation of New Industries

By: Daniel P. Gross and Maria P. Roche

Government R&D programs have a long history in supporting industry development, yet their impacts are often overlooked in strategy research. We examine how a large, coordinated, government-funded effort to develop radar in World War II spawned a new high-tech industry.... View Details

Keywords: Research and Development; Policy; Business and Government Relations; Technological Innovation; Collaborative Innovation and Invention

Article

Time-Driven Activity-Based Costing in Breast Cancer Care Delivery

By: Navraj S. Nagra, Elena Tsangaris, Jessica Means, Michael J. Hassett, Laura S. Dominici, Jennifer R. Bellon, Justin Broyles, Robert S. Kaplan, Thomas W. Feeley and Andrea L. Pusic

We used time-driven activity-based costing (TDABC) to calculate the complete cost of breast cancer care—initial treatment planning, chemotherapy, radiation therapy, surgical resection and reconstruction, and ancillary services (psychosocial oncology, physical therapy.... View Details

Keywords: Healthcare; Time-Driven Activity-Based Costing; Health Care and Treatment; Cost

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November 15, 2021
Article

Putting Your Corporate Purpose to Work

By: Hubert Joly

Making a company purpose come to life is an arduous journey that requires a multi-pronged and sustained approach. Yet as hard as it is, the journey is well worth it and will yield positive transformation not only for the company, but also for the people who work there.... View Details

Keywords: Organizations; Mission and Purpose; Corporate Strategy; Management Practices and Processes; Organizational Culture; Business and Stakeholder Relations

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Article

Missing the Near Miss: Recognizing Valuable Learning Opportunities in Radiation Oncology

By: Palak Kundu, Olivia Jung, Luca F. Valle, Amy C. Edmondson, Nzhde Agazaryan, John Hegde, Michael Steinberg and Ann Raldow

“Near miss” events are valuable low-cost learning opportunities in radiation oncology as they do not result in patient harm and are more pervasive than adverse events that do. Near misses vary depending on the presence of a latent error of behavior or process, and the... View Details

Keywords: Radiation Oncology; Cognitive Biases; Health Care and Treatment; Learning

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Article

Resilience vs. Vulnerability: Psychological Safety and Reporting of Near Misses with Varying Proximity to Harm in Radiation Oncology

By: Palak Kundu, Olivia Jung, Amy C. Edmondson, Nzhde Agazaryan, John Hegde, Michael Steinberg and Ann Raldow

Background
Psychological safety, a shared belief that interpersonal risk taking is safe, is an important determinant of incident reporting. However, how psychological safety affects near-miss reporting is unclear, as near misses contain contrasting cues that... View Details

Keywords: Psychological Safety; Near-miss Reporting; Health Care and Treatment; Safety

December 2020 (Revised May 2021)
Technical Note

Tales of Life-changing Innovations: High Quality and Radiation Free | Note on the Development of Magnetic Resonance Imaging (through the 1990s)

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins

Article

Psychological Safety and Near Miss Events in Radiation Oncology

By: Palak Kundu, Olivia Jung, Kathy Rose, Chonlawan Khaothiemsang, Nzhde Agazaryan, Amy C. Edmondson, Michael L. Steinberg and Ann C. Raldow

Background: Near miss events, defined as harm averted due to chance, are learning opportunities in radiation oncology. Psychological safety is a feature of a learning environment characterized by interpersonal risk taking. We examine the effects of near miss type and... View Details

2024
Working Paper

Magnetic Resonance Imaging—High Quality and Radiation Free: Case Histories of Transformational Advances

By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins

This case history describes how Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically, we chronicle 1) the development of foundational techniques and prototypes (through the 1970s);... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

Article

Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting

By: Raymond H. Mak, Michael G. Endres, Jin Hyun Paik, Rinat A. Sergeev, Hugo Aerts, Christopher L. Williams, Karim R. Lakhani and Eva C. Guinan

Importance: Radiation therapy (RT) is a critical cancer treatment, but the existing radiation oncologist work force does not meet growing global demand. One key physician task in RT planning involves tumor segmentation for targeting, which requires substantial... View Details

Keywords: Crowdsourcing; AI Algorithms; Health Care and Treatment; Collaborative Innovation and Invention; AI and Machine Learning

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October 2018 (Revised August 2023)
Case

Safecast: Bootstrapping Human Capital to Big Data

By: Ethan Bernstein and Stephanie Marton

On March 11, 2011, at 2:46pm, a 9.1-on-the-Richter-scale, six-minute long earthquake unleashed a tsunami that ravaged the Tohoku region of Japan, damaging the Fukushima Daiichi Nuclear Power facility and releasing sufficient radioactive material into the air and ocean... View Details

Article

Patterns of Failure after Involved Field Radiation Therapy for Pediatric and Young Adult Hodgkin Lymphoma

By: Minh-Phuong Huynh-Le, Amanda J. Walker, Scott Duke Kominers, Ido Paz-Priel, Moody D. Wharam and Stephanie A. Terezakis

Involved field radiation therapy (IFRT) is integral in curative therapy for Hodgkin lymphoma (HL), although primarily used in patients with intermediate/high‐risk HL. We present failure patterns and clinical outcomes in a cohort of pediatric and young adult patients... View Details

Keywords: Hematology/oncology; Hodgkin Lymphoma; Involved Field Radiation Therapy; Health Disorders; Health Care and Treatment

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September 2012
Supplement

Intraoperative Radiotherapy for Breast Cancer (B)

The intraoperative radiotherapy (IORT) business at Carl Zeiss Meditec had struggled with growth since the time of the (A) case. Though the unit had grown revenues in excess of 50% and had exceeded its EBIT target, it faced several key strategic choices. Should it... View Details

Keywords: Radiotherapy; Breast Cancer; Brachytherapy; Therapeutic Radiation; Oncology; Oncology Treatment Systems; Elekta AB; Varian Medical Systems; Xoft; Electronic Brachytherapy; Intraoperative Radiotherapy; Disruptive Innovation; Health Care and Treatment; Entrepreneurship; Technological Innovation; Growth and Development Strategy; Health Industry; Germany

September 2012 (Revised August 2014)
Background Note

Note on Radiation Therapy, Stereotaxis, and Stereotactic Radiosurgery

By: Regina E. Herzlinger, Regina E. Herzlinger, T. Forcht Dagi and T. Forcht Dagi

January 2001 (Revised July 2003)
Case

Pharmacyclics: Financing Research & Development

By: Malcolm P. Baker, Richard S. Ruback and Aldo Sesia

Pharmacyclics (NASDAQ: PCYC), a pharmaceutical company that manufactures products that will improve existing therapeutic treatments for cancer, arteriosclerosis, and retinal disease, was considering a $60 million private placement in February 2000. The company had more... View Details

Keywords: Valuation; Cash Flow; Financing and Loans; Business Startups; Financial Strategy; Medical Devices and Supplies Industry; Pharmaceutical Industry; Health Industry

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