Publications

August 2023 (Revised May 2024)
Case

Dicerna Pharmaceuticals: Decision Making in Clinical Trial Design and Operations

By: Satish Tadikonda and Amanda McEwen

The success or failure of Dicerna Pharmaceuticals (Dicerna) as an emerging pharmaceutical company would likely hinge on its lead drug candidate Nedosiran and the company’s ability to see it successfully through clinical development. Ralf Rosskamp, Chief Medical... View Details

Keywords: Business Strategy; Health Testing and Trials; Product Development; Governing Rules, Regulations, and Reforms; Pharmaceutical Industry

August 2023
Case

WayCool: Reimagining the Food Supply Chain

By: Paul Gompers and Kairavi Dey

Founded in 2015, WayCool, is an Indian agri-tech start-up that built a B2B operation acquiring fruits and vegetables from product-specific agriculture companies and small-holding farmers. It sold them to business customers, such as local retail stores, restaurants, and... View Details

Keywords: Agribusiness; Digital Transformation; Operations; Business Strategy; Supply Chain; Performance; Business Startups; Growth and Development Strategy; Agriculture and Agribusiness Industry; Food and Beverage Industry; Technology Industry; Web Services Industry; Asia; South Asia

August 2023
Case

Reimagining Hindustan Unilever (A)

By: Sunil Gupta and Rachna Tahilyani

In the fall of 2019, the CEO and MD of Hindustan Unilever (HUL), India’s largest fast-moving consumer goods (FMCG) firm, is wondering what to do about their experiments to digitize distribution. Despite three years of intense efforts, their apps to empower retailers... View Details

Keywords: Experimentation; Digital Transformation; Digital Strategy; Leading Change; Distribution; Decisions; Organizational Change and Adaptation; Consumer Behavior; E-commerce; Competition; Performance; Business Strategy; Marketing; Transformation; Consumer Products Industry; Asia; India

August 2023
Supplement

Reimagining Hindustan Unilever (B)

By: Sunil Gupta and Rachna Tahilyani

In April 2023, as the CEO and MD of Hindustan Unilever (HUL), India’s largest fast-moving consumer goods (FMCG) firm, prepared to hand over the firm’s reins to his successor, he proudly reflected on the last decade. His quest to digitally transform HUL into an... View Details

Keywords: Experimentation; Digital Transformation; Digital Strategy; Leading Change; Organizational Change and Adaptation; Business Strategy; Marketing; Performance; Competition; E-commerce; Consumer Behavior; Transformation; Distribution; Decisions; Consumer Products Industry; Asia; India

July 2023
Case

Crocs: Using Community-Centric Marketing to Make Ugly Iconic

By: Ayelet Israeli and Anne V. Wilson

In 2022, the Crocs Classic Clog was the best-selling item of clothing on Amazon, the brand was one of the fastest growing brands in the U.S., and global net revenue had increased to approximately $3.6 billion. By most accounts, Crocs had become the “it” shoe. Crocs... View Details

Keywords: Brands and Branding; Product Development; Growth and Development; Customer Value and Value Chain; Digital Marketing; Digital Strategy; Segmentation; Advertising; Consumer Products Industry; Apparel and Accessories Industry; United States

July 2023
Case

Honeycomb

By: Jeffrey J. Bussgang and Kumba Sennaar

Honeycomb, an audio app enabling seniors to record stories and save family memories, suddenly draws interest from a younger user demographic. The co-founders consider pivoting to better serve this new user demographic. How should they think about strategy, brand, and... View Details

Keywords: Entrepreneurship; Venture Capital; Operations; Business Startups; Customer Focus and Relationships; Age; Brands and Branding; Technology Industry; United States

July 2023
Supplement

Honeycomb (B): Jumping on The Generative AI Bandwagon?

By: Jeffrey J. Bussgang and Kumba Sennaar

Honeycomb, an audio app enabling users to record stories and save family memories, considers pivoting to embrace generative AI. What should the co-founders business model look like if they pursued this new direction? View Details

Keywords: Entrepreneurship; Venture Capital; Operations; Business Startups; Business Model; AI and Machine Learning; Technology Industry; United States

July 2023 (Revised May 2024)
Case

Vytal: Packaging-as-a-Service

By: George Serafeim, Michael W. Toffel, Lena Duchene and Daniela Beyersdorfer

The Germany-based startup Vytal operated the largest digital-native reusable packaging-as-a-service network globally, having raised nearly €15 million, established a large network of restaurant partners, and prevented the use of millions of single-use take-out food... View Details

July 2023
Case

DayTwo: Going to Market with Gut Microbiome (Abridged)

By: Ayelet Israeli

DayTwo is a young Israeli startup that applies research on the gut microbiome and machine learning algorithms to deliver personalized nutritional recommendations to its users in order to minimize blood sugar spikes after meals. After a first year of trial rollout in... View Details

Keywords: Business Startups; AI and Machine Learning; Nutrition; Market Entry and Exit; Product Marketing; Distribution Channels

2025
Working Paper

Managing Remote Work Quality: Evidence from Auditing Management Systems Standards

