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  • November 2020 (Revised February 2022)
  • Case

CommonSpirit Health: Integrating a Merger of Equals

By: Robert S. Huckman, Hise Gibson and Nicole Gilmore
Soon after closing the 2019 merger of Catholic Health Initiatives (CHI) and Dignity Health to create CommonSpirit Health, Lloyd Dean and Kevin Lofton-–jointly appointed to the role of CEO—must make several operational and strategic decisions related to the integration... View Details
Keywords: Health Care Delivery; Hospital; Merger; Merger Integration; Hospital Mergers; Health Information Technology; CEOs; Health Care and Treatment; Mergers and Acquisitions; Integration; Leadership; Customer Value and Value Chain; Decision Choices and Conditions; Governance; Information Technology; Health Industry; United States
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Huckman, Robert S., Hise Gibson, and Nicole Gilmore. "CommonSpirit Health: Integrating a Merger of Equals." Harvard Business School Case 621-034, November 2020. (Revised February 2022.)
  • 2009
  • Chapter

The Decline and Renewal of British Multinational Banking.

By: G. Jones and Lucy Newton
This chapter discusses the renaissance of British multinational banking from the 1990s. British commercial banks had pioneered multinational banking during the 19th century, but they were unable to build on this legacy during the new wave of global banking that began... View Details
Keywords: Financial Crisis; Commercial Banking; International Finance; Multinational Firms and Management; Strategy; Banking Industry; Great Britain
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Jones, G., and Lucy Newton. "The Decline and Renewal of British Multinational Banking." In Business in Britain in the Twentieth Century, edited by Richard Coopey and Peter Lyth. Oxford: Oxford University Press, 2009.
  • Article

Thinking About Technology: Applying a Cognitive Lens to Technical Change

We apply a cognitive lens to understanding technology trajectories across the life cycle by developing a co-evolutionary model of technological frames and technology. Applying that model to each stage of the technology life cycle, we identify conditions under which a... View Details
Keywords: Technology; Transformation; Outcome or Result; Economics; Cognition and Thinking; Business Model; Forecasting and Prediction
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Kaplan, Sarah, and Mary Tripsas. "Thinking About Technology: Applying a Cognitive Lens to Technical Change." Research Policy 37, no. 5 (June 2008): 790–805.
  • 2018
  • Book

Driving Digital Strategy: A Guide to Reimagining Your Business

By: Sunil Gupta
Disruption and transformation get a lot of hype and for good reason. Digital technologies have disrupted entire industries and incumbents have often struggled in this new world. Typical approaches used by legacy players such as using technology to improve efficiency,... View Details
Keywords: Marketing; Information Technology; Transformation; Strategy; Competitive Advantage; Value Creation; Customer Focus and Relationships; Organizational Structure; Digital Strategy
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Gupta, Sunil. Driving Digital Strategy: A Guide to Reimagining Your Business. Boston: Harvard Business Review Press, 2018.
  • 2004
  • Working Paper

Thinking About Technology: Applying a Cognitive Lens to Technical Change

We apply a cognitive lens to understanding technology trajectories across the life cycle by developing a coevolutionary model of technological frames and technology. Applying that model to each stage of the technology life cycle, we identify conditions under which a... View Details
Keywords: Design; Fluctuation; Technology; Perception
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Kaplan, Sarah, and Mary Tripsas. "Thinking About Technology: Applying a Cognitive Lens to Technical Change." Harvard Business School Working Paper, No. 04-039, January 2004. (Revised September 2006, August 2007, April 2008.)
  • June 2001
  • Background Note

IT Asset: the "Legacy" System Problem

By: Richard L. Nolan
Describes the legacy system problem facing traditional companies as they strive to build strategic I-Nets. Identifies the key trends amplifying legacy system problems that cause IT assets to become IT liabilities. View Details
Keywords: Trends; Management Systems; Problems and Challenges; Business Strategy; Information Technology
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Nolan, Richard L. IT Asset: the "Legacy" System Problem. Harvard Business School Background Note 301-148, June 2001.
  • 15 Jun 2007
  • Research & Ideas

Remembering Alfred Chandler

in the School's Business History Group to reflect on Chandler's legacy and to share personal memories. To listen to this interview with professor Richard Tedlow, click on the triangular play button below. The Macromedia Flash plug-in is... View Details
Keywords: by Sean Silverthorne
  • April 2022
  • Case

