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Publications

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      • 2025
      • Working Paper

      Too Much, Too Soon? Early Funding, Technological Unconventionality, and Innovation Capabilities

      By: Harsh Ketkar and Maria Roche
      The availability of financial resources significantly shapes firm innovation outcomes, especially for early-stage, innovation-focused technology firms. However, prior research has provided conflicting findings about this relationship: On the one hand, resource... View Details
      Keywords: Startups; Technology Strategy; Novelty; Unconventionality; Resource Constraints; Early Stage Firms; Business Startups; Technological Innovation; Entrepreneurial Finance
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      Ketkar, Harsh, and Maria Roche. "Too Much, Too Soon? Early Funding, Technological Unconventionality, and Innovation Capabilities." Harvard Business School Working Paper, No. 25-032, December 2024. (Revised February 2025.)
      • December 2024
      • Case

      Xtalic

      By: Joshua Lev Krieger and Jim Matheson
      This case study examines the commercialization efforts of Xtalic, a startup founded by MIT scientists based on their discovery of a novel material science method to protect metal substrates. The case focuses on the strategic decisions involved in bringing this... View Details
      Keywords: Innovation & Entrepreneurship; Innovation and Management; Entrepreneurial Finance; Entrepreneurship; Business Model; Business Startups; Agreements and Arrangements; Science-Based Business; Commercialization
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      Krieger, Joshua Lev, and Jim Matheson. "Xtalic." Harvard Business School Case 825-103, December 2024.
      • December 2024
      • Article

      Proximate (Co-)Working: Knowledge Spillovers and Social Interactions

      By: Maria P. Roche, Alexander Oettl and Christian Catalini
      We examine the influence of physical proximity on between-start-up knowledge spillovers at one of the largest technology coworking hubs in the United States. Relying on the exogenous assignment of office space to the hub’s 251 start-ups, we find that proximity... View Details
      Keywords: Knowledge Integration; Coworking; Microgeography; Business Startups; Technology Adoption; Diversity; Interpersonal Communication; Knowledge Sharing; Geographic Location
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      Roche, Maria P., Alexander Oettl, and Christian Catalini. "Proximate (Co-)Working: Knowledge Spillovers and Social Interactions." Management Science 70, no. 12 (December 2024): 8245–8264.
      • November 2024
      • Case

      Demond Martin and WellWithAll

      By: Hise Gibson, Archie L. Jones and Ai-Ling Jamila Malone
      This case study chronicles the transformative entrepreneurial path of Demond Martin, co-founder and CEO of WellWithAll, a health and wellness startup. Motivated by a pivotal life experience and deep concern for racial health inequities, Martin transitions from a... View Details
      Keywords: Customers; Diversity; Ethnicity; Race; Health; Recruitment; Leadership Style; Management Style; Brands and Branding; Marketing Strategy; Product Launch; Product Positioning; Organizational Culture; Mission and Purpose; Relationships; Trust; Business Strategy; Competitive Strategy; Competitive Advantage; Investment; Business Startups; Transition; Entrepreneurship; Consumer Products Industry; Retail Industry; Health Industry; United States; Chicago; Boston; Atlanta; North Carolina; District of Columbia
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      Gibson, Hise, Archie L. Jones, and Ai-Ling Jamila Malone. "Demond Martin and WellWithAll." Harvard Business School Case 625-041, November 2024.
      • November 2024
      • Supplement

      AlphaGo (C): Birth of a New Intelligence

      By: Shikhar Ghosh and Shweta Bagai
      This case, the final of a three-part series, explores DeepMind's pivotal transition from mastering games to solving real-world scientific challenges. In December 2020, DeepMind's AI system AlphaFold 2 achieved a breakthrough by solving protein folding—a 50-year-old... View Details
      Keywords: Autonomy; Deep Learning; Drug Discovery; Healthcare Innovation; Neural Networks; Scientific Research; Technology Startup; AI and Machine Learning; Technological Innovation; Research and Development; Business Model; Business Strategy; Open Source Distribution; Technology Industry; United States
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      Ghosh, Shikhar, and Shweta Bagai. "AlphaGo (C): Birth of a New Intelligence." Harvard Business School Supplement 825-075, November 2024.
      • November 2024
      • Teaching Note

      Mercado Bitcoin: M&A, IPO, or Series B?

