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      • July 2023 (Revised July 2024)
      • Case

      Miracle Therapeutics: Negotiating an IP License (A)

      By: Satish Tadikonda, Michael Singer, William Marks and Wendi Yajnik
      (General Experience Case) Beth Sharp and Jennifer Brilliant founded Miracle Therapeutics based on intellectual property developed by Brilliant and her post-doctoral student, John Supreme, in Brilliant’s lab at Elite University (EU). Miracle will have to obtain a... View Details
      Keywords: Business Startups; Entrepreneurship; Patents; Negotiation Process
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      Tadikonda, Satish, Michael Singer, William Marks, and Wendi Yajnik. "Miracle Therapeutics: Negotiating an IP License (A)." Harvard Business School Case 824-020, July 2023. (Revised July 2024.)
      • June 2023
      • Case

      Barton Malow: Building From the Top-Down

      By: Hise O. Gibson and Alicia Dadlani
      In 2023, Detroit-based Barton Malow completed the first high-rise building in the U.S. built from the top-down using LIFTbuild, a patented methodology that aimed to make construction safer and more efficient. By completing building work at ground level and then... View Details
      Keywords: Growth and Development Strategy; Innovation and Invention; Construction Industry
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      Gibson, Hise O., and Alicia Dadlani. "Barton Malow: Building From the Top-Down." Harvard Business School Case 623-060, June 2023.
      • April 2023
      • Case

      Elliott Management: Capital Allocation in Biopharma

      By: Amitabh Chandra, Paul Clancy and Lauren Gunasti
      The case explores the intersection of capital allocation and shareholder activism in the biopharmaceutical industry. As many biopharma companies face looming patent expirations for key medicines, the case asks the question of whether investing in R&D and M&A is an... View Details
      Keywords: Finance; Strategy; Capital Allocation; Biopharmaceutical Industry; Shareholder Activism; Investment Activism; Resource Allocation; Research and Development; Business and Shareholder Relations; Corporate Strategy; Pharmaceutical Industry
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      Chandra, Amitabh, Paul Clancy, and Lauren Gunasti. "Elliott Management: Capital Allocation in Biopharma." Harvard Business School Case 623-045, April 2023.
      • March 2023
      • Article

      Attracting the Sharks: Corporate Innovation and Securities Class Action Lawsuits

      By: Elisabeth Kempf and Oliver Spalt
      This paper provides novel evidence suggesting that securities class action lawsuits, a central pillar of the U.S. litigation and corporate governance system, can constitute an obstacle to valuable corporate innovation. We first establish that valuable innovation output... View Details
      Keywords: Class-action Litigation; Turnover; Lawsuits and Litigation; Innovation and Invention; Risk and Uncertainty
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      Kempf, Elisabeth, and Oliver Spalt. "Attracting the Sharks: Corporate Innovation and Securities Class Action Lawsuits." Management Science 69, no. 3 (March 2023): 1323–1934.
      • Working Paper

      Diversification as an Adaptive Learning Process: An Empirical Study of General-Purpose and Market-Specific Technological Know-How in New Market Entry

      By: Dominika Kinga Randle and Gary P. Pisano
      An enduring trait of modern corporations is their propensity to diversify into multiple lines of business. Penrosian theories conceptualize diversification as a strategy to exploit a firm’s fungible, yet “untradeable,” resources and point to redeployment of... View Details
      Keywords: Growth and Development Strategy; Technology Adoption; Diversification; Market Entry and Exit; Transformation
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      Randle, Dominika Kinga, and Gary P. Pisano. "Diversification as an Adaptive Learning Process: An Empirical Study of General-Purpose and Market-Specific Technological Know-How in New Market Entry." Harvard Business School Working Paper, No. 23-032, December 2022.
      • 2021
      • Working Paper