The First Opium War and Global Free Trade

By: Jeremy Friedman and Allison Lazarus
The First Opium War (1839-1842) symbolized the peak of the era of European imperialism, with a political and cultural legacy that remains potent to this day. The British Empire, “acquired in a fit of absent-mindedness” as one observer famously claimed, seemed to be... View Details
Keywords: Imperialism; Narcotics; Importing; History; Globalized Markets and Industries; Trade; Social Issues
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Friedman, Jeremy, and Allison Lazarus. "The First Opium War and Global Free Trade." Harvard Business School Case 722-052, April 2022.
  • December 2014 (Revised August 2015)
  • Case

Improving Melanoma Screening: MELA Sciences

By: Regina E. Herzlinger, Kevin Schulman and Frédéric Dijols
MELA is a start-up medical device company looking to develop a novel technology to help physicians diagnose a deadly skin cancer, melanoma. The case reviews the FDA medical device development process, the development path pursued by MELA, and the regulatory and... View Details
Keywords: Healthcare Industry; Health Care; Health; Health Care and Treatment; Health Testing and Trials; Health Industry; United States
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Herzlinger, Regina E., Kevin Schulman, and Frédéric Dijols. "Improving Melanoma Screening: MELA Sciences." Harvard Business School Case 315-042, December 2014. (Revised August 2015.)
  • 28 Aug 2006
  • Research & Ideas

Online Match-Making with Virtual Dates

interactions, Frost and Norton are also exploring the social implications of people seeking relationships online and the possibility for technology to influence the initial tone and trajectory of... View Details
Keywords: by Martha Lagace; Publishing
  • October 2018 (Revised September 2020)
  • Case

Testing Autonomy in Pittsburgh

By: Mitchell Weiss and Brittany Urick
Pittsburgh’s mayor had been among the first to welcome self-driving vehicles but was now one of many needing to react after a pedestrian fatality involving an autonomous Uber in Arizona. He had originally preferred to roll out “the red carpet” instead of the “red... View Details
Keywords: Public Entrepreneurship; Government Innovation; Government Experimentation; Autonomous Vehicles; Mayor; Mayor Peduto; Cities; Mobility; Automation; Uber; Argo Ai; Aurora Innovation; Aptiv; Entrepreneurship; Public Sector; Innovation and Invention; Transportation; City; Safety; Business and Government Relations; Transportation Industry; Auto Industry; United States; Pennsylvania; Pittsburgh
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Weiss, Mitchell, and Brittany Urick. "Testing Autonomy in Pittsburgh." Harvard Business School Case 819-059, October 2018. (Revised September 2020.)
  • October 29, 2020
  • Article

How to Build a Digital Brand That Lasts

By: William Collis and David Collis
What makes a brand durable even as business models, technology and consumer behavior radically change? The key is that durable brands are adaptable brands—even legacy ones. To create durability, apply the MACE framework: 1) Mastery: Give your consumers... View Details
Keywords: Brands and Branding; Business Model; Adaptation; Framework
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Collis, William, and David Collis. "How to Build a Digital Brand That Lasts." Harvard Business Review Digital Articles (October 29, 2020).
  • September 1998 (Revised May 2002)
  • Case

Cisco Systems, Inc.: Implementing ERP

By: Robert D. Austin, Richard L. Nolan and Mark J. Cotteleer
Reviews Cisco System's approach to implementing Oracle's Enterprise Resource Planning (ERP) software product. This case chronologically reviews the diverse, critical success factors and obstacles facing Cisco during its implementation. Cisco faced the need for... View Details
Keywords: Information Technology; Applications and Software; Technology Adoption; Complexity; Information Management
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Austin, Robert D., Richard L. Nolan, and Mark J. Cotteleer. "Cisco Systems, Inc.: Implementing ERP." Harvard Business School Case 699-022, September 1998. (Revised May 2002.)
  • Article

Did Bank Distress Stifle Innovation During the Great Depression?

