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      • September 2021 (Revised October 2022)
      • Supplement

      Hester Pharmaceuticals (B): Securing Supply

      By: Dante Roscini and John Masko
      Supplements the (A) case. In late 2020, demand for Hester Pharmaceutical’s (Hester’s) breakthrough oncology drug Akrozumab was outstripping the company’s most optimistic projections. In order to increase manufacturing capacity and meet the demand, Hester was... View Details
      Keywords: COVID-19 Pandemic; Cost vs Benefits; Trade; Supply Chain; Global Strategy; Buildings and Facilities; Operations; Health Care and Treatment; Demand and Consumers; Global Range; Globalized Markets and Industries; Pharmaceutical Industry; Italy; China; United States; Germany
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      Roscini, Dante, and John Masko. "Hester Pharmaceuticals (B): Securing Supply." Harvard Business School Supplement 722-009, September 2021. (Revised October 2022.)
      • August 2021 (Revised November 2023)
      • Teaching Note

      Coats: Supply Chain Challenges

      By: Willy C. Shih
      Teaching Note for HBS Case No. 621-115.
      Faced with continuing cost pressure, should Coats, the world's largest thread maker, relocate some of its make-to-stock manufacturing to an ultra-low-cost region while leaving make-to-order demand close to customers? View Details
      Keywords: Inventory Management; Supply Chain; Inventory; Supply Chain Management; Operations; Apparel and Accessories Industry; Asia
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      Shih, Willy C. "Coats: Supply Chain Challenges." Harvard Business School Teaching Note 622-034, August 2021. (Revised November 2023.)
      • Summer 2021
      • Article

      The Cost and Evolution of Quality at Cipla Ltd, 1935–2016

      By: Muhammad H. Zaman and Tarun Khanna
      This article examines the evolution of Indian pharmaceutical manufacturer Cipla towards producing drugs that met the quality standards of European and U.S. regulators. It employs new research in Cipla’s corporate archives, the Creating Emerging Markets database, and... View Details
      Keywords: Cipla; Pharmaceuticals; Drug Quality; Generics; Quality; Standards; Information Technology; Cost; Organizational Culture; Business History; Pharmaceutical Industry; India
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      Zaman, Muhammad H., and Tarun Khanna. "The Cost and Evolution of Quality at Cipla Ltd, 1935–2016." Business History Review 95, no. 2 (Summer 2021): 249–274.
      • February 2021
      • Case

      Digital Manufacturing at Amgen

      By: Shane Greenstein, Kyle R. Myers and Sarah Mehta
      This case discusses efforts made by biotechnology (biotech) company Amgen to introduce digital technologies into its manufacturing processes. Doing so is complicated by the fact that the process for manufacturing biologics—or therapeutics made from living cells—is... View Details
      Keywords: Digital Technologies; Change; Change Management; Decision Making; Cost vs Benefits; Decisions; Information; Analytics and Data Science; Innovation and Invention; Innovation and Management; Innovation Leadership; Innovation Strategy; Technological Innovation; Jobs and Positions; Knowledge; Leadership; Organizational Culture; Science; Strategy; Information Technology; Technology Adoption; Biotechnology Industry; Pharmaceutical Industry; United States; California; Puerto Rico; Rhode Island
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      Greenstein, Shane, Kyle R. Myers, and Sarah Mehta. "Digital Manufacturing at Amgen." Harvard Business School Case 621-008, February 2021.
      • Article

      Variety of Innovation in Global Value Chains

      By: Giulio Buciuni and Gary P. Pisano
      This article analyzes how the geography and organization of pre- and production stages in Global Value Chains (GVC) contribute to lead firms' innovation development. A novel approach in GVC studies is introduced based on transaction cost economics (TCE) and the... View Details
      Keywords: GVC; Global Value Chains; Manufacturing; Production; Global Range; Innovation and Invention
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      Buciuni, Giulio, and Gary P. Pisano. "Variety of Innovation in Global Value Chains." Art. 101167. Journal of World Business 56, no. 2 (February 2021).
      • September 2020
      • Teaching Note

      TransDigm in 2017: The Beginning of the End or the End of the Beginning?

