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- Faculty Publications (3,211)
- January 2023
- Case
Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery
By: Regina Herzlinger and Brian Walker
What should a successful executive (HBS Baker Scholar) assess as her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to successfully commercialize Cleave Therapeutics’ drug for a cancer with no current successful... View Details
Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
Herzlinger, Regina, and Brian Walker. "Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery." Harvard Business School Case 323-045, January 2023.
- January–February 2023
- Article
Data-Driven COVID-19 Vaccine Development for Janssen
By: Dimitris Bertsimas, Michael Lingzhi Li, Xinggang Liu, Jennings Xu and Najat Khan
The COVID-19 pandemic has spurred extensive vaccine research worldwide. One crucial part of vaccine development is the phase III clinical trial that assesses the vaccine for safety and efficacy in the prevention of COVID-19. In this work, we enumerate the first... View Details
Keywords: COVID-19; Health Testing and Trials; Forecasting and Prediction; AI and Machine Learning; Research; Pharmaceutical Industry
Bertsimas, Dimitris, Michael Lingzhi Li, Xinggang Liu, Jennings Xu, and Najat Khan. "Data-Driven COVID-19 Vaccine Development for Janssen." INFORMS Journal on Applied Analytics 53, no. 1 (January–February 2023): 70–84.
- December 2022 (Revised April 2023)
- Technical Note
Technical Note on ESG and Impact Investing in Real Estate
Segel, Arthur I., Dwight Angelini, Matt Kelly, Elisha Baker, and Miguel Goncalves. "Technical Note on ESG and Impact Investing in Real Estate." Harvard Business School Technical Note 223-015, December 2022. (Revised April 2023.)
- December 2022 (Revised May 2023)
- Case
Iberdrola: Leading the Energy Revolution
By: Juan Alcácer and Emer Moloney
At the end of 2019, Ignacio Galán, the Chairman and CEO of the world's third largest utility, Iberdrola, reflected on his almost 20 years at the company. He managed a portfolio of three very different businesses, each with their own specific opportunities and... View Details
Keywords: Energy; Energy Generation; Energy Sources; Non-Renewable Energy; Renewable Energy; Engineering; Innovation and Management; Innovation Leadership; Innovation Strategy; Technological Innovation; Leadership; Growth and Development Strategy; Market Timing; Industry Growth; Mission and Purpose; Strategy; Energy Industry; Green Technology Industry; Utilities Industry; Transportation Industry; Auto Industry; Spain; United Kingdom; United States; Brazil; Mexico
Alcácer, Juan, and Emer Moloney. "Iberdrola: Leading the Energy Revolution." Harvard Business School Case 723-398, December 2022. (Revised May 2023.)
- December 8, 2022
- Article
What Companies Still Get Wrong about Layoffs
By: Sandra J. Sucher and Marilyn Morgan Westner
Research has long shown that layoffs have a detrimental effect on individuals and on corporate performance. The short-term cost savings provided by a layoff are often overshadowed by bad publicity, loss of knowledge, weakened engagement, higher voluntary turnover, and... View Details
Sucher, Sandra J., and Marilyn Morgan Westner. "What Companies Still Get Wrong about Layoffs." Harvard Business Review (website) (December 8, 2022).
- December 13, 2022
- Article
6 Ways Companies Fail to Help Workers Grow
By: Joseph Fuller, Matthew Sigelman and Nik Dawson
The authors recently studied Fortune 250 companies and ranked them based on the lived experience of three million of their U.S. workers. One of their key findings was that even top-ranked firms fail to deliver consistently on worker advancement. To understand why this... View Details
Keywords: Personal Development and Career; Training; Business Model; Outcome or Result; Performance Evaluation; Opportunities
Fuller, Joseph, Matthew Sigelman, and Nik Dawson. "6 Ways Companies Fail to Help Workers Grow." Harvard Business Review Digital Articles (December 13, 2022).
- December 2022
- Article
Conflicting Interests and the Effect of Fiduciary Duty: Evidence from Variable Annuities
By: Mark Egan, Shan Ge and Johnny Tang
We examine the variable annuity market to study conflicts of interest and the effect of fiduciary duty in brokerage markets. Insurers typically pay brokers higher commissions for selling more expensive annuities. Our results indicate that sales are four times as... View Details
Keywords: Variable Annuity; Brokers; Fiduciary Duty; Finance; Investment; Insurance; Conflict of Interests; Financial Services Industry; Insurance Industry; United States
Egan, Mark, Shan Ge, and Johnny Tang. "Conflicting Interests and the Effect of Fiduciary Duty: Evidence from Variable Annuities." Review of Financial Studies 35, no. 12 (December 2022): 5334–5386.
