Publications

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26 Mar 2012
Research & Ideas

What Neuroscience Tells Us About Consumer Desire

In the early 1950s, two scientists at McGill University inadvertently discovered an area of the rodent brain dubbed "the pleasure center," located deep in the nucleus accumbens. When a group of lab rats had the opportunity to stimulate their own pleasure... View Details

Keywords: by Carmen Nobel; Consumer Products

November 2023 (Revised March 2024)
Case

Infarm: Betting the (Indoor) Farm on Food Security

By: Elie Ofek

In the summer of 2023, the co-founders of Infarm, a controlled environment agriculture (CEA) company, were contemplating a major pivot going forward. While Infarm had successfully shown it could grow over 75 products—mainly herbs, leafy greens and mushrooms—in modular... View Details

Keywords: Plant-Based Agribusiness; Business Model; Market Entry and Exit; Science-Based Business; Business Strategy; Transition; Agriculture and Agribusiness Industry; Europe; North America; Toronto; Northeastern United States

May 2008
Case

Sensors Unlimited: Bringing InGaAs Technology to the Market

By: Willy C. Shih

Sensors Unlimited was a small start-up in short-wavelength infrared imaging. Its learning base came out of Bell Labs, RCA's Sarnoff Lab, and the Rockwell Science Center, and as it built its capabilities and ventured into new application areas, it discovered a “killer... View Details

Keywords: Applied Optics; Mergers and Acquisitions; Business Startups; Growth and Development Strategy; Science-Based Business; Commercialization; Aerospace Industry; Technology Industry

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Confronting Climate Change: Risks and Opportunities

emissions, and greentech. More resources from HBS: HBS Working Knowledge - keep updated about Harvard Business School faculty on issues including science-based businesses, environmental sustainability, and climate change. HBS... View Details

February 2009
Teaching Note

Syndexa and Technology Transfer at Harvard University (TN)

By: Richard G. Hamermesh

Teaching Note for [808073]. View Details

Keywords: Agreements and Arrangements; Commercialization; Science-Based Business; Research; Rights; Pharmaceutical Industry

15 Oct 2013
First Look

First Look: October 15

a Technology Company or a Beauty Company? Jon Flint came up with the idea of a science-based beauty company while talking with his hairdresser about the problems with typical hair and skin care products. Together with a small team that... View Details

Keywords: Sean Silverthorne

01 Mar 2005
News

Campaign Passes Goal, Continues

organizations and communities they join. “What we do here has a deep and broad impact on society as a whole. The School really is a pioneer. Just look at our current research in entrepreneurship and social enterprise, and our new initiatives in health care, education... View Details

Keywords: Colleges, Universities, and Professional Schools; Educational Services; Religious, Grantmaking, Civic, Professional, and Similar Organizations; Personal Services

February 2007 (Revised April 2010)
Case

Wyeth Pharmaceuticals: Spurring Scientific Creativity with Metrics

By: Robert S. Huckman, Gary P. Pisano and Mark Rennella

Describes the reorganization of the drug discovery organization at Wyeth Pharmaceuticals and focuses on the decisions to: (1) centralize decision-making within drug discovery and (2) institute numerical metrics--jointly affecting all R&D scientists--for the progression... View Details

Keywords: Decision Making; Measurement and Metrics; Business Processes; Organizational Structure; Research and Development; Science-Based Business; Creativity; Pharmaceutical Industry

September 2023 (Revised April 2024)
Case

Atomwise: Strategic Opportunities in AI for Pharma

By: Satish Tadikonda

Abraham Heifets and his co-founder, Izhar Wallach, had founded Atomwise to develop i) an AI engine to transform drug discovery by creating better medicines faster, and ii) a machine learning-based discovery engine that combined the power of convolutional neural... View Details

Keywords: Business Model; Business Startups; AI and Machine Learning; Science-Based Business; Technological Innovation; Biotechnology Industry; Pharmaceutical Industry

September 2024
Case

Myeloma Investment Fund

By: Kyle Myers and Scott Sawaya

This case explores a critical decision facing the Myeloma Investment Fund (MIF) as it evaluates two investment opportunities aimed at accelerating a cure for multiple myeloma.