      By: Benjamin C. Esty and Daniel Fisher
      Teaching Note for HBS Case No. 720-422. TransDigm was a highly acquisitive company that manufactured a wide range of highly engineered aerospace parts for both military and commercial customers. Over the ten years ending in 2016, its stock price had increase ten times,... View Details
      Keywords: Value Capturing; Pricing Strategy; Supplier Power; Buyer Power; Porter's Five Forces; Bargaining Power; Monopoly; Aerospace; Acquisition Strategy; Value Drivers; Ethical Behavior; Regulation; Growth Strategy; Business Ethics; Defense; Procurement; Sustainability; Value-Based Business Strategy; Acquisition; Ethics; Private Equity; Financial Strategy; Growth Management; Performance Evaluation; Business Strategy; Competitive Strategy; Horizontal Integration; Value Creation; Competitive Advantage; Aerospace Industry; Air Transportation Industry; United States
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      Esty, Benjamin C., and Daniel Fisher. "TransDigm in 2017: The Beginning of the End or the End of the Beginning?" Harvard Business School Teaching Note 721-353, September 2020.
      • May 2020 (Revised June 2020)
      • Case

      TransDigm's Acquisition and Integration of Arkwin Industries

      By: Benjamin C. Esty and Daniel W. Fisher
      In May 2013, TransDigm, a company that manufactured a wide range of highly engineered aerospace parts for both military and civilian aircraft, announced it was buying Arkwin Industries for $286 million in cash (3 times Arkwin’s sales of $91 million). Having acquired... View Details
      Keywords: Business Model; Value Creation; Strategy; Acquisition; Integration; Talent and Talent Management; Aerospace Industry
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      Esty, Benjamin C., and Daniel W. Fisher. "TransDigm's Acquisition and Integration of Arkwin Industries." Harvard Business School Case 720-467, May 2020. (Revised June 2020.)
      • April 2020 (Revised April 2023)
      • Supplement

      TransDigm in 2017: The Beginning of the End or the End of the Beginning?

      By: Benjamin C. Esty and Daniel Fisher
      TransDigm was a highly acquisitive company that manufactured a wide range of highly engineered aerospace parts for both military and commercial customers. Over the ten years ending in 2016, its stock price had increase ten times, and both EBITDA and revenues had grown... View Details
      Keywords: Acquisition; Ethics; Private Equity; Financial Strategy; Growth Management; Performance Evaluation; Business Strategy; Competitive Strategy; Horizontal Integration; Value Creation; Competitive Advantage; Aerospace Industry; Air Transportation Industry; United States
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      Esty, Benjamin C., and Daniel Fisher. "TransDigm in 2017: The Beginning of the End or the End of the Beginning?" Harvard Business School Spreadsheet Supplement 720-855, April 2020. (Revised April 2023.)
      • April 2020 (Revised April 2023)
      • Case

      TransDigm in 2017: The Beginning of the End or the End of the Beginning?

      By: Benjamin C. Esty and Daniel Fisher
      TransDigm was a highly acquisitive company that manufactured a wide range of highly engineered aerospace parts for both military and commercial customers. Over the ten years ending in 2016, its stock price had increased ten times, and both EBITDA and revenues had grown... View Details
      Keywords: Value Capturing; Pricing Strategy; Supplier Power; Buyer Power; Porter's Five Forces; Bargaining Power; Aerospace; Acquisition Strategy; Value Drivers; Ethical Behavior; Regulation; Growth Strategy; Business Ethics; Defense; Procurement; Sustainability; Value-Based Business Strategy; Acquisition; Ethics; Private Equity; Financial Strategy; Growth Management; Performance Evaluation; Business Strategy; Competitive Strategy; Horizontal Integration; Value Creation; Competitive Advantage; Monopoly; Aerospace Industry; Air Transportation Industry; United States
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      Esty, Benjamin C., and Daniel Fisher. "TransDigm in 2017: The Beginning of the End or the End of the Beginning?" Harvard Business School Case 720-422, April 2020. (Revised April 2023.)
      • December 2019
      • Case

      Bill & Melinda Gates Foundation: Shaping the Vaccine Manufacturing Ecosystem (Abridged)

