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      • January 2018
      • Supplement

      BeiGene Supplemental PowerPoint

      By: Willy C. Shih and Jimmy Zhang
      BeiGene was a biopharmaceutical company founded on exploiting a temporal regulatory policy discontinuity. Because of regulatory challenges in China, most innovative new drugs launched there four to six years after their initial U.S. launches. This gave BeiGene a window... View Details
      Keywords: Biotechnology; Pharmaceutical Company; Pharmaceuticals; China; Regulatory Environment; Business Strategy; Innovation Strategy; Situation or Environment; Pharmaceutical Industry; Pharmaceutical Industry; China
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      Shih, Willy C., and Jimmy Zhang. "BeiGene Supplemental PowerPoint." Harvard Business School PowerPoint Supplement 618-043, January 2018.
      • January 2018
      • Teaching Note

      BeiGene

      By: Willy Shih and Jimmy Zhang
      Teaching Note for HBS No. 618-033. View Details
      Keywords: Biotechnology; Drug Development; Corporate Strategy; Business Startups; Technological Innovation; Situation or Environment; Biotechnology Industry; Biotechnology Industry; China
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      Shih, Willy, and Jimmy Zhang. "BeiGene." Harvard Business School Teaching Note 618-039, January 2018.
      • November 2017
      • Case

      Passion and Strategy: Novozymes' Embrace of the UN Sustainable Development Goals

      By: Andy Zelleke and Emilie Billaud
      This case explores the sustainability efforts at Novozymes, the world's largest and oldest producer of industrial enzymes. In 2015, the Danish company became the world’s first company known to have crafted a new corporate strategy based on the United Nations... View Details
      Keywords: Corporate Governance; Transformation; Environmental Sustainability; Corporate Social Responsibility and Impact; Mission and Purpose; Business and Shareholder Relations; Business and Stakeholder Relations; Business Strategy; Organizational Culture; Organizational Change and Adaptation; Biotechnology Industry; Europe; Denmark
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      Zelleke, Andy, and Emilie Billaud. "Passion and Strategy: Novozymes' Embrace of the UN Sustainable Development Goals." Harvard Business School Case 318-088, November 2017.
      • November 2017
      • Case

      BeiGene

      By: Willy Shih and Jimmy Zhang
      BeiGene was a biopharmaceutical company founded on exploiting a temporal regulatory policy discontinuity. Because of regulatory challenges in China, most innovative new drugs launched there four to six years after their initial U.S. launches. This gave BeiGene a window... View Details
      Keywords: Biotechnology; Pharmaceutical Company; Pharmaceuticals; China; Regulatory Environment; Business Strategy; Business Startups; Innovation Strategy; Situation or Environment; Pharmaceutical Industry; China
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      Shih, Willy, and Jimmy Zhang. "BeiGene." Harvard Business School Case 618-033, November 2017.
      • November 2016
      • Supplement

      Alnylam Pharmaceuticals: Building Value from the IP Estate (B)

      By: Vicki Sato, Willy Shih and Matt Higgins
      The leader of a pioneering biotech company in the siRNA space weighs his options for scaling production capacity in advance of an anticipated commercial launch. Operational complexity and relative merits of in-house manufacturing versus a contractor model are... View Details
      Keywords: Pharmaceutical Companies; Pharmaceutical Industry; Biotech; Biotechnology; Operational Complexity; Strategy; Manufacturing; Production; Strategic Planning; Intellectual Property; Biotechnology Industry; United States
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      Sato, Vicki, Willy Shih, and Matt Higgins. "Alnylam Pharmaceuticals: Building Value from the IP Estate (B)." Harvard Business School Supplement 617-022, November 2016.
      • November 2016
      • Case

      Anthony Starks at InSiL Therapeutics (A)

