Publications
Publications
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- All HBS Web
(604)
- Faculty Publications (76)
- April 12, 2022
- Article
Evaluation of Individual and Ensemble Probabilistic Forecasts of COVID-19 Mortality in the United States
By: Estee Y. Cramer, Evan L. Ray, Velma K. Lopez, Johannes Bracher, Andrea Brennen, Alvaro J. Castro Rivadeneira, Michael Lingzhi Li and et al.
Short-term probabilistic forecasts of the trajectory of the COVID-19 pandemic in the United States have served as a visible and important communication channel between the scientific modeling community and both the general public and decision-makers. Forecasting models... View Details
- Article
Potentially Long-Lasting Effects of the Pandemic on Scientists
By: Jian Gao, Yian Yin, Kyle R. Myers, Karim R. Lakhani and Dashun Wang
Two surveys of principal investigators conducted between April 2020 and January 2021 reveal that while the COVID-19 pandemic’s initial impacts on scientists’ research time seem alleviated, there has been a decline in the rate of initiating new projects. This dimension... View Details
- May 2021
- Case
The SMA Foundation: Steering Therapeutic Research and Development in a Rare Disease
By: Amitabh Chandra, Spencer Lee-Rey and Caroline Marra
This case explores incentives for rare disease drug development by chronicling the role of the Spinal Muscular Atrophy (SMA) Foundation in forming strategic partnerships with the scientific research community and pharmaceutical developers to transform the trajectory... View Details
- February 2021 (Revised September 2022)
- Case
Marie Curie: Changing the World
By: Robert Simons and Shirley Sun
This case describes the rise of Marie Curie from a poor family in Poland to the pinnacle of scientific fame. The case describes how Curie, as a young woman interested in science, found a way to earn a doctorate at the Sorbonne and perform pathbreaking research on... View Details
- 2020
- Working Paper
When Do Experts Listen to Other Experts? The Role of Negative Information in Expert Evaluations for Novel Projects
By: Jacqueline N. Lane, Misha Teplitskiy, Gary Gray, Hardeep Ranu, Michael Menietti, Eva C. Guinan and Karim R. Lakhani
The evaluation of novel projects lies at the heart of scientific and technological innovation, and yet literature suggests that this process is subject to inconsistency and potential biases. This paper investigates the role of information sharing among experts as the... View Details
- 2020
- Working Paper
Scientific Production: An Exploration into Organization, Resource Allocation, and Funding
By: Jerry Thursby, Marie Thursby, Karim R. Lakhani, Kyle R. Myers, Nina Cohodes, Sarah Bratt, Dennis Byrski, Hannah Cohoon and Maria Roche
Production of scientific knowledge is core to civilizational advancement in economic and material wellbeing of societies. Despite its fundamental importance, however, a systematic effort to quantitatively study the factors underlying scientific production, particularly... View Details
- March 2020
- Case
ZEISS Group: Organize by Customer Culture?
By: Willy C. Shih
How should ZEISS, the German manufacturer of precision optical and optoelectronic systems manage two historic businesses that operated fairly autonomously? The Industrial Quality Solutions (IQS) business sold measurement equipment to manufacturing companies in sectors... View Details
- Article
A Field Experiment on Search Costs and the Formation of Scientific Collaborations
By: Kevin Boudreau, Tom Brady, Ina Ganguli, Patrick Gaule, Eva C. Guinan, Anthony Hollenberg and Karim R. Lakhani
We present the results of a field experiment conducted at Harvard Medical School to understand the extent to which search costs affect matching among scientific collaborators. We generated exogenous variation in search costs for pairs of potential collaborators by... View Details
- September 2017
- Case
Sensing (and Monetizing) Happiness at Hitachi
By: Ethan Bernstein and Stephanie Marton
Inspired by research linking happiness and productivity, Hitachi had invested in developing new “people analytics” technologies to help companies increase employee happiness. Hitachi had begun manufacturing high-tech badges that quantify a wearer’s activity patterns.... View Details
- 2017
- Article
True Happiness: The Role of Morality in the Concept of Happiness
By: Jonathan Phillips, Julian De Freitas, Christian Mott, June Gruber and Joshua Knobe
Recent scientific research has settled on a purely descriptive definition of happiness that is focused solely on agents' psychological states (high positive affect, low negative affect, high life satisfaction). In contrast to this understanding, recent research has... View Details
- Winter 2017
- Article
Why Big Data Isn't Enough
By: Sen Chai and Willy C. Shih