      By: Willy Shih
      This case describes the efforts of the Bill & Melinda Gates Foundation to lower the cost of producing vaccines to prevent polio infections. It is an abridged version of HBS Case No. 620-021 with less emphasis on comparison between traditional and the new compact... View Details
      Keywords: Vaccine; Manufacturing; Barriers To Entry; Production; Cost; Technological Innovation; Market Entry and Exit; Pharmaceutical Industry
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      Shih, Willy. "Bill & Melinda Gates Foundation: Shaping the Vaccine Manufacturing Ecosystem (Abridged)." Harvard Business School Case 620-071, December 2019.
      • November 2019
      • Case

      Celebrity Fashions Limited (A)

      By: V.G. Narayanan, Tanvi Deshpande and Shreya Ramachandran
      In May 2017 in Chennai, India, the chairman of Celebrity Fashions doubted whether the company could last until the end of the year. Venkatesh Rajagopal had found that the company, a readymade garment manufacturing and exporter he founded in 1989, was having a hard time... View Details
      Keywords: Turnarounds; Operations; Management; Financial Condition; Problems and Challenges; Communication; Organizational Change and Adaptation; Transformation; Manufacturing Industry; Manufacturing Industry
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      Narayanan, V.G., Tanvi Deshpande, and Shreya Ramachandran. "Celebrity Fashions Limited (A)." Harvard Business School Case 120-053, November 2019.
      • October 2019
      • Supplement

      Airbus vs. Boeing (L): Discontinuing the A380 (February 2019)

      By: Ramon Casadesus-Masanell and Karen Elterman
      This case describes Airbus’ February 2019 announcement that it was ending production of the A380, with the last delivery scheduled for 2021. The announcement followed an order cancellation by Emirates, a major customer of the A380. The A380 had faced significant... View Details
      Keywords: Product Development; Air Transportation; Projects; Competition; Manufacturing Industry; Manufacturing Industry; United States; Europe
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      Casadesus-Masanell, Ramon, and Karen Elterman. "Airbus vs. Boeing (L): Discontinuing the A380 (February 2019)." Harvard Business School Supplement 720-387, October 2019.
      • September 2019
      • Case

      Bill & Melinda Gates Foundation: Shaping the Vaccine Manufacturing Ecosystem

      By: Willy C. Shih
      Vaccines for children has been a long-standing focus for the Bill & Melinda Gates Foundation, and its critical role in public health made its production an important economic and political issue. This case describes the Foundation's investment in a breakthrough vaccine... View Details
      Keywords: Vaccine; Production; Supply Chain; Product; Manufacturing Industry; Manufacturing Industry; Manufacturing Industry; Belgium
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      Shih, Willy C. "Bill & Melinda Gates Foundation: Shaping the Vaccine Manufacturing Ecosystem." Harvard Business School Case 620-021, September 2019.
      • September 2019
      • Case

      Teaming Up to Win the Rail Deal at GE (A)

      By: Amy Edmondson, Ranjay Gulati and Rachna Tahilyani
      In 2012, Nalin Jain, then head of GE aviation for South Asia, was given the added responsibility for GE’s transportation business in India, including bidding for a $2.5 billion contract to manufacture, service and maintain 1,000 diesel locomotives for state owned... View Details
      Keywords: Recruitment; Selection and Staffing; Human Capital; Groups and Teams; Leadership Style; Leading Change; Organizational Design; Organizational Structure; Manufacturing Industry; Manufacturing Industry; Manufacturing Industry; Manufacturing Industry; United States; India
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      Edmondson, Amy, Ranjay Gulati, and Rachna Tahilyani. "Teaming Up to Win the Rail Deal at GE (A)." Harvard Business School Case 420-058, September 2019.
      • April 2019
      • Case

      Barber Cardiosystems

      By: Ranjay Gulati and Paul S. Myers
      Barber Cardiosystems, based in Melbourne, Australia, designs and manufactures therapeutic devices used for treatment of coronary conditions. Over four decades, it has grown to be among the top 200 medical device companies in the world. It competes against much larger... View Details
      Keywords: Organizational Behavior; Strategic Alignment; Cost Management; Performance Productivity; Organizational Culture; Motivation and Incentives; Organizational Design; Strategy; Leadership; Medical Devices and Supplies Industry; Australia
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      Gulati, Ranjay, and Paul S. Myers. "Barber Cardiosystems." Harvard Business School Brief Case 919-505, April 2019.
      • April 2019 (Revised April 2021)
      • Case

