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April 8, 2025
Article

Creating Workplaces Free of Forever Chemicals

By: Joseph G. Allen, Heather A. Henrikson and Michael W. Toffel

Forever chemicals are toxic and widely used in buildings and yet they remain on the rise globally with little regulation to control them. In the United States, for example, Environmental Protection Agency (EPA) regulations currently cover only forever chemicals in... View Details

Keywords: Occupational Health; Safety Regulations; Regulation; Working Conditions; Governing Rules, Regulations, and Reforms; Safety; Health

February 2025
Supplement

Intenseye: Powering Workplace Health and Safety with AI (B)

By: Michael W. Toffel, Shane Greenstein and Sadika El Hariri

Intenseye used its $25 million series A funds to refine and expand its digital safety platform while refining its target markets and ideal customer profile. As the company implemented new approaches to create value for its clients, such as developing an AI-powered... View Details

February 2025
Case

Abiomed: A Change of Heart

By: Satish Tadikonda, Faith Robertson and William Marks

After acquiring Impella CardioSystems AG in May 2005, Abiomed Inc., a company focused on cardiac care, ran into a dilemma. Its Impella 2.5 device was approved for use in the European Union, but CEO Michael Minogue had seemingly bet the company's future on the ability... View Details

Keywords: Mergers and Acquisitions; Governing Rules, Regulations, and Reforms; Health Care and Treatment; Business and Government Relations; Medical Devices and Supplies Industry; European Union; United States

February 2025
Case

Abiomed: Clinical Trials and Tribulations

By: Satish Tadikonda, Faith Robertson and William Marks

After receiving 510(k) clearance for the Impella 2.5 device, Abiomed had proceeded to conduct a premarket approval (PMA) process as well to prove clinical superiority, earn greater protection, and extend commercial runway. However, in the middle of the clinical trial... View Details

Keywords: Corporate Disclosure; Governing Rules, Regulations, and Reforms; Health Testing and Trials; Medical Devices and Supplies Industry

February 2025
Article

Disclosure, Humanizing, and Contextual Vulnerability of Generative AI Chatbots

By: Julian De Freitas and I. Glenn Cohen

In the wake of recent advancements in generative AI, regulatory bodies are trying to keep pace. One key decision is whether to require app makers to disclose the use of generative AI-powered chatbots in their products. We suggest that some generative AI-based chatbots... View Details

Keywords: AI and Machine Learning; Governing Rules, Regulations, and Reforms; Applications and Software; Well-being

January 2025
Teaching Note

Vytal: Packaging-as-a-Service

By: George Serafeim, Michael W. Toffel and Stacy Straaberg

Teaching Note for HBS Case No. 124-007. The Germany-based startup Vytal operated the largest digital-native reusable packaging-as-a-service network globally, having raised nearly €15 million, established a large network of restaurant partners, and prevented the use of... View Details

December 2024
Case

Blue Cross Blue Shield of Michigan (BCBSM): The AI Journey

By: Shikhar Ghosh

In early 2024, Bill Fandrich, Executive VP and CIO of Blue Cross Blue Shield of Michigan (BCBSM), faced a critical decision about AI adoption within the organization. Fandrich had championed AI implementation at BCBSM. After successfully developing three AI... View Details

November 2024
Case

Polish Agro: Where Do We Grow from Here?

By: Willy C. Shih, Lena Duchene and Daniela Beyersdorfer

By July 2024, Polish Agro had grown into one of Poland’s fastest-growing agribusinesses, with €230 million in revenue, 82 employees, and operations across Northern Poland. The company supported farmers with essential agricultural inputs like fertilizers and seeds,... View Details

October 2024
Case

Tonik

By: Andy Wu, Maliha Malek Quadir and Aticus Peterson

This case study examines Tonik, the first digital bank in the Philippines, as it navigates the challenges of scaling its lending operations and achieving profitability in an evolving fintech landscape. It explores Tonik's journey from its launch in 2018 to early 2024,... View Details

Keywords: Business Startups; Financing and Loans; Profit; Governing Rules, Regulations, and Reforms; Growth and Development Strategy; Emerging Markets; Entrepreneurship; Product; Banking Industry; Financial Services Industry; Technology Industry; Philippines

October 2024
Article

Medicare Part D Protected-Class Policy Is Associated with Lower Drug Rebates

By: Pragya Kakani, Michael Anne Kyle, Amitabh Chandra and Luca Maini

Medicare Part D does not allow plans to exclude drugs in six protected classes from their formularies, which may limit plans’ ability to negotiate rebates and lead to higher spending. We estimated the association between protected-class status, US-level estimated... View Details

Keywords: Insurance; Health Care and Treatment; Governing Rules, Regulations, and Reforms; United States

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September 2024
Case

Cathay Cargo: Turnaround Short Haul, or Double Crew Long Haul?