There is a growing belief that sophisticated algorithms can explore huge databases and find relationships independent of any preconceived hypotheses. But in businesses that involve scientific research and technological innovation, this approach is misguided and... View Details
- Article
One Obstacle to Curing Cancer: Patient Data Isn't Shared
By: Richard G. Hamermesh and Kathy Giusti
Precision Medicine requires large datasets to identify the mutations that lead to various cancers. Currently, genomic information is hoarded in fragmented silos within numerous academic medical centers, pharmaceutical companies, and some disease-based foundations. For... View Details
Keywords: Healthcare; Technological And Scientific Innovation; Cancer Care In The U.S.; Cancer Treatment; Precision Medicine; Personalized Medicine; Data Sharing; Technological Innovation; Analytics and Data Science; Health Disorders; Medical Specialties; Research and Development; Customization and Personalization; Health Industry; United States
- October 2016 (Revised September 2017)
- Case
The CRISPR-Cas9 Quarrel
By: Richard G. Hamermesh and Matthew G. Preble
In mid-2016, the Broad Institute and the University of California, Berkeley were in the middle of a contentious patent dispute over which entity controlled a breakthrough gene editing technology called CRISPR-Cas9. With CRISPR-Cas9, scientists might soon be able to... View Details
- October 2016
- Article
Looking Across and Looking Beyond the Knowledge Frontier: Intellectual Distance and Resource Allocation in Science
By: Kevin J. Boudreau, Eva Guinan, Karim R. Lakhani and Christoph Riedl
Selecting among alternative innovative projects is a core management task in all innovating organizations. In this paper, we focus on the evaluation of frontier scientific research projects. We argue that the "intellectual distance" between the knowledge embodied in... View Details
- February 2016
- Article
Bridging Science and Technology Through Academic-Industry Partnerships
By: Sen Chai and Willy C. Shih
Partnerships that foster the translation of scientific advances emerging from academic research organizations into commercialized products at private firms are a policy tool that has attracted increased interest. This paper examines empirical data from the Danish... View Details
- November 2014
- Case
Napalm: From Soldiers Field to Trang Bang
By: Tom Nicholas and Jonas Peter Akins
Napalm is one of the most destructive weapons ever to be invented. Yet, at its original inception it was nothing more than a technical challenge, and it was never intended to be used in indiscriminate antipersonnel warfare. The pathway of its development by a Harvard... View Details
- April 2014
- Case
Merrimack Pharmaceuticals, Inc. (A)
By: Amy C. Edmondson, Bethany S. Gerstein and Melissa Valentine
In 2006, Merrimack Pharmaceuticals was a fast-growing biotechnology company. Its leadership team was divided over whether to keep R&D organized in functional departments or transition to interdisciplinary teams. As a small company, Merrimack's R&D organization had... View Details
- 26 Feb 2015 - 28 Feb 2015
- Conference Presentation
Is That All There Is to Happiness?
By: J. Phillips, C. Mott, Julian De Freitas, J. Gruber and J. Knobe
Happiness researchers have started to converge on a conception of
happiness that involves some combination of high positive affect,
low negative affect, and high life satisfaction. We present three
studies which demonstrate that the ordinary understanding... View Details
- September 2013
- Article
Prizes, Publicity, and Patents: Non-Monetary Awards as a Mechanism to Encourage Innovation
By: Petra Moser and Tom Nicholas
This paper exploits the selection of prize-winning technologies among exhibitors at the Crystal Palace Exhibition in 1851 to examine whether—and how—ex post prizes that are awarded to high-quality innovations may encourage future innovation. U.S. patent data... View Details
- July 2013 (Revised November 2021)
- Module Note
Exploration vs. Exploitation
By: Willy Shih
This module note introduces James March's concept of exploration and exploitation, and the management challenge of balancing the allocation of resources to the two activities in the firm. The note also touches on the O'Reilly and Tushman paper on the ambidextrous... View Details
Keywords: Exploration And Exploitation; Exploitation; Research; Scientific Research; Product Commercialization; Innovation and Invention; Innovation and Management; Innovation Leadership; Innovation Strategy; Technological Innovation; Knowledge Acquisition; Growth and Development Strategy; Resource Allocation; Strategic Planning; Research and Development; Science-Based Business; Corporate Strategy; Knowledge Sharing; Biotechnology Industry; Information Technology Industry; Manufacturing Industry; Medical Devices and Supplies Industry; Pharmaceutical Industry; Semiconductor Industry; Technology Industry; United States