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2010
Working Paper

From Bench to Board: Gender Differences in University Scientists' Participation in Commercial Science

This paper examines gender differences in the participation of university life science faculty in commercial science. Based on theory and field interviews, we develop hypotheses regarding how scientists' productivity, co-authorship networks, and institutional... View Details

Keywords: Business Startups; For-Profit Firms; Gender Characteristics; Higher Education; Entrepreneurship; Governing and Advisory Boards; Science-Based Business; Nonprofit Organizations; Biotechnology Industry

November 2002 (Revised June 2003)
Case

Monsanto: Leadership in a New Environment

By: Ray A. Goldberg, James Weber and James M Beagle

Monsanto is the biotechnology leader in agriculture. How does it use its leadership in Round Up to fund long-term research and development in biotechnology that is acceptable to the priority system of consumers in different parts of the world? Includes color exhibits. View Details

Keywords: Research and Development; Science-Based Business; Food; Business or Company Management; Agribusiness; Industry Growth; Customer Focus and Relationships; Globalization; Leadership; Biotechnology Industry; Agriculture and Agribusiness Industry; United States

December 2009 (Revised April 2012)
Case

Neoprene

By: Tom Nicholas and Felipe Tamega Fernandes

In 1931, during one of the worst economic crises in U.S. history, Du Pont announced the discovery of an innovative rubber synthetic product—neoprene. Yet at the time of the announcement, Du Pont did not have any neoprene to sell. Manufacturing facilities were still... View Details

Keywords: Financial Crisis; Business History; Innovation and Invention; Product Development; Risk and Uncertainty; Science-Based Business; Commercialization; Chemical Industry; United States

December 2023 (Revised March 2024)
Case

Manufacturing Moderna's Future

By: Satish Tadikonda and William Marks

In 2019, Moderna faced long odds of survival having failed to develop a successful clinical program out of the vast platform technology they had built around mRNA. Nearly overnight, the company skyrocketed to success with a vaccine for COVID-19, leading to an extremely... View Details

Keywords: Health Pandemics; Health Testing and Trials; Technological Innovation; Product Development; Production; Science-Based Business; Biotechnology Industry

September 2007 (Revised May 2009)
Case

Syndexa and Technology Transfer at Harvard University

By: Richard G. Hamermesh and David Kiron

Gokhan Hotamisligil is a star researcher at Harvard School of Public Health who has made groundbreaking discoveries linking fat cells, inflammation, and diabetes. He now wants to form a company to commercialize these discoveries. At the same time, Isaac Kohlberg, the... View Details

Keywords: Business Startups; Higher Education; Entrepreneurship; Innovation and Invention; Intellectual Property; Rights; Agreements and Arrangements; Science-Based Business; Commercialization; Biotechnology Industry; Health Industry

May 2006
Case

A123Systems

By: H. Kent Bowen, Kenneth P Morse and Douglass Cannon

A 123Systems was a young company that was founded on basic materials science research at the Massachusetts Institute of Technology. A co-founder of the company, Yet-Ming Chiang, was a full professor at MIT and served as scientific adviser. Intellectual property based... View Details

Keywords: Intellectual Property; Business Startups; Research and Development; Commercialization; Technological Innovation; Science-Based Business; Product Development; Battery Industry; Electronics Industry; Massachusetts

September 2023 (Revised November 2023)
Case

Seeds of Innovation: GALY's Quest to Cultivate the Future of Agriculture in the Lab

By: George Serafeim and Michael Norris

In 2023, Luciano Bueno, CEO and founder of plant cell culture agriculture company GALY, was considering the best path forward for his company as he planned to pitch Series B investors. GALY, founded in 2019, aimed to produce cotton and other crops from cells grown in... View Details

Keywords: Business Model; Green Technology; Goods and Commodities; Growth and Development Strategy; Science-Based Business; Entrepreneurship; Plant-Based Agribusiness; Business Startups; Decisions; Technological Innovation; Production; Agriculture and Agribusiness Industry; Technology Industry; Boston; Sao Paulo

11 Nov 2015
Working Paper Summaries

Public R&D Investments and Private-sector Patenting: Evidence from NIH Funding Rules

Keywords: by Danielle Li; Health; Biotechnology; Pharmaceutical; Medical Devices & Supplies

August 2011 (Revised October 2011)
Case

PureTech Ventures in 2011

By: Andrei Hagiu, Cesar Castro and Sarah Murphy

In early May 2011, Daphne Zohar, founder and managing partner of PureTech Ventures, a life science venture creation company in Boston, MA, was reviewing a term sheet she had just received from a venture capital (VC) firm for one of PureTech's portfolio companies. The... View Details

Keywords: Business Ventures; Business Startups; Venture Capital; Investment; Innovation and Invention; Negotiation; Partners and Partnerships; Science-Based Business; Opportunities; Boston

December 2000
Case

CellFor, Inc.

By: Ray A. Goldberg, Carin-Isabel Knoop, Frantz Edward Alphonse and Laure Mougeot Stroock

A new private company has developed a process to clone and multiply seeds for the forestry industry. View Details

Keywords: Business Startups; Transition; Technological Innovation; Private Ownership; Research and Development; Science-Based Business; Technology Adoption; Forestry Industry

October 2016
Article

Looking Across and Looking Beyond the Knowledge Frontier: Intellectual Distance and Resource Allocation in Science

By: Kevin J. Boudreau, Eva Guinan, Karim R. Lakhani and Christoph Riedl

Selecting among alternative innovative projects is a core management task in all innovating organizations. In this paper, we focus on the evaluation of frontier scientific research projects. We argue that the "intellectual distance" between the knowledge embodied in... View Details

Keywords: Knowledge; Innovation; Novelty; Evaluation; Resource Allocation; Decision Choices and Conditions; Innovation and Management; Science-Based Business; Experience and Expertise

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November 2001
Case

Aventis CropScience and StarLink Corn

By: Ray A. Goldberg and James M Beagle

Aventis CropScience responds to the discovery of an unapproved corn variety in food supplies and draws lessons for the company, industry, and governments. View Details

Keywords: Policy; Governing Rules, Regulations, and Reforms; Food; Science-Based Business; Outcome or Result; Governance Compliance; Problems and Challenges; Nutrition; Food and Beverage Industry

June 2019
Teaching Note

Zebra Medical Vision

By: Shane Greenstein and Sarah Gulick

Teaching note is meant to accompany Zebra Medical Vision case, which offers a look at a company’s decisions as a small startup competing with other startups and major technology companies. It also demonstrates the challenges faced by a machine learning company working... View Details

Keywords: Business Startups; Science-Based Business; Applications and Software; Patents; Cross-Cultural and Cross-Border Issues; Health Care and Treatment; Health Industry; Medical Devices and Supplies Industry; Technology Industry; Israel

October 2012
Teaching Plan

Vertex Pharmaceuticals and the Cystic Fibrosis Foundation: Venture Philanthropy Funding for Biotech (TP)

By: Robert F. Higgins

This is the teaching note related to HBS case 808005. In 2001, Vertex Pharmaceuticals Incorporated acquired the San Diego-based biotech company, Aurora Biosciences. The combination of Vertex's and Aurora's technologies would improve the flow of novel drug candidates... View Details

Keywords: Venture Philanthropy; Biotechnology; Funding Philanthropy Venture; Cystic Fibrosis; Foundations; Pharmaceuticals; Mergers and Acquisitions; For-Profit Firms; Venture Capital; Philanthropy and Charitable Giving; Science-Based Business; Nonprofit Organizations; Pharmaceutical Industry; Biotechnology Industry; United States; San Diego

January 2011 (Revised July 2012)
Case

Arcadia Biosciences: Seeds of Change (Abridged)

By: Arthur A. Daemmrich

Arcadia Biosciences is seeking to introduce genetically modified rice to China that will lower farmers' costs and generate environmental benefits through reduced greenhouse gas emissions. The case describes challenges facing this small agricultural biotechnology... View Details

Keywords: Plant-Based Agribusiness; Intellectual Property; Genetics; Environmental Sustainability; Science-Based Business; Climate Change; Agriculture and Agribusiness Industry; Biotechnology Industry; China

April 2020
Teaching Note

Indigo Agriculture: Harnessing Nature

By: Michael W. Toffel and James Barnett

Teaching Note for HBS No. 620-024. Indigo Agriculture used a digital-enabled research and development (R&D) process to launch its initial product, microbial coatings for agricultural seeds, which increase crop yields while reducing the need for fertilizers. In doing... View Details

Keywords: Operations; Supply Chain; Social Enterprise; Product Development; Distribution Channels; Business Strategy; Digital Platforms; Science-Based Business; Agriculture and Agribusiness Industry; Green Technology Industry; United States; Massachusetts

17 Feb 2010
First Look

First Look: Feb. 17

Working PapersThe Evolution of Science-Based Business: Innovating How We Innovate Author:Gary P. Pisano An abstract in unavailable at this time. Download the paper: http://www.hbs.edu/research/pdf/10-062.pdf PublicationsTargeted... View Details

Keywords: Martha Lagace

May 2008
Case

Sensors Unlimited: Bringing InGaAs Technology to the Market

By: Willy C. Shih

Sensors Unlimited was a small start-up in short-wavelength infrared imaging. Its learning base came out of Bell Labs, RCA's Sarnoff Lab, and the Rockwell Science Center, and as it built its capabilities and ventured into new application areas, it discovered a “killer... View Details

Keywords: Applied Optics; Mergers and Acquisitions; Business Startups; Growth and Development Strategy; Science-Based Business; Commercialization; Aerospace Industry; Technology Industry

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October 2019 (Revised November 2019)
Case

C16 Biosciences: Lab-Grown Palm Oil

By: Jeffrey J. Bussgang and Olivia Hull

Synthetic biology start-up C16 Biosciences wants to solve a big problem: replace palm oil, a major contributor to deforestation and climate change, with a lab-grown substitute. CEO Shara Ticku has ambitious plans to supply her lab-grown palm oil to food manufacturers,... View Details

Keywords: Science-Based Business; Environmental Sustainability; Social Entrepreneurship; Product Development; Product Positioning; Venture Capital; Strategy; Decision Making; Food and Beverage Industry; Consumer Products Industry

2015
Case

Advanced Leadership Pathways: Torsten Thiele and the Global Ocean Trust

By: Rosabeth Moss Kanter and Brian Hoffstein

Following a successful career in finance, Torsten Thiele devoted himself full-time to the challenging cause of ocean conservation and stewardship. In August 2015, Thiele had already come a long way in spearheading initiatives towards the protection of the ocean: from... View Details

Keywords: Environment; Natural Environment; Environmental Sustainability; Pollutants; Science-Based Business; Climate Change; Social Enterprise; Leadership

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