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      • September 2022
      • Article

      Find and Replace: R&D Investment Following the Erosion of Existing Products

      By: Joshua L. Krieger, Xuelin Li and Richard T. Thakor
      How do innovative firms react when existing products experience negative shocks? We explore this question with detailed project-level data from drug development firms. Using FDA Public Health Advisories as idiosyncratic negative shocks to approved drugs, we first... View Details
      Keywords: R&D Investments; Drug Development; Product Shocks; M&A; Biopharmaceutical Industry; FDA; System Shocks; Research and Development; Investment; Decision Making; Pharmaceutical Industry
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      Krieger, Joshua L., Xuelin Li, and Richard T. Thakor. "Find and Replace: R&D Investment Following the Erosion of Existing Products." Management Science 68, no. 9 (September 2022): 6552–6571.
      • September 2022
      • Article

      Giving a Buck or Making a Buck? Donations by Pharmaceutical Manufacturers to Independent Patient Assistance Charities

      By: Leemore Dafny, Christopher Ody and Teresa Rokos
      The federal Anti-Kickback Statute prohibits biopharmaceutical manufacturers from directly covering Medicare enrollees’ out-of-pocket spending for the drugs they manufacture, but manufacturers may donate to independent patient assistance charities and earmark donations... View Details
      Keywords: Cost Sharing; Prescription Drugs; Drug Spending; Medicare; Dual Eligibility; Cost; Health Care and Treatment; Philanthropy and Charitable Giving; Pharmaceutical Industry
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      Dafny, Leemore, Christopher Ody, and Teresa Rokos. "Giving a Buck or Making a Buck? Donations by Pharmaceutical Manufacturers to Independent Patient Assistance Charities." Health Affairs 41, no. 9 (September 2022).
      • August 2022 (Revised September 2023)
      • Case

      Evaluating the Impact of Hillside Harvest

      By: Archie L. Jones, Mel Martin and Amy Klopfenstein
      In fall 2021, the HBS Impact Investment Fund student team had just finished their last round of due diligence on the BIPOC-founded premium hot sauce company Hillside Harvest. They thought the business had a fine performance, showing potential to grow into a successful... View Details
      Keywords: Impact Investing; Entrepreneurship; Social Entrepreneurship; Finance; Investment; Food; Financial Services Industry; Financial Services Industry; United States; Massachusetts
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      Jones, Archie L., Mel Martin, and Amy Klopfenstein. "Evaluating the Impact of Hillside Harvest." Harvard Business School Case 823-017, August 2022. (Revised September 2023.)
      • August 2022
      • Background Note

      Retail Media Networks

      By: Eva Ascarza, Ayelet Israeli and Celine Chammas
      In 2022, retail media was one of the fastest growing segments in digital advertising. A retail media network (RMN) allows a retailer to use its assets for advertising. Retailers set up an advertising business by allowing marketers to buy advertising space across their... View Details
      Keywords: Advertisers; Advertising Media; Media And Broadcasting Industry; Retail; Retail Analytics; Retail Promotion; Retailing; Ecommerce; E-Commerce Strategy; E-commerce; Marketing Communication; Targeting; Targeted Advertising; Targeted Marketing; Advertising; Marketing; Marketing Communications; Marketing Strategy; Brands and Branding; Media; Marketing Channels; Retail Industry; Consumer Products Industry; Advertising Industry; United States
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      Ascarza, Eva, Ayelet Israeli, and Celine Chammas. "Retail Media Networks." Harvard Business School Background Note 523-029, August 2022.
      • August 2022 (Revised December 2022)
      • Case

      Iluméxico: For Every Family to Have Power

      By: Brian Trelstad, Isa Oliveres and Jenyfeer Martinez Buitrago
      In 2022, Manuel Wiechers, the CEO of Iluméxico, a for-profit social enterprise that provided off-grid solar energy services in rural Mexico, was finalizing his presentation for the company’s upcoming board meeting. In the 12 years since Wiechers had co-founded... View Details
      Keywords: Social Entrepreneurship; Social Enterprise; Energy; Energy Policy; Energy Generation; Energy Sources; Growth Management; Business and Government Relations; Equity; Internet and the Web; Business Model; Energy Industry; Mexico; Latin America
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      Trelstad, Brian, Isa Oliveres, and Jenyfeer Martinez Buitrago. "Iluméxico: For Every Family to Have Power." Harvard Business School Case 323-026, August 2022. (Revised December 2022.)
      • August 2022 (Revised January 2025)
      • Case

      NOW PT (A): Should We Invest?

