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- June 2024 (Revised December 2024)
- Case
Lana Ghanem: Pushing the Boundaries of Health Care Through Venture Capital
By: Joshua D. Margolis and Ahmed Dahawy
Lana Ghanem, managing director of Hikma Ventures, the corporate venture arm of larger pharmaceutical group Hikma, is considering how to grow the venture arm as well as progress her own career. Over the past few years Hikma's executive team had been pressuring the... View Details
Keywords: Business Divisions; Corporate Entrepreneurship; Investment; Corporate Governance; Health Care and Treatment; Leadership Development; Business or Company Management; Growth and Development Strategy; Business Strategy; Venture Capital; Personal Development and Career; Health Industry; Pharmaceutical Industry; Jordan
- 2024
- Working Paper
Incrementality Representation Learning: Synergizing Past Experiments for Intervention Personalization
This paper introduces Incrementality Representation Learning (IRL), a novel multitask representation learning framework that predicts heterogeneous causal effects of marketing interventions. By leveraging past experiments, IRL efficiently designs and targets... View Details
- June 2024
- Article
Real Growth in Space Manufacturing Output Substantially Exceeds Growth in the Overall Space Economy
By: Tina Highfill and Matthew Weinzierl
Accurately measuring real economic output in the space economy is made difficult by the rapid increase in capabilities and decrease in prices of launch and satellite technologies achieved over the past two decades. Nominal measures of output in space will tend to... View Details
- April 2024 (Revised August 2024)
- Case
The Engine
By: Joshua Lev Krieger, Jim Matheson, Fiona Murray and Nicholas Christman
The Engine, a venture capital firm founded by MIT to fill a gap in the technology funding landscape by commercializing breakthrough science and technology. Led by managing partner and CEO Katie Rae, the Engine's unique approach involved an unusually longer fund life,... View Details
- February 2024 (Revised March 2025)
- Case
Moving Science: The Rowland Institute at Harvard
By: Maria P. Roche
Set in 2022, this case describes the considerations involved in organizing the physical relocation of the Rowland Institute at Harvard (RIH), a research institute established in 1980 by Edwin H. Land, the founder of the Polaroid Corporation, for the advancement of... View Details
- January 2024
- Case
Relativity Space, Vertical Integration, and Additive Manufacturing's Role in Space
By: Matthew C. Weinzierl, Brendan L. Rosseau and Jack Goodwin
- January 2024 (Revised January 2025)
- Case
Huawei: Resilience amid Autarky and Adversity
By: William C. Kirby and Daniel Fu
In September 2023, Huawei made a dramatic return to the global smartphone space with the launch of its Mate 60 Pro smartphone, equipped with an indigenously designed, 7nm chip. This came despite a myriad of export controls and restrictions imposed against the company... View Details
Keywords: International Strategy; Semiconductors; Smartphone; Government And Politics; Government And Business; Digital Infrastructure; 5G; Political Risk; Business and Government Relations; Global Strategy; Multinational Firms and Management; Governing Rules, Regulations, and Reforms; AI and Machine Learning; Mobile and Wireless Technology; Leadership; Retirement; Corporate Strategy; Technology Industry; China; United States; Europe; Asia; Middle East
- December 18, 2023
- Article
Are Everywhere Stores the New Face of Retail?