- 2022
- Article
Pills in a World of Activism and ESG
By: Guhan Subramanian and Caley Petrucci
Easterbrook and Fischel’s The Economic Structure of Corporate Law advances their now famous passivity thesis, which posits that managers should remain passive in the face of an unsolicited tender offer for the company’s shares. Consistent with the broader... View Details
Subramanian, Guhan, and Caley Petrucci. "Pills in a World of Activism and ESG." University of Chicago Business Law Review 1 (2022): 417–439.
- 2022
- Book
Private Equity
By: Paul A. Gompers and Steven N. Kaplan
This Advanced Introduction provides an illustrative guide to private equity, integrating insights from academic research with examples to derive practical recommendations. Paul Gompers and Steven Kaplan begin by reviewing the history of private equity then exploring... View Details
Gompers, Paul A., and Steven N. Kaplan. Private Equity. Elgar Advanced Introductions. London: Edward Elgar Publishing, 2022.
- December 2022 (Revised August 2023)
- Case
Ribbit Capital and the Gauntlet Investment Opportunity
By: Shai Bernstein and Allison M. Ciechanover
Ten-year-old, Palo Alto-based Ribbit Capital is best-known for its global investments in fintech. The firm was also an early advocate of crypto and blockchain, having invested in more than two dozen startups in the space in the past decade. In the Spring of 2022,... View Details
Keywords: Alternative Assets; Cryptocurrency; Business Startups; Investment Portfolio; Decision Choices and Conditions; Negotiation Deal; Governing Rules, Regulations, and Reforms; Venture Capital; Financial Services Industry; California
Bernstein, Shai, and Allison M. Ciechanover. "Ribbit Capital and the Gauntlet Investment Opportunity." Harvard Business School Case 823-038, December 2022. (Revised August 2023.)
- Winter 2022
- Article
Vaccines and the COVID-19 Pandemic: Lessons from Failure and Success
By: Scott Duke Kominers and Alex Tabarrok
The losses from the global COVID-19 pandemic have been staggering—trillions in economic costs, on top of significant losses of life, health, and well-being. The world made significant and successful investments in vaccines to mitigate the pandemic, yet there were... View Details
Keywords: COVID-19; Vaccination; Market Design; Health Pandemics; Loss; Outcome or Result; Opportunities; Crisis Management
Kominers, Scott Duke, and Alex Tabarrok. "Vaccines and the COVID-19 Pandemic: Lessons from Failure and Success." Oxford Review of Economic Policy 38, no. 4 (Winter 2022): 719–741.
- November 2022 (Revised March 2024)
- Background Note
The Role of ESG in Investment Strategy
By: Vikram S Gandhi, Christopher Diak and Radhika Kak
- November 2022
- Case
Ajax Health: A New Model for Medical Technology Innovation
By: Regina E. Herzlinger and Ben Creo
This case teaches key success factors for both startup and established MedTech firms. It examines how to structure a firm to maximize innovation and financial returns with organizational structures that better align the incentives for the different skill sets... View Details
Keywords: Business Startups; Success; Innovation Strategy; Mergers and Acquisitions; Market Entry and Exit; Financial Strategy; Business Model; Partners and Partnerships; Entrepreneurship; Private Equity; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry
Herzlinger, Regina E., and Ben Creo. "Ajax Health: A New Model for Medical Technology Innovation." Harvard Business School Case 323-043, November 2022.
- November 2022
- Case
The Battle Among Channels for Marketing Pharmaceuticals: UpScript, Pharmacy Benefit Managers, and Direct-to-Consumer Sales
By: Regina E. Herzlinger and Tiffany Farrell
Can an online, direct-to-consumer pharmacy both improve the quality and speed of care for patients who need branded drugs and stabilize profits for pharmaceutical manufacturers? UpScript, after years spent achieving legal and regulatory compliance and simultaneous... View Details
Keywords: DTC; Internet and the Web; Marketing Channels; Customer Value and Value Chain; Governing Rules, Regulations, and Reforms; Competitive Strategy; Service Delivery; Growth and Development Strategy; Pharmaceutical Industry; Health Industry; Retail Industry
Herzlinger, Regina E., and Tiffany Farrell. "The Battle Among Channels for Marketing Pharmaceuticals: UpScript, Pharmacy Benefit Managers, and Direct-to-Consumer Sales." Harvard Business School Case 323-031, November 2022.