      The Contribution of High-Skilled Immigrants to Innovation in the United States

      By: Shai Bernstein, Rebecca Diamond, Abhisit Jiranaphawiboon, Timothy McQuade and Beatriz Pousada
      We characterize the contribution of immigrants to US innovation, both through their direct productivity as well as through their indirect spillover effects on their native collaborators. To do so, we link patent records to a database containing the first five digits of... View Details
      Keywords: Innovation; Economic Growth; Immigrants; Innovation and Invention; Collaborative Innovation and Invention; Patents; Innovation Strategy
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      Bernstein, Shai, Rebecca Diamond, Abhisit Jiranaphawiboon, Timothy McQuade, and Beatriz Pousada. "The Contribution of High-Skilled Immigrants to Innovation in the United States." Harvard Business School Working Paper, No. 22-065, December 2021. (NBER Working Paper Series, No. 30797, December 2022.)
      • July 2022
      • Article

      Estimating Spillovers from Publicly Funded R&D: Evidence from the US Department of Energy

      By: Kyle Myers and Lauren Lanahan
      We quantify the magnitude of R&D spillovers created by grants to small firms from the US Department of Energy. Our empirical strategy leverages variation due to state-specific matching policies, and we develop a new approach to measuring both geographic and... View Details
      Keywords: Innovation; Energy; R&D; Grants; Innovation and Invention; Research and Development; Patents; Performance; United States
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      Myers, Kyle, and Lauren Lanahan. "Estimating Spillovers from Publicly Funded R&D: Evidence from the US Department of Energy." American Economic Review 112, no. 7 (July 2022): 2393–2423.
      • June 2022
      • Article

      The Use and Misuse of Patent Data: Issues for Finance and Beyond

      By: Josh Lerner and Amit Seru
      Patents and citations are powerful tools for understanding innovation increasingly used in financial economics (and management research more broadly). Biases may result, however, from the interactions between the truncation of patents and citations and the changing... View Details
      Keywords: Patents; Analytics and Data Science; Corporate Finance; Research
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      Lerner, Josh, and Amit Seru. "The Use and Misuse of Patent Data: Issues for Finance and Beyond." Review of Financial Studies 35, no. 6 (June 2022): 2667–2704.
      • March 2022
      • Article

      Winner Takes All? Tech Clusters, Population Centers, and the Spatial Transformation of U.S. Invention

      By: Brad Chattergoon and William R. Kerr
      U.S. invention has become increasingly concentrated around major tech centers since the 1970s, with implications for how much cities across the country share in concomitant local benefits. Is invention becoming a winner-takes-all race? We explore the rising spatial... View Details
      Keywords: Clusters; Invention; Agglomeration; Artificial Intelligence; Innovation and Invention; Patents; Applications and Software; Industry Clusters; AI and Machine Learning
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      Chattergoon, Brad, and William R. Kerr. "Winner Takes All? Tech Clusters, Population Centers, and the Spatial Transformation of U.S. Invention." Art. 104418. Research Policy 51, no. 2 (March 2022).
      • February 2022
      • Article

      Taxation and Innovation in the 20th Century

      By: Ufuk Akcigit, John Grigsby, Tom Nicholas and Stefanie Stantcheva
      This paper studies the effect of corporate and personal taxes on innovation in the United States over the twentieth century. We build a panel of the universe of inventors who patent since 1920, and a historical state-level corporate tax database with corporate tax... View Details
      Keywords: Innovation; Income Taxes; Corporate Taxation; Firms; Inventors; State Taxation; Business Taxation; R&D Tax Credits; Taxation; Innovation and Invention; History; United States
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      Akcigit, Ufuk, John Grigsby, Tom Nicholas, and Stefanie Stantcheva. "Taxation and Innovation in the 20th Century." Quarterly Journal of Economics 137, no. 1 (February 2022): 329–385.
      • Winter 2021
      • Article

      Can Staggered Boards Improve Value? Causal Evidence from Massachusetts

      By: Robert Daines, Shelley Xin Li and Charles C.Y. Wang
      We study the effect of staggered boards (SBs) using a quasi-experiment: a 1990 law that imposed an SB on all Massachusetts-incorporated firms. The law led to an increase in Tobin's Q, investment in CAPEX and R&D, patents, higher-quality patented innovations, and... View Details
      Keywords: Staggered Board; Entrenchment; Life-cycle; Tobin's Q; Innovation; Profitability; Investor Composition; Governing and Advisory Boards; Investment; Innovation and Invention; Institutional Investing; Value
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      Daines, Robert, Shelley Xin Li, and Charles C.Y. Wang. "Can Staggered Boards Improve Value? Causal Evidence from Massachusetts." Contemporary Accounting Research 38, no. 4 (Winter 2021): 3053–3084.
      • 2021
      • Working Paper

