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      • June 2018 (Revised November 2018)
      • Case

      Innovation at Insigne Health

      By: Srikant M. Datar, Linda A. Cyr and Caitlin N. Bowler
      Insigne Health is a fictional for-profit, integrated health insurer/health care provider whose leadership believes that by shifting members’ focus from “sickness” to “well-being” it could increase the overall health of its insured population and decrease the resources... View Details
      Keywords: Design Thinking; Behavior Change; Chronic Disease; Health Care; Health Care and Treatment; Design; Behavior; Change; Innovation and Management
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      Datar, Srikant M., Linda A. Cyr, and Caitlin N. Bowler. "Innovation at Insigne Health." Harvard Business School Case 118-042, June 2018. (Revised November 2018.)
      • May 2018 (Revised January 2019)
      • Teaching Note

      Nashton Partners and Its Search Fund Process

      By: Richard S. Ruback, Royce Yudkoff and Ahron Rosenfeld
      Teaching Note for HBS No. 212-006. In 2008, Jay Davis (HBS’ 08) and Jason Pananos (HBS’ 08) formed Nashton Partners and raised $500,000 from investors to fund their search. After 30 months of searching, and exhausting the money they raised to fund their search, Davis... View Details
      Keywords: Search Fund; Acquisition; Capital Structure; Financing and Loans; Investment Funds; Partners and Partnerships
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      Ruback, Richard S., Royce Yudkoff, and Ahron Rosenfeld. "Nashton Partners and Its Search Fund Process." Harvard Business School Teaching Note 218-120, May 2018. (Revised January 2019.)
      • Article

      Why Apps for Managing Chronic Disease Haven't Been Widely Used, and How to Fix It

      By: Robert S. Huckman and Ariel Dora Stern
      Keywords: Health Care; Digital Health; Chronic Disease; App; Health Information Technology; Information Technology; Health Industry; United States
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      Huckman, Robert S., and Ariel Dora Stern. "Why Apps for Managing Chronic Disease Haven't Been Widely Used, and How to Fix It." Harvard Business Review (website) (April 4, 2018).
      • March 2018
      • Teaching Note

      Twine Health

      By: Robert S. Huckman and Ariel D. Stern
      In late 2014, Dr. John Moore (CEO), Frank Moss (chairman), and Scott Gilroy (CTO) of Twine Health (Twine) had to resolve several challenges that threatened to restrict the widespread dissemination of its sole product, Twine. Twine was a cloud-based platform that... View Details
      Keywords: Health Care; Chronic Disease; Digital Health; Health Acceleration Challenge; Strategy; Disease Management; Health; Health Care and Treatment; Information Technology; Mobile and Wireless Technology; Technology Adoption; Health Industry; United States; Massachusetts
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      Huckman, Robert S., and Ariel D. Stern. "Twine Health." Harvard Business School Teaching Note 618-055, March 2018.
      • January 2018 (Revised January 2019)
      • Case

      ZappRx

      By: Jeffrey J. Bussgang and Olivia Hull
      In October 2015, ZappRx founder Zoe Barry is deciding between two business models for her health technology start-up. Her product, a software application that aims to expedite the prescription fulfillment process for patients with rare diseases, has attracted interest... View Details
      Keywords: Speciality Drugs; Hub Services; Pivot; Speciality Prescriptions; Health Care and Treatment; Customization and Personalization; Internet and the Web; Business Model; Decision Choices and Conditions; Pharmaceutical Industry; Massachusetts
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      Bussgang, Jeffrey J., and Olivia Hull. "ZappRx." Harvard Business School Case 818-001, January 2018. (Revised January 2019.)
      • January 2018
      • Article

      Innovation Incentives and Biomarkers

      By: Ariel Dora Stern, Brian M. Alexander and Amitabh Chandra
      Previously, we have discussed the importance of economic incentives in shaping markets for precision medicines. Here we consider incentives for biomarker development, including discovery and establishment. Biomarkers can reveal valuable information regarding diagnosis... View Details
      Keywords: Health Care and Treatment; Innovation and Invention; Research and Development; Markets
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      Stern, Ariel Dora, Brian M. Alexander, and Amitabh Chandra. "Innovation Incentives and Biomarkers." Clinical Pharmacology & Therapeutics 103, no. 1 (January 2018): 34–36.
      • November 2017
      • Article