      Wayfair

      By: Jeffrey F. Rayport, Susie L. Ma and Matthew G. Preble
      In 2016 Niraj Shah and Steve Conine, founders of online home goods retailer Wayfair, are faced with a decision about how to improve user experience on their e-commerce sites. A key driver of consumer interest and conversion to purchase in the home category is visual... View Details
      Keywords: Visual Assets; Corporate Entrepreneurship; Decision Making; Business or Company Management; Growth Management; Innovation and Invention; Operations; Strategy; Technology; Retail Industry; Service Industry; United States; Massachusetts
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      Rayport, Jeffrey F., Susie L. Ma, and Matthew G. Preble. "Wayfair." Harvard Business School Case 819-045, April 2019. (Revised April 2021.)
      • December 2018
      • Case

      Choosy

      By: Jeffrey J. Bussgang and Julia Kelley
      Founded in 2017, Choosy is a data-driven fashion startup that uses algorithms to identify styles trending on social media. After manufacturing similar items using a China-based supply chain, Choosy sells them to consumers through its website and social media pages.... View Details
      Keywords: Artificial Intelligence; Algorithms; Machine Learning; Neural Networks; Instagram; Influencer; Fast Fashion; Design; Customer Satisfaction; Customer Focus and Relationships; Decision Making; Cost vs Benefits; Innovation and Invention; Brands and Branding; Product Positioning; Demand and Consumers; Supply Chain; Production; Logistics; Business Model; Expansion; Internet and the Web; Mobile and Wireless Technology; Digital Platforms; Social Media; Technology Industry; Fashion Industry; North and Central America; United States; New York (state, US); New York (city, NY)
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      Bussgang, Jeffrey J., and Julia Kelley. "Choosy." Harvard Business School Case 819-054, December 2018.
      • November 2018 (Revised June 2019)
      • Case

      ofo

      By: Mitchell Weiss
      Dai Wei and his co-founders grew Beijing-based ofo from a school-based startup to a bike-share behemoth in a matter of months, topped an all-out market-share battle fueled with almost $1 billion in venture capital, provided 2 billion bicycle rides, soaked up the... View Details
      Keywords: Ofo; Bikeshare; Scale; Platforms; Government As A Platform; Platform Mechanics; Dai Wei; Dockless Bikes; Mobike; Bike-share; Online-to-offline; Mobility; Digital Platforms; Infrastructure; Transportation; Bicycle Transportation; Growth and Development Strategy; Bicycle Industry; China; Beijing
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      Weiss, Mitchell. "ofo." Harvard Business School Case 819-063, November 2018. (Revised June 2019.)
      • September 2018 (Revised January 2019)
      • Case

      Sobha Group Real Estate: Backward Integration for Quality

      By: John Macomber and Alpana Thapar
      From humble beginnings in Kerala, India, Mr. PNC Menon built a reputation for quality, detail, and trustworthiness, earning him major construction commissions in the Gulf region. This paved the way for venturing into real estate development in Dubai, UAE. Striving to... View Details
      Keywords: Real Estate; Backward Integration; Land Acquisition; Raising Capital; Construction; Family Business; Decision Making; Joint Ventures; Quality; Real Estate Industry; Construction Industry; India; Middle East; Dubai
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      Macomber, John, and Alpana Thapar. "Sobha Group Real Estate: Backward Integration for Quality." Harvard Business School Case 219-034, September 2018. (Revised January 2019.)
      • July 2018 (Revised July 2018)
      • Teaching Note

      Argentina Power—Don’t Cry for Me Argentina

      By: Nori Gerardo Lietz and Sayiddah Fatima McCree
      Teaching Note for HBS No. 218-041. This case concerns a complex potential energy infrastructure investment in Argentina by a global conglomerate shortly after Mauricio Macri (“Macri”) became President of Argentina in 2015. The central issues are (i) why was a country... View Details
      Keywords: Argentina; Argentine Exceptionalism; Infrastructure Finance; Investing; Finance; Inflation and Deflation; Government and Politics; Energy Generation; Infrastructure; Utilities Industry; Energy Industry; Financial Services Industry; Argentina; South America
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      Lietz, Nori Gerardo, and Sayiddah Fatima McCree. "Argentina Power—Don’t Cry for Me Argentina." Harvard Business School Teaching Note 219-010, July 2018. (Revised July 2018.)
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