      By: Raymond Kluender, Emanuele Colonnelli and Sabrina Howell
      Teaching Note for HBS Case No. 825-047. In April 2021, Brazilian cryptocurrency platform Mercado Bitcoin, had to decide how to scale: go public, M&A with a bank, or take a VC big check. In a highly volatile market, Roberto Dagnoni, chairman of the board, viewed the... View Details
      Keywords: Cryptocurrency; Mergers and Acquisitions; Business Growth and Maturation; Business Startups; Decision Making; Going Public; Ownership Stake; Strategic Planning; Venture Capital; Problems and Challenges; Business Cycles; Digital Platforms; Emerging Markets; Market Timing; Expansion; Diversification; Valuation; Value Creation; Investment Funds; Initial Public Offering; Price; Price Bubble; Negotiation Offer; Information Technology Industry; Financial Services Industry; Brazil; Latin America
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      Kluender, Raymond, Emanuele Colonnelli, and Sabrina Howell. "Mercado Bitcoin: M&A, IPO, or Series B?" Harvard Business School Teaching Note 825-092, November 2024.
      • November 2024
      • Supplement

      Clara Wu Tsai and Brooklyn Loan Innovation (B)

      By: Archie Jones, Mathieu Davis, Mourya Mamidala and Max Hancock
      This (B) case provides an update on “Clara Wu Tsai and Brooklyn Loan Innovation (A)” View Details
      Keywords: Business Startups; Social Entrepreneurship; Venture Capital; Banks and Banking; United States; New York (city, NY)
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      Jones, Archie, Mathieu Davis, Mourya Mamidala, and Max Hancock. "Clara Wu Tsai and Brooklyn Loan Innovation (B)." Harvard Business School Supplement 825-098, November 2024.
      • 2024
      • Working Paper

      Catalysts for Climate Solutions: Corporate Responses to Venture Capital Financing of Climate-tech Startups

      By: Shirley Lu, George Serafeim and Simon Xu
      We study whether incumbent firms increase their product focus on climate solutions in response to venture capital (VC) financing of climate-tech startups. Using large language models to measure a firm's focus on climate solutions, we find that incumbents in similar... View Details
      Keywords: Climate Finance; Climate Change; Technological Innovation; Entrepreneurship; Venture Capital; Private Equity; Environmental Sustainability; Business Startups
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      Lu, Shirley, George Serafeim, and Simon Xu. "Catalysts for Climate Solutions: Corporate Responses to Venture Capital Financing of Climate-tech Startups." Harvard Business School Working Paper, No. 25-025, November 2024.
      • October 2024
      • Case

      Tonik

      By: Andy Wu, Maliha Malek Quadir and Aticus Peterson
      This case study examines Tonik, the first digital bank in the Philippines, as it navigates the challenges of scaling its lending operations and achieving profitability in an evolving fintech landscape. It explores Tonik's journey from its launch in 2018 to early 2024,... View Details
      Keywords: Business Startups; Financing and Loans; Profit; Governing Rules, Regulations, and Reforms; Growth and Development Strategy; Emerging Markets; Entrepreneurship; Product; Banking Industry; Financial Services Industry; Technology Industry; Philippines
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      Wu, Andy, Maliha Malek Quadir, and Aticus Peterson. "Tonik." Harvard Business School Case 725-404, October 2024.
      • October 2024 (Revised November 2024)
      • Case

      SWEN Blue Ocean: Impact Investing Goes to Sea

      By: Vikram S Gandhi and David Allen
      In August 2023, SWEN Blue Ocean, a €170 million impact fund that invested in startups contributing to ocean sustainability, faced a critical investment decision. Part of SWEN Capital Partners, an €8 billion, Paris-based private equity fund, Blue Ocean was co-founded in... View Details
      Keywords: Communication Technology; Environmental Sustainability; Green Technology; Venture Capital; Private Equity; Investment Funds; Science-Based Business; Technological Innovation; Financial Services Industry; France; Paris; Italy
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      Gandhi, Vikram S., and David Allen. "SWEN Blue Ocean: Impact Investing Goes to Sea." Harvard Business School Case 325-013, October 2024. (Revised November 2024.)
      • 2024
      • Working Paper

      Priors, Experiments, Learning and Persuasion in (Bayesian) Entrepreneurial Finance