By: Willy Shih and Billy Chan

Tom Owen, Director Cargo at Cathay Pacific Airways, had a problem. During the Covid-19 pandemic, the grounding of passenger flights meant the sudden loss of 50% of the airline's cargo carrying capacity. But the bigger challenge was that the Hong Kong government imposed... View Details

Keywords: Operations; Resource Allocation; Cash Flow; Governing Rules, Regulations, and Reforms; Health Pandemics; Organizational Change and Adaptation; Decision Choices and Conditions; Air Transportation Industry; Hong Kong

August 2024
Case

Scaling Seven Starling

By: Ryan W. Buell and Carin-Isabel Knoop

Seven Starling, a maternal mental health startup, is scaling its digital clinic model. Seven Starling addresses perinatal mental health challenges by providing licensed therapists, peer support, and medication to mothers across five states, with a hybrid care model... View Details

Keywords: Business Model; Business Startups; Health Care and Treatment; Growth and Development Strategy; Mission and Purpose; Health Industry

August 2024
Case

Sky Therapeutics: Innovating in Digital Therapeutics

By: Satish Tadikonda, Olivia Reszczynski and William Marks

Shad Faraz and Alex Youssef were intrigued by the opportunities in the relatively new area of Digital Therapeutics. Despite initial successes, early entrants had struggled with reimbursement and revenue-predictability challenges. However, venture investors still... View Details

Keywords: Business Startups; Entrepreneurship; Mission and Purpose; Health Care and Treatment; Technological Innovation; Business Strategy; Health Industry; Health Industry

August 2024 (Revised August 2024)
Background Note

Note on Adherence in Healthcare

By: Regina E. Herzlinger, Zachery Page and Ben Creo

This note provides an overview of adherence in healthcare. It discusses systemwide costs of non-adherence, common barriers to adherence, relevant stakeholders, novel compliance tactics, and the impact on digital therapeutic adoption. It is recommended as a companion to... View Details

Keywords: Health Care and Treatment; Behavior; Health Industry

July 2024
Case

Replika AI: Alleviating Loneliness (A)

By: Shikhar Ghosh and Shweta Bagai

Eugenia Kuyda launched Replika AI in 2017 as an empathetic digital companion to combat loneliness and provide emotional support. The platform surged in popularity during the COVID-19 pandemic, offering non-judgmental support to isolated users. By 2023, Replika boasted... View Details

Keywords: Entrepreneurship; Ethics; Health Pandemics; AI and Machine Learning; Well-being; Technology Industry

June 2024
Article

It Is Time to Consider More Price Regulation in Health Care

By: Sherry Glied and Amitabh Chandra

Keywords: Price; Governing Rules, Regulations, and Reforms; Health Industry

May 2024 (Revised January 2025)
Technical Note

Health Care Payment in the United States

By: Robert S. Huckman, Jeff Charca and Craig Garthwaite

This document provides an overview of how various actors (e.g., physicians, hospitals, and other health care providers) are paid in the United States health care system. It is particularly focused on features of the payment system that contribute to strategic decisions... View Details

Keywords: Compensation and Benefits; Organizational Change and Adaptation; Health Industry

May 2024
Article

The Health Risks of Generative AI-Based Wellness Apps

By: Julian De Freitas and G. Cohen

Artifcial intelligence (AI)-enabled chatbots are increasingly being used to help people manage their mental health. Chatbots for mental health and particularly ‘wellness’ applications currently exist in a regulatory ‘gray area’. Indeed, most generative AI-powered... View Details

Keywords: AI and Machine Learning; Well-being; Governing Rules, Regulations, and Reforms; Applications and Software

April 2024
Case

Dr. Tom Mihaljevic and Cleveland Clinic

By: Linda A. Hill and Lydia Begag

In December 2022, Dr. Tomislav (“Tom”) Mihaljevic, CEO and President of Cleveland Clinic, was reflecting on the last few years at the hospital, marked both by unprecedented challenges and remarkable achievements. Cleveland Clinic had recently been ranked the world’s... View Details

April 2024 (Revised July 2024)
Case

Unleashing Human Magic at Best Buy

By: Leonard A. Schlesinger, Sunil Gupta and Amram Migdal

The case examines the transformation of Best Buy under CEO Hubert Joly's leadership from 2012. Facing significant business challenges, including competition from online and physical retailers, Joly implemented the "Renew Blue" turnaround strategy, which focused on... View Details

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