      Winner Takes All? Tech Clusters, Population Centers, and the Spatial Transformation of U.S. Invention

      By: Brad Chattergoon and William R. Kerr
      U.S. invention has become increasingly concentrated around major tech centers since the 1970s, with implications for how much cities across the country share in concomitant local benefits. Is invention becoming a winner-takes-all race? We explore the rising spatial... View Details
      Keywords: Invention; Innovation; Artificial Intelligence; Clusters; Agglomeration; Innovation and Invention; Patents; Applications and Software; Industry Clusters; United States
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      Chattergoon, Brad, and William R. Kerr. "Winner Takes All? Tech Clusters, Population Centers, and the Spatial Transformation of U.S. Invention." Harvard Business School Working Paper, No. 22-027, October 2021. (NBER Working Paper Series, No. 29456, November 2021.)
      • 2021
      • Other Unpublished Work

      Computer-Implemented Methods and Systems for Measuring, Estimating, and Managing Economic Outcomes and Technical Debt in Software Systems and Projects: US Patent 11,126,427 B2

      By: Daniel J. Sturtevant, Carliss Baldwin, Alan MacCormack, Sunny Ahn and Sean Gilliland
      An interrelated set of tools and methods is disclosed for: (1) measuring the relationship between software source code attributes (such as code quality, design quality, test quality, and complexity metrics) and software economics outcome metrics (such as... View Details
      Keywords: Technical Debt; Applications and Software; Economics; Measurement and Metrics; Patents
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      Sturtevant, Daniel J., Carliss Baldwin, Alan MacCormack, Sunny Ahn, and Sean Gilliland. "Computer-Implemented Methods and Systems for Measuring, Estimating, and Managing Economic Outcomes and Technical Debt in Software Systems and Projects: US Patent 11,126,427 B2." Cambridge, MA, September 2021.
      • June 18, 2021
      • Article

      Who Do We Invent for? Patents by Women Focus More on Women's Health, but Few Women Get to Invent

      By: Rembrand Koning, Sampsa Samila and John-Paul Ferguson
      Women engage in less commercial patenting and invention than do men, which may affect what is invented. Using text analysis of all U.S. biomedical patents filed from 1976 through 2010, we found that patents with all-female inventor teams are 35% more likely than... View Details
      Keywords: Innovation; Gender Bias; Health; Innovation and Invention; Research; Patents; Gender; Prejudice and Bias
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      Koning, Rembrand, Sampsa Samila, and John-Paul Ferguson. "Who Do We Invent for? Patents by Women Focus More on Women's Health, but Few Women Get to Invent." Science 372, no. 6548 (June 18, 2021): 1345–1348.
      • May 2021
      • Case

      Inclusive Innovation at Mass General Brigham

      By: Katherine Baldiga Coffman and Olivia Hull
      Massachusetts General Brigham (MGB) Chief Innovation Officer Christopher Coburn had overseen a period of exciting transformation and growth in healthcare innovation at MGB. In November 2019, the health system was the largest recipient of National Institutes of Health... View Details
      Keywords: Inclusion; Innovation; Invention; Gender; Business Startups; Investment Funds; Private Equity; Health Care and Treatment; Innovation Strategy; Technological Innovation; Intellectual Property; Copyright; Patents; Research; Research and Development; Diversification; Technology; Health Industry; Massachusetts; Boston
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      Coffman, Katherine Baldiga, and Olivia Hull. "Inclusive Innovation at Mass General Brigham." Harvard Business School Case 921-006, May 2021.
      • January 2021 (Revised June 2021)
      • Case

