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  • All HBS Web  (1,806)
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  • October 2010 (Revised November 2010)
  • Background Note

Plavix: Drugs in the Age of Personalized Medicine

By: Richard G. Hamermesh, Mara G. Aspinall and Rachel Gordon
PIavix, one of the world's best selling drugs in 2010, appears to have a limited future. Its patent was due to expire soon, and recently new data had been discovered that indicated that a small subset of the population would be at risk for stroke, heart attack, or even... View Details
Keywords: Health Care and Treatment; Product Positioning; Business and Government Relations; Genetics; Competitive Strategy; Pharmaceutical Industry
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Hamermesh, Richard G., Mara G. Aspinall, and Rachel Gordon. "Plavix: Drugs in the Age of Personalized Medicine." Harvard Business School Background Note 811-001, October 2010. (Revised November 2010.)
  • June 2007 (Revised January 2008)
  • Case

Joel Klein and Leadership in the NYC Public Schools

By: Christopher Marquis, Doug Guthrie, Richard Arum and Abby Larson
Reviews the work of the New York City School Chancellor Joel Klein and his attempt to create a Leadership Academy in order to better train principals to lead New York City public schools. Assesses what leadership skills and strategies are necessary for Klein to create... View Details
Keywords: Education; Training; Leadership Development; Management Skills; Organizational Design; Performance Improvement; Education Industry; New York (city, NY)
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Marquis, Christopher, Doug Guthrie, Richard Arum, and Abby Larson. "Joel Klein and Leadership in the NYC Public Schools." Harvard Business School Case 407-065, June 2007. (Revised January 2008.)

    The Comprehensive Effects of Sales Force Management: A Dynamic Structural Analysis of Selection, Compensation, and Training

    This study provides a comprehensive model of an agent’s behavior in response to multiple sales management instruments, including compensation, recruiting/termination, and training. The model takes into account many of the key elements that constitute a realistic... View Details
    • Fast Answer

    Patent terminology: Provisional vs nonprovisional

    What is the difference between a provisional and non-provisional patent application? A nonprovisional patent application is normally considered the "regular" utility patent application. It’s what you file to get the USPTO... View Details
    • Web

    Great American Business Leaders of the 20th Century - Leadership

    1985–1995 Scott D. Cook Intuit, 1983–1994 Adolph Coors Adolph Coors Brewing Company, 1873–1923 Peter H. Coors Adolph Coors Brewing Company, 1993–2000 William K. Coors Adolph Coors Brewing Company, 1970–1993 Helen K. Copley Copley Newspapers, 1973–1997 Ira C. Copley... View Details
    • February 2025
    • Article

    Innovations in Evaluating Ambulatory Costs of Cystic Fibrosis Care: A Comparative Study Across Multidisciplinary Care Centers in Ireland and the United States

    By: Emma Brady, Ryan C. Perkins, Kate Cullen, Gregory S. Sawicki, Robert S. Kaplan and Gerardine Doyle
    Lead clinicians at two large pediatric cystic fibrosis (CF) centers in the United States and Ireland measured and compared their ambulatory care costs. The clinicians selected three strata of patients (0–11 months, 1–5 years, and 6–17 years of age). Process maps were... View Details
    Keywords: Health Care and Treatment; Cost; Service Delivery; Resource Allocation; Health Industry
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    Brady, Emma, Ryan C. Perkins, Kate Cullen, Gregory S. Sawicki, Robert S. Kaplan, and Gerardine Doyle. "Innovations in Evaluating Ambulatory Costs of Cystic Fibrosis Care: A Comparative Study Across Multidisciplinary Care Centers in Ireland and the United States." NEJM Catalyst Innovations in Care Delivery 6, no. 2 (February 2025).
    • July 2021
    • Article

    Redistribution through Markets

    By: Piotr Dworczak, Scott Duke Kominers and Mohammad Akbarpour
    Policymakers frequently use price regulations as a response to inequality in the markets they control. In this paper, we examine the optimal structure of such policies from the perspective of mechanism design. We study a buyer-seller market in which agents have private... View Details
    Keywords: Optimal Mechanism Design; Redistribution; Inequality; Welfare Theorems; Market Design; Equality and Inequality
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    Dworczak, Piotr, Scott Duke Kominers, and Mohammad Akbarpour. "Redistribution through Markets." Econometrica 89, no. 4 (July 2021): 1665–1698. (Authors' names are in certified random order.)
    • 2012
    • Article

