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  • All HBS Web  (164)
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    • News  (42)
    • Research  (57)
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  • All HBS Web  (164)
    • People  (1)
    • News  (42)
    • Research  (57)
    • Events  (6)
    • Multimedia  (4)
  • Faculty Publications  (34)
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  • June 2016
  • Case

Alnylam: Building a Biotechnology Powerhouse

By: Kevin Schulman
Alnylam is an early stage biomedical technology focused on commercial development of a novel technology platform, siRNA. This technology offered promise to treat rare genetic disorders that could not be treated with other technologies. Alnlyam's development entailed... View Details
Keywords: Technological Innovation; Commercialization; Health Disorders; Intellectual Property; Biotechnology Industry
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Schulman, Kevin. "Alnylam: Building a Biotechnology Powerhouse." Harvard Business School Case 316-113, June 2016.
  • June 18, 2021
  • Article

Who Do We Invent for? Patents by Women Focus More on Women's Health, but Few Women Get to Invent

By: Rembrand Koning, Sampsa Samila and John-Paul Ferguson
Women engage in less commercial patenting and invention than do men, which may affect what is invented. Using text analysis of all U.S. biomedical patents filed from 1976 through 2010, we found that patents with all-female inventor teams are 35% more likely than... View Details
Keywords: Innovation; Gender Bias; Health; Innovation and Invention; Research; Patents; Gender; Prejudice and Bias
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Koning, Rembrand, Sampsa Samila, and John-Paul Ferguson. "Who Do We Invent for? Patents by Women Focus More on Women's Health, but Few Women Get to Invent." Science 372, no. 6548 (June 18, 2021): 1345–1348.
  • May 2020
  • Article

Inventor Gender and the Direction of Invention

By: Rembrand Koning, Sampsa Samila and John-Paul Ferguson
We study whether increasing the share of female inventors leads to more biomedical inventions that focus on the needs of women. After accounting for detailed disease-technology, disease-year, and technology-year fixed effects, we find that a 10 percentage point... View Details
Keywords: Innovation and Invention; Gender; Patents
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Koning, Rembrand, Sampsa Samila, and John-Paul Ferguson. "Inventor Gender and the Direction of Invention." AEA Papers and Proceedings 110 (May 2020): 250–254.
  • March 2008 (Revised June 2008)
  • Case

The Broad Institute: Applying the Power of Genomics to Medicine

By: Vicki L. Sato and Rachel Gordon
In June 2003, Harvard University and MIT announced an unprecedented partnership to create a biomedical institute, The Broad Institute. The culture of the Broad centered on science, and those involved considered it to be at the edge of the scientific frontier. In just... View Details
Keywords: Education; Health Care and Treatment; Innovation Leadership; Growth and Development Strategy; Organizational Culture; Partners and Partnerships; Research and Development; Genetics
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Sato, Vicki L., and Rachel Gordon. "The Broad Institute: Applying the Power of Genomics to Medicine." Harvard Business School Case 608-114, March 2008. (Revised June 2008.)
  • 21 Nov 2008
  • Working Paper Summaries

Applicant and Examiner Citations in U.S. Patents: An Overview and Analysis

Keywords: by Juan Alcacer
  • 25 Aug 2015
  • First Look

First Look Tuesday

which required U.S. patent applications be published 18 months after their filing date rather than at patent grant, on the timing of licensing deals in the biomedical industry. We find that post-AIPA, U.S. patent applications are... View Details
  • 2016
  • Working Paper

Patent Publication and the Market for Ideas

By: Deepak Hegde and Hong Luo
In this paper, we study the effect of invention disclosure through patent publication on the market for ideas. We do so by analyzing the effects of the American Inventor's Protection Act of 1999 (AIPA)—which required US patent applications to be published 18 months... View Details
Keywords: Patents; Biotechnology Industry
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Hegde, Deepak, and Hong Luo. "Patent Publication and the Market for Ideas." Working Paper, February 2016. (Accepted for publication in Management Science.)
  • May 2021
  • Article

Making Doctors Effective Managers and Leaders: A Matter of Health and Well-Being

By: Lisa Rotenstein, Robert S. Huckman and Christine K. Cassel
The COVID-19 crisis has forced physicians to make daily decisions that require knowledge and skills they did not acquire as part of their biomedical training. Physicians are being called upon to be both managers—able to set processes and structures—and leaders—capable... View Details
Keywords: Health Care and Treatment; Management; Leadership; Health Pandemics; Health Industry
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Rotenstein, Lisa, Robert S. Huckman, and Christine K. Cassel. "Making Doctors Effective Managers and Leaders: A Matter of Health and Well-Being." Academic Medicine 96, no. 5 (May 2021).
  • November 2019
  • Case

The Genesis Lab at Novartis

By: Amy C. Edmondson, Ranjay Gulati, Patrick J. Healy and Kerry Herman
Novartis' Genesis Labs program, launched in 2016 as part of Novartis Institutes for Biomedical Research (NIBR), hosted pitch competitions where teams of NIBR scientists proposed ideas to explore that aimed to revolutionize drug discovery. The goal was to break down... View Details
Keywords: Drug Discovery; Health Care and Treatment; Research and Development; Innovation and Invention; Programs; Management
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Edmondson, Amy C., Ranjay Gulati, Patrick J. Healy, and Kerry Herman. "The Genesis Lab at Novartis." Harvard Business School Case 620-007, November 2019.
  • February 2018
  • Article