      Hester Pharmaceuticals (A): A Pricing Dilemma

      By: Dante Roscini and John Masko
      In August 2019, the leadership of Hester Pharmaceuticals (Hester) had a problem. Italy promised to be a key market for their new breakthrough oncology drug Akrozumab, but for almost two years, its single-payer healthcare system had been unable to agree with Hester on a... View Details
      Keywords: Macroeconomics; Trade; Price; Global Range; Global Strategy; Globalized Markets and Industries; Health Care and Treatment; Patents; Monopoly; Negotiation; Business and Government Relations; Risk and Uncertainty; Human Needs; Business Strategy; Commercialization; Pharmaceutical Industry; Italy
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      Roscini, Dante, and John Masko. "Hester Pharmaceuticals (A): A Pricing Dilemma." Harvard Business School Case 721-001, January 2021. (Revised June 2021.)
      • January 2021
      • Article

      Commuting and Innovation: Are Closer Inventors More Productive?

      By: Hongyu Xiao, Andy Wu and Jaeho Kim
      We estimate the causal effect of workplace–home commuting distance on inventor productivity. We construct a novel panel of U.S. inventors with precisely measured workplace–home distances and inventor-level productivity. Our identification strategy exploits firm office... View Details
      Keywords: Commuting; Proximity; Inventors; Innovation; Relocation; Telecommuting; Geographic Location; Technological Innovation; Innovation and Management; Innovation Strategy; United States
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      Xiao, Hongyu, Andy Wu, and Jaeho Kim. "Commuting and Innovation: Are Closer Inventors More Productive?" Art. 103300. Journal of Urban Economics 121 (January 2021).
      • December 2020
      • Article

      Different Founders, Different Firms: A Comparative Analysis of Academic and Non-academic Startups

      By: Maria P. Roche, Annamaria Conti and Frank T. Rothaermel
      What role do differences in founders' occupational backgrounds play in new venture performance? Analyzing a novel dataset of 2,998 founders creating 1,723 innovative startups in biomedicine, we find that the likelihood and hazard of achieving a liquidity event are... View Details
      Keywords: Founders; Innovation; Occupational Imprinting; Academic Startups; Non-academic Startups; Founder Heterogeneity; Business Startups; Innovation and Invention; Performance; Demographics; Analysis
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      Roche, Maria P., Annamaria Conti, and Frank T. Rothaermel. "Different Founders, Different Firms: A Comparative Analysis of Academic and Non-academic Startups." Special Issue on Innovative Start-Ups and Policy Initiatives. Research Policy 49, no. 10 (December 2020).
      • 2020
      • Working Paper

      The ESG-Innovation Disconnect: Evidence from Green Patenting

      By: Lauren Cohen, Umit G. Gurun and Quoc H. Nguyen
      No firm or sector of the global economy is untouched by innovation. In equilibrium, innovators will flock to (and innovation will occur where) the returns to innovative capital are the highest. In this paper, we document a strong empirical pattern in green patent... View Details
      Keywords: ESG (Environmental, Social, Governance) Performance; Investment; Decision Making; Policy; Energy; Green Technology; Technological Innovation; Patents
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      Cohen, Lauren, Umit G. Gurun, and Quoc H. Nguyen. "The ESG-Innovation Disconnect: Evidence from Green Patenting." NBER Working Paper Series, No. 27990, October 2020. (Winner of the Fordham University Gabelli School of Business – PVH Corp. Global Thought Leadership Grant on Corporate Social Responsibility, 2020.)
      • Article

      Foreign Competition and Domestic Innovation: Evidence from U.S. Patents

      By: David Autor, David Dorn, Gordon H. Hanson, Gary P. Pisano and Pian Shu
      Manufacturing accounts for more than three-quarters of U.S. corporate patents. The competitive shock to this sector emanating from China's economic ascent could in theory either augment or stifle U.S. innovation. Using three decades of U.S. patents matched to corporate... View Details
      Keywords: Patents; Production; Trade; Competition; Innovation and Invention; United States
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      Autor, David, David Dorn, Gordon H. Hanson, Gary P. Pisano, and Pian Shu. "Foreign Competition and Domestic Innovation: Evidence from U.S. Patents." American Economic Review: Insights 2, no. 3 (September 2020): 357–374.
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