By: Ramana Nanda and Tom Nicholas
We find a negative relationship between bank distress and the level, quality, and trajectory of firm-level innovation during the Great Depression, particularly for R&D firms operating in capital intensive industries. However, we also show that because a sufficient... View Details
Keywords: Great Depression; R&D; Bank Distress; Patents; Research and Development; Financial Crisis; Banks and Banking; Innovation and Invention; Banking Industry; United States
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Nanda, Ramana, and Tom Nicholas. "Did Bank Distress Stifle Innovation During the Great Depression?" Journal of Financial Economics 114, no. 2 (November 2014): 273–292.
  • September–October 2020
  • Article

The Past, Present, and (Near) Future of Gene Therapy and Gene Editing

By: Julia Pian, Amitabh Chandra and Ariel Dora Stern
Emerging gene therapy and gene-editing technologies will have a growing impact on patient lives and health-care delivery. We analyzed a decade of data on clinical trials and venture capital investments to understand the likely trajectory of genetically focused... View Details
Keywords: Gene Therapy; Gene Editing; Impact; Health Care and Treatment; Technological Innovation; Health Testing and Trials; Venture Capital; Change
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Pian, Julia, Amitabh Chandra, and Ariel Dora Stern. "The Past, Present, and (Near) Future of Gene Therapy and Gene Editing." NEJM Catalyst Innovations in Care Delivery 1, no. 5 (September–October 2020).
  • 2013
  • Working Paper

Did Bank Distress Stifle Innovation During the Great Depression?

By: Ramana Nanda and Tom Nicholas
We find a negative relationship between bank distress and the level, quality and trajectory of firm-level innovation during the Great Depression, particularly for R&D firms operating in capital intensive industries. However, we also show that because a sufficient... View Details
Keywords: Great Depression; R&D; Bank Distress; Patents; Research and Development; Financial Crisis; Innovation and Invention; Banks and Banking; Banking Industry; United States
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Nanda, Ramana, and Tom Nicholas. "Did Bank Distress Stifle Innovation During the Great Depression?" Harvard Business School Working Paper, No. 12-106, May 2012. (Revised October 2013. Revise and Resubmit, Journal of Financial Economics.)
  • October 2004 (Revised December 2005)
  • Case

Rakuten

By: F. Warren McFarlan, Andrew P. McAfee, Thomas R. Eisenmann and Masako Egawa
Rakuten, a native Japanese, e-commerce start-up and highly successful company, is expanding into new categories and new countries. It must figure out how to continue its trajectory of growth and profitability. A rewritten version of an earlier case. View Details
Keywords: Business Growth and Maturation; Global Strategy; Growth and Development Strategy; Technology Industry; Technology Industry; Japan
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McFarlan, F. Warren, Andrew P. McAfee, Thomas R. Eisenmann, and Masako Egawa. "Rakuten." Harvard Business School Case 305-050, October 2004. (Revised December 2005.)
  • 2009
  • Article

Synthesis by Microbes or Chemists? Pharmaceutical Research and Manufacturing in the Antibiotic Era

By: Arthur A. Daemmrich
This article presents a case study of the rise of Pfizer as a leading pharmaceutical company, with a focus on changing relationships between manufacturing technology and R&D between the mid-1940s and the mid-1960s. Pfizer first moved into pharmaceuticals through... View Details
Keywords: Research and Development; Production; Technology; Transformation; Relationships; Success; Organizations; Programs; Chemicals; Alignment; Pharmaceutical Industry; United States
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Daemmrich, Arthur A. "Synthesis by Microbes or Chemists? Pharmaceutical Research and Manufacturing in the Antibiotic Era." History and Technology 23, no. 3 (2009): 237–256.
  • March 2025
  • Case

Harvey: AI for Lawyers

By: Suraj Srinivasan, Charles Krumholz and Radhika Kak
In early 2025, Winston Weinberg and Gabe Pereyra, co-founders of Harvey AI, reflected on the company’s meteoric rise as a pioneer in AI-powered legal technology. Since its founding in 2022, Harvey had transformed how lawyers approached research, drafting, and document... View Details
Keywords: Innovation Strategy; Business Startups; AI and Machine Learning; Technological Innovation; Growth and Development Strategy; Product Positioning; Technology Industry; Technology Industry; New York (city, NY); San Francisco; London
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Srinivasan, Suraj, Charles Krumholz, and Radhika Kak. "Harvey: AI for Lawyers." Harvard Business School Case 125-087, March 2025.
  • October 14, 2022
  • Article

The Challenges of Transforming Twitter

By: Andy Wu and Goran Calic
Elon Musk may be an idiosyncratic leader, but if he buys Twitter he’ll face a familiar business challenge: how to transform a legacy tech company. Faced with this challenge, leaders should follow five principles: 1) prioritize an objective, 2) communicate the strategy,... View Details
Keywords: Transformation; Corporate Strategy; Change Management; Leading Change; Technology Industry
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Wu, Andy, and Goran Calic. "The Challenges of Transforming Twitter." Harvard Business Review (website) (October 14, 2022).
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