      By: Ramana Nanda
      At the heart of entrepreneurial finance lies a persuasion challenge: regardless of the strength of an entrepreneur’s belief in the potential of their idea, they typically need to convince investors to provide the financial capital required for its... View Details
      Keywords: Entrepreneurial Finance; Business Startups; Communication Intention and Meaning; Prejudice and Bias
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      Nanda, Ramana. "Priors, Experiments, Learning and Persuasion in (Bayesian) Entrepreneurial Finance." Harvard Business School Working Paper, No. 25-020, October 2024.
      • September 2024
      • Case

      TechEnergy Ventures: Innovating Through Corporate Venture Capital

      By: Rebecca Karp and Lena Duchene
      This case examines TechEnergy Ventures, the corporate venture capital (CVC) arm of the Techint Group, and its role in scaling innovation within the energy sector. Founded in 2021, TechEnergy Ventures operates with a mandate to invest in disruptive technologies to... View Details
      Keywords: Transition; Alternative Energy; Renewable Energy; Metals and Minerals; Mining; Corporate Entrepreneurship; Climate Change; Environmental Sustainability; Corporate Finance; Venture Capital; Financial Strategy; Investment Portfolio; Growth and Development Strategy; Adaptation; Diversification; Innovation Strategy; Energy Industry; Financial Services Industry; Italy; Europe; Latin America; Argentina
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      Karp, Rebecca, and Lena Duchene. "TechEnergy Ventures: Innovating Through Corporate Venture Capital." Harvard Business School Case 725-393, September 2024.
      • September 2024
      • Case

      Comun: Partners in Peril

      By: Jeffrey J. Bussgang and Alexis Lefort
      In spring 2023, Abiel Gutierrez and Andres Santos, co-founders of Comun, faced a critical decision at their fintech startup serving Latino immigrants. Having launched their product the previous year, they experienced rapid growth but encountered rising fraud and... View Details
      Keywords: Fintech; Business Development; Venture Capital; Business Startups; Partners and Partnerships; Governing Rules, Regulations, and Reforms; Financial Services Industry; Banking Industry; Latin America; United States
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      Bussgang, Jeffrey J., and Alexis Lefort. "Comun: Partners in Peril." Harvard Business School Case 825-036, September 2024.
      • September 2024
      • Case

      Myeloma Investment Fund

      By: Kyle Myers and Scott Sawaya
      This case explores a critical decision facing the Myeloma Investment Fund (MIF) as it evaluates two investment opportunities aimed at accelerating a cure for multiple myeloma.

      The MIF, a venture philanthropy fund, must choose between two distinct paths. One... View Details
      Keywords: Venture Philanthropy; Biomedical Research; Investing For Impact; Innovation & Entrepreneurship; Venture Capital; Science-Based Business; Philanthropy and Charitable Giving; Decision Making; Health Care and Treatment; Biotechnology Industry; Pharmaceutical Industry
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      Myers, Kyle, and Scott Sawaya. "Myeloma Investment Fund." Harvard Business School Case 625-047, September 2024.
      • September 2024
      • Case

      XYZ Robotics

      By: Jeffrey J. Bussgang, Brian Mao Fu, Shu Lin and Jamie Gong
      Founded in 2018, XYZ Robotics was a China-based startup specializing in robotic picking solutions and 3D machine vision products. Amid an economic downturn and intense competition, the company faced considerable financial challenges and needed to determine the best way... View Details
      Keywords: Robotics; 3D Systems; China; Resource Allocation; Business Startups; Competition; Product; Economic Slowdown and Stagnation; Technology Industry; China
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      Bussgang, Jeffrey J., Brian Mao Fu, Shu Lin, and Jamie Gong. "XYZ Robotics." Harvard Business School Case 825-059, September 2024.
      • September 2024
      • Article

      Networking Frictions in Venture Capital, and the Gender Gap in Entrepreneurship

      By: Sabrina T. Howell and Ramana Nanda
      We find that male participants in Harvard Business School’s New Venture Competition who were randomly exposed to more VC investors on their panel were substantially more likely to start a VC-backed startup post-graduation, indicating that access to investors impacts... View Details
      Keywords: Networks; Information Frictions; Venture Capital; Gender; Business Startups; Entrepreneurship
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      Howell, Sabrina T., and Ramana Nanda. "Networking Frictions in Venture Capital, and the Gender Gap in Entrepreneurship." Journal of Financial and Quantitative Analysis 59, no. 6 (September 2024): 2733–2761.
      • August 2024
      • Case

