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  • January 2018
  • Article

Big Data and Big Cities: The Promises and Limitations of Improved Measures of Urban Life

By: Edward L. Glaeser, Scott Duke Kominers, Michael Luca and Nikhil Naik
New, "big" data sources allow measurement of city characteristics and outcome variables at higher frequencies and finer geographic scales than ever before. However, big data will not solve large urban social science questions on its own. Big data has the most value for... View Details
Keywords: Analytics and Data Science; Urban Scope; City
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Glaeser, Edward L., Scott Duke Kominers, Michael Luca, and Nikhil Naik. "Big Data and Big Cities: The Promises and Limitations of Improved Measures of Urban Life." Economic Inquiry 56, no. 1 (January 2018): 114–137.
  • October 2023 (Revised November 2023)
  • Case

Sprout Solutions

By: Jeffrey J. Bussgang, Bonnie Yining Cao and Dawn H. Lau
Husband-and-wife co-founders Patrick and Alexandria Gentry had built Sprout Solutions to be one of the biggest Software-as-a-Service human resources management platforms in the Philippines, guided by the mission to "impact the life of every Filipino by improving... View Details
Keywords: Software; Startup; Technology Ventures; Human Resources; Management; Growth and Development Strategy; Emerging Markets; Business Startups; Applications and Software; Venture Capital; Philippines
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Bussgang, Jeffrey J., Bonnie Yining Cao, and Dawn H. Lau. "Sprout Solutions." Harvard Business School Case 824-052, October 2023. (Revised November 2023.)
  • January 2014 (Revised December 2014)
  • Case

GenapSys: Business Models for the Genome

By: Richard G. Hamermesh, Joseph B. Fuller and Matthew Preble

GenapSys, a California-based startup, was soon to release a new DNA sequencer that the company's founder, Hesaam Esfandyarpour, believed was truly revolutionary. The sequencer would be substantially less expensive—potentially costing just a few thousand dollars—and... View Details

Keywords: DNA Sequencing; Life Sciences; Business Model; Innovation & Entrepreneurship; Health Care and Treatment; Genetics; Business Strategy; Technology Industry; Technology Industry; Technology Industry; Technology Industry; Technology Industry; United States
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Hamermesh, Richard G., Joseph B. Fuller, and Matthew Preble. "GenapSys: Business Models for the Genome." Harvard Business School Case 814-050, January 2014. (Revised December 2014.)
  • November 2022 (Revised April 2024)
  • Case

Martine Rothblatt and United Therapeutics: A Series of Implausible Dreams

By: Debora L. Spar and Julia M. Comeau
In 1990, satellite expert and Sirius XM founder Martine Rothblatt was determined to save the life of her seven-year-old daughter, Jenesis, who was diagnosed with a terminal illness called Pulmonary Arterial Hypertension (PAH). At the time, there was little medication... View Details
Keywords: Pharmaceutical Companies; Technological And Scientific Innovation; Organ Donation; Health Care and Treatment; Health Disorders; Innovation and Invention; Pharmaceutical Industry; Medical Devices and Supplies Industry; United States; District of Columbia
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Spar, Debora L., and Julia M. Comeau. "Martine Rothblatt and United Therapeutics: A Series of Implausible Dreams." Harvard Business School Case 323-039, November 2022. (Revised April 2024.)
  • November 2024
  • Teaching Note

Martine Rothblatt and United Therapeutics: A Series of Implausible Dreams

By: Debora L. Spar and Julia M. Comeau
Teaching Note for HBS Case No. 323-039. In 1990, satellite expert and Sirius XM founder Martine Rothblatt was determined to save the life of her seven-year-old daughter, Jenesis, who was diagnosed with a terminal illness called Pulmonary Arterial Hypertension (PAH). At... View Details
Keywords: Pharmaceutical Companies; Technological And Scientific Innovation; Organ Donation; Health Care and Treatment; Health Disorders; Innovation and Invention; Growth and Development Strategy; Product Development; Pharmaceutical Industry; Medical Devices and Supplies Industry; United States; District of Columbia
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Spar, Debora L., and Julia M. Comeau. "Martine Rothblatt and United Therapeutics: A Series of Implausible Dreams." Harvard Business School Teaching Note 325-058, November 2024.
  • 18 Jul 2023
  • Interview

