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  • October 2016 (Revised February 2017)
  • Teaching Note

Alvogen

By: Daniel Isenberg, William R. Kerr and Alexis Brownell
Alvogen is an Icelandic pharmaceutical company that makes and sells generic drugs. Founder and CEO Robert Wessman is deciding whether to take on private equity investors willing to buy out all shareholders, merge with a large and publicly-traded US pharmaceutical... View Details
Keywords: Biotechnology; Globalization; Entrepreneurship; Biotechnology Industry
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Isenberg, Daniel, William R. Kerr, and Alexis Brownell. "Alvogen." Harvard Business School Teaching Note 817-057, October 2016. (Revised February 2017.)
  • April 2002
  • Article

Internal Capital Markets and Firm-Level Compensation Incentives for Division Managers

By: Julie Wulf
Do multidivisional firms structure compensation contracts for division managers to mitigate incentive problems in their internal capital markets? I find evidence that compensation and investment incentives are substitutes: firms providing a stronger link to firm... View Details
Keywords: Capital Markets; Executive Compensation; Capital Budgeting; Motivation and Incentives; Profit; Decisions; Resource Allocation; Performance; Investment; Contracts
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Wulf, Julie. "Internal Capital Markets and Firm-Level Compensation Incentives for Division Managers." Journal of Labor Economics 20, no. 2 (April 2002): S219–S262.
  • 2022
  • Working Paper

The Disagreement Problem in Explainable Machine Learning: A Practitioner's Perspective

By: Satyapriya Krishna, Tessa Han, Alex Gu, Javin Pombra, Shahin Jabbari, Steven Wu and Himabindu Lakkaraju
As various post hoc explanation methods are increasingly being leveraged to explain complex models in high-stakes settings, it becomes critical to develop a deeper understanding of if and when the explanations output by these methods disagree with each other, and how... View Details
Keywords: AI and Machine Learning; Analytics and Data Science; Mathematical Methods
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Krishna, Satyapriya, Tessa Han, Alex Gu, Javin Pombra, Shahin Jabbari, Steven Wu, and Himabindu Lakkaraju. "The Disagreement Problem in Explainable Machine Learning: A Practitioner's Perspective." Working Paper, 2022.
  • 24 Aug 2012
  • Working Paper Summaries

Equalizing Outcomes vs. Equalizing Opportunities: Optimal Taxation when Children’s Abilities Depend on Parents’ Resources

Keywords: by Alexander Gelber & Matthew Weinzierl
  • 2020
  • Working Paper

Sex Selection and the Indian Marriage Market

By: Reshmaan N. Hussam
I consider the widespread phenomenon of sex ratios skewed by parental preference. Edlund (1999) proposes that if parents prefer sons and permit only women to marry up in social class, sexes will segregate by wealth in equilibrium. Using data on 30,000 Indian children,... View Details
Keywords: Sex Selection; Marriage Market; Bargaining Power; Gender; Information Technology; Household; Outcome or Result; India
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Hussam, Reshmaan N. "Sex Selection and the Indian Marriage Market." Harvard Business School Working Paper, No. 18-029, September 2017. (Revised October 2020.)
  • 2017
  • Working Paper

Firm Selection and Corporate Cash Holdings

By: Juliane Begenau and Berardino Palazzo
Among stock market entrants, more firms over time are R&D intensive with initially lower profitability but higher growth potential. This sample-selection effect determines the secular trend in U.S. public firms’ cash holdings. A stylized firm industry model allows us... View Details
Keywords: Initial Public Offering; Market Entry and Exit; Supply and Industry; Research and Development
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Begenau, Juliane, and Berardino Palazzo. "Firm Selection and Corporate Cash Holdings." NBER Working Paper Series, No. 23249, March 2017. (Revised February 2017. Harvard Business School Working Paper, No. 16-130, May 2016)
  • 2012
  • Article

Patent Policy, Patent Pools, and the Accumulation of Claims in Sequential Innovation

By: Gaston Llanes and Stefano Trento
We present a dynamic model where the accumulation of patents generates an increasing number of claims on sequential innovation. We compare innovation activity under three regimes—patents, no-patents, and patent pools—and find that none of them can reach the first best.... View Details
Keywords: Patents; Taxation; Innovation and Invention
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Llanes, Gaston, and Stefano Trento. "Patent Policy, Patent Pools, and the Accumulation of Claims in Sequential Innovation." Economic Theory 50, no. 3 (August 2012): 703–725.
  • 2024
  • Article

Learning Under Random Distributional Shifts

By: Kirk Bansak, Elisabeth Paulson and Dominik Rothenhäusler
Algorithmic assignment of refugees and asylum seekers to locations within host countries has gained attention in recent years, with implementations in the U.S. and Switzerland. These approaches use data on past arrivals to generate machine learning models that can... View Details
Keywords: AI