      By: Gary Pisano and Vicki Sato
      When Bruce Wayne hired Anthony Starks, he thought he had hit a home run by getting the most brilliant and passionate scientist-leader in the field to be his CSO. But a few months in, Wayne and Starks begin to clash over crucial forward-looking decisions about the... View Details
      Keywords: Biotech; Silicon; Managing Innovation; Management Challenges; Managing People; Managing Organization; R&D; R&D Project Management; Platform; Venture Capital; Drug Discovery; management; Biotechnology Industry; California
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      Pisano, Gary, and Vicki Sato. "Anthony Starks at InSiL Therapeutics (A)." Harvard Business School Case 617-029, November 2016.
      • November 2016 (Revised December 2016)
      • Supplement

      Anthony Starks at InSiL Therapeutics (B)

      By: Vicki Sato and Gary Pisano
      This case accompanies the (A) case from Anthony Starks's perspective. View Details
      Keywords: Biotech; Management Challenges; R&D; R&D Project Management; Management; Biotechnology Industry; California
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      Sato, Vicki, and Gary Pisano. "Anthony Starks at InSiL Therapeutics (B)." Harvard Business School Supplement 617-030, November 2016. (Revised December 2016.)
      • November 2016
      • Case

      QuintilesIMS: Biosimilar Marketing in England

      By: John A. Quelch and Emily C. Boudreau
      QuintilesIMS was a leading healthcare consulting firm best known for its data and information offerings as well as its market research and management consulting services for life science companies. By 2015, the company was expanding beyond the biopharmaceutical... View Details
      Keywords: Health; Pharmaceutical Industry; Biotech; Marketing; Health Care and Treatment; Biotechnology Industry; England
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      Quelch, John A., and Emily C. Boudreau. "QuintilesIMS: Biosimilar Marketing in England." Harvard Business School Case 517-054, November 2016.
      • October 2016 (Revised September 2017)
      • Case

      The CRISPR-Cas9 Quarrel

      By: Richard G. Hamermesh and Matthew G. Preble
      In mid-2016, the Broad Institute and the University of California, Berkeley were in the middle of a contentious patent dispute over which entity controlled a breakthrough gene editing technology called CRISPR-Cas9. With CRISPR-Cas9, scientists might soon be able to... View Details
      Keywords: CRISPR; Broad Institute; University Of California Berkeley; Intellectual Property; Patents; Law; Lawsuits and Litigation; Science; Genetics; Entrepreneurship; Biotechnology Industry; United States
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      Hamermesh, Richard G., and Matthew G. Preble. "The CRISPR-Cas9 Quarrel." Harvard Business School Case 817-020, October 2016. (Revised September 2017.)
      • October 2016 (Revised February 2017)
      • Teaching Note

      Alvogen

      By: Daniel Isenberg, William R. Kerr and Alexis Brownell
      Alvogen is an Icelandic pharmaceutical company that makes and sells generic drugs. Founder and CEO Robert Wessman is deciding whether to take on private equity investors willing to buy out all shareholders, merge with a large and publicly-traded US pharmaceutical... View Details
      Keywords: Biotechnology; Globalization; Entrepreneurship; Biotechnology Industry
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      Isenberg, Daniel, William R. Kerr, and Alexis Brownell. "Alvogen." Harvard Business School Teaching Note 817-057, October 2016. (Revised February 2017.)
      • May 25, 2016
      • Comment

      How Consumers and Businesses are Reshaping Public Health

      By: John A. Quelch
      Healthcare and education are two issues in which citizens around the world, rich and poor, are passionately interested. It has long been appreciated that the way that a society treats its youngest and oldest members says much about its moral maturity. Economic... View Details
      Keywords: Healthcare; Consumer Power; Innovation In Healthcare Delivery; Mobile Healthcare; Transition; Transformation; Trends; Customer Satisfaction; Customer Value and Value Chain; Health Care and Treatment; Information; Collaborative Innovation and Invention; Independent Innovation and Invention; Innovation and Management; Innovation Leadership; Management; Marketing; Markets; Planning; Problems and Challenges; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; South America; North and Central America; Middle East; Europe; Asia
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      Quelch, John A. "How Consumers and Businesses are Reshaping Public Health." Harvard Business School Working Knowledge (May 25, 2016).
      • May 20, 2016
      • Comment