Jeffrey Rayport on Product Market Fit, Profit Market Fit and Whiplash, and More

By: Jeffrey F. Rayport and Doug Levin
This episode of "Lessons from Startup Life" podcast features Jeffrey Rayport, Senior Lecturer of Business Administration at the Harvard Business School. Jeffrey specializes in teaching and researching growth-stage technology ventures and their scalability. Prior to... View Details
Keywords: Scaling And Growth; Start-up; Diversity; Equity; Inclusion; Technology; Business Startups; Product Marketing; Business Growth and Maturation
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"Jeffrey Rayport on Product Market Fit, Profit Market Fit and Whiplash, and More." Lessons from a Startup Life (podcast), July 18, 2023.
  • February 2014
  • Case

BGI: Data-driven Research

By: Willy Shih and Sen Chai
BGI has the largest installed gene-sequencing capacity in the world, and to Zhang Gengyun, general manager of the Life Sciences Division, this represented an opportunity to apply his training as a plant breeder and his early career work as a biochemist to improving... View Details
Keywords: Genomics; Gene Sequencing; Life Sciences; Plant Breeding; Human Genome Program; Beijing Genomics Institute; BGI; Rice Genome; Technological Innovation; Innovation Strategy; Research; Research and Development; Science; Genetics; Science-Based Business; Strategy; Commercialization; Corporate Strategy; Information Technology; Applications and Software; Agriculture and Agribusiness Industry; Biotechnology Industry; Food and Beverage Industry; China; United States
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Shih, Willy, and Sen Chai. "BGI: Data-driven Research." Harvard Business School Case 614-056, February 2014.
  • April 2023 (Revised September 2023)
  • Case

Apple's iPhone Revolution: Pioneering the Circular Economy

By: George Serafeim
When asked to identify an example of a circular economy business model that has generated billions in revenues for a company, ChatGPT, the famous chatbot that in 2022 rocked the world with its ability to perform a variety of tasks, immediately identified and... View Details
Keywords: Iphone; Smartphone; Waste Management; Recycling; Innovation; Product Upgrade; Product Life Cycle; Sustainability; Climate Impact; Digital; Business Model Innovation; Climate Change; Information Technology; Business Model; Electronics Industry; Information Technology Industry
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Serafeim, George. "Apple's iPhone Revolution: Pioneering the Circular Economy." Harvard Business School Case 123-089, April 2023. (Revised September 2023.)
  • January 2023 (Revised May 2023)
  • Case

Steve Jobs: Changing the World

By: Robert Simons and Shirley Sun
This case traces the life of Steve Jobs who throughout his career flaunted convention and chose an unusual path to success. The case describes how Jobs, as young man, acquired an appreciation for aesthetics and the liberal arts, but was also quick to recognize and... View Details
Keywords: Entrepreneurship; Technology; Business Startups; Personal Characteristics; Leadership Style; Innovation; Work-life Balance; Innovation Leadership; Power and Influence; Success; Information Technology Industry; United States
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Simons, Robert, and Shirley Sun. "Steve Jobs: Changing the World." Harvard Business School Case 123-022, January 2023. (Revised May 2023.)
  • Teaching Interest

Overview

Teaching has been a lifelong passion of mine. As the third generation of academics in my family, I see good teaching as a means to give back and to encourage others to share my passion for discovery. I’ve been very lucky to have many teaching opportunities, both as an... View Details
Keywords: Big Data; Technology Strategy; Machine Learning; Data Science; "Marketing Analytics"; Data Visualization; Analysis; Technological Innovation; Innovation and Invention; Intellectual Property; Corporate Strategy; Software; Information Technology; Entrepreneurship; Marketing; Technology Industry; Technology Industry; Technology Industry; Technology Industry; Technology Industry
  • January 2017
  • Case

