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October 2012
Teaching Plan

Vertex Pharmaceuticals and the Cystic Fibrosis Foundation: Venture Philanthropy Funding for Biotech (TP)

By: Robert F. Higgins

This is the teaching note related to HBS case 808005. In 2001, Vertex Pharmaceuticals Incorporated acquired the San Diego-based biotech company, Aurora Biosciences. The combination of Vertex's and Aurora's technologies would improve the flow of novel drug candidates... View Details

Keywords: Venture Philanthropy; Biotechnology; Funding Philanthropy Venture; Cystic Fibrosis; Foundations; Pharmaceuticals; Mergers and Acquisitions; For-Profit Firms; Venture Capital; Philanthropy and Charitable Giving; Science-Based Business; Nonprofit Organizations; Pharmaceutical Industry; Biotechnology Industry; United States; San Diego

May 2008
Case

Sensors Unlimited: Bringing InGaAs Technology to the Market

By: Willy C. Shih

Sensors Unlimited was a small start-up in short-wavelength infrared imaging. Its learning base came out of Bell Labs, RCA's Sarnoff Lab, and the Rockwell Science Center, and as it built its capabilities and ventured into new application areas, it discovered a “killer... View Details

Keywords: Applied Optics; Mergers and Acquisitions; Business Startups; Growth and Development Strategy; Science-Based Business; Commercialization; Aerospace Industry; Technology Industry

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August 2024 (Revised November 2024)
Case

Commonwealth Fusion Systems: Born at Scale

By: Joshua Lev Krieger, Jim Matheson, Kyle Myers, Gunnar Trumbull and Richard Vietor

This case study chronicles the journey of Commonwealth Fusion Systems (CFS) on its ambitious mission to commercialize fusion energy and become the world’s leading provider of fusion power plants. Emerging from a “special arrangement” with MIT's Plasma Science and... View Details

Keywords: Nuclear Energy; Innovation; Entrepreneurship; Entrepreneurial Finance; Energy Generation; Commercialization; Science-Based Business; Technological Innovation; Market Entry and Exit; Energy Industry

January 2011 (Revised July 2012)
Case

Arcadia Biosciences: Seeds of Change (Abridged)

By: Arthur A. Daemmrich

Arcadia Biosciences is seeking to introduce genetically modified rice to China that will lower farmers' costs and generate environmental benefits through reduced greenhouse gas emissions. The case describes challenges facing this small agricultural biotechnology... View Details

Keywords: Plant-Based Agribusiness; Intellectual Property; Genetics; Environmental Sustainability; Science-Based Business; Climate Change; Agriculture and Agribusiness Industry; Biotechnology Industry; China

18 Apr 2019
Research & Ideas

Open Innovation Contestants Build AI-Based Cancer Tool

article, “Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting,” is co-authored by Harvard Business School Professor Karim R. Lakhani and seven colleagues with expertise in radiation... View Details

Keywords: by Martha Lagace; Health; Medical Devices & Supplies

December 2009 (Revised April 2012)
Case

Neoprene

By: Tom Nicholas and Felipe Tamega Fernandes

In 1931, during one of the worst economic crises in U.S. history, Du Pont announced the discovery of an innovative rubber synthetic product—neoprene. Yet at the time of the announcement, Du Pont did not have any neoprene to sell. Manufacturing facilities were still... View Details

Keywords: Financial Crisis; Business History; Innovation and Invention; Product Development; Risk and Uncertainty; Science-Based Business; Commercialization; Chemical Industry; United States

2015
Case

Advanced Leadership Pathways: Torsten Thiele and the Global Ocean Trust

By: Rosabeth Moss Kanter and Brian Hoffstein

Following a successful career in finance, Torsten Thiele devoted himself full-time to the challenging cause of ocean conservation and stewardship. In August 2015, Thiele had already come a long way in spearheading initiatives towards the protection of the ocean: from... View Details

Keywords: Environment; Natural Environment; Environmental Sustainability; Pollutants; Science-Based Business; Climate Change; Social Enterprise; Leadership

September 2007 (Revised May 2009)
Case

Syndexa and Technology Transfer at Harvard University

By: Richard G. Hamermesh and David Kiron

Gokhan Hotamisligil is a star researcher at Harvard School of Public Health who has made groundbreaking discoveries linking fat cells, inflammation, and diabetes. He now wants to form a company to commercialize these discoveries. At the same time, Isaac Kohlberg, the... View Details

Keywords: Business Startups; Higher Education; Entrepreneurship; Innovation and Invention; Intellectual Property; Rights; Agreements and Arrangements; Science-Based Business; Commercialization; Biotechnology Industry; Health Industry

May 2006
Case

A123Systems

By: H. Kent Bowen, Kenneth P Morse and Douglass Cannon

A 123Systems was a young company that was founded on basic materials science research at the Massachusetts Institute of Technology. A co-founder of the company, Yet-Ming Chiang, was a full professor at MIT and served as scientific adviser. Intellectual property based... View Details

Keywords: Intellectual Property; Business Startups; Research and Development; Commercialization; Technological Innovation; Science-Based Business; Product Development; Battery Industry; Electronics Industry; Massachusetts

August 2011 (Revised October 2011)
Case

PureTech Ventures in 2011

By: Andrei Hagiu, Cesar Castro and Sarah Murphy

In early May 2011, Daphne Zohar, founder and managing partner of PureTech Ventures, a life science venture creation company in Boston, MA, was reviewing a term sheet she had just received from a venture capital (VC) firm for one of PureTech's portfolio companies. The... View Details

Keywords: Business Ventures; Business Startups; Venture Capital; Investment; Innovation and Invention; Negotiation; Partners and Partnerships; Science-Based Business; Opportunities; Boston

December 2000
Case

CellFor, Inc.

