Publications

October 2012
Case

GSK's Acquisition of Sirtris: Independence or Integration? (Abridged)

By: Toby Stuart and James Weber

An executive from pharmaceutical company GSK must choose how much to integrate a recently acquired biotechnology firm, Sirtris. Moncef Slaoui, GSK's global head of R&D, championed the acquisition of Sirtris to gain access to its potentially revolutionary science.... View Details

Keywords: Mergers and Acquisitions; Resource Allocation; Organizational Change and Adaptation; Organizational Culture; Organizational Structure; Research and Development; Science-Based Business; Integration

October 1998 (Revised December 1999)
Case

Gene Research, the Mapping of Life and the Global Economy

By: Ray A. Goldberg and Juan Enriquez-Cabot

A new firm is being created to speed up the process of mapping humans, animals, and plants by combining gene technology with rapid gene identification to improve the health and well being of the human population and the productivity of crops and animals. How does one... View Details

Keywords: Information Technology; Organizational Structure; Technological Innovation; Business Processes; Health Care and Treatment; Performance Productivity; Welfare; Agribusiness; Genetics; Science-Based Business; Biotechnology Industry; Agriculture and Agribusiness Industry

July 2004 (Revised March 2006)
Case

RosettaNet and ebXML: Betting on the Right eBusiness Standard

By: F. Warren McFarlan and Veronika Belokhvostova

A major enterprise software company must select which technologies to support, based on their long-term and short-term viability and benefits. The protagonist is involved in the release of the B2B integration component of major enterprise software whose purpose is to... View Details

Keywords: Communication Technology; Customer Focus and Relationships; Markets; Standards; Science-Based Business; Situation or Environment; Applications and Software; Technology Adoption; Information Technology Industry

October 2024 (Revised November 2024)
Case

SWEN Blue Ocean: Impact Investing Goes to Sea

By: Vikram S Gandhi and David Allen

In August 2023, SWEN Blue Ocean, a €170 million impact fund that invested in startups contributing to ocean sustainability, faced a critical investment decision. Part of SWEN Capital Partners, an €8 billion, Paris-based private equity fund, Blue Ocean was co-founded in... View Details

Keywords: Communication Technology; Environmental Sustainability; Green Technology; Finance; Capital; Venture Capital; Private Equity; Investment; Investment Funds; Science-Based Business; Financial Services Industry; France; Paris; Italy

May 2006 (Revised June 2006)
Case

Codon Devices

By: Joseph B. Lassiter III and David Kiron

In December 2005, 40-year-old John Danner was about to make his first presentation to the board of directors of Codon Devices, a one-year-old biotechnology start-up based in Cambridge, Massachusetts. After a month as the company's CEO, Danner was prepared to lay out... View Details

Keywords: Strategic Planning; Venture Capital; Intellectual Property; Governing and Advisory Boards; Genetics; Competitive Advantage; Science-Based Business; Business Startups; Growth and Development Strategy; Biotechnology Industry; Cambridge

Find at Harvard

September 1993 (Revised October 1994)
Case

Environment and International Trade

By: Forest L. Reinhardt

During the 1990s, environmental activists became interested in trade issues for the first time. Whereas GATT, the General Agreement on Tariffs and Trade, had previously been the province of trade specialists, a new poster popular among environmentalists depicted the... View Details

Keywords: Trade; Environmental Sustainability; Science-Based Business; Policy; Government and Politics; Agreements and Arrangements; Alliances; Globalization; International Relations; Conflict of Interests

February 2014
Case

BGI: Data-driven Research

By: Willy Shih and Sen Chai

BGI has the largest installed gene-sequencing capacity in the world, and to Zhang Gengyun, general manager of the Life Sciences Division, this represented an opportunity to apply his training as a plant breeder and his early career work as a biochemist to improving... View Details

January 2017 (Revised December 2017)
Case

Carmichael Roberts: To Create a Private Equity Firm?