    Demand and Capacity Management in Air Transportation

    This paper summarizes research trends and opportunities in the area of managing air transportation demand and capacity. Capacity constraints and resulting congestion and low schedule reliability currently impose large costs on airlines and their passengers. Significant... View Details
    Keywords: Demand Management; Capacity Management; Mathematical Modeling; Congestion And Delays; Trends And Opportunities; Demand and Consumers; Air Transportation; Mathematical Methods; Performance Capacity; Air Transportation Industry
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    Barnhart, Cynthia, Douglas S. Fearing, Amedeo Odoni, and Vikrant Vaze. "Demand and Capacity Management in Air Transportation." EURO Journal on Transportation and Logistics 1, nos. 1-2 (2012): 135–155.
    • October, 2022
    • Article

    The Economic Dynamics of Competing Power Generation Sources

    By: Gunther Glenk and Stefan Reichelstein
    Competing power generation sources have experienced considerable shifts in both their revenue potential and their costs in recent years. Here we introduce the concept of Levelized Profit Margins (LPM) to capture the changing unit economics of both intermittent and... View Details
    Keywords: Renewable Energy; Intermittant; Cost Accounting; Profitability Analysis; Learning-by-doing; Cannibalization Effect; Energy; Environmental Management; Investment; Operations; Technological Innovation; Utilities Industry; Utilities Industry; Utilities Industry; Utilities Industry; Europe; North America; South America; Africa; Asia
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    Glenk, Gunther, and Stefan Reichelstein. "The Economic Dynamics of Competing Power Generation Sources." Art. 112758. Renewable and Sustainable Energy Reviews 168 (October, 2022).
    • Web

    Podcast - Business & Environment

    Mike Toffel speaks with Pasi Miettinen, CEO of Sagewell, a company that uses AI to help utilities and their customers manage energy demand efficiently. Pasi explains how Sagewell’s technology helps reduce peak electricity usage, which in... View Details
    • 22 Mar 2011
    • Working Paper Summaries

    Platform Competition under Asymmetric Information

    Keywords: by Hanna Halaburda & Yaron Yehezkel; Technology
    • January 2025
    • Technical Note

    Get Cool: Air Conditioning Industry Background

    By: Rosabeth Moss Kanter and Jacob A. Small
    The “air conditioning paradox” is tied to climate change: the more the planet warms, the greater the need for cooling (due to the dangers of extreme heat as well as comfort within buildings), but the use of electricity-powered AC contributes to further warming. There... View Details
    Keywords: Appliances; Global Warming; Energy Efficiency; Climate Change; Venture Capital; Demand and Consumers; Distribution Channels; Green Technology; United States; Asia
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    Kanter, Rosabeth Moss, and Jacob A. Small. "Get Cool: Air Conditioning Industry Background." Harvard Business School Technical Note 325-077, January 2025.
    • May 2024
    • Supplement

    HubSpot and Motion AI (B): Generative AI Opportunities

    By: Jill Avery
    The technologies driving artificial intelligence (AI) had progressed significantly since HubSpot’s acquisition of Motion AI in 2017. Generative AI was the newest major development. Software-as-a-service (SaaS) companies such as HubSpot were analyzing how generative AI... View Details
    Keywords: Artificial Intelligence; CRM; Chatbots; Sales Management; Generative Ai; SaaS; Marketing; Sales; AI and Machine Learning; Customer Relationship Management; Applications and Software; Technological Innovation; Competitive Advantage; Technology Industry; United States
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    Avery, Jill. "HubSpot and Motion AI (B): Generative AI Opportunities." Harvard Business School Supplement 524-088, May 2024.
    • 2016
    • Conference Paper

    The Pressing Game: Optimal Defensive Disruption in Soccer

    By: Iavor I. Bojinov and Luke Bornn
    Soccer, the most watched sport in the world, is a dynamic game where a team’s success relies on both team strategy and individual player contributions. Passing is a cardinal soccer skill and a key factor in strategy development; it helps the team to keep the ball... View Details
    Keywords: Soccer; Strategy; Disruption
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    Bojinov, Iavor I., and Luke Bornn. "The Pressing Game: Optimal Defensive Disruption in Soccer." Paper presented at the MIT Sloan School of Management, Cambridge, MA, March 2016.
    • August 2018 (Revised September 2018)
    • Supplement