By: David R. Bell, Santiago Gallino and Antonio Moreno
Historically, customer engagement and product fulfillment occurred in the same place — a traditional retail store. But today, retailers are beginning to explore how they can create opportunities for customers to engage with products in native environments. A related... View Details
- 2023
- Article
MoPe: Model Perturbation-based Privacy Attacks on Language Models
By: Marvin Li, Jason Wang, Jeffrey Wang and Seth Neel
Recent work has shown that Large Language Models (LLMs) can unintentionally leak sensitive information present in their training data. In this paper, we present Model Perturbations (MoPe), a new method to identify with high confidence if a given text is in the training... View Details
- November 2023 (Revised April 2024)
- Case
Khanmigo: Revolutionizing Learning with GenAI
By: William A. Sahlman, Allison M. Ciechanover and Emily Grandjean
Already a leader in the edtech space since its 2008 launch, Khan Academy was now one of the first edtech organizations to embrace generative artificial intelligence ("genAI"). In March 2023, Khan Academy began beta testing Khanmigo, a genAI “guide” and tutor built with... View Details
- October 2023 (Revised April 2024)
- Case
TetraScience: Unlocking the Power of Scientific Data
By: Satish Tadikonda and William Marks
After pivoting from a focus on hardware to a focus on scientific data, TetraScience, led by veteran SaaS executive, Patrick Grady and Founder Spin Wang, has embarked on a journey from nearly cash-out to a player in the scientific data management space. This case... View Details
- October 2023 (Revised June 2024)
- Case
Catalent: Catalyzing the Next Era of Growth
By: Satish Tadikonda, William Marks and Kevin Emancipator
Catalent's newly appointed CEO, Alessandro Maselli, experienced the highs of the pharmaceutical contract development manufacturing (CDMO) space during COVID-19 while helping Moderna and others bring vaccines to market quickly and safely. After rushing to add capacity... View Details
- September 2023 (Revised December 2023)
- Case
TetraScience: Noise and Signal
By: Thomas R. Eisenmann and Tom Quinn
In 2019, TetraScience CEO “Spin” Wang needed advice. Five years earlier, he had cofounded a startup that saw early success with a hardware product designed to help laboratory scientists in the biotechnology and pharmaceutical spaces more easily collect data from... View Details
Keywords: Entrepreneurship; Business Growth and Maturation; Business Organization; Restructuring; Forecasting and Prediction; Digital Platforms; Analytics and Data Science; AI and Machine Learning; Organizational Structure; Network Effects; Competitive Strategy; Biotechnology Industry; Pharmaceutical Industry; United States; Boston
- August 2023
- Case
Augmenix: Space to Think Differently
By: Satish Tadikonda and Sidhant Jena
Amar Sawhney, a serial medtech entrepreneur, had founded Augmenix to develop and commercialize a hydrogel-based medical device called SpaceOAR as an adjunctive technology to core radiation therapy. This technology was used to protect organs at risk (OAR) during... View Details
- August 2023 (Revised August 2023)
- Case
Sky Therapeutics: Innovating in Digital Therapeutics
By: Satish Tadikonda, Olivia Reszczynski and William Marks
Shad Faraz and Alex Youssef were intrigued by the opportunities in the relatively new area of Digital Therapeutics. Despite initial successes, early entrants had struggled with reimbursement and revenue-predictability challenges. However, venture investors still... View Details
- May 2023
- Course Overview Note
Space: Public and Commercial Economics (SPACE)
SPACE is a course with two goals: to use the tools of economics to better understand the rapidly evolving space sector, and to train the next generation of commercial space leaders. We pursue these goals through a systematic study of the growing space economy,... View Details
- April 2023
- Case
Twitter: The Freedom to Speak Freely and Be Heard
By: Randolph B. Cohen, Carin-Isabel Knoop and Mel Martin
In April 2022, serial entrepreneur Elon Musk announced that he would be interested in purchasing the social media site Twitter for $44 billion. With more than 100 million twitter followers, Musk had historically leveraged the site to engage with the customers of his... View Details
- April 2023
- Case
Ryan Serhant: Time Management for Repeatable Success (A)
By: Ashley Whillans and Hawken Lord
From an open-concept 90’s-style stone and wood cabin in Dublin, New Hampshire, Ryan Serhant reflected on his career as a real estate broker. As Ryan stared into the fireplace that featured prominently in the center of the house, he wondered whether the period of... View Details
- 2023
- Article
Estimating Causal Peer Influence in Homophilous Social Networks by Inferring Latent Locations.
By: Edward McFowland III and Cosma Rohilla Shalizi
Social influence cannot be identified from purely observational data on social networks, because such influence is generically confounded with latent homophily, that is, with a node’s network partners being informative about the node’s attributes and therefore its... View Details
- 2023
- Working Paper
Remote Work across Jobs, Companies, and Space
By: Stephen Hansen, Peter John Lambert, Nick Bloom, Steven J. Davis, Raffaella Sadun and Bledi Taska
The pandemic catalyzed an enduring shift to remote work. To measure and characterize
this shift, we examine more than 250 million job vacancy postings across five
English-speaking countries. Our measurements rely on a state-of-the-art language-processing
framework... View Details