• December 2023 (Revised March 2024)
• Case

Manufacturing Moderna's Future

By: Satish Tadikonda and William Marks

In 2019, Moderna faced long odds of survival having failed to develop a successful clinical program out of the vast platform technology they had built around mRNA. Nearly overnight, the company skyrocketed to success with a vaccine for COVID-19, leading to an extremely... View Details

Keywords: Health Pandemics; Health Testing and Trials; Technological Innovation; Product Development; Production; Science-Based Business; Biotechnology Industry

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Tadikonda, Satish, and William Marks. "Manufacturing Moderna's Future." Harvard Business School Case 824-076, December 2023. (Revised March 2024.)

• 2025
• Working Paper

Enhancing Treatment Effect Prediction on Privacy-Protected Data: An Honest Post-Processing Approach

By: Ta-Wei Huang and Eva Ascarza

As firms increasingly rely on customer data for personalization, concerns over privacy and regulatory compliance have grown. Local Differential Privacy (LDP) offers strong individual-level protection by injecting noise into data before collection. While... View Details

Keywords: Targeted Intervention; Conditional Average Treatment Effect Estimation; Differential Privacy; Honest Estimation; Post-processing; Analytics and Data Science; Consumer Behavior; Marketing

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Huang, Ta-Wei, and Eva Ascarza. "Enhancing Treatment Effect Prediction on Privacy-Protected Data: An Honest Post-Processing Approach." Harvard Business School Working Paper, No. 24-034, December 2023. (Revised March 2025.)

• December 2023
• Case

Raízen: Helping to Decarbonize the World?

By: Gunnar Trumbull, Pedro Levindo, Daniel Tong and Rafaella Mazza

Raízen, the world’s largest sugar and ethanol producer, strived to find ways to expand the second-generation ethanol (E2G) market, which it pioneered. The company planned to invest R$24 billion (around $4.6 billion) in 20 production plants, with a total capacity to... View Details

Keywords: Plant-Based Agribusiness; Factories, Labs, and Plants; Renewable Energy; Environmental Sustainability; Production; Expansion; Agriculture and Agribusiness Industry; Energy Industry; Brazil; Europe; North America; United States; Argentina; Paraguay

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Trumbull, Gunnar, Pedro Levindo, Daniel Tong, and Rafaella Mazza. "Raízen: Helping to Decarbonize the World?" Harvard Business School Case 724-014, December 2023.

• December 2023 (Revised July 2024)
• Case

Boortmalt: The Master Maltster

By: Forest Reinhardt, Jose B Alvarez, Damien McLoughlin, Lena Duchene and Emer Moloney

By May 2023, Boortmalt was the world’s leading producer of malt, with a production capacity of 3 million tonnes, 15% of global market share, and 27 malting plants across five continents. It had recently acquired a major competitor and had sustained an EBITDA growth of... View Details

Keywords: Plant-Based Agribusiness; Mergers and Acquisitions; Talent and Talent Management; Customer Focus and Relationships; Values and Beliefs; Financing and Loans; Employee Relationship Management; Collaborative Innovation and Invention; Innovation Leadership; Knowledge Sharing; Leadership Style; Business or Company Management; Growth and Development Strategy; Growth Management; Management Style; Resource Allocation; Corporate Social Responsibility and Impact; Strategic Planning; Environmental Sustainability; Organizational Culture; Agriculture and Agribusiness Industry; Belgium; Europe

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Reinhardt, Forest, Jose B Alvarez, Damien McLoughlin, Lena Duchene, and Emer Moloney. "Boortmalt: The Master Maltster." Harvard Business School Case 724-021, December 2023. (Revised July 2024.)

• December 2023
• Case

Santa Elena: Table Grape Production in Chile's Water-Challenged Regions

By: Forest Reinhardt, Jenyfeer Martinez Buitrago and Mariana Cal

In the fiscal year ending in September 2022, Santa Elena, Chile’s fifth-ranking table grape exporter, a grape producer and exporter since 1980, had exported around 3.5 million boxes (18-pound each). But, due to a 13-year-long drought that plagued table grape-growing... View Details

Keywords: Plant-Based Agribusiness; Climate Change; Environmental Regulation; Environmental Sustainability; Natural Resources; Food; Environmental Law; Problems and Challenges; Weather; Adaptation; Business Strategy; Organizational Change and Adaptation; Agriculture and Agribusiness Industry; Chile; South America; Latin America

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Reinhardt, Forest, Jenyfeer Martinez Buitrago, and Mariana Cal. "Santa Elena: Table Grape Production in Chile's Water-Challenged Regions." Harvard Business School Case 724-019, December 2023.

