Publications

March 2018
Case

Sandra Brown Goes Digital (A): The Promise and Perils of Social Movements in a Healthcare Company

By: Rosabeth Moss Kanter and Jonathan Cohen

As a middle manager at a biotechnology company, Sandra Brown harnessed digital tools and social media to engage others and build campaigns for change in the company. This case follows her career at the company and describes the challenges she faced as a change agent,... View Details

Keywords: Digital; Engagement; Stakeholder Engagement; Grassroots Movement; Organization Change And Adaptation; Quality; Health Care; Health Care Industry; Career Path; Leading Change; Management; Innovation and Management; Personal Development and Career; Organizational Change and Adaptation; Biotechnology Industry; Biotechnology Industry

March 2018 (Revised May 2018)
Case

Celgene

By: Malcolm Baker and Emily McComb

In February 2011, Adam Koppel, a managing director at Brookside Capital, the public equity arm of Bain Capital, must decide whether to increase or exit the firm’s position in Celgene Corporation. News has emerged that raises potential safety concerns associated with... View Details

Keywords: Life Sciences; Biotechnology; Public Market Investing; Celgene; Revlimid; Hedge Fund; Growth Stocks; Valuation; Investment; Decision Choices and Conditions; Analysis; Biotechnology Industry

March 2018 (Revised May 2018)
Supplement

Celgene (B)

By: Malcolm Baker and Emily McComb

Supplements the (A) case. View Details

Keywords: Life Sciences; Biotechnology; Public Market Investing; Celgene; Revlimid; Hedge Fund; Growth Stocks; Valuation; Investment; Decision Choices and Conditions; Analysis; Biotechnology Industry

January 2018
Supplement

BeiGene Supplemental PowerPoint

By: Willy C. Shih and Jimmy Zhang

BeiGene was a biopharmaceutical company founded on exploiting a temporal regulatory policy discontinuity. Because of regulatory challenges in China, most innovative new drugs launched there four to six years after their initial U.S. launches. This gave BeiGene a window... View Details

Keywords: Biotechnology; Pharmaceutical Company; Pharmaceuticals; China; Regulatory Environment; Business Strategy; Innovation Strategy; Situation or Environment; Biotechnology Industry; Biotechnology Industry; China

January 2018
Teaching Note

BeiGene

By: Willy Shih and Jimmy Zhang

Teaching Note for HBS No. 618-033. View Details

Keywords: Biotechnology; Drug Development; Corporate Strategy; Business Startups; Technological Innovation; Situation or Environment; Biotechnology Industry; Biotechnology Industry; China

November 2017
Case

Passion and Strategy: Novozymes' Embrace of the UN Sustainable Development Goals

By: Andy Zelleke and Emilie Billaud

This case explores the sustainability efforts at Novozymes, the world's largest and oldest producer of industrial enzymes. In 2015, the Danish company became the world’s first company known to have crafted a new corporate strategy based on the United Nations... View Details

Keywords: Corporate Governance; Transformation; Environmental Sustainability; Corporate Social Responsibility and Impact; Mission and Purpose; Business and Shareholder Relations; Business and Stakeholder Relations; Business Strategy; Organizational Culture; Organizational Change and Adaptation; Biotechnology Industry; Europe; Denmark

November 2017
Case

BeiGene

By: Willy Shih and Jimmy Zhang

BeiGene was a biopharmaceutical company founded on exploiting a temporal regulatory policy discontinuity. Because of regulatory challenges in China, most innovative new drugs launched there four to six years after their initial U.S. launches. This gave BeiGene a window... View Details

Keywords: Biotechnology; Pharmaceutical Company; Pharmaceuticals; China; Regulatory Environment; Business Strategy; Business Startups; Innovation Strategy; Situation or Environment; Pharmaceutical Industry; China

November 2016
Supplement

Alnylam Pharmaceuticals: Building Value from the IP Estate (B)

By: Vicki Sato, Willy Shih and Matt Higgins

The leader of a pioneering biotech company in the siRNA space weighs his options for scaling production capacity in advance of an anticipated commercial launch. Operational complexity and relative merits of in-house manufacturing versus a contractor model are... View Details

Keywords: Pharmaceutical Companies; Pharmaceutical Industry; Biotech; Biotechnology; Operational Complexity; Strategy; Manufacturing; Production; Strategic Planning; Intellectual Property; Biotechnology Industry; United States