    LendingClub (C): Gradient Boosting & Payoff Matrix

    By: Srikant M. Datar and Caitlin N. Bowler
    This case builds directly on the LendingClub (A) and (B) cases. In this case students follow Emily Figel as she builds an even more sophisticated model using the gradient boosted tree method to predict, with some probability, whether a borrower would repay or default... View Details
    Keywords: Data Analytics; Data Science; Investment; Financing and Loans; Analytics and Data Science; Analysis; Forecasting and Prediction
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    Datar, Srikant M., and Caitlin N. Bowler. "LendingClub (C): Gradient Boosting & Payoff Matrix." Harvard Business School Supplement 119-022, August 2018. (Revised September 2018.)
    • 2016
    • Chapter

    Fiscal Issues for Cross-Border Natural Resource Projects

    By: Joseph Bell and Jasmina Chauvin
    Projects that cross national boundaries give rise to the complex question of how the project's taxable income should be allocated among the national entities. This chapter utilizes a hypothetical mining project with the mine and infrastructure in two different... View Details
    Keywords: Extractive Industries; Business & Government Relations; Transfer Pricing; Taxation; Infrastructure; Cross-Cultural and Cross-Border Issues; Business and Government Relations; Mining Industry
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    Bell, Joseph, and Jasmina Chauvin. "Fiscal Issues for Cross-Border Natural Resource Projects." Chap. 8 in International Taxation and the Extractive Industries, edited by Philip Daniel, Michael Keen, Artur Świstak, and Victor Thuronyi, 190–214. Routledge Studies in Development Economics. Routledge, 2016.
    • May 2023 (Revised May 2023)
    • Case

    Stay or Go? Sarah Reynolds Kensington Partners

    By: David G. Fubini, Amr Seifeldin and Patrick Sanguineti
    Sarah Reynolds, a relatively new Partner at the global Kensington Partners strategy consulting firm, has headed the firm's Telecommunications Group for a few years. Thanks to her stellar track record with clients, she has brought the group a range of accolades and... View Details
    Keywords: Consulting; Consulting Firms; Client Service; Career Management
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    Fubini, David G., Amr Seifeldin, and Patrick Sanguineti. "Stay or Go? Sarah Reynolds Kensington Partners." Harvard Business School Case 423-091, May 2023. (Revised May 2023.)
    • December 2016
    • Article

    The Effects of Endowment Size and Strategy Method on Third Party Punishment

    By: Jillian J. Jordan, Katherine McAuliffe and David G. Rand
    Numerous experiments have shown that people often engage in third-party punishment (3PP) of selfish behavior. This evidence has been used to argue that people respond to selfishness with anger, and get utility from punishing those who mistreat others. Elements of the... View Details
    Keywords: Third-party Punishment; Norm-enforcement; Strategy Method; Economic Games; Cooperation; Emotions; Fairness
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    Jordan, Jillian J., Katherine McAuliffe, and David G. Rand. "The Effects of Endowment Size and Strategy Method on Third Party Punishment." Experimental Economics 19, no. 4 (December 2016): 741–763.
    • Article

    Optimal Value and Growth Tilts in Long-Horizon Portfolios

    By: Jakub W. Jurek and Luis M. Viceira
    We develop an analytical solution to the dynamic portfolio choice problem of an investor with power utility defined over wealth at a finite horizon, who faces a time-varying investment opportunity set, parameterized using a flexible vector autoregression. We apply this... View Details
    Keywords: Decision Choices and Conditions; Private Equity; Investment; Investment Portfolio; Asset Pricing; Value
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    Jurek, Jakub W., and Luis M. Viceira. "Optimal Value and Growth Tilts in Long-Horizon Portfolios." Review of Finance 15, no. 1 (January 2011): 29–74.
    • 09 Jan 2024
    • In Practice

    Harnessing AI: What Businesses Need to Know in ChatGPT’s Second Year

    worrying about where people sit, organizations will focus on whether their workforce has the right toolsets and skillsets. Understanding and utilizing tools, data, and algorithms are key skills for this rapidly evolving AI future. As we... View Details
    Keywords: by Rachel Layne; Information Technology
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