Publications

July 2013
Case

Novozymes: Establishing the Cellulosic Ethanol Value Chain

By: Willy Shih and Sen Chai

As the world's largest producer of industrial enzymes, Novozymes had invested heavily for many years to bio-engineer enzymes that could break down cellulose into fermentable sugar. In 2010, the company had launched what it thought would become a breakthrough product... View Details

09 Mar 2018
News

Master Protocols in Oncology: A Review of the Landscape

June 1997 (Revised March 2001)
Case

Genset Initial Public Offering (A)

By: Paul A. Gompers and Jeffrey M. Anapolsky

Pascal Brandys, founder and CEO of Genset, must decide whether to take this young biotechnology company public. If so, should he do a dual offering in both France and the U.S.? The case also explores the business models in genomics research. View Details

Keywords: Business Model; Initial Public Offering; Genetics; Going Public; Management Teams; Biotechnology Industry; France; United States

21 Jun 2017
News

A New Approach to Safely Sharing Cancer Patients’ Data

Article

One Obstacle to Curing Cancer: Patient Data Isn't Shared

By: Richard G. Hamermesh and Kathy Giusti

Precision Medicine requires large datasets to identify the mutations that lead to various cancers. Currently, genomic information is hoarded in fragmented silos within numerous academic medical centers, pharmaceutical companies, and some disease-based foundations. For... View Details

Keywords: Healthcare; Technological And Scientific Innovation; Cancer Care In The U.S.; Cancer Treatment; Precision Medicine; Personalized Medicine; Data Sharing; Technological Innovation; Analytics and Data Science; Health Disorders; Medical Specialties; Research and Development; Customization and Personalization; Health Industry; United States

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21 Jun 2018
Video

KPMA HBX Live Cracking the Data Aggregation Problem - Richard Hamermesh

Article

Beyond Magic Bullets: True Innovation in Health Care

By: Vaibhav A. Narayan, Marco Mohwinckel, Gary Pisano, Michael Yang and Husseini Manji

The molecular medicine revolution—based on advances in fields such as genomics and network modeling in the decade since the human genome sequence was completed—has changed the way we think about, study, and approach the development of novel therapies. However, these... View Details

Keywords: Integration; Business Model; Organizational Structure; Health Care and Treatment; Innovation and Invention; Pharmaceutical Industry

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Mitchell Tang graduated in 2016 from the University of Pennsylvania, where he completed dual-degrees in computational biology and economics as part of the Vagelos Program in Life Sciences and Management (LSM). While at Penn, Mitchell was involved in research at the... View Details

April 2002
Case

In vivo to in vitro to in silico: Coping with Tidal Waves of Data at Biogen

By: Juan Enriquez-Cabot, Gary P. Pisano and Gaye Bok

Biogen is a successful biotech company facing a critical juncture. CEO John Mullen ponders how technological changes introduced into the research function will shape larger corporate decisions. This world in which biotechnology companies operated had changed... View Details

Keywords: Change; Decisions; Product Development; Research and Development; Expansion; Technology; Biotechnology Industry

2003
Case

Corning Microarray Technologies

By: Vijay Govindarajan, Chris Trimble and Gautam Bellur

In mid-2000, the scientific community reached a momentous milestone—the complete mapping of the human genome. Researchers in the field of genomics were anxious to dig into a tremendous array of newly possible scientific inquiries, and needed efficient experimental... View Details

Keywords: Expansion; Genetics; Manufacturing Industry; Industrial Products Industry

December 2000
Case

Friona Industries, L.P.

By: Ray A. Goldberg, Carin-Isabel Knoop and Cate Reavis

As the food industry becomes more sophisticated, and as genomics and other factors provide for quality control from the producers to the consumers in the food chain, the beef industry has been one of the last commodity systems to organize the vertical systems to... View Details

Keywords: Customer Satisfaction; Customer Value and Value Chain; Food; Management Systems; Supply and Industry; Performance Consistency; Quality; Partners and Partnerships; Food and Beverage Industry; Retail Industry

16 Mar 2017
News

Three Harvard Experts Explain How Economics Can Shape Precision Medicines

September 2017 (Revised February 2023)
Case

Intermountain Healthcare: Pursuing Precision Medicine

By: Richard G. Hamermesh, Kathy E. Giusti, Robert S. Huckman and Julia Kelley

Headquartered in Salt Lake City, Intermountain Healthcare operates 23 hospitals and hundreds of clinics in Utah and Idaho and provides insurance to approximately 850,000 patients through its insurance arm, SelectHealth. In 2013, Intermountain, known for its commitment... View Details

Keywords: Precision Medicine; Healthcare; Innovation; Cancer; Cancer Research; Health Care; Technology; Health Care and Treatment; Innovation Leadership; Disruptive Innovation; Entrepreneurship; Decision Choices and Conditions; Health Industry; Insurance Industry; Utah; United States; North America

2023
Working Paper

PRIMO: Private Regression in Multiple Outcomes

By: Seth Neel

We introduce a new differentially private regression setting we call Private Regression in Multiple Outcomes (PRIMO), inspired the common situation where a data analyst wants to perform a set of l regressions while preserving privacy, where the covariates... View Details

Keywords: Analytics and Data Science; Mathematical Methods

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30 Mar 2020
News

Why Is the U.S. Behind on Coronavirus Testing?

October 2011
Case

Gene Sequencing: Staking a Position in an Expanding Industry

By: Richard G. Hamermesh, Mara Aspinall and Phillip Andrews

Towards the end of 2010, companies in the gene sequencing industry were pushing aggressive R&D programs to develop technologies and products in the race to sequence the entire human genome at a cost of $1,000. It remained to be seen when the "$1,000 genome" would... View Details

Keywords: Genetics; Business Growth and Maturation; Business Plan; Competition; Venture Capital; Biotechnology Industry

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09 Mar 2009
News

2009, Not 1992

January 2002 (Revised October 2005)
Case

General Electric Medical Systems 2002

By: Tarun Khanna and James Weber

Discusses one of General Electric's flagship divisions--the world's leading provider of medical diagnostic imaging equipment. Provides an opportunity to examine a multinational confronting massive technological and demographic changes around the world. Genomics has... View Details

Keywords: Information Technology; Business Model; Change Management; Multinational Firms and Management; Genetics; Customer Value and Value Chain; Age; Medical Devices and Supplies Industry; China; United States

August 2009 (Revised January 2012)
Case

Pandora: Royalties Kill the Web Radio Star? (A)

By: Robert C. Pozen and Alex Curtis Rosenfeld

Joe Kennedy, president and CEO of Pandora, one of the largest and most popular web (Internet) radio broadcasters, had just received bad news. The Copyright Royalty Board (CRB) had announced its decision to increase the royalties required to be paid by the web radio... View Details

Keywords: Profit; Governing Rules, Regulations, and Reforms; Copyright; Laws and Statutes; Rights; Internet and the Web; Media and Broadcasting Industry