Danaher Corporation, 2007–2017

By: John R. Wells and Gabriel Ellsworth
On July 2, 2016, Danaher Corporation completed the spinoff of Fortive Corporation. The previous day, Danaher’s stock price had reached an all-time high. In 2015, Danaher had decided to split off its test and measurement, fuel and fleet management, and automation... View Details
Keywords: Danaher; Fortive; Larry Culp; Beckman Coulter; Pall; Life Sciences; Diagnostics; Environmental Operations; Water Management; Dental; Testing; Measurement; Fuel; Fleet Management; Automation; Toolmaking; Tools; Disease Management; Continuous Improvement; Toyota Production System; Divestiture; Spinoffs; Spin-off; Networks; Acquisition; Mergers and Acquisitions; Business Conglomerates; Business Divisions; Business Subsidiaries; Business Units; Business Growth and Maturation; Business Model; For-Profit Firms; Joint Ventures; Restructuring; Engineering; Chemicals; Construction; Machinery and Machining; Profit; Revenue; Globalized Firms and Management; Multinational Firms and Management; Health; Health Care and Treatment; Health Disorders; Medical Specialties; Business History; Job Cuts and Outsourcing; Business or Company Management; Growth and Development Strategy; Management Analysis, Tools, and Techniques; Management Practices and Processes; Management Succession; Management Systems; Resource Allocation; Market Entry and Exit; Measurement and Metrics; Logistics; Business Processes; Organizational Change and Adaptation; Public Ownership; Problems and Challenges; Science; Genetics; Natural Environment; Wastes and Waste Processing; Science-Based Business; Opportunities; Strategy; Adaptation; Business Strategy; Competition; Competitive Strategy; Competitive Advantage; Consolidation; Corporate Strategy; Diversification; Expansion; Technology; Software; Technology Networks; Technology Platform; Value; Valuation; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; Information Technology Industry; United States; District of Columbia
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Wells, John R., and Gabriel Ellsworth. "Danaher Corporation, 2007–2017." Harvard Business School Case 717-464, January 2017.
  • September 2013
  • Case

Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired

By: Rosabeth Moss Kanter, Juliane Calingo Schwetz and Patricia Bissett Higgins
In July 2012, retired United States Army Major General Gale Pollock created Elevivo, a venture that worked on developing a comprehensive disease management software system to support the growing number of visually impaired individuals by providing them with tailored... View Details
Keywords: United States; Health Care; Health Care Education; Insurance Companies; Disease Management; Technology; Military; Leadership Skills; Health; Health Care and Treatment; Education; Insurance; Information Technology; Entrepreneurship; Leadership; Information Technology Industry; Information Technology Industry; United States
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Kanter, Rosabeth Moss, Juliane Calingo Schwetz, and Patricia Bissett Higgins. "Advanced Leadership Pathways: General Gale Pollock and Services for the Vision Impaired." Harvard Business School Case 314-029, September 2013.
  • Article

Thinking About Technology: Applying a Cognitive Lens to Technical Change

We apply a cognitive lens to understanding technology trajectories across the life cycle by developing a co-evolutionary model of technological frames and technology. Applying that model to each stage of the technology life cycle, we identify conditions under which a... View Details
Keywords: Technology; Transformation; Outcome or Result; Economics; Cognition and Thinking; Business Model; Forecasting and Prediction
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Kaplan, Sarah, and Mary Tripsas. "Thinking About Technology: Applying a Cognitive Lens to Technical Change." Research Policy 37, no. 5 (June 2008): 790–805.
  • 2004
  • Working Paper

Thinking About Technology: Applying a Cognitive Lens to Technical Change

We apply a cognitive lens to understanding technology trajectories across the life cycle by developing a coevolutionary model of technological frames and technology. Applying that model to each stage of the technology life cycle, we identify conditions under which a... View Details
Keywords: Design; Fluctuation; Technology; Perception
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Kaplan, Sarah, and Mary Tripsas. "Thinking About Technology: Applying a Cognitive Lens to Technical Change." Harvard Business School Working Paper, No. 04-039, January 2004. (Revised September 2006, August 2007, April 2008.)
  • November 2016 (Revised April 2017)
  • Case

