Publications

February 2010
Case

Amyris Biotechnologies: Commercializing Biofuel

By: Gary P. Pisano and Alison Berkley Wagonfeld

In 2009, Amyris Biotechnologies was building a plant in Brazil that used synthetic biology to convert sugarcane into both renewable fuels and renewable chemicals. The Amyris' marketing team was investigating the commercial interest for both types of products, while the... View Details

Keywords: Renewable Energy; Chemicals; Risk Management; Product Marketing; Product Development; Production; Environmental Sustainability; Commercialization; Biotechnology Industry; Brazil

November 1989 (Revised August 1994)
Supplement

Du Pont's Titanium Dioxide Business (B)

Provides students with the opportunity to track industry evolution over time, to explore the role that signaling may play in such evolution, and to construct and validate industry scenarios. View Details

Keywords: Analysis; Supply and Industry; Chemical Industry

September 1991 (Revised February 1993)
Case

Burroughs Wellcome and AZT (A)

By: Willis M. Emmons III

Burroughs Wellcome Co., developer of AZT, the first drug approved by the U.S. Food and Drug Administration for the treatment of Acquired Immune Deficiency Syndrome (AIDS), finds itself under siege in September 1989 by AIDS activists and various segments of the U.S.... View Details

Keywords: Governing Rules, Regulations, and Reforms; Ethics; Business and Government Relations; Communication Strategy; Health Care and Treatment; Monopoly; Intellectual Property; Research and Development; Price; Pharmaceutical Industry; London

September 1996 (Revised December 1997)
Case

Cytec Industries' Spin-Off (A): Sink or Swim?

In the wake of market pressure to restructure, American Cyanamid spun off its poorly performing Chemicals Unit into a new publicly traded corporation, Cytec Industries. In addition to weak operations, Cytec inherited the bulk of Cyanamid's environmental and... View Details

Keywords: Organizational Change and Adaptation; Management Practices and Processes; Restructuring; Performance Improvement; Chemical Industry; United States

October 1990 (Revised April 1991)
Case

RU 486 (A)

By: Joseph L. Badaracco Jr.

Describes the factors faced by Roussel UCLAF, a French drug company, in deciding whether and how to market a controversial new drug, RU 486, which is often called "the French abortion pill." Roussel's decision involved its relations with the French government, its... View Details

Keywords: Judgments; Ethics; Product Launch; Negotiation; Outcome or Result; Performance; Business and Government Relations; Health Industry; Health Industry; France; Germany; United States

July 1997 (Revised April 1998)
Case

Chase Manhattan Corporation: The Making of America's Largest Bank

By: Stuart C. Gilson and Cedric Escalle

Chase Bank and Chemical Bank intend to merge, producing the largest commercial bank in the United States, the fourth largest in the world. Projected financial benefits under the merger reflect significant planned reduction in operating costs, including 17,000 employee... View Details

Keywords: Commercial Banking; Profit; Corporate Strategy; Value Creation; Restructuring; Negotiation; Mergers and Acquisitions; Risk and Uncertainty; Resignation and Termination; Revenue; Banking Industry; United States

October 1994 (Revised January 1995)
Case

Rhone-Poulenc (A) and (B) Condensed

Rhone-Poulenc, France's largest chemical firm, has achieved a major position in the United States as the result of an ambitious series of acquisitions. As it expanded in the United States from 1986 to 1990, Rhone-Poulenc management sought to take a "hands-off" approach... View Details

Keywords: Organizational Change and Adaptation; Multinational Firms and Management; Organizational Structure; Chemical Industry; France; United States

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September 1993
Case

Rhone-Poulenc (B)

Rhone-Poulenc, France's largest chemical firm, has achieved a major position in the United States as the result of an ambitious series of acquisitions. As it expanded in the United States from 1986 to 1990, Rhone-Poulenc management sought to take a "hands-off" approach... View Details

Keywords: Organizational Change and Adaptation; Multinational Firms and Management; Organizational Structure; Chemical Industry; France; United States

2022
Article

Missing Novelty in Drug Development

By: Joshua Krieger, Danielle Li and Dimitris Papanikolaou

We provide evidence that risk aversion leads pharmaceutical firms to underinvest in radical innovation. We introduce a new measure of drug novelty based on chemical similarity and show that firms face a risk-reward trade-off: novel drug candidates are less likely to... View Details

Keywords: Drug Development; Risk Aversion; Research and Development; Innovation and Invention; Investment; Pharmaceutical Industry

September 1993
Case

Rhone-Poulenc (A)