      A Retrospective Analysis of Hypertension Screening at a Mass Gathering in India: Implications for Non-communicable Disease Control Strategies

      By: S. Balsari, P. Vemulapalli, M. Gofine, K. Oswal, R. Merchant, S. Saunik, G. Greenough and T. Khanna
      Cardiovascular disease is the leading cause of mortality from noncommunicable diseases (NCD) in India. The government’s National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke seeks to increase capacity building, screening,... View Details
      Keywords: Health Disorders; Health Care and Treatment; Problems and Challenges; India
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      Balsari, S., P. Vemulapalli, M. Gofine, K. Oswal, R. Merchant, S. Saunik, G. Greenough, and T. Khanna. "A Retrospective Analysis of Hypertension Screening at a Mass Gathering in India: Implications for Non-communicable Disease Control Strategies." Journal of Human Hypertension 31, no. 11 (November 2017): 750–753.
      • May 2017
      • Teaching Plan

      Neurotrack and the Alzheimer's Puzzle

      By: Richard G. Hamermesh and Carin-Isabel Knoop
      Teaching Note for HBS No. 816-072. View Details
      Keywords: Health Care; Alzheimer's Disease; Career Path; Life Science Business
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      Hamermesh, Richard G., and Carin-Isabel Knoop. "Neurotrack and the Alzheimer's Puzzle." Harvard Business School Teaching Plan 817-140, May 2017.
      • January 2017
      • Supplement

      Intrapreneurship at DaVita HealthCare Partners: Cash Flow Tool

      By: Joseph B. Fuller and Christopher Payton
      DaVita Healthcare Partners Inc. (DaVita) is one of the U.S.'s leading dialysis providers, a process whereby persons with end-stage renal disease (ESRD) are connected to a machine that performs the functions of a healthy kidney. Kent Thiry, DaVita's CEO, has expanded... View Details
      Keywords: Intrapreneurship; Entrepreneurial Organizations; Startup Management; Startup; Strategic Positioning; Corporate Entrepreneurship; Corporate Strategy; Business Startups; Strategic Planning; Competitive Strategy; Health Industry; United States
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      Fuller, Joseph B., and Christopher Payton. "Intrapreneurship at DaVita HealthCare Partners: Cash Flow Tool." Harvard Business School Spreadsheet Supplement 317-703, January 2017.
      • October 2016 (Revised November 2016)
      • Case

      Innovating Beyond Ochsner

      By: Richard G. Hamermesh and Olivia Hull
      The Ochsner Health System has developed a proprietary software tool designed to treat hypertension. Built into the system’s electronic medical records, the Hypertension Digital Medicine program allows patients to record their blood pressure at home and share readings... View Details
      Keywords: Electronic Medical Records; Telemedicine; Hypertension; High Blood Pressure; Chronic Disease; Entrepreneurship; Health Disorders; Business Model; Business Startups; Innovation and Invention; Growth Management; Marketing Strategy; Product Launch; Product Positioning; Science-Based Business; Business Strategy; Health Industry; Technology Industry; New Orleans; Louisiana
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      Hamermesh, Richard G., and Olivia Hull. "Innovating Beyond Ochsner." Harvard Business School Case 817-028, October 2016. (Revised November 2016.)
      • October 2016 (Revised September 2017)
      • Case

