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      • January 2014
      • Supplement

      Fred Khosravi and AccessClosure (C)

      By: Richard Hamermesh and Lauren Barley
      On September 11, 2013, the three-judge panel of the U.S. Court of Appeals for the Federal Circuit denied St. Jude's request to rehear an appeal on the "double patenting" ruling for the '439 patent. Further, it removed the injunction threat that was hanging over the... View Details
      Keywords: Medical Devices; Vascular Closure Device; Patent Litigation; Patenting; Biomedical Research; Biotechnology; Biotech; Technological Innovation; Patents; Health Care and Treatment; Biotechnology Industry; United States
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      Hamermesh, Richard, and Lauren Barley. "Fred Khosravi and AccessClosure (C)." Harvard Business School Supplement 814-074, January 2014.
      • January 2014 (Revised December 2014)
      • Case

      GenapSys: Business Models for the Genome

      By: Richard G. Hamermesh, Joseph B. Fuller and Matthew Preble

      GenapSys, a California-based startup, was soon to release a new DNA sequencer that the company's founder, Hesaam Esfandyarpour, believed was truly revolutionary. The sequencer would be substantially less expensive—potentially costing just a few thousand dollars—and... View Details

      Keywords: DNA Sequencing; Life Sciences; Business Model; Innovation & Entrepreneurship; Health Care and Treatment; Genetics; Business Strategy; Technology Industry; Technology Industry; Technology Industry; Technology Industry; Technology Industry; United States
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      Hamermesh, Richard G., Joseph B. Fuller, and Matthew Preble. "GenapSys: Business Models for the Genome." Harvard Business School Case 814-050, January 2014. (Revised December 2014.)
      • December 2013 (Revised February 2014)
      • Supplement

      Reinventing Brainlab (B)

      By: Regina E. Herzlinger and Karol Misztal
      The management of Germany's Brainlab AG, a leading provider of software-driven oncology and surgery solutions, needs to evaluate strategic options for proceeding without an exclusive hardware partner in its most profitable business segment. View Details
      Keywords: Strategy; Information Infrastructure; Applications and Software; Medical Specialties; Information Technology Industry; Information Technology Industry; Germany
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      Herzlinger, Regina E., and Karol Misztal. "Reinventing Brainlab (B)." Harvard Business School Supplement 314-054, December 2013. (Revised February 2014.)
      • January–February 2014
      • Other Article

      Barriers to Health Care Innovation: Regina Herzlinger Warns That Innovators Need to Know What Obstacles They Face and How to Overcome Them

      By: Regina E. Herzlinger
      Health care in the United States and in most other developed countries is ailing, says Regina E. Herzlinger. A chaired professor of business administration specializing in health care at Harvard Business School, Herzlinger says that although the world has witnessed... View Details
      Keywords: Healthcare; Healthcare IT; Innovation; Health Care and Treatment; Health; Information Technology; Innovation and Invention; Technology Industry; Technology Industry; United States
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      Herzlinger, Regina E. "Barriers to Health Care Innovation: Regina Herzlinger Warns That Innovators Need to Know What Obstacles They Face and How to Overcome Them." IEEE Pulse 5, no. 1 (January–February 2014): 43–45.
      • Article

      Applying KISS to Healthcare Information Technology

      By: Regina E. Herzlinger, Margo Seltzer and Mark Gaynor
      Current public and private healthcare information technology initiatives have failed to achieve secure integration among providers. Applying the "keep it simple, stupid" principle offers the key guidance for solving this problem. View Details
      Keywords: Technology; Health Care; Public Health; Information Technology Industry; Computer Networks; Computer Services Industries; Software; Hardware; Medical Services; Health Care and Treatment; Information Technology; Applications and Software; Information Infrastructure; Standards; Technology Industry; Technology Industry; United States
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      Herzlinger, Regina E., Margo Seltzer, and Mark Gaynor. "Applying KISS to Healthcare Information Technology." Computer 46, no. 11 (November 2013): 72–74.
      • October 2013 (Revised April 2015)
      • Case

