Publications

Educators

May 2020
Article

Inventor Gender and the Direction of Invention

By: Rembrand Koning, Sampsa Samila and John-Paul Ferguson

We study whether increasing the share of female inventors leads to more biomedical inventions that focus on the needs of women. After accounting for detailed disease-technology, disease-year, and technology-year fixed effects, we find that a 10 percentage point... View Details

Keywords: Innovation and Invention; Gender; Patents

June 18, 2021
Article

Who Do We Invent for? Patents by Women Focus More on Women's Health, but Few Women Get to Invent

By: Rembrand Koning, Sampsa Samila and John-Paul Ferguson

Women engage in less commercial patenting and invention than do men, which may affect what is invented. Using text analysis of all U.S. biomedical patents filed from 1976 through 2010, we found that patents with all-female inventor teams are 35% more likely than... View Details

Keywords: Innovation; Gender Bias; Health; Innovation and Invention; Research; Patents; Gender; Prejudice and Bias

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March 2008 (Revised June 2008)
Case

The Broad Institute: Applying the Power of Genomics to Medicine

By: Vicki L. Sato and Rachel Gordon

In June 2003, Harvard University and MIT announced an unprecedented partnership to create a biomedical institute, The Broad Institute. The culture of the Broad centered on science, and those involved considered it to be at the edge of the scientific frontier. In just... View Details

Keywords: Education; Health Care and Treatment; Innovation Leadership; Growth and Development Strategy; Organizational Culture; Partners and Partnerships; Research and Development; Genetics

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May 2021
Article

Making Doctors Effective Managers and Leaders: A Matter of Health and Well-Being

By: Lisa Rotenstein, Robert S. Huckman and Christine K. Cassel

The COVID-19 crisis has forced physicians to make daily decisions that require knowledge and skills they did not acquire as part of their biomedical training. Physicians are being called upon to be both managers—able to set processes and structures—and leaders—capable... View Details

Keywords: Health Care and Treatment; Management; Leadership; Health Pandemics; Health Industry

21 Nov 2008
Working Paper Summaries

Applicant and Examiner Citations in U.S. Patents: An Overview and Analysis

Keywords: by Juan Alcacer

2016
Working Paper

Patent Publication and the Market for Ideas

By: Deepak Hegde and Hong Luo

In this paper, we study the effect of invention disclosure through patent publication on the market for ideas. We do so by analyzing the effects of the American Inventor's Protection Act of 1999 (AIPA)—which required US patent applications to be published 18 months... View Details

Keywords: Patents; Biotechnology Industry

November 2019
Case

The Genesis Lab at Novartis

By: Amy C. Edmondson, Ranjay Gulati, Patrick J. Healy and Kerry Herman

Novartis' Genesis Labs program, launched in 2016 as part of Novartis Institutes for Biomedical Research (NIBR), hosted pitch competitions where teams of NIBR scientists proposed ideas to explore that aimed to revolutionize drug discovery. The goal was to break down... View Details

Keywords: Drug Discovery; Health Care and Treatment; Research and Development; Innovation and Invention; Programs; Management

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25 Aug 2015
First Look

First Look Tuesday

which required U.S. patent applications be published 18 months after their filing date rather than at patent grant, on the timing of licensing deals in the biomedical industry. We find that post-AIPA, U.S. patent applications are... View Details

February 2018
Article

Patent Publication and the Market for Ideas

By: Deepak Hegde and Hong Luo

In this paper, we study the effect of invention disclosure through patent publication on the market for ideas. We do so by analyzing the effects of the American Inventor's Protection Act of 1999 (AIPA)—which required U.S. patent applications to be published 18 months... View Details

Keywords: Licensing; Patent Publication; Invention Disclosure; Patents; Information Publishing; Innovation and Invention; Knowledge Dissemination

September 15, 2021
Article

Improving Deconvolution Methods in Biology Through Open Innovation Competitions: An Application to the Connectivity Map

By: Andrea Blasco, Ted Natoli, Michael G. Endres, Rinat A. Sergeev, Steven Randazzo, Jin Hyun Paik, N.J. Maximilian Macaluso, Rajiv Narayan, Xiaodong Lu, David Peck, Karim R. Lakhani and Aravind Subramanian

A recurring problem in biomedical research is how to isolate signals of distinct populations (cell types, tissues, and genes) from composite measures obtained by a single analyte or sensor. Existing computational deconvolution approaches work well in many specific... View Details

Keywords: Deconvolution; Methods; Open Innovation Competition; Genomics; Research; Innovation and Invention

Research Summary

Moral Reasoning & Experimental Political Philosophy

In this work, we demonstrate a new and morally significant effect on judgment and decision-making. This research is inspired by the work of John Rawls, widely regarded as the most important political philosopher of the 20th Century. Here we apply the central... View Details

Keywords: Ethics; Fairness; Distributive Justice

2009
Working Paper

Social Influence Given (Partially) Deliberate Matching: Career Imprints in the Creation of Academic Entrepreneurs

By: Pierre Azoulay, Christopher C. Liu and Toby E. Stuart

Actors often match with associates on a small set of dimensions that matter most for the particular relationship at hand. In so doing, they are exposed to unanticipated social influences because counterparts have more interests, attitudes, and preferences than would-be... View Details

Keywords: Entrepreneurship; Patents; Marketplace Matching; Mathematical Methods; Science-Based Business; Power and Influence; Social and Collaborative Networks; Biotechnology Industry

2001
Chapter

Publicly Funded Science and the Productivity of the Pharmaceutical Industry

By: Rebecca Henderson and Ian Cockburn

U.S. taxpayers funded $14.8 billion of health related research last year, four times the amount that was spent in 1970 in real terms. In this paper we evaluate the impact of these huge expenditures on the technological performance of the pharmaceutical industry. While... View Details

Keywords: Public Sector; Science-Based Business; Research and Development; Sovereign Finance; Pharmaceutical Industry