Rhone-Poulenc, France's largest chemical firm, with revenues of more than $7 billion in 1985, seeks to dramatically expand its presence in the United States. From 1986 to 1990, Rhone-Poulenc undertakes 18 separate acquisitions, ranging from small entrepreneurial firms... View Details

Keywords: Integration; Globalized Firms and Management; Acquisition; Chemical Industry; France

March 2001
Article

Technological Acquisitions and the Innovation Performance of Acquiring Firms: A Longitudinal Study

By: Gautam Ahuja and Riitta Katila

This paper examines the impact of acquisitions on the subsequent innovation performance of acquiring firms in the chemicals industry. We distinguish between technological acquisitions, acquisitions in which technology is a component of the acquired firm's assets, and... View Details

Keywords: Innovation; Acquisitions; Knowledge; Strategy; Knowledge Acquisition; Acquisition; Innovation and Invention; Chemical Industry

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Paul Gompers, Professor of Business Administration at the Harvard Business School, specializes in research on financial issues related to start-up, high growth, and newly public companies. Professor Gompers has an appointment in both the View Details

Keywords: information technology industry; information technology industry; information technology industry; information technology industry; information technology industry; information technology industry; information technology industry; information technology industry

September 1986 (Revised February 2007)
Case

Solagen: Process Improvement in the Manufacture of Gelatin at Kodak

By: Dorothy A. Leonard and Brian DeLacey

Kodak must decide whether to make a major investment in a production facility designed around a new technique for producing the gelatin critical to so many film and paper products. Currently, gelatin making is an arcane art, unchanged in 150 years and heavily dependent... View Details

Keywords: Arts; Buildings and Facilities; Factories, Labs, and Plants; Experience and Expertise; Engineering; Investment; Time Management; Production; Research and Development; Semiconductor Industry

Article

The Evolution of Science-Based Business: Innovating How We Innovate

By: Gary P. Pisano

Science has long been connected to innovation and to business. As early as the late 19th century, chemical companies, realizing the commercial potential of science, created the first industrial research laboratories. During much of the 20th century, large-scale... View Details

Keywords: Entrepreneurship; Governance; Innovation and Management; Risk Management; Research and Development; Science-Based Business; Commercialization

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October 1992 (Revised August 1994)
Case

Allied-Signal: Managing the Hazardous Waste Liability Risk

By: Richard H.K. Vietor and Edward Prewitt

Allied-Signal, Inc., one of the world's oldest chemical companies and today a diversified conglomerate, is liable for clean-up costs of old hazardous waste sites. These costs are substantial: reserves grew to nearly $500 million in 1991. Attempting to avoid further... View Details

Keywords: Wastes and Waste Processing; Environmental Sustainability; Programs; Cost Management; Policy; Government Legislation; Factories, Labs, and Plants; Governance Compliance; Legal Liability; Chemical Industry; United States; Europe

September 2011
Case

China Development Bank

By: Li Jin, Matthew Preble and Aldo Sesia

In May 2011, Chairman Chen Yuan of the China Development Bank (CDB) was thinking back on CDB's financing of a major project between Petroleo Brasileiro SA (Petrobras), Brazil's state-owned oil and gas producer and China Petroleum & Chemical Corporation (Sinopec), one... View Details

Keywords: International Finance; Emerging Markets; Energy Sources; Banks and Banking; Energy Industry; Brazil; China

December 2017 (Revised December 2018)
Case

OCP Group

By: Kristin Fabbe, Forest Reinhardt, Natalie Kindred and Alpana Thapar

This case explores the strategy of OCP Group, the 95% state-owned Moroccan firm charged with managing the North African country’s vast reserves of phosphate. Phosphate was one of the most vital macronutrients for plant health, along with nitrogen and potassium, and... View Details

Keywords: OCP; OCP Group; Casablanca; Chemicals; Operations; Transformation; Competitive Strategy; Competitive Advantage; Chemical Industry; Morocco

14 Jul 2020
Research & Ideas

Restarting Under Uncertainty: Managerial Experiences from Around the World

decisions more quickly and reliably. Case 3: Preempt the threats Brazil Energy Biomass is an energy producer, generating steam from biomass and selling the energy to industrial clients in take-or-pay contracts. The company has two plants... View Details

Keywords: by Raffaella Sadun, Andrea Bertoni, Alexia Delfino, Giovanni Fassio, and Mariapaola Testa

January 1990 (Revised October 1993)
Case

Monsanto's March into Biotechnology (A)

By: Gary P. Pisano

Very early in the history of biotechnology (about 1979), Monsanto made a major commitment to move into this field. This case recounts the history from the point of view of the eminent scientist hired to head up corporate R&D. He took Monsanto from a very traditional... View Details

Keywords: History; Transition; Biotechnology Industry; Biotechnology Industry