Patent Publication and the Market for Ideas

By: Deepak Hegde and Hong Luo
In this paper, we study the effect of invention disclosure through patent publication on the market for ideas. We do so by analyzing the effects of the American Inventor's Protection Act of 1999 (AIPA)—which required U.S. patent applications to be published 18 months... View Details
Keywords: Licensing; Patent Publication; Invention Disclosure; Patents; Information Publishing; Innovation and Invention; Knowledge Dissemination
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Hegde, Deepak, and Hong Luo. "Patent Publication and the Market for Ideas." Management Science 64, no. 2 (February 2018): 652–672.
  • September 15, 2021
  • Article

Improving Deconvolution Methods in Biology Through Open Innovation Competitions: An Application to the Connectivity Map

By: Andrea Blasco, Ted Natoli, Michael G. Endres, Rinat A. Sergeev, Steven Randazzo, Jin Hyun Paik, N.J. Maximilian Macaluso, Rajiv Narayan, Xiaodong Lu, David Peck, Karim R. Lakhani and Aravind Subramanian
A recurring problem in biomedical research is how to isolate signals of distinct populations (cell types, tissues, and genes) from composite measures obtained by a single analyte or sensor. Existing computational deconvolution approaches work well in many specific... View Details
Keywords: Deconvolution; Methods; Open Innovation Competition; Genomics; Research; Innovation and Invention
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Blasco, Andrea, Ted Natoli, Michael G. Endres, Rinat A. Sergeev, Steven Randazzo, Jin Hyun Paik, N.J. Maximilian Macaluso, Rajiv Narayan, Xiaodong Lu, David Peck, Karim R. Lakhani, and Aravind Subramanian. "Improving Deconvolution Methods in Biology Through Open Innovation Competitions: An Application to the Connectivity Map." Bioinformatics 37, no. 18 (September 15, 2021).
  • Research Summary

Moral Reasoning & Experimental Political Philosophy

In this work, we demonstrate a new and morally significant effect on judgment and decision-making. This research is inspired by the work of John Rawls, widely regarded as the most important political philosopher of the 20th Century. Here we apply the central... View Details
Keywords: Ethics; Fairness; Distributive Justice
  • 2009
  • Working Paper

Social Influence Given (Partially) Deliberate Matching: Career Imprints in the Creation of Academic Entrepreneurs

By: Pierre Azoulay, Christopher C. Liu and Toby E. Stuart
Actors often match with associates on a small set of dimensions that matter most for the particular relationship at hand. In so doing, they are exposed to unanticipated social influences because counterparts have more interests, attitudes, and preferences than would-be... View Details
Keywords: Entrepreneurship; Patents; Marketplace Matching; Mathematical Methods; Science-Based Business; Power and Influence; Social and Collaborative Networks; Biotechnology Industry
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Azoulay, Pierre, Christopher C. Liu, and Toby E. Stuart. "Social Influence Given (Partially) Deliberate Matching: Career Imprints in the Creation of Academic Entrepreneurs." Harvard Business School Working Paper, No. 09-136, May 2009.
  • 28 Aug 2023
  • Research & Ideas

The Clock Is Ticking: 3 Ways to Manage Your Time Better

biomedical research institute. We measured employees’ daily work locations using building-badge swipe data, as well as various work and work-life outcomes via biweekly surveys. We found that each employee’s individual outcomes—such as... View Details
Keywords: by Kristen Senz
  • 2001
  • Chapter

Publicly Funded Science and the Productivity of the Pharmaceutical Industry

By: Rebecca Henderson and Ian Cockburn
U.S. taxpayers funded $14.8 billion of health related research last year, four times the amount that was spent in 1970 in real terms. In this paper we evaluate the impact of these huge expenditures on the technological performance of the pharmaceutical industry. While... View Details
Keywords: Public Sector; Science-Based Business; Research and Development; Sovereign Finance; Pharmaceutical Industry
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Henderson, Rebecca, and Ian Cockburn. "Publicly Funded Science and the Productivity of the Pharmaceutical Industry." In Innovation Policy and the Economy, Volume 1, edited by Adam B. Jaffe, Josh Lerner, and Scott Stern, 1–34. MIT Press, 2001.
  • 11 Jun 2009
  • Working Paper Summaries

Social Influence Given (Partially) Deliberate Matching: Career Imprints in the Creation of Academic Entrepreneurs

Keywords: by Pierre Azoulay, Christopher C. Liu & Toby E. Stuart
  • 22 Apr 2009
  • Working Paper Summaries

Where is the Pharmacy to the World? International Regulatory Variation and Pharmaceutical Industry Location

Keywords: by Arthur Daemmrich; Pharmaceutical
  • 22 Feb 2022
  • Research & Ideas

Lack of Female Scientists Means Fewer Medical Treatments for Women

treatments that primarily benefit women, yet an examination of biomedical patents filed over a 30-year period revealed a significant shortage of inventions targeting women’s health versus the large volume of new products for male... View Details
Keywords: by Kristen Senz
  • 20 May 2013
  • Op-Ed

Making America an Industrial Powerhouse Again

industries. Research funded by the Defense Advanced Research Projects Agency (DARPA) sowed the seeds for the internet and advanced computer graphics. And massive investments by the National Institutes of Health in biomedical research,... View Details
Keywords: by Gary Pisano; Manufacturing
  • 26 Jul 2024
  • Research & Ideas

Why Great Ideas Get Stuck in Universities

commercial hindrance. A recent study of more than 500 biomedical startups suggests that ventures rooted in the core research of their founders have a more challenging time reaching key measures of success, such as raising capital or... View Details
Keywords: by Ben Rand; Biotechnology; Health
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