• 2023
• Article

Benchmarking Large Language Models on CMExam—A Comprehensive Chinese Medical Exam Dataset

By: Junling Liu, Peilin Zhou, Yining Hua, Dading Chong, Zhongyu Tian, Andrew Liu, Helin Wang, Chenyu You, Zhenhua Guo, Lei Zhu and Michael Lingzhi Li

Recent advancements in large language models (LLMs) have transformed the field of question answering (QA). However, evaluating LLMs in the medical field is challenging due to the lack of standardized and comprehensive datasets. To address this gap, we introduce CMExam,... View Details

Keywords: Large Language Model; AI and Machine Learning; Analytics and Data Science; Health Industry

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Liu, Junling, Peilin Zhou, Yining Hua, Dading Chong, Zhongyu Tian, Andrew Liu, Helin Wang, Chenyu You, Zhenhua Guo, Lei Zhu, and Michael Lingzhi Li. "Benchmarking Large Language Models on CMExam—A Comprehensive Chinese Medical Exam Dataset." Conference on Neural Information Processing Systems (NeurIPS), Datasets and Benchmarks Track 36 (2023).

• 2023
• Other Article

The Harvard USPTO Patent Dataset: A Large-Scale, Well-Structured, and Multi-Purpose Corpus of Patent Applications

By: Mirac Suzgun, Luke Melas-Kyriazi, Suproteem K. Sarkar, Scott Duke Kominers and Stuart Shieber

Innovation is a major driver of economic and social development, and information about many kinds of innovation is embedded in semi-structured data from patents and patent applications. Though the impact and novelty of innovations expressed in patent data are difficult... View Details

Keywords: USPTO; Natural Language Processing; Classification; Summarization; Patent Novelty; Patent Trolls; Patent Enforceability; Patents; Innovation and Invention; Intellectual Property; AI and Machine Learning; Analytics and Data Science

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Suzgun, Mirac, Luke Melas-Kyriazi, Suproteem K. Sarkar, Scott Duke Kominers, and Stuart Shieber. "The Harvard USPTO Patent Dataset: A Large-Scale, Well-Structured, and Multi-Purpose Corpus of Patent Applications." Conference on Neural Information Processing Systems (NeurIPS), Datasets and Benchmarks Track 36 (2023).

• November 2023
• Case

Gabon Special Economic Zone

By: John Macomber and Wale Lawal

Tropical rain forest covers about 80% of the West African nation of Gabon, part of the Congo Basin and the "lungs of the world." Gabon is one of the first nations to earn revenue from carbon sequestration...as long as the rain forest remains intact. There are... View Details

Keywords: Economic Development; Forestry; Wood; Carbon Credits; Supply Chain; Economic Growth; Developing Countries and Economies; Climate Change; Environmental Sustainability; Government Administration; Business and Government Relations; Strategy; Forest Products Industry; Africa; Gabon

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Macomber, John, and Wale Lawal. "Gabon Special Economic Zone." Harvard Business School Case 224-012, November 2023.

• November 2023 (Revised April 2024)
• Case

BiomX: Bringing Phage Back to the Stage

By: Paul A. Gompers, Elie Ofek, Orna Dan and Emilie Billaud

In the spring of 2023, and following the favorable results of a trial involving its phage cocktail for treating lung infections among cystic fibrosis (CF) patients, the leadership of BiomX had several critical issues to wrestle with. First, given its precarious... View Details

Keywords: Working Capital; Financing and Loans; Health Testing and Trials; Product Development; Research and Development; Science-Based Business; Commercialization; Biotechnology Industry; Pharmaceutical Industry

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Gompers, Paul A., Elie Ofek, Orna Dan, and Emilie Billaud. "BiomX: Bringing Phage Back to the Stage." Harvard Business School Case 524-051, November 2023. (Revised April 2024.)

• November 2023 (Revised November 2024)
• Case

Decarbonizing Shipping at A.P. Møller-Maersk (A)

By: Willy Shih, Michael W. Toffel and Kelsey Carter

Container shipping was responsible for moving more than 80% of globally traded goods, and almost 3% of global greenhouse gas emissions. A.P. Møller-Maersk, one of the top three container lines, conducted an extensive lifecycle assessment (LCA) of alternative fuels,... View Details

Keywords: Greenhouse Gas Emissions; Energy Sources; Environmental Sustainability; Ship Transportation; Shipping Industry

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Shih, Willy, Michael W. Toffel, and Kelsey Carter. "Decarbonizing Shipping at A.P. Møller-Maersk (A)." Harvard Business School Case 624-049, November 2023. (Revised November 2024.)