      By: George A Riedel, Amy Klopfenstein and Mel Martin
      In fall 2021, a team of students from the HBS Impact Investing Fund considered Neurologic Optimal Wellness Physical Therapy (NOW PT) for a potential investment. Dr. Banks, the founder of NOW PT, drove to visit patients. She sought an investment from the fund to open a... View Details
      Keywords: Entrepreneurship; Social Entrepreneurship; Finance; Investment; Health; Health Care and Treatment; Medical Specialties; Buildings and Facilities; Financial Services Industry; Financial Services Industry; North and Central America; United States; Massachusetts
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      Riedel, George A., Amy Klopfenstein, and Mel Martin. "NOW PT (A): Should We Invest?" Harvard Business School Case 323-009, August 2022. (Revised January 2025.)
      • August 2022
      • Supplement

      NOW PT (B): Should We Invest?

      By: George A. Riedel, Amy Klopfenstein and Mel Martin
      This (B) case examines the results of the HBS Impact Investment Fund student team’s diligence on Neurologic Optimal Wellness Physical Therapy (NOW PT). After examining Springfield’s demographics, anticipated PT demand, local competition, and NOW PT’s financial... View Details
      Keywords: Entrepreneurship; Social Entrepreneurship; Finance; Investment; Health; Health Care and Treatment; Medical Specialties; Buildings and Facilities; Financial Services Industry; Financial Services Industry; North and Central America; United States; Massachusetts
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      Riedel, George A., Amy Klopfenstein, and Mel Martin. "NOW PT (B): Should We Invest?" Harvard Business School Supplement 323-014, August 2022.
      • August 2022
      • Case

      SuperRare: Turning an NFT Marketplace into a DAO

      By: Jeffrey J. Bussgang, Scott Duke Kominers and Amy Klopfenstein
      In June 2021, John Crain and Jonathan Perkins, the founders of SuperRare, a marketplace for non-fungible tokens (NFTs), contemplate whether to transform their company into a decentralized autonomous organization (DAO). Crain and Perkins founded SuperRare in 2018 to... View Details
      Keywords: NFTs; Crypto Economy; Alternative Assets; DAOs; Arts; Governance; Governance Controls; Governing Rules, Regulations, and Reforms; Information Technology; Technology Adoption; Internet and the Web; Digital Platforms; Innovation and Invention; Technological Innovation; Disruptive Innovation; Finance; Currency; Investment; Markets; Auctions; Bids and Bidding; Demand and Consumers; Network Effects; Market Design; Market Transactions; Market Timing; Web Services Industry; North and Central America; United States
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      Bussgang, Jeffrey J., Scott Duke Kominers, and Amy Klopfenstein. "SuperRare: Turning an NFT Marketplace into a DAO." Harvard Business School Case 823-027, August 2022.
      • August 2022 (Revised May 2025)
      • Case

      Fresh Food Generation

      By: Brian Trelstad, Amy Klopfenstein and Mel Martin
      This case highlights one of five BIPOC entrepreneurs in the Boston area as part of the HBS Impact Investment Fund. In fall 2021, a team of HBS students reviewed the financial statements of Fresh Food Generation (FFG), a Dorchester, Massachusetts-based food service... View Details
      Keywords: Impact Investing; Investment; Entrepreneurial Finance; Entrepreneurship; Race; Food and Beverage Industry; Boston
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      Trelstad, Brian, Amy Klopfenstein, and Mel Martin. "Fresh Food Generation." Harvard Business School Case 323-010, August 2022. (Revised May 2025.)
      • August 2022
      • Article

      Availability of New Medicines in the U.S. and Germany From 2004 to 2018

      By: Katharina Blankart, Huseyin Naci and Amitabh Chandra
      Importance: Germany's unique approach to coverage determination and pricing has ensured that effective medicines remain on the market, often at prices reduced through negotiation. However, less is known about trade-offs of this approach with regard to initial... View Details
      Keywords: Market Entry and Exit; Price; Market Timing; Governing Rules, Regulations, and Reforms; Pharmaceutical Industry; United States; Germany
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      Blankart, Katharina, Huseyin Naci, and Amitabh Chandra. "Availability of New Medicines in the U.S. and Germany From 2004 to 2018." e2229231. JAMA Network Open 5, no. 8 (August 2022).
      • August, 2022
      • Article