By: Steven Rogers and Kenneth J. Cooper

Carmichael Roberts, a rare African-American venture capitalist, considered leaving his general partnership in a private equity firm near Boston and setting up his own in 2015. He weighed whether the timing was right, with the economy still not fully recovered from the... View Details

February 2020
Supplement

Indigo Agriculture: Harnessing Nature

By: Michael W. Toffel and James Barnett

Indigo Agriculture used a digital-enabled research and development (R&D) process to launch its initial product, microbial coatings for agricultural seeds, which increase crop yields while reducing the need for fertilizers. In doing so, the company developed direct... View Details

Keywords: Operations; Supply Chain; Social Enterprise; Product Development; Distribution Channels; Business Strategy; Digital Platforms; Environmental Sustainability; Science-Based Business; Climate Change; Agriculture and Agribusiness Industry; Green Technology Industry; United States; Massachusetts

01 Mar 2003
News

Inside the Revolution

humanity discovered how to use fire,” says Enriquez’s colleague, HBS associate professor Jonathan West. West, who had been researching the semiconductor industry for some ten years, came to the life sciences field rather recently. Increasingly intrigued by how... View Details

Keywords: Garry Emmons; Eileen McCluskey; Jonathan West; Life Sciences Project; LSP; Colleges, Universities, and Professional Schools; Educational Services

August 1991 (Revised March 1993)
Case

Champion International Corp.: Timber, Trade, and the Northern Spotted Owl

By: Forest L. Reinhardt

Champion's forest products division owns timberlands, sawmills, and plywood mills in the Pacific Northwest. The listing of the northern spotted owl as an endangered species, and restrictions on exports of logs from state-owned lands, have disrupted the stumpage, log... View Details

Keywords: Science-Based Business; Natural Environment; Product Marketing; Governing Rules, Regulations, and Reforms; Government and Politics; Environmental Sustainability; Corporate Strategy; Trade; Decisions; Management Teams; Forest Products Industry; North and Central America

November 2019 (Revised June 2020)
Case

Indigo Agriculture: Harnessing Nature

By: Marco Iansiti, Michael W. Toffel and James Barnett

Indigo Agriculture used a digital-enabled research and development (R&D) process to launch its initial product, microbial coatings for agricultural seeds, which increase crop yields while reducing the need for fertilizers. In doing so, the company developed direct... View Details

Keywords: Carbon Sequestration; Operations; Supply Chain; Social Enterprise; Product Development; Distribution Channels; Business Strategy; Digital Platforms; Environmental Sustainability; Science-Based Business; Climate Change; Agriculture and Agribusiness Industry; Green Technology Industry; United States; Massachusetts

September 2023 (Revised November 2023)
Case

Seeds of Innovation: GALY's Quest to Cultivate the Future of Agriculture in the Lab

By: George Serafeim and Michael Norris

In 2023, Luciano Bueno, CEO and founder of plant cell culture agriculture company GALY, was considering the best path forward for his company as he planned to pitch Series B investors. GALY, founded in 2019, aimed to produce cotton and other crops from cells grown in... View Details

Keywords: Business Model; Green Technology; Goods and Commodities; Growth and Development Strategy; Science-Based Business; Entrepreneurship; Plant-Based Agribusiness; Business Startups; Decisions; Technological Innovation; Production; Agriculture and Agribusiness Industry; Technology Industry; Boston; Sao Paulo

17 Oct 2012
Research & Ideas

America Needs a Manufacturing Renaissance

huge role, even in highly market-oriented economies like America's. There was nothing natural about the creation of the United States' strength in science-based industries. Government policy played a critical role. After World War II, the... View Details

Keywords: by Gary P. Pisano & Willy C. Shih; Manufacturing

November 2012
Case

CSIRO: The Light Metals Flagship Decision

By: Willy Shih, Margaret P. Pierson and Dawn Lau

This case explores the challenge of investing in basic research as a public good. CSIRO was Australia's leading science and research agency, and it was chartered to enhance national prosperity through R&D. Its Flagships program was designed to align research interests... View Details

November 2016 (Revised November 2016)
Case

Radial Analytics Probes Post-Acute Care

By: Richard G. Hamermesh and Olivia Hull

Thaddeus Fulford-Jones and Eric Weiss, founders of healthcare technology startup Radial Analytics, have been busy developing a software program designed to save hospitals money and improve patient outcomes by producing customized care plans for patients leaving the... View Details

Keywords: Electronic Medical Records; Electronic Health Records; Data Science; Entrepreneurship; Health Care and Treatment; Business Model; Business Startups; Innovation and Invention; Growth Management; Marketing Strategy; Product Launch; Product Positioning; Science-Based Business; Business Strategy; Health Industry; Technology Industry; Cambridge; Massachusetts

October 2016 (Revised November 2016)
Case

Innovating Beyond Ochsner

By: Richard G. Hamermesh and Olivia Hull

The Ochsner Health System has developed a proprietary software tool designed to treat hypertension. Built into the system’s electronic medical records, the Hypertension Digital Medicine program allows patients to record their blood pressure at home and share readings... View Details