The MIF, a venture philanthropy fund, must choose between two distinct paths. One... View Details

Keywords: Venture Philanthropy; Biomedical Research; Investing For Impact; Innovation ＆ Entrepreneurship; Venture Capital; Science-Based Business; Philanthropy and Charitable Giving; Decision Making; Health Care and Treatment; Biotechnology Industry; Pharmaceutical Industry

2010
Working Paper

Boundary Spanning in a For-profit Research Lab: An Exploration of the Interface Between Commerce and Academe

By: Christopher C. Liu and Toby E. Stuart

In innovative industries, private-sector companies increasingly are participants in open communities of science and technology. To participate in the system of exchange in such communities, firms often publicly disclose what would otherwise remain private discoveries.... View Details

Keywords: For-Profit Firms; Higher Education; Information Publishing; Innovation and Invention; Science-Based Business; Social and Collaborative Networks; Boundaries; Biotechnology Industry; Pharmaceutical Industry

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2001
Chapter

Publicly Funded Science and the Productivity of the Pharmaceutical Industry

By: Rebecca Henderson and Ian Cockburn

U.S. taxpayers funded $14.8 billion of health related research last year, four times the amount that was spent in 1970 in real terms. In this paper we evaluate the impact of these huge expenditures on the technological performance of the pharmaceutical industry. While... View Details

Keywords: Public Sector; Science-Based Business; Research and Development; Sovereign Finance; Pharmaceutical Industry

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June 2011 (Revised October 2013)
Case

Gene Patents (A)

By: Richard Hamermesh, David Kiron and Phillip Andrews

In March 2010, U.S. District Court Judge Robert Sweet overturned 30 years of legal precedent and ruled that unaltered human genes could not be patented. This case reviews patent law and how it relates to our increasing knowledge of the Human Genome. The case issues... View Details

Keywords: Courts and Trials; Patents; Genetics; Judgments; Science-Based Business; Biotechnology Industry; United States

August 2024 (Revised November 2024)
Case

Commonwealth Fusion Systems: Born at Scale

By: Joshua Lev Krieger, Jim Matheson, Kyle Myers, Gunnar Trumbull and Richard Vietor

This case study chronicles the journey of Commonwealth Fusion Systems (CFS) on its ambitious mission to commercialize fusion energy and become the world’s leading provider of fusion power plants. Emerging from a “special arrangement” with MIT's Plasma Science and... View Details

Keywords: Nuclear Energy; Innovation; Entrepreneurship; Entrepreneurial Finance; Energy Generation; Commercialization; Science-Based Business; Technological Innovation; Market Entry and Exit; Energy Industry

January 2011 (Revised July 2012)
Case

Arcadia Biosciences: Seeds of Change (Abridged)

By: Arthur A. Daemmrich

Arcadia Biosciences is seeking to introduce genetically modified rice to China that will lower farmers' costs and generate environmental benefits through reduced greenhouse gas emissions. The case describes challenges facing this small agricultural biotechnology... View Details

Keywords: Plant-Based Agribusiness; Intellectual Property; Genetics; Environmental Sustainability; Science-Based Business; Climate Change; Agriculture and Agribusiness Industry; Biotechnology Industry; China

01 Jan 2008
News

John Doerr, MBA 1976

San Francisco. It focused on two areas where Doerr would soon have tremendous influence: information technology and science-based business. “The main thing we do— that we’ve always done—is build upon the best ideas of entrepreneurs,”... View Details

24 Sep 2007
Research & Ideas

The FDA: What Will the Next 100 Years Bring?

'magnetic poles' of sorts. The FDA's work has a basis in fundamental science, both laboratory-based for product inspections and more clinical for the review of mountains of data produced in drug trials. Agency employees rightfully are drawn toward the pole of making... View Details

Keywords: by Sean Silverthorne; Biotechnology; Consumer Products; Food & Beverage; Health

1992
Chapter

Issues of Participation and Rights Allocation in Tradeable Permits Systems to Reduce Greenhouse Gas Emissions

By: James K. Sebenius and Michael Grubb

Keywords: Corporate Social Responsibility and Impact; Climate Change; Pollutants; Science-Based Business