- November 2022
- Technical Note
National Security and Transnational Capitalism
By: Meg Rithmire
Though the relationship between national security and transnational commerce had long been interrogated and contested, the 2020s saw the escalation of concerns about insecurity and interdependence. These concerns manifested in a suite of institutional innovations and... View Details
Rithmire, Meg. "National Security and Transnational Capitalism." Harvard Business School Technical Note 723-016, November 2022.
- November 2022 (Revised February 2024)
- Case
The Globalization of Manchester City Football Group
By: Maria P. Roche, Tiona Zuzul, Exequiel Hernandez and Amy Klopfenstein
This case describes the efforts of City Football Group (CFG) to purchase Esporte Clube Bahia (Bahia), a Brazilian professional soccer club. CFG’s strategy was to acquire under-performing clubs worldwide, invest money in high-profile players, and improve the teams’... View Details
Keywords: Business Ventures; Acquisition; Business Conglomerates; Geography; Geographic Location; Geographic Scope; Globalization; Global Strategy; Globalized Markets and Industries; Markets; Demand and Consumers; Marketing; Brands and Branding; Organizations; Organizational Change and Adaptation; Sports; Strategy; Competition; Competitive Advantage; Diversification; Expansion; Sports Industry; Europe; United Kingdom; England; South America; Brazil
Roche, Maria P., Tiona Zuzul, Exequiel Hernandez, and Amy Klopfenstein. "The Globalization of Manchester City Football Group." Harvard Business School Case 723-391, November 2022. (Revised February 2024.)
- November 2022 (Revised April 2024)
- Case
Martine Rothblatt and United Therapeutics: A Series of Implausible Dreams
By: Debora L. Spar and Julia M. Comeau
In 1990, satellite expert and Sirius XM founder Martine Rothblatt was determined to save the life of her seven-year-old daughter, Jenesis, who was diagnosed with a terminal illness called Pulmonary Arterial Hypertension (PAH). At the time, there was little medication... View Details
Keywords: Pharmaceutical Companies; Technological And Scientific Innovation; Organ Donation; Health Care and Treatment; Health Disorders; Innovation and Invention; Medical Devices and Supplies Industry; Medical Devices and Supplies Industry; United States; District of Columbia
Spar, Debora L., and Julia M. Comeau. "Martine Rothblatt and United Therapeutics: A Series of Implausible Dreams." Harvard Business School Case 323-039, November 2022. (Revised April 2024.)
- 2023
- Article
Green Bargains: Leveraging Public Investment to Advance Climate Regulation
By: Jonas Meckling and Jesse Strecker
Climate policy has entered a new era as public investment is increasingly moving to center stage, including recovery spending and long-term climate investment plans. While essential for decarbonization, public investment is not enough – the carrots of investment need... View Details
Keywords: Government and Politics; Environmental Regulation; Climate Change; Policy; Motivation and Incentives
Meckling, Jonas, and Jesse Strecker. "Green Bargains: Leveraging Public Investment to Advance Climate Regulation." Climate Policy 23, no. 4 (2023): 418–429.
- 2022
- Working Paper
How Do Investors Value ESG?
By: Malcolm Baker, Mark Egan and Suproteem K. Sarkar
Environmental, social, and governance (ESG) objectives have risen to near the top of the agenda for corporate executives and boards, driven in large part by their perceptions of shareholder interest. We quantify the value that shareholders place on ESG using a revealed... View Details
Keywords: Investment; Investment Portfolio; Corporate Social Responsibility and Impact; Business and Shareholder Relations; Environmental Sustainability; Governance; Financial Services Industry; United States
Baker, Malcolm, Mark Egan, and Suproteem K. Sarkar. "How Do Investors Value ESG?" NBER Working Paper Series, No. 30708, December 2022. (Harvard Business School Working Paper, No. 23-028, November 2022.)
- November 2022 (Revised September 2023)
- Technical Note
SAFE Notes: An Introduction
By: Álvaro Rodríguez Arregui and Jo Tango
A SAFE ("Simple Agreement for Future Equity") is a security increasingly used in seed financings. Not equity or debt, SAFEs allow founders to "get capital now and sell equity later." This Technical Note covers: 1. What is a SAFE and why use one?, 2. The key concepts... View Details
Rodríguez Arregui, Álvaro, and Jo Tango. "SAFE Notes: An Introduction." Harvard Business School Technical Note 823-026, November 2022. (Revised September 2023.)