      Scaling Seven Starling

      By: Ryan W. Buell and Carin-Isabel Knoop
      Seven Starling, a maternal mental health startup, is scaling its digital clinic model. Seven Starling addresses perinatal mental health challenges by providing licensed therapists, peer support, and medication to mothers across five states, with a hybrid care model... View Details
      Keywords: Business Model; Business Startups; Health Care and Treatment; Growth and Development Strategy; Mission and Purpose; Health Industry
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      Buell, Ryan W., and Carin-Isabel Knoop. "Scaling Seven Starling." Harvard Business School Case 625-046, August 2024.
      • August 2024
      • Case

      Sky Therapeutics: Innovating in Digital Therapeutics

      By: Satish Tadikonda, Olivia Reszczynski and William Marks
      Shad Faraz and Alex Youssef were intrigued by the opportunities in the relatively new area of Digital Therapeutics. Despite initial successes, early entrants had struggled with reimbursement and revenue-predictability challenges. However, venture investors still... View Details
      Keywords: Business Startups; Entrepreneurship; Mission and Purpose; Health Care and Treatment; Technological Innovation; Business Strategy; Health Industry; Technology Industry
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      Tadikonda, Satish, Olivia Reszczynski, and William Marks. "Sky Therapeutics: Innovating in Digital Therapeutics." Harvard Business School Case 825-071, August 2024.
      • August 2024 (Revised November 2024)
      • Case

      Mercado Bitcoin: M&A, IPO, or Series B?

      By: Raymond Kluender, Emanuele Colonnelli, Sabrina T. Howell and Karina Souza
      In April 2021, Brazilian cryptocurrency platform Mercado Bitcoin had to decide how to scale: go public, M&A with a bank, or take a VC big check. In a highly volatile market, Roberto Dagnoni, chairman of the board, viewed the unprecedent crypto momentum as a window of... View Details
      Keywords: Cryptocurrency; Mergers and Acquisitions; Business Growth and Maturation; Business Startups; Decision Making; Going Public; Ownership Stake; Strategic Planning; Venture Capital; Problems and Challenges; Business Cycles; Digital Platforms; Emerging Markets; Market Timing; Expansion; Diversification; Valuation; Value Creation; Investment Funds; Initial Public Offering; Price; Price Bubble; Negotiation Offer; Financial Liquidity; Information Technology Industry; Financial Services Industry; Latin America; South America; Brazil; Sao Paulo; United States
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      Kluender, Raymond, Emanuele Colonnelli, Sabrina T. Howell, and Karina Souza. "Mercado Bitcoin: M&A, IPO, or Series B?" Harvard Business School Case 825-047, August 2024. (Revised November 2024.)
      • July 2024
      • Case

      Jacqueline Cook at Vendasta: Debating an IPO

      By: Reza Satchu, Tom Quinn and Andrew Kosc
      In May 2021, after a surge in demand for digital services that prompted high valuations for startups across the Canadian tech sector, Saskatchewan-based Vendasta entered the final stages of the initial public offering (IPO) process. COO Jacqueline Cook had invested her... View Details
      Keywords: Business Growth and Maturation; Business Startups; Interpersonal Communication; Cost vs Benefits; Forecasting and Prediction; Business Cycles; Entrepreneurship; Fairness; Capital Markets; Private Equity; Investment Banking; Stock Options; Financial Markets; Initial Public Offering; Institutional Investing; Price Bubble; Digital Platforms; Digital Transformation; Internet and the Web; Leadership; Growth and Development Strategy; Managerial Roles; Agreements and Arrangements; Going Public; Ownership Stake; Performance Expectations; Work-Life Balance; Strategic Planning; Business and Stakeholder Relations; Rank and Position; Risk and Uncertainty; Opportunities; Happiness; Reputation; Status and Position; Well-being; Information Technology Industry; Retail Industry; Canada
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      Satchu, Reza, Tom Quinn, and Andrew Kosc. "Jacqueline Cook at Vendasta: Debating an IPO." Harvard Business School Case 825-037, July 2024.
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