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      • 2022
      • Working Paper

      Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation

      By: Amitabh Chandra, Jennifer Kao, Kathleen Miller and Ariel D. Stern
      Regulators of new products confront a tradeoff between speeding a new product to market and collecting additional product quality information. The FDA’s Breakthrough Therapy Designation (BTD) provides an opportunity to understand if a regulator can use new policy to... View Details
      Keywords: Research and Development; Governing Rules, Regulations, and Reforms; Product Development
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      Chandra, Amitabh, Jennifer Kao, Kathleen Miller, and Ariel D. Stern. "Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation." NBER Working Paper Series, No. 30712, December 2022.
      • December 2022
      • Article

      The Contribution of Price Growth to Pharmaceutical Revenue Growth in the United States: Evidence from Medicines Sold in Retail Pharmacies

      By: Pragya Kakani, Michael Chernew and Amitabh Chandra
      Context: To what extent does pharmaceutical revenue growth depend on new medicines versus increasing prices for existing medicines? Moreover, does using list prices, as is commonly done, instead of prices net of confidential rebates offered by manufacturers, which are... View Details
      Keywords: Revenue; Price; Policy; Business Strategy; Pharmaceutical Industry
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      Kakani, Pragya, Michael Chernew, and Amitabh Chandra. "The Contribution of Price Growth to Pharmaceutical Revenue Growth in the United States: Evidence from Medicines Sold in Retail Pharmacies." Journal of Health Politics, Policy and Law 47, no. 6 (December 2022): 629–648.
      • November 2022 (Revised March 2023)
      • Supplement

      JUUL and the Vaping Revolution: A 2022 Update

      By: Michael W. Toffel and Sarah Mehta
      This slide deck provides a brief update (2019-2022) on the rise and fall of JUUL Labs, the maker of the popular JUUL e-cigarette. View Details
      Keywords: Electronic Cigarettes; E-Cigarettes; Vaping; Nicotine Replacement; JUUL; Juuling; Government Regulation; Advertising; Advertising Campaigns; Digital Marketing; Customers; Innovation and Invention; Innovation Strategy; Marketing; Ethics; Brands and Branding; Marketing Communications; Marketing Strategy; Product Marketing; Corporate Social Responsibility and Impact; Social Issues; Technology Industry; California
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      Toffel, Michael W., and Sarah Mehta. "JUUL and the Vaping Revolution: A 2022 Update." Harvard Business School PowerPoint Supplement 623-012, November 2022. (Revised March 2023.)
      • November 2022 (Revised March 2023)
      • Supplement

      JUUL and the Vaping Revolution: A 2022 Update

      By: Michael W. Toffel and Sarah Mehta
      This case provides a brief update (2019-2022) on the rise and fall of JUUL Labs, the maker of the popular JUUL e-cigarette. View Details
      Keywords: Electronic Cigarettes; E-Cigarettes; Vaping; Nicotine Replacement; JUUL; Juuling; Government Regulation; Advertising; Advertising Campaigns; Digital Marketing; Customers; Innovation and Invention; Innovation Strategy; Marketing; Ethics; Brands and Branding; Marketing Communications; Marketing Strategy; Product Marketing; Corporate Social Responsibility and Impact; Social Issues; Technology Industry; California
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      Toffel, Michael W., and Sarah Mehta. "JUUL and the Vaping Revolution: A 2022 Update." Harvard Business School Supplement 623-011, November 2022. (Revised March 2023.)
      • November–December 2022
      • Article

      The Value of Descriptive Analytics: Evidence from Online Retailers

      By: Ron Berman and Ayelet Israeli
      Does the adoption of descriptive analytics impact online retailer performance, and if so, how? We use the synthetic difference-in-differences method to analyze the staggered adoption of a retail analytics dashboard by more than 1,500 e-commerce websites, and we find an... View Details
      Keywords: Descriptive Analytics; Big Data; Synthetic Control; E-commerce; Online Retail; Difference-in-differences; Martech; Internet and the Web; Analytics and Data Science; Performance; Marketing; Retail Industry
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      Berman, Ron, and Ayelet Israeli. "The Value of Descriptive Analytics: Evidence from Online Retailers." Marketing Science 41, no. 6 (November–December 2022): 1074–1096.
      • October 2022 (Revised November 2023)
      • Case