      Changing Ingroup Boundaries: The Effect of Immigration on Race Relations in the United States

      By: Vasiliki Fouka and Marco Tabellini
      How do social group boundaries evolve? Does the appearance of a new outgroup change the ingroup's perceptions of other outgroups? We introduce a conceptual framework of context-dependent categorization, in which exposure to one minority leads to recategorization of... View Details
      Keywords: In-group-out-group Relations; Ingroup-outgroup Relations; Immigration; Race; Relationships; United States
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      Fouka, Vasiliki, and Marco Tabellini. "Changing Ingroup Boundaries: The Effect of Immigration on Race Relations in the United States." American Political Science Review 116, no. 3 (August, 2022): 968–984. (Featured in the Boston Globe, Washington Post, and HBS Working Knowledge.)
      • 2022
      • Article

      Data Poisoning Attacks on Off-Policy Evaluation Methods

      By: Elita Lobo, Harvineet Singh, Marek Petrik, Cynthia Rudin and Himabindu Lakkaraju
      Off-policy Evaluation (OPE) methods are a crucial tool for evaluating policies in high-stakes domains such as healthcare, where exploration is often infeasible, unethical, or expensive. However, the extent to which such methods can be trusted under adversarial threats... View Details
      Keywords: Analytics and Data Science; Cybersecurity; Mathematical Methods
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      Lobo, Elita, Harvineet Singh, Marek Petrik, Cynthia Rudin, and Himabindu Lakkaraju. "Data Poisoning Attacks on Off-Policy Evaluation Methods." Proceedings of the Conference on Uncertainty in Artificial Intelligence (UAI) 38th (2022): 1264–1274.
      • 2022
      • Article

      Fairness via Explanation Quality: Evaluating Disparities in the Quality of Post hoc Explanations

      By: Jessica Dai, Sohini Upadhyay, Ulrich Aivodji, Stephen Bach and Himabindu Lakkaraju
      As post hoc explanation methods are increasingly being leveraged to explain complex models in high-stakes settings, it becomes critical to ensure that the quality of the resulting explanations is consistently high across all subgroups of a population. For instance, it... View Details
      Keywords: Prejudice and Bias; Mathematical Methods; Research; Analytics and Data Science
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      Dai, Jessica, Sohini Upadhyay, Ulrich Aivodji, Stephen Bach, and Himabindu Lakkaraju. "Fairness via Explanation Quality: Evaluating Disparities in the Quality of Post hoc Explanations." Proceedings of the AAAI/ACM Conference on Artificial Intelligence, Ethics, and Society (2022): 203–214.
      • 2022
      • Article

      Nonparametric Subset Scanning for Detection of Heteroscedasticity

      By: Charles R. Doss and Edward McFowland III
      We propose Heteroscedastic Subset Scan (HSS), a novel method for identifying covariates that are responsible for violations of the homoscedasticity assumption in regression settings. Viewing the problem as one of anomalous pattern detection, we use subset scanning... View Details
      Keywords: Scan Statistics; Anomaly Detection; Regression; Model Diagnostics
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      Doss, Charles R., and Edward McFowland III. "Nonparametric Subset Scanning for Detection of Heteroscedasticity." Journal of Computational and Graphical Statistics 31, no. 3 (2022): 813–823.
      • 2022
      • Working Paper

      Overreaction and Diagnostic Expectations in Macroeconomics

      By: Pedro Bordalo, Nicola Gennaioli and Andrei Shleifer
      We present the case for the centrality of overreaction in expectations for addressing important challenges in finance and macroeconomics. First, non-rational expectations by market participants can be measured and modeled in ways that address some of the key challenges... View Details
      Keywords: Overreaction; Rational Expectations; Macroeconomics; Market Participation; Social Psychology
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      Bordalo, Pedro, Nicola Gennaioli, and Andrei Shleifer. "Overreaction and Diagnostic Expectations in Macroeconomics." NBER Working Paper Series, No. 30356, August 2022.
      • 2022
      • Article