      World Health Organization Lacks Leadership to Combat Pandemics

      By: John A. Quelch
      When it comes to emergency preparedness for pandemics, the World Health Organization is falling short. It has not provided prompt and clear leadership to the world in combating either the Ebola or Zika viruses. Its leadership has been low energy, its representatives... View Details
      Keywords: Global Health; World Health Organization; World Bank; Pandemics; Emergency Preparedness; Experience and Expertise; Decisions; Forecasting and Prediction; Communication Strategy; Nonverbal Communication; Framework; Governance; Government and Politics; Health; Management; Practice; Problems and Challenges; Projects; Risk and Uncertainty; Human Needs; Civil Society or Community; Social Issues; Welfare or Wellbeing; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Africa; Asia; Europe; Latin America; North and Central America; South America; West Indies
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      Quelch, John A. "World Health Organization Lacks Leadership to Combat Pandemics." Harvard Business School Working Knowledge (May 20, 2016).
      • March 2016
      • Article

      Environmental Demands and the Emergence of Social Structure: Technological Dynamism and Interorganizational Network Forms

      By: Adam Tatarynowicz, Maxim Sytch and Ranjay Gulati
      This study investigates the origins of variation in the structures of interorganizational networks across industries. We combine empirical analyses of existing interorganizational networks in six industries with an agent-based simulation model of network emergence.... View Details
      Keywords: Interorganizatonal Relationships; Social Networks; Network Emergence; Interorganizational Networks; Information Technology; Networks; Organizational Structure; Social and Collaborative Networks; Social Media
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      Tatarynowicz, Adam, Maxim Sytch, and Ranjay Gulati. "Environmental Demands and the Emergence of Social Structure: Technological Dynamism and Interorganizational Network Forms." Administrative Science Quarterly 61, no. 1 (March 2016): 52–86.
      • January 2016 (Revised February 2016)
      • Course Overview Note

      The Sustainable Core: Operations Management

      By: Michael W. Toffel and L. Beril Toktay
      This note is designed to help faculty embed environmental sustainability content into their core Operations Management course at the MBA or undergraduate level. It can also be used to identify cases with environmental content that can be used in operations electives... View Details
      Keywords: Environmental Management; Operations Management; Sustainable Operations; Environmental Regulation; Operations; Supply Chain; Supply Chain Management; Agriculture and Agribusiness Industry; Agriculture and Agribusiness Industry; Agriculture and Agribusiness Industry; Agriculture and Agribusiness Industry; Agriculture and Agribusiness Industry; Agriculture and Agribusiness Industry
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      Toffel, Michael W., and L. Beril Toktay. "The Sustainable Core: Operations Management." Harvard Business School Course Overview Note 616-022, January 2016. (Revised February 2016.)
      • 2016
      • Book

      Consumers, Corporations, and Public Health: A Case-Based Approach to Sustainable Business

      By: John A. Quelch
      The public health footprint associated with corporate behavior has come under increased scrutiny in the last decade, with an increased expectation that private profit not come at the expense of consumer welfare.

      Consumers, Corporations, and Public... View Details
      Keywords: Consumer; Corporate Culture; Public Health; Consumer Behavior; Marketing Strategy; Corporate Strategy; Health; Innovation and Invention; Innovation and Management; Supply Chain Management; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Advertising Industry; Asia; Oceania; North and Central America; Middle East; Latin America; Europe
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      Quelch, John A. Consumers, Corporations, and Public Health: A Case-Based Approach to Sustainable Business. New York: Oxford University Press, 2016.
      • Article