By: Ashley Palmarozzo, Michael W. Toffel and Melissa Ouellet

Remote work has become more common, providing operational flexibility and productivity benefits, but questions remain about whether and how it affects work quality. We investigate the quality effects of remote work in a context in which remote work separates workers... View Details

Keywords: Audit; Auditing; Remote Work; Compliance; Assessment; Environment; Management Systems; Quality Management; Quality Management System; Quality; Operations; Supply Chain Management; Environmental Management; Safety

SSRN

2023
Working Paper

The Complexity of Economic Decisions

By: Xavier Gabaix and Thomas Graeber

We propose a theory of the complexity of economic decisions. Leveraging a macroeconomic framework of production functions, we conceptualize the mind as a cognitive economy, where a task’s complexity is determined by its composition of cognitive operations. Complexity... View Details

Keywords: Decisions; Complexity; Perception; Consumer Behavior; Production

June 2023 (Revised July 2024)
Case

Biogen and the Aduhelm Melee

By: Amitabh Chandra and Lauren Gunasti

Alzheimer's Disease is a devastating condition affecting millions of Americans. At this time, there is no cure. In 2021, Biogen's Aduhelm (aducanumab) received FDA approval under the accelerated approval pathway after a controversial approval process.

This... View Details

Keywords: Health Testing and Trials; Governing Rules, Regulations, and Reforms; Valuation; Product Development; Pharmaceutical Industry

2024
Working Paper

Second- versus Third-party Audit Quality: Evidence from Global Supply Chain Monitoring

By: Maria R. Ibanez, Ashley Palmarozzo, Jodi L. Short and Michael W. Toffel

Capitalizing on the superior credibility and flexibility and potential lower cost of external assessments, many global buyers are relying less on their own employee (“second-party”) auditors and more on third-party auditors to monitor and prevent environmental and... View Details

Keywords: Auditing; Audit Quality; Working Conditions; Sustainability; Empirical Operations; Empirical Service Operations; Sustainability Management; Corporate Accountability; Corporate Social Responsibility and Impact; Supply Chain Management

SSRN

June 2023 (Revised August 2023)
Background Note

Subscription Models: Recurring Revenues for Lasting Growth

By: Elie Ofek and Amy Konary

This note offers a comprehensive exposition to subscription revenue models and aims to explain their recent rise. It covers the advantages to firms of employing a subscription-based approach to monetization (as opposed to “one-off” upfront payment), as well as the... View Details

Keywords: Business Model; Revenue; Product Design

June 2023 (Revised November 2023)
Case

Sober Sidekick

By: Jeffrey J. Bussgang and Kumba Sennaar

Case on the nascent business model of a mobile health IT startup. In particular, should they pivot away from their successful lead generation business model to charging health plans. View Details

Keywords: Entrepreneurship; Venture Capital; Operations; Business Startups; Business Model; Health Industry; United States

June 12, 2023
Article

How AI Will Accelerate the Circular Economy

By: Shirley Lu and George Serafeim

Despite living on a planet with finite resources, our economy remains largely linear and full of single-use products. The shift toward a circular economy, where companies recover or recycle resources, has hit roadblocks, including low value of used products and high... View Details

Keywords: Recycling; Materials Management; Innovation and Management; Technological Innovation; Climate Change; Environmental Sustainability; AI and Machine Learning; Operations; Industrial Products Industry; Consumer Products Industry; Technology Industry

June 2023
Teaching Note

Taiwan Semiconductor Manufacturing Company Limited: Global Leadership in Chipmaking

By: William C. Kirby and Noah B. Truwit

Teaching Note for HBS Case No. 321-126. The general purpose of this case is to explore the evolving nature of business relations across the Taiwan strait, focusing on the prominence of Taiwan's high-tech industry. After the legendary founder of Taiwan Semiconductor... View Details

Keywords: Geopolitical Units; Government and Politics; Competition; Production; Disruption; Semiconductor Industry; Manufacturing Industry; Taiwan; Taiwan Strait; China

June, 2023
Article

Walking the Purpose-Talk Inside a Large Company: Sustainable Product Development as an Instance of Divergent Change

By: Marissa Kimsey, Thijs Geradts and Julie Battilana

There is a growing interest in large companies pursuing a new purpose—changing their core reason for being from a singular focus on financial gain to a renewed responsibility to people and the planet alongside profit. Yet knowledge of how a large company can walk that... View Details

Keywords: Product Development; Environmental Sustainability; Mission and Purpose; Leading Change

Find at Harvard

May 2023
Case

CMA CGM: Reducing the Carbon Footprint of Container Shipping

By: Willy C. Shih and Emilie Billaud

Marine transport is the most cost-effective way to move large volumes over long distances, and container shipping is the backbone of international trade in goods. Yet shipping contributed 3% of worldwide greenhouse gas emissions, and the deep-sea segment, which... View Details

Keywords: Container Shipping; Logistic Regression; Trade Links; Decarbonization; Environmental Strategies; Environmental Impact; Globalization; Trade; Environmental Regulation; Logistics; Supply Chain; Governance Compliance; Shipping Industry; European Union; Asia; North America