      Framebridge (A): Reimagining Custom Framing

      By: Rembrand Koning and Alicia Dadlani
      In December 2018, Susan Tynan, founder and CEO of Framebridge, a four-year-old venture-backed startup that sold online custom framing, formulated plans for the future. Her vision was to revolutionize the $4 billion industry by making custom framing easy, transparent,... View Details
      Keywords: Business Startups; Business Strategy; Entrepreneurship; Operations; Consumer Products Industry; United States; District of Columbia; Kentucky
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      Koning, Rembrand, and Alicia Dadlani. "Framebridge (A): Reimagining Custom Framing." Harvard Business School Case 723-352, October 2022. (Revised November 2023.)
      • September 2022
      • Case

      ROI vs. ROI: The Grupo Baobá Family Office

      By: Lauren Cohen, Hao Gao, Jiawei Ye and Grace Headinger
      Fernando Scodro, a third-generation member of his family, mulled over the next step in integrating an ESG strategy into his family office’s investment portfolio. While his family office, Grupo Baobá, had made excellent progress in incorporating his family’s values into... View Details
      Keywords: Impact Investing; ESG; Green Building; Family; Partnership; Latin America; Brazil; Buildings and Facilities; Green Buildings; Family Business; Family and Family Relationships; Financial Management; Partners and Partnerships; Financial Services Industry; Brazil; Latin America
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      Cohen, Lauren, Hao Gao, Jiawei Ye, and Grace Headinger. "ROI vs. ROI: The Grupo Baobá Family Office." Harvard Business School Case 223-018, September 2022.
      • 2025
      • Working Paper

      Algorithmic Assortment Curation: An Empirical Study of Buybox in Online Marketplaces

      By: Santiago Gallino, Nil Karacaoglu and Antonio Moreno
      Most online sales worldwide take place in marketplaces that connect sellers and buyers. The presence of numerous third-party sellers leads to a proliferation of listings for each product, making it difficult for customers to choose between the available options. Online... View Details
      Keywords: Algorithms; E-commerce; Sales; Digital Marketing; Internet and the Web; Customer Satisfaction
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      Gallino, Santiago, Nil Karacaoglu, and Antonio Moreno. "Algorithmic Assortment Curation: An Empirical Study of Buybox in Online Marketplaces." Working Paper, 2025.
      • 2024
      • Working Paper

      The Impact of the Chinese Exclusion Act on the Economic Development of the Western U.S.

      By: Joe Long, Carlo Medici, Nancy Qian and Marco Tabellini
      This paper investigates the economic consequences of the 1882 Chinese Exclusion Act, which banned immigration from China. The Act reduced the number of Chinese workers of all skill levels living in the United States. It also reduced the labor supply and the quality of... View Details
      Keywords: Growth; Productivity; Economic Development; Business History; Economic Slowdown and Stagnation; Business and Government Relations; Prejudice and Bias; Government Legislation; Immigration; United States
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      Long, Joe, Carlo Medici, Nancy Qian, and Marco Tabellini. "The Impact of the Chinese Exclusion Act on the Economic Development of the Western U.S." Harvard Business School Working Paper, No. 23-008, August 2022. (Revised September 2024. Featured in Bloomberg, at Hoover Institute, VoxEU, NBER Digest, NPR, Forbes, The New Yorker, HBS Working Knowledge, and Cato Institute, quoted here.)
      • July 2022
      • Case

      General Mills: Responding to the Killing of George Floyd (A)

      By: Debora L. Spar and Alicia Dadlani
      Jeff Harmening, CEO of General Mills, one of the world's largest manufacturers of breakfast cereals and packaged foods, was deeply disturbed and instantly aware that he and General Mills would need to respond. George Floyd, an African-American man who had been accused... View Details
      Keywords: Race; Decisions; Social Issues; Corporate Social Responsibility and Impact; Consumer Products Industry; Consumer Products Industry; Minneapolis; Minnesota; United States
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      Spar, Debora L., and Alicia Dadlani. "General Mills: Responding to the Killing of George Floyd (A)." Harvard Business School Case 323-019, July 2022.
      • July 2022
      • Supplement