      What to Know About Locating in a Cluster

      By: Willy C. Shih and Sen Chai
      As a study of two industry clusters in Denmark shows, factors that can make clusters attractive—easy people movement and knowledge spillovers—can also make it harder for individual companies to retain proprietary knowledge. View Details
      Keywords: Clusters; Clustering; Competitiveness; Life Sciences; Telecommunications; Science-based; Research And Development; Industry Clusters; Research; Innovation Strategy; Innovation and Management; Geographic Location; Pharmaceutical Industry; Pharmaceutical Industry; Pharmaceutical Industry; Pharmaceutical Industry; Denmark
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      Shih, Willy C., and Sen Chai. "What to Know About Locating in a Cluster." Art. 57117. MIT Sloan Management Review 57, no. 1 (Fall 2015): 104–107.
      • May 2015
      • Case

      Transforming Alkermes into a Global Biopharmaceutical Company

      By: C. Fritz Foley and Nicholas Haas
      In the summer of 2011, Jim Frates, CFO of Alkermes faced choices about how to finance the acquisition of Dublin, Ireland-based Elan Drug Technologies (EDT)—a deal that was expected to close in the fall. The case describes the history of Alkermes, provides information... View Details
      Keywords: Financing; Debt; Merger; CFO; Financial Management; Biotechnology Industry; Biotechnology Industry; United States; Europe
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      Foley, C. Fritz, and Nicholas Haas. "Transforming Alkermes into a Global Biopharmaceutical Company." Harvard Business School Case 215-079, May 2015.
      • February 2015 (Revised November 2015)
      • Supplement

      Building an Integrated Biopharma Company: Crucell (B)

      By: Richard G. Hamermesh, Marianne Van Der Steen and Susan Harmeling
      The Crucell (B) case updates events at Crucell since 2009. In September, 2009, Johnson & Johnson acquired 18% of Crucell for $400 million. This investment was part of a business development deal. Subsequently, in 2012, Johnson & Johnson acquired Crucell for $2.8... View Details
      Keywords: Biotechnology; Biopharmacy Company; Licensing Agreements In Biopharmacy; Licensing; Human Cell-line Technology; Vaccine; Healthcare Innovation; Global Health; Entrepreneurship; Health Care and Treatment; Acquisition; Innovation and Invention; Biotechnology Industry; Biotechnology Industry
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      Hamermesh, Richard G., Marianne Van Der Steen, and Susan Harmeling. "Building an Integrated Biopharma Company: Crucell (B)." Harvard Business School Supplement 815-086, February 2015. (Revised November 2015.)
      • February 2015 (Revised November 2015)
      • Case

      Building an Integrated Biopharma Company: Crucell (A)

      By: Richard G. Hamermesh, Marianne Van Der Steen and Susan S. Harmeling
      By 2009, Crucell had become the largest biopharma company in the Netherlands and a symbol of national pride. The case traces the evolution of the company from a University spin-off into a fully-integrated company. Crucell's success, particularly in the vaccine space,... View Details
      Keywords: Biotechnology; Biopharmacy Company; Licensing; Licensing Agreements In Biopharmacy; Human Cell-line Technology; Vaccine; Healthcare Innovation; Global Health; Partners and Partnerships; Entrepreneurship; Growth and Development Strategy; Biotechnology Industry; Biotechnology Industry; Netherlands
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      Hamermesh, Richard G., Marianne Van Der Steen, and Susan S. Harmeling. "Building an Integrated Biopharma Company: Crucell (A)." Harvard Business School Case 815-085, February 2015. (Revised November 2015.)
      • September 2014
      • Case

      Pfizer's Centers for Therapeutic Innovation (CTI)

      By: Gary Pisano, James Weber and Kait Szydlowski
      In 2010, Pfizer established four small research units in New York, Boston, San Francisco, and San Diego located close to several premier Academic Medical Centers (AMCs), or hospitals with adjoining medical schools. The goal of these units was to redesign collaboration... View Details
      Keywords: Drug Development; Academic Collaboration; Research And Development; Innovation; Translational Research; Management; Operations; Problems and Challenges; Research; Science; Information Technology; Strategy; Biotechnology Industry; Biotechnology Industry; North and Central America; Europe; Asia
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      Pisano, Gary, James Weber, and Kait Szydlowski. "Pfizer's Centers for Therapeutic Innovation (CTI)." Harvard Business School Case 615-024, September 2014.
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