By: Ray A. Goldberg, Carin-Isabel Knoop, Frantz Edward Alphonse and Laure Mougeot Stroock

A new private company has developed a process to clone and multiply seeds for the forestry industry. View Details

Keywords: Business Startups; Transition; Technological Innovation; Private Ownership; Research and Development; Science-Based Business; Technology Adoption; Forestry Industry

2001
Chapter

Publicly Funded Science and the Productivity of the Pharmaceutical Industry

By: Rebecca Henderson and Ian Cockburn

U.S. taxpayers funded $14.8 billion of health related research last year, four times the amount that was spent in 1970 in real terms. In this paper we evaluate the impact of these huge expenditures on the technological performance of the pharmaceutical industry. While... View Details

Keywords: Public Sector; Science-Based Business; Research and Development; Sovereign Finance; Pharmaceutical Industry

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June 2011 (Revised October 2013)
Case

Gene Patents (A)

By: Richard Hamermesh, David Kiron and Phillip Andrews

In March 2010, U.S. District Court Judge Robert Sweet overturned 30 years of legal precedent and ruled that unaltered human genes could not be patented. This case reviews patent law and how it relates to our increasing knowledge of the Human Genome. The case issues... View Details

Keywords: Courts and Trials; Patents; Genetics; Judgments; Science-Based Business; Biotechnology Industry; United States

November 2021 (Revised May 2022)
Case

QuantumScape's Mission to Revolutionize Energy Storage for a Sustainable Future

By: William A. Sahlman, Allison M. Ciechanover and Jeff Huizinga

QuantumScape CEO Jagdeep Singh juggles the many activities required to lead the next-generation battery pioneer. Founded in 2010, QuantumScape’s mission was to develop new “solid-state” car batteries that would improve upon traditional lithium-ion batteries in key... View Details

Keywords: Batteries; Electric Vehicles; SPACs; Innovation and Management; Technological Innovation; Science-Based Business; Environmental Sustainability; Auto Industry; Energy Industry; California; San Jose

April 2020
Teaching Note

Indigo Agriculture: Harnessing Nature

By: Michael W. Toffel and James Barnett

Teaching Note for HBS No. 620-024. Indigo Agriculture used a digital-enabled research and development (R&D) process to launch its initial product, microbial coatings for agricultural seeds, which increase crop yields while reducing the need for fertilizers. In doing... View Details

Keywords: Operations; Supply Chain; Social Enterprise; Product Development; Distribution Channels; Business Strategy; Digital Platforms; Science-Based Business; Agriculture and Agribusiness Industry; Green Technology Industry; United States; Massachusetts

March 2025
Case

Niramai: An AI Solution to Save Lives

By: Rembrand Koning, Maria P. Roche and Kairavi Dey

Founded in 2017, Niramai developed Thermalytix, a breast cancer screening tool. Thermalytix used a high-resolution thermal sensing device and machine learning algorithms to analyze thermal images and detect tumors. Its patented solution leveraged big data analytics,... View Details

Keywords: Entrepreneurship; AI and Machine Learning; Technology Adoption; Health Care and Treatment; Innovation and Management; Entrepreneurial Finance; Business Strategy; Science-Based Business; Technology Industry; Health Industry; Asia; India; South Asia

May 2006 (Revised June 2006)
Case

Codon Devices

By: Joseph B. Lassiter III and David Kiron

In December 2005, 40-year-old John Danner was about to make his first presentation to the board of directors of Codon Devices, a one-year-old biotechnology start-up based in Cambridge, Massachusetts. After a month as the company's CEO, Danner was prepared to lay out... View Details

Keywords: Strategic Planning; Venture Capital; Intellectual Property; Governing and Advisory Boards; Genetics; Competitive Advantage; Science-Based Business; Business Startups; Growth and Development Strategy; Biotechnology Industry; Cambridge

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February 2007 (Revised April 2010)
Case

Wyeth Pharmaceuticals: Spurring Scientific Creativity with Metrics

By: Robert S. Huckman, Gary P. Pisano and Mark Rennella

Describes the reorganization of the drug discovery organization at Wyeth Pharmaceuticals and focuses on the decisions to: (1) centralize decision-making within drug discovery and (2) institute numerical metrics--jointly affecting all R&D scientists--for the progression... View Details

Keywords: Decision Making; Measurement and Metrics; Business Processes; Organizational Structure; Research and Development; Science-Based Business; Creativity; Pharmaceutical Industry

December 2008 (Revised January 2011)
Case

Arcadia Biosciences: Seeds of Change

By: Arthur A. Daemmrich, Forest L. Reinhardt and Mary Louise Shelman

Arcadia Biosciences is an entrepreneurial California agricultural biotech company seeking to earn carbon credits by modifying commodity crops for use in China and India. Eric Rey, Arcadia's CEO, faced a strategic inflection point in early September 2008. The company... View Details

Keywords: Business Startups; Entrepreneurship; Growth and Development Strategy; Environmental Sustainability; Science-Based Business; Climate Change; Agriculture and Agribusiness Industry; Biotechnology Industry; China; India; California

01 Mar 2005
News

Campaign Passes Goal, Continues

SALTER: student financial aid vital to HBS. With little fanfare, The Campaign for Harvard Business School reached the $500 million mark at the end of 2004. The School’s first-ever campaign will continue through its December 2005... View Details

Keywords: Colleges, Universities, and Professional Schools; Educational Services; Religious, Grantmaking, Civic, Professional, and Similar Organizations; Personal Services

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