      General Mills: Responding to the Killing of George Floyd (B)

      By: Debora L. Spar and Alicia Dadlani
      Jeff Harmening, CEO of General Mills, one of the world's largest manufacturers of breakfast cereals and packaged foods, was deeply disturbed and instantly aware that he and General Mills would need to respond. George Floyd, an African-American man who had been accused... View Details
      Keywords: Race; Decisions; Social Issues; Corporate Social Responsibility and Impact; Consumer Products Industry; Minneapolis; Minnesota; United States
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      Spar, Debora L., and Alicia Dadlani. "General Mills: Responding to the Killing of George Floyd (B)." Harvard Business School Supplement 323-020, July 2022.
      • July 2022
      • Teaching Plan

      Wellthy: The Economics of Caring

      By: Brian Trelstad
      Teaching Plan for HBS Case No. 320-028. In 2014, Lindsay Jurist-Rosner (MBA ’09) founded Wellthy, a B2C business that coordinates care for working professionals seeking help to support loved ones with chronic diseases or aging parents. With personal experience as a... View Details
      Keywords: B2B Vs. B2C; Future Of Work; Health; Social Entrepreneurship; Growth and Development Strategy; Health Care and Treatment; Recruitment; Corporate Social Responsibility and Impact; Health Industry; United States
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      Trelstad, Brian. "Wellthy: The Economics of Caring." Harvard Business School Teaching Plan 322-076, July 2022.
      • June 2022
      • Case

      Michelin’s Green Gold Bahia Program: Leaving With Grace

      By: Sandra J. Sucher, Shalene Gupta and Susan J. Winterberg
      In 2015, the top management of French tire-maker Michelin, was evaluating Michelin’s approach to divesting its rubber plantations ten years after incorporating a novel strategy.
      In 2004, Michelin had a Brazilian rubber challenge. Its Bahía plantation had been hit... View Details
      Keywords: Divestment; Supply Chain Management; Natural Resources; Corporate Accountability; Corporate Social Responsibility and Impact; Rubber Industry; Auto Industry; Brazil; France
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      Sucher, Sandra J., Shalene Gupta, and Susan J. Winterberg. "Michelin’s Green Gold Bahia Program: Leaving With Grace." Harvard Business School Case 322-132, June 2022.
      • June 2022
      • Case

      PFA Pensions: The Climate Plus Product

      By: Daniel Green, Victoria Ivashina and Alys Ferragamo
      The case explores whether alternative investments play a unique role in achieving low carbon dioxide emissions at the portfolio level. This case is set in April of 2020 and follows Kasper Ahrndt Lorenzen, Chief Investment Officer, and Peter Tind Larsen, Head of... View Details
      Keywords: Carbon Emissions; Carbon Footprint; Alternative Assets; Alternative Investment Vehicles; Pension Fund Investing; Private Equity; Renewable Energy; Investment Portfolio; Corporate Social Responsibility and Impact; Environmental Sustainability; Denmark
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      Green, Daniel, Victoria Ivashina, and Alys Ferragamo. "PFA Pensions: The Climate Plus Product." Harvard Business School Case 222-088, June 2022.
      • June 2022
      • Teaching Note

      Bespoken Spirits: Disrupting Distilling

      By: Benjamin C. Esty and Daniel Fisher
      Teaching Note for HBS Case No. 721-419. On October 7, 2020, Bespoken Spirits publicly announced it had received $2.6 million of seed funding for its “sustainable maturation process,” a process that could produce award-winning whiskeys in just days rather than years... View Details
      Keywords: B2B Vs. B2C; Technological Innovation; Business Startups; Cost Management; Business Model; Consumer Products Industry; Consumer Products Industry; Consumer Products Industry
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      Esty, Benjamin C., and Daniel Fisher. "Bespoken Spirits: Disrupting Distilling." Harvard Business School Teaching Note 722-457, June 2022.
      • Article

      Multitasking While Driving: A Time Use Study of Commuting Knowledge Workers to Assess Current and Future Uses