      Myomo: Getting Sales in Motion

      By: Frank V. Cespedes, Shikhar Ghosh and Matthew Preble
      In late 2012, the management team of Myomo, a startup which had designed a unique myoelectric arm brace for patients with dysfunctional arms, was deciding which of the three sales models the company had tested to pursue as its sales strategy going forward. Each model... View Details
      Keywords: Technological Innovation; Information Technology; Marketing Strategy; Decision Choices and Conditions; Health Care and Treatment; Business Startups; Sales; Growth and Development Strategy; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry
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      Cespedes, Frank V., Shikhar Ghosh, and Matthew Preble. "Myomo: Getting Sales in Motion." Harvard Business School Case 814-034, October 2013. (Revised April 2015.)
      • October 2013 (Revised January 2014)
      • Supplement

      Fred Khosravi and AccessClosure (B)

      By: Richard G. Hamermesh and Lauren Barley
      It was January 2013, and Fred Khosravi, chairman of the board of AccessClosure Inc., wondered what the new year had in store for him and AccessClosure, the company he founded in late 2002. Khosravi was cautiously optimistic—the Mountain View, California-based medical... View Details
      Keywords: Medical Devices; Vascular Closure Device; Patent Litigation; Patenting; Biomedical Research; Biotechnology; Biotech; Technological Innovation; Patents; Health Care and Treatment; Biotechnology Industry; United States; California
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      Hamermesh, Richard G., and Lauren Barley. "Fred Khosravi and AccessClosure (B)." Harvard Business School Supplement 814-038, October 2013. (Revised January 2014.)
      • September 2013
      • Case

      Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired

      By: Rosabeth Moss Kanter, Juliane Calingo Schwetz and Patricia Bissett Higgins
      In July 2012, retired United States Army Major General Gale Pollock created Elevivo, a venture that worked on developing a comprehensive disease management software system to support the growing number of visually impaired individuals by providing them with tailored... View Details
      Keywords: United States; Health Care; Health Care Education; Insurance Companies; Disease Management; Technology; Military; Leadership Skills; Health; Health Care and Treatment; Education; Insurance; Information Technology; Entrepreneurship; Leadership; Information Technology Industry; Information Technology Industry; United States
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      Kanter, Rosabeth Moss, Juliane Calingo Schwetz, and Patricia Bissett Higgins. "Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired." Harvard Business School Case 314-029, September 2013.
      • September 2013 (Revised August 2015)
      • Background Note

      Leadership and Teaming

      By: Ethan Bernstein
      Small differences in the leadership of teams can have large consequences for the success of their efforts. Many initiatives fail not because of a fatal error in judgment or insufficient ideas, knowledge, motivation, or capabilities to deliver a solution. They fail... View Details
      Keywords: Teams; Teaming; Leadership And Managing People; Leadership; Team Effectiveness; Team Performance; Team Design; Team Leadership; Teamwork; Team Process; Team Function; Team Launch; 60/30/10 Rule; Team Boundary; Distribution Of Leadership Authority; Self-Managed Teams; Virtual Teams; Unbounded Teams; Acts Of Leadership; Execution Teams; Decision Making Teams; Creativity Teams; Team Size; Task Design; Team Timeline; Team Roles; Team Representation; Diversity; Team Familiarity; Collective Intelligence; Team Stages Of Development; Team Coaching; Performance Pressure; X-Teams; Team Focus; Interaction; Management Teams; Managerial Roles; Management Systems; Management Style; Management Skills; Management Practices and Processes; Organizational Design; Organizational Structure; Performance Effectiveness; Performance Efficiency; Performance Productivity; Groups and Teams; Networks; Social Psychology; Behavior; Conflict and Resolution; Creativity; Social and Collaborative Networks; Satisfaction; Prejudice and Bias; Power and Influence; Personal Characteristics; Familiarity; Cognition and Thinking; Attitudes; Projects; Organizational Culture; Organizational Change and Adaptation; Leadership Development; Leadership Style; Leading Change; Knowledge Use and Leverage; Knowledge Sharing; Collaborative Innovation and Invention; Innovation and Management; Innovation Leadership; Design; Interpersonal Communication; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Green Technology Industry; Asia; North and Central America; South America; Atlantic Ocean; Central Asia; Europe; Latin America; Middle East; Oceania; West Indies
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      Bernstein, Ethan. "Leadership and Teaming." Harvard Business School Background Note 414-033, September 2013. (Revised August 2015.)
      • 2013
      • Case

      Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired

      By: Rosabeth M. Kanter, Juliane Calingo Schwetz and Patricia Bissett Higgins
      In July 2012, retired United States Army Major General Gale Pollock created Elevivo, a venture that worked on developing a comprehensive disease management software system to support the growing number of visually impaired individuals by providing them with tailored... View Details
      Keywords: Disease Management; Health; Health Care and Treatment; Education; Information Technology; Insurance; Entrepreneurship; Leadership; Information Technology Industry; Information Technology Industry; United States
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      Kanter, Rosabeth M., Juliane Calingo Schwetz, and Patricia Bissett Higgins. "Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired." Harvard Business Publishing Case 314-029, 2013.
      • July 2013 (Revised November 2021)
      • Module Note

      Exploration vs. Exploitation

      By: Willy Shih
      This module note introduces James March's concept of exploration and exploitation, and the management challenge of balancing the allocation of resources to the two activities in the firm. The note also touches on the O'Reilly and Tushman paper on the ambidextrous... View Details
      Keywords: Exploration And Exploitation; Exploitation; Research; Scientific Research; Product Commercialization; Innovation and Invention; Innovation and Management; Innovation Leadership; Innovation Strategy; Technological Innovation; Knowledge Acquisition; Growth and Development Strategy; Resource Allocation; Strategic Planning; Research and Development; Science-Based Business; Corporate Strategy; Knowledge Sharing; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; United States
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      Shih, Willy. "Exploration vs. Exploitation." Harvard Business School Module Note 614-004, July 2013. (Revised November 2021.)
      • Article

      Beyond Magic Bullets: True Innovation in Health Care

      By: Vaibhav A. Narayan, Marco Mohwinckel, Gary Pisano, Michael Yang and Husseini Manji
      The molecular medicine revolution—based on advances in fields such as genomics and network modeling in the decade since the human genome sequence was completed—has changed the way we think about, study, and approach the development of novel therapies. However, these... View Details
      Keywords: Integration; Business Model; Organizational Structure; Health Care and Treatment; Innovation and Invention; Pharmaceutical Industry
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      Narayan, Vaibhav A., Marco Mohwinckel, Gary Pisano, Michael Yang, and Husseini Manji. "Beyond Magic Bullets: True Innovation in Health Care." Nature Reviews: Drug Discovery 12, no. 2 (February 2013): 85–86.
      • September 2012 (Revised March 2014)
      • Case

      Reinventing Brainlab (A)

      By: Regina E. Herzlinger, Vincent Dessain and Karol Misztal
      The management of Germany's Brainlab AG, a leading provider of software-driven oncology and surgery solutions, needs to evaluate strategic options for proceeding without an exclusive hardware partner in its most profitable business segment. View Details
      Keywords: Strategy; Information Infrastructure; Applications and Software; Medical Specialties; Health Care and Treatment; Information Technology Industry; Information Technology Industry; Germany
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      Herzlinger, Regina E., Vincent Dessain, and Karol Misztal. "Reinventing Brainlab (A)." Harvard Business School Case 313-069, September 2012. (Revised March 2014.)
      • September 2012
      • Supplement

      Intraoperative Radiotherapy for Breast Cancer (B)

      By: Willy Shih
      The intraoperative radiotherapy (IORT) business at Carl Zeiss Meditec had struggled with growth since the time of the (A) case. Though the unit had grown revenues in excess of 50% and had exceeded its EBIT target, it faced several key strategic choices. Should it... View Details
      Keywords: Radiotherapy; Breast Cancer; Brachytherapy; Therapeutic Radiation; Oncology; Oncology Treatment Systems; Elekta AB; Varian Medical Systems; Xoft; Electronic Brachytherapy; Intraoperative Radiotherapy; Disruptive Innovation; Health Care and Treatment; Entrepreneurship; Technological Innovation; Growth and Development Strategy; Health Industry; Germany
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      Shih, Willy. "Intraoperative Radiotherapy for Breast Cancer (B)." Harvard Business School Supplement 613-040, September 2012.
      • June 2012
      • Case

      Innovating at AT&T: Partnering to Lead the Broadband Revolution

      By: Lynda M. Applegate, Phillip Andrews and Kerry Herman
      In 2010, the U.S. retail market value for next-generation non-handset wirelessly-enabled devices was just over $1 billion. By 2011 it had grown 1,141% to $13.2 billion and was forecast to reach $24.7 billion in 2015. At the same time, user demand for data was surging... View Details
      Keywords: Innovation & Entrepreneurship; Team Leadership; Emerging Technologies; Business Models; Business To Business; Corporate Vision; Growth Strategy; Corporate Culture; Innovation and Invention; Corporate Entrepreneurship; Partners and Partnerships; Leadership; Mobile and Wireless Technology; Growth and Development Strategy; Globalized Firms and Management; Business Model; Technology Industry; United States
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      Applegate, Lynda M., Phillip Andrews, and Kerry Herman. "Innovating at AT&T: Partnering to Lead the Broadband Revolution." Harvard Business School Case 812-124, June 2012.
      • November 2011 (Revised August 2012)
      • Case