Basecamp: Pricing

By: Frank Cespedes and Robb Fitzsimmons
A data analyst at Basecamp is evaluating the results of pricing research and its potential implications for the venture’s latest version of its project management software product. View Details
Keywords: Pricing; Entrepreneurial Management; Data Analysis; Marketing; Customer Acquisition; Customer Retention; Value Proposition; Sales Management; Product Management; Market Research; Life Time Value; Testing; Entrepreneurship; Analytics and Data Science; Customers; Value; Sales; Product Marketing; United States
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Cespedes, Frank, and Robb Fitzsimmons. "Basecamp: Pricing." Harvard Business School Case 817-067, November 2016. (Revised April 2017.)
  • April 2014 (Revised January 2015)
  • Background Note

Note on Mobile Healthcare

By: John A. Quelch and Margaret L. Rodriguez
Delivering health care to the global population was a challenge. Health care costs accounted for ten percent of world GDP by 2013. In the U.S., health care costs were expected to top $3.1 trillion in 2014. New technologies, shortages of trained personnel and... View Details
Keywords: Health Care; Mobile; Mobile App; Public Health; Startups; Hardware; Software; Telemedicine; Global; Medical Devices; Medical Services; Medical Solutions; Entrepreneurs; Government And Business; Technological Change; Health Care and Treatment; Entrepreneurship; Government and Politics; Technological Innovation; Applications and Software; Information Infrastructure; Technology Industry; Technology Industry
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Quelch, John A., and Margaret L. Rodriguez. "Note on Mobile Healthcare." Harvard Business School Background Note 514-122, April 2014. (Revised January 2015.)
  • December 2004 (Revised April 2014)
  • Case

Stan Lapidus: Profile of a Medical Entrepreneur

By: Robert F. Higgins and Sophie LaMontagne
Describes the career path and insights of Stanley Lapidus, a successful serial entrepreneur in the medical and life sciences industry. Lapidus is the founder of Cytyc Corp. (NASDAQ: CYTC) and EXACT Sciences (NASDAQ: EXAS) and is currently the CEO of his third start-up,... View Details
Keywords: Business Startups; Experience and Expertise; Entrepreneurship; Venture Capital; Managerial Roles; Health Industry
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Higgins, Robert F., and Sophie LaMontagne. "Stan Lapidus: Profile of a Medical Entrepreneur." Harvard Business School Case 805-087, December 2004. (Revised April 2014.)
  • September 2010 (Revised November 2010)
  • Case

Ze-gen: Commercializing Clean Tech

By: Lynda M. Applegate, Kaitlyn Lyons and Scott Prozeller
The Ze-gen case covers the first five years in the life of a clean-tech start-up. Ze-gen had developed an innovative technology that converted solid waste into synthesis gas (called syngas). This technology was in testing at the company's pilot plant, built next to the... View Details
Keywords: Business Startups; Renewable Energy; Entrepreneurship; Financing and Loans; Environmental Sustainability; Commercialization; Green Technology Industry; New Bedford
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Applegate, Lynda M., Kaitlyn Lyons, and Scott Prozeller. "Ze-gen: Commercializing Clean Tech." Harvard Business School Case 811-014, September 2010. (Revised November 2010.)
  • 21 Aug 2023
  • Book

You’re More Than Your Job: 3 Tips for a Healthier Work-Life Balance

Future-Proof Your Career, Avoid Burnout, and Build a Life Bigger than Your Business Card, which explains how to treat work-life calibration as you would a financial portfolio, through concepts like diversification. “There’s a calculus of:... View Details
Keywords: by Kara Baskin
  • April 2020 (Revised October 2021)
  • Case

SpaceX, Economies of Scale, and a Revolution in Space Access

By: Matthew C. Weinzierl, Kylie Lucas and Mehak Sarang
From the time he transformed the world of online banking, Elon Musk established himself as a bold innovator. After selling X.com to PayPal in 2002, he founded a series of revolutionary start-ups, starting with Space Exploration Technologies (SpaceX). Hoping to "make... View Details
Keywords: Space Tech; Space Access; Vision; Economies Of Scale; Technological Innovation; Emerging Markets; Commercialization; Finance; Aerospace Industry
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Weinzierl, Matthew C., Kylie Lucas, and Mehak Sarang. "SpaceX, Economies of Scale, and a Revolution in Space Access." Harvard Business School Case 720-027, April 2020. (Revised October 2021.)
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