      Towards Robust Off-Policy Evaluation via Human Inputs

      By: Harvineet Singh, Shalmali Joshi, Finale Doshi-Velez and Himabindu Lakkaraju
      Off-policy Evaluation (OPE) methods are crucial tools for evaluating policies in high-stakes domains such as healthcare, where direct deployment is often infeasible, unethical, or expensive. When deployment environments are expected to undergo changes (that is, dataset... View Details
      Keywords: Analytics and Data Science; Research
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      Singh, Harvineet, Shalmali Joshi, Finale Doshi-Velez, and Himabindu Lakkaraju. "Towards Robust Off-Policy Evaluation via Human Inputs." Proceedings of the AAAI/ACM Conference on Artificial Intelligence, Ethics, and Society (2022): 686–699.
      • July 2022
      • Case

      boAt Lifestyle

      By: Rajiv Lal and Kairavi Dey
      boAt began as a lifestyle brand in the consumer electronics category in 2016 with the aim of bringing affordable, durable, and fashionable audio products and accessories to millennials and Gen-Z customers in India. Born in 2016 with Amazon India as its only sales... View Details
      Keywords: Marketing; Brands and Branding; Initial Public Offering; Digital Marketing; Product Development; Product Marketing; Business or Company Management; Web Services Industry; Web Services Industry; Web Services Industry; Asia; India
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      Lal, Rajiv, and Kairavi Dey. "boAt Lifestyle." Harvard Business School Case 523-019, July 2022.
      • July 2022
      • Case

      Operation Overlord

      By: Boris Groysberg, Greg Goullet, Katherine Connolly Baden and Sarah L. Abbott
      On June 6, 1944, nearly 5,000 ships, 11,000 planes, and 160,000 infantrymen under an Allied joint-command of American, British, and Canadian leaders were sent across the English Channel, with hopes of re-establishing a foothold in Nazi-occupied France. Known as D-Day,... View Details
      Keywords: Execution; Data Analytics; Leadership; Planning; Operations; Crisis Management; War; Organizational Structure; Decision Choices and Conditions; Information Management; France; England
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      Groysberg, Boris, Greg Goullet, Katherine Connolly Baden, and Sarah L. Abbott. "Operation Overlord." Harvard Business School Case 422-098, July 2022.
      • July 2022
      • Teaching Note

      Arçelik (A), (B): From a Dealer Network to an Omnichannel Experience

      By: Ayelet Israeli, Fares Khrais and Menna Hassan
      Arçelik Turkey, the country’s market leader in household appliances, was at an omnichannel crossroads in January 2020. Arçelik was a B2B player utilizing a dealership network with an umbrella of brands and had one of the largest brick-and-mortar store networks in... View Details
      Keywords: Digital Marketing; Bricks And Mortar; Franchise Management; Franchising; Dealer Network; Dealers; B2B; B2B2C; Tradition; Culture Change; Cultural Adaptation; Omnichannel; Omnichannel Retail; Omni-channel; Omnichannel Retailing; Sales Channels; Sales Channel Development; Channel Management; Channels Of Distribution; Marketplace; Platforms; Collaboration; Online Channel; Online Data; Online Sales; Online Shopping; Online; Retail; Retailing; Disruption; Transformation; Franchise Ownership; Change Management; Partners and Partnerships; Consumer Behavior; Sales; Internet and the Web; Marketing Strategy; Conflict and Resolution; Conflict Management; Organizational Culture; Distribution Channels; Digital Transformation; Electronics Industry; Retail Industry; Consumer Products Industry; Turkey
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      Israeli, Ayelet, Fares Khrais, and Menna Hassan. "Arçelik (A), (B): From a Dealer Network to an Omnichannel Experience." Harvard Business School Teaching Note 523-009, July 2022.
      • 2022
      • Working Paper

      Pricing Power in Advertising Markets: Theory and Evidence

      By: Matthew Gentzkow, Jesse M. Shapiro, Frank Yang and Ali Yurukoglu
      Existing theories of media competition imply that advertisers will pay a lower price in equilibrium to reach consumers who multi-home across competing outlets. We generalize and extend this theoretical result and test it using data from television and social media... View Details
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      Gentzkow, Matthew, Jesse M. Shapiro, Frank Yang, and Ali Yurukoglu. "Pricing Power in Advertising Markets: Theory and Evidence." NBER Working Paper Series, No. 30278, July 2022.
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