      Healthymagination at GE Healthcare Systems

      By: Vineet Kumar and V. Kasturi Rangan
      Jeff Immelt, the CEO of GE, introduced a new innovation strategy named "healthymagination" in 2009. With cost, quality, and access as its three pillars, healthymagination ensures a strong focus for new product introduction efforts all around GE. But will this focus... View Details
      Keywords: Innovation and Invention; Product Marketing; Marketing Strategy; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry
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      Kumar, Vineet, and V. Kasturi Rangan. "Healthymagination at GE Healthcare Systems." Harvard Business School Case 512-039, November 2011. (Revised August 2012.)
      • July 2011 (Revised January 2013)
      • Case

      Digital Microscopy Is Making Me Crazy!

      By: Willy Shih
      For Carl Zeiss Microimaging, modular hardware and software enabled customers to tailor Zeiss's broad range of microscopy systems hardware and software to meet a wide range of needs from basic scientific research in the biological and medical sciences to clinical... View Details
      Keywords: Information Infrastructure; Applications and Software; Corporate Strategy; Disruptive Innovation; Science-Based Business; Management Analysis, Tools, and Techniques; Business Conglomerates; Digital Platforms; Opportunities; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry
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      Shih, Willy. "Digital Microscopy Is Making Me Crazy!" Harvard Business School Case 612-002, July 2011. (Revised January 2013.)
      • November 2010 (Revised January 2011)
      • Case

      Computerized Provider Order Entry at Emory Healthcare

      By: Richard G. Hamermesh, F. Warren McFarlan, Mark Keil, Andrew Katz, Michael Morgan and David LaBorde
      The Computerized Provider Order Entry at Emory Healthcare case presents one hospital system's efforts to implement computerized provider order entry (CPOE) across all of its hospitals and the challenges they faced in doing so. Issues such as standardization of care,... View Details
      Keywords: Health Care and Treatment; Information Management; Management Systems; Standards; Service Delivery; Business Processes; Organizational Change and Adaptation; Projects; Information Technology; Applications and Software; Health Industry
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      Hamermesh, Richard G., F. Warren McFarlan, Mark Keil, Andrew Katz, Michael Morgan, and David LaBorde. "Computerized Provider Order Entry at Emory Healthcare." Harvard Business School Case 311-061, November 2010. (Revised January 2011.)
      • November 2009 (Revised December 2009)
      • Case

      GTC Biotherapeutics: Developing Medicines in the Milk of Goats

      By: Ray A. Goldberg and Sarah Morton
      GTC is the first company in the animal world to receive FDA approval of a transgenic pharmaceutical. What are the implications for other firms in plants and animals and their opportunities to produce new medicines in an economical and safe fashion? View Details
      Keywords: Health Care and Treatment; Animal-Based Agribusiness; Plant-Based Agribusiness; Science-Based Business; Medical Specialties; Product; Technological Innovation; Health Industry; Pharmaceutical Industry; United States
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      Goldberg, Ray A., and Sarah Morton. "GTC Biotherapeutics: Developing Medicines in the Milk of Goats." Harvard Business School Case 910-403, November 2009. (Revised December 2009.)
      • October 2009 (Revised August 2014)
      • Case

      Tengion: Bringing Regenerative Medicine to Life

      By: Elie Ofek and Polly Ross Ribatt
      Tengion is a young biotech company that is at the frontier of regenerative medicine—a nascent field that seeks to promote the creation of new cells and tissue to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects. In late... View Details
      Keywords: Decision Choices and Conditions; Financial Crisis; Entrepreneurship; Health Care and Treatment; Technological Innovation; Product Launch; Product Development; Research and Development; Biotechnology Industry; United States
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      Ofek, Elie, and Polly Ross Ribatt. "Tengion: Bringing Regenerative Medicine to Life." Harvard Business School Case 510-031, October 2009. (Revised August 2014.)
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