      The CRISPR-Cas9 Quarrel

      By: Richard G. Hamermesh and Matthew G. Preble
      In mid-2016, the Broad Institute and the University of California, Berkeley were in the middle of a contentious patent dispute over which entity controlled a breakthrough gene editing technology called CRISPR-Cas9. With CRISPR-Cas9, scientists might soon be able to... View Details
      Keywords: CRISPR; Broad Institute; University Of California Berkeley; Intellectual Property; Patents; Law; Lawsuits and Litigation; Science; Genetics; Entrepreneurship; Biotechnology Industry; United States
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      Hamermesh, Richard G., and Matthew G. Preble. "The CRISPR-Cas9 Quarrel." Harvard Business School Case 817-020, October 2016. (Revised September 2017.)
      • August 2016 (Revised August 2016)
      • Teaching Note

      Intrapreneurship at DaVita Healthcare Partners

      By: Joseph B. Fuller and Matthew Preble
      DaVita Healthcare Partners Inc. (DaVita) is one of the U.S.'s leading dialysis providers, a process whereby persons with end-stage renal disease (ESRD) are connected to a machine that performs the functions of a healthy kidney. Kent Thiry, DaVita's CEO, has expanded... View Details
      Keywords: Intrapreneurship; Entrepreneurial Organizations; Startup Management; Startup; Strategic Positioning; Corporate Entrepreneurship; Corporate Strategy; Business Startups; Strategic Planning; Competitive Strategy; Health Industry; United States
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      Fuller, Joseph B., and Matthew Preble. "Intrapreneurship at DaVita Healthcare Partners." Harvard Business School Teaching Note 317-020, August 2016. (Revised August 2016.)
      • May 25, 2016
      • Comment

      How Consumers and Businesses are Reshaping Public Health

      By: John A. Quelch
      Healthcare and education are two issues in which citizens around the world, rich and poor, are passionately interested. It has long been appreciated that the way that a society treats its youngest and oldest members says much about its moral maturity. Economic... View Details
      Keywords: Healthcare; Consumer Power; Innovation In Healthcare Delivery; Mobile Healthcare; Transition; Transformation; Trends; Customer Satisfaction; Customer Value and Value Chain; Health Care and Treatment; Information; Collaborative Innovation and Invention; Independent Innovation and Invention; Innovation and Management; Innovation Leadership; Management; Marketing; Markets; Planning; Problems and Challenges; Biotechnology Industry; Chemical Industry; Consumer Products Industry; Distribution Industry; Fashion Industry; Food and Beverage Industry; Green Technology Industry; Health Industry; Insurance Industry; Medical Devices and Supplies Industry; Pharmaceutical Industry; Public Administration Industry; South America; North and Central America; Middle East; Europe; Asia
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      Quelch, John A. "How Consumers and Businesses are Reshaping Public Health." Harvard Business School Working Knowledge (May 25, 2016).
      • February 2016
      • Teaching Note

      Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired

      By: Rosabeth M. Kanter, Tessa Natanay Hamilton and Ai-Ling Jamila Malone
      Following a successful military career as an Army Nurse, achieving rank as Major General, becoming the first female Acting Surgeon General of the Army, and the 22nd Chief of the Army Nurse Corps, Pollock developed a vested interest in improving the lives of the... View Details
      Keywords: Health
      Citation
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      Kanter, Rosabeth M., Tessa Natanay Hamilton, and Ai-Ling Jamila Malone. "Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired." Harvard Business School Teaching Note 316-036, February 2016.
      • February 2016 (Revised September 2017)
      • Case

      Neurotrack and the Alzheimer's Puzzle

      By: Richard G. Hamermesh, Liz Kind and Carin-Isabel Knoop
      Elli Kaplan founded Neurotrack in 2012 with a breakthrough noninvasive cognitive diagnostics test that will detect Alzheimer's disease in its earliest pre-symptomatic stages. While the company has gained great traction in the three years since it was started, with no... View Details
      Keywords: Alzheimer's Disease; Diagnostics; Healthcare; Entrepreneurship; Health Disorders; Science-Based Business; Business Model; Medical Devices and Supplies Industry; United States
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      Hamermesh, Richard G., Liz Kind, and Carin-Isabel Knoop. "Neurotrack and the Alzheimer's Puzzle." Harvard Business School Case 816-072, February 2016. (Revised September 2017.)
      • 2016
      • Teaching Note

      Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired

      By: Rosabeth M. Kanter, Tessa Natanay Hamilton and Ai-Ling Jamila Malone
      Teaching note for case 314029. Following a successful military career as an Army Nurse, achieving rank as Major General, becoming the first female Acting Surgeon General of the Army, and the 22nd Chief of the Army Nurse Corps, Pollock developed a vested interest in... View Details
      Keywords: Health Care; Health Care Education; Insurance Companies; Military; Leadership Skills; Health Care and Treatment; Education; Insurance; Business Startups; Information Technology; Applications and Software; Change Management; Health Industry; Information Technology Industry
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      Kanter, Rosabeth M., Tessa Natanay Hamilton, and Ai-Ling Jamila Malone. "Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired." Harvard Business Publishing Teaching Note 316-036, 2016. (Harvard Advanced Leadership Initiative.)
      • 2016
      • Article

      Penalized Fast Subset Scanning

      By: Skyler Speakman, Sriram Somanchi, Edward McFowland III and Daniel B. Neill
      We present the penalized fast subset scan (PFSS), a new and general framework for scalable and accurate pattern detection. PFSS enables exact and efficient identification of the most anomalous subsets of the data, as measured by a likelihood ratio scan statistic.... View Details
      Keywords: Disease Surveillance; Likelihood Ratio Statistic; Pattern Detection; Scan Statistic; Mathematical Methods
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      Speakman, Skyler, Sriram Somanchi, Edward McFowland III, and Daniel B. Neill. "Penalized Fast Subset Scanning." Journal of Computational and Graphical Statistics 25, no. 2 (2016): 382–404. (Selected for “Best of JCGS” invited session by the journal’s editor in chief.)
      • September 2015
      • Article

      Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago

      By: Abel Kho, John Cashy, Kathryn Jackson, Adam Pah, Satyender Goel, Jorn Boehnke, John Eric Humphries, Scott Duke Kominers and et al.
      Objective
      To design and implement a tool that creates a secure, privacy preserving linkage of electronic health record (EHR) data across multiple sites in a large metropolitan area in the United States (Chicago, IL), for use in clinical... View Details
      Keywords: Information; Customers; Safety; Rights; Ethics; Entrepreneurship; Health Care and Treatment; Health Industry; Chicago
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      Kho, Abel, John Cashy, Kathryn Jackson, Adam Pah, Satyender Goel, Jorn Boehnke, John Eric Humphries, Scott Duke Kominers, and et al. "Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago." Journal of the American Medical Informatics Association 22, no. 5 (September 2015): 1072–1080.
      • July 2015
      • Background Note

      The State of U.S. Public Health: Challenges and Trends

      By: Rosabeth M. Kanter, Howard Koh and Pamela Yatsko
      The World Health Organization defines health as "a state of complete physical, mental, and social well-being and not merely the absence of disease and infirmity." For many Americans, the World Health Organization's definition of true health seems unattainable, given... View Details
      Keywords: Public Health; Public Sector; Health Care and Treatment; Health Industry; United States
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      Kanter, Rosabeth M., Howard Koh, and Pamela Yatsko. "The State of U.S. Public Health: Challenges and Trends." Harvard Business School Background Note 316-001, July 2015.
      • 2015
      • Article

      Scalable Detection of Anomalous Patterns With Connectivity Constraints

      By: Skyler Speakman, Edward McFowland III and Daniel B. Neill
      We present GraphScan, a novel method for detecting arbitrarily shaped connected clusters in graph or network data. Given a graph structure, data observed at each node, and a score function defining the anomalousness of a set of nodes, GraphScan can efficiently and... View Details
      Keywords: Biosurveillance; Event Detection; Graph Mining; Scan Statistics; Spatial Scan Statistic
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      Speakman, Skyler, Edward McFowland III, and Daniel B. Neill. "Scalable Detection of Anomalous Patterns With Connectivity Constraints." Journal of Computational and Graphical Statistics 24, no. 4 (2015): 1014–1033.
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