November 2016
Case

Anthony Starks at InSiL Therapeutics (A)

By: Gary Pisano and Vicki Sato

When Bruce Wayne hired Anthony Starks, he thought he had hit a home run by getting the most brilliant and passionate scientist-leader in the field to be his CSO. But a few months in, Wayne and Starks begin to clash over crucial forward-looking decisions about the... View Details

Keywords: Biotech; Silicon; Managing Innovation; Management Challenges; Managing People; Managing Organization; R＆D; R＆D Project Management; Platform; Venture Capital; Drug Discovery; management; Biotechnology Industry; California

November 2016 (Revised December 2016)
Supplement

Anthony Starks at InSiL Therapeutics (B)

By: Vicki Sato and Gary Pisano

This case accompanies the (A) case from Anthony Starks's perspective. View Details

Keywords: Biotech; Management Challenges; R＆D; R＆D Project Management; Management; Biotechnology Industry; California

November 2016
Case

QuintilesIMS: Biosimilar Marketing in England

By: John A. Quelch and Emily C. Boudreau

QuintilesIMS was a leading healthcare consulting firm best known for its data and information offerings as well as its market research and management consulting services for life science companies. By 2015, the company was expanding beyond the biopharmaceutical... View Details

Keywords: Health; Pharmaceutical Industry; Biotech; Marketing; Health Care and Treatment; Biotechnology Industry; England

October 2016 (Revised September 2017)
Case

The CRISPR-Cas9 Quarrel

By: Richard G. Hamermesh and Matthew G. Preble

In mid-2016, the Broad Institute and the University of California, Berkeley were in the middle of a contentious patent dispute over which entity controlled a breakthrough gene editing technology called CRISPR-Cas9. With CRISPR-Cas9, scientists might soon be able to... View Details

Keywords: CRISPR; Broad Institute; University Of California Berkeley; Intellectual Property; Patents; Law; Lawsuits and Litigation; Science; Genetics; Entrepreneurship; Biotechnology Industry; United States

October 2016 (Revised February 2017)
Teaching Note

Alvogen

By: Daniel Isenberg, William R. Kerr and Alexis Brownell

Alvogen is an Icelandic pharmaceutical company that makes and sells generic drugs. Founder and CEO Robert Wessman is deciding whether to take on private equity investors willing to buy out all shareholders, merge with a large and publicly-traded US pharmaceutical... View Details

Keywords: Biotechnology; Globalization; Entrepreneurship; Biotechnology Industry

May 25, 2016
Comment

How Consumers and Businesses are Reshaping Public Health

By: John A. Quelch

Healthcare and education are two issues in which citizens around the world, rich and poor, are passionately interested. It has long been appreciated that the way that a society treats its youngest and oldest members says much about its moral maturity. Economic... View Details

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May 20, 2016
Comment

World Health Organization Lacks Leadership to Combat Pandemics

By: John A. Quelch

When it comes to emergency preparedness for pandemics, the World Health Organization is falling short. It has not provided prompt and clear leadership to the world in combating either the Ebola or Zika viruses. Its leadership has been low energy, its representatives... View Details

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March 2016
Article

Environmental Demands and the Emergence of Social Structure: Technological Dynamism and Interorganizational Network Forms

By: Adam Tatarynowicz, Maxim Sytch and Ranjay Gulati

This study investigates the origins of variation in the structures of interorganizational networks across industries. We combine empirical analyses of existing interorganizational networks in six industries with an agent-based simulation model of network emergence.... View Details

Keywords: Interorganizatonal Relationships; Social Networks; Network Emergence; Interorganizational Networks; Information Technology; Networks; Organizational Structure; Social and Collaborative Networks; Social Media

Find at Harvard

January 2016 (Revised February 2016)
Course Overview Note

The Sustainable Core: Operations Management

By: Michael W. Toffel and L. Beril Toktay

This note is designed to help faculty embed environmental sustainability content into their core Operations Management course at the MBA or undergraduate level. It can also be used to identify cases with environmental content that can be used in operations electives... View Details

Keywords: Environmental Management; Operations Management; Sustainable Operations; Environmental Regulation; Operations; Supply Chain; Supply Chain Management; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry; Biotechnology Industry