      By: Thomaz Teodorovicz, Andrew L. Kun, Raffaella Sadun and Orit Shaer
      Commuting has enormous impact on individuals, families, organizations, and society. Advances in vehicle automation may help workers employ the time spent commuting in productive work-tasks or wellbeing activities. To achieve this goal, however, we need to develop a... View Details
      Keywords: In-vehicle User Interfaces; Time-use Study; Automated Vehicles; Knowledge Workers; Commuting
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      Teodorovicz, Thomaz, Andrew L. Kun, Raffaella Sadun, and Orit Shaer. "Multitasking While Driving: A Time Use Study of Commuting Knowledge Workers to Assess Current and Future Uses." International Journal of Human-Computer Studies 162 (June 2022).
      • 2022
      • Working Paper

      An Anatomy of Performance Monitoring

      By: Achyuta Adhvaryu, Anant Nyshadham and Jorge Tamayo
      Performance monitoring is a mainstay management tool in most organizations. Yet we still know little about whether—and why—better monitoring yields better performance in practice. To shed light on these questions, we study the introduction of a performance monitoring... View Details
      Keywords: Performance Monitoring; Worker Skills; Skill Depreciation; Managerial Inattention; On-the-job Training; Productivity; Multitasking; Quick Serve Restaurants; Performance Evaluation; Employees; Competency and Skills; Training; Performance Productivity; Management; Information Technology; Food and Beverage Industry; Puerto Rico
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      Adhvaryu, Achyuta, Anant Nyshadham, and Jorge Tamayo. "An Anatomy of Performance Monitoring." Harvard Business School Working Paper, No. 22-066, March 2022. (R&R Journal of Political Economy.)
      • 2023
      • Working Paper

      Can Evidence-Based Information Shift Preferences Towards Trade Policy?

      By: Laura Alfaro, Maggie X. Chen and Davin Chor
      Amid public skepticism about trade, we investigate whether evidence-based information--a concise statement of a research finding--can shape preferences towards trade policy. Across survey experiments conducted over 2018-2022 on U.S. general population samples, we... View Details
      Keywords: Evidence; Preference; Trade Policy; Information; Trade; Policy; Attitudes
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      Alfaro, Laura, Maggie X. Chen, and Davin Chor. "Can Evidence-Based Information Shift Preferences Towards Trade Policy?" Harvard Business School Working Paper, No. 22-062, March 2022. (Revised October 2024. NBER Working Paper Series, No. 31240, May 2023)
      • March 2022
      • Article

      Assessing the Impact of the COVID-19 Pandemic on Clinician Ambulatory Electronic Health Record Use

      By: A Jay Holmgren, Lance Downing, Mitchell Tang, Christopher Sharp, Christopher Longhurst and Robert S. Huckman
      Objective: The COVID-19 pandemic changed clinician electronic health record (EHR) work in a multitude of ways. To evaluate how, we measure ambulatory clinician EHR use in the United States throughout the COVID-19 pandemic.

      Materials and Methods: We use EHR... View Details
      Keywords: Health Care; Electronic Health Records; Productivity; COVID-19 Pandemic; Health Care and Treatment; Health Pandemics; Information Technology; Performance Productivity; United States
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      Holmgren, A Jay, Lance Downing, Mitchell Tang, Christopher Sharp, Christopher Longhurst, and Robert S. Huckman. "Assessing the Impact of the COVID-19 Pandemic on Clinician Ambulatory Electronic Health Record Use." Journal of the American Medical Informatics Association 29, no. 3 (March 2022): 453–460.
      • March 2022
      • Article

      Estimating the Effectiveness of Permanent Price Reductions for Competing Products Using Multivariate Bayesian Structural Time Series Models

      By: Fiammetta Menchetti and Iavor Bojinov
      Researchers regularly use synthetic control methods for estimating causal effects when a sub-set of units receive a single persistent treatment, and the rest are unaffected by the change. In many applications, however, units not assigned to treatment are nevertheless... View Details
      Keywords: Causal Inference; Partial Interference; Synthetic Controls; Bayesian Structural Time Series; Mathematical Methods
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      Menchetti, Fiammetta, and Iavor Bojinov. "Estimating the Effectiveness of Permanent Price Reductions for Competing Products Using Multivariate Bayesian Structural Time Series Models." Annals of Applied Statistics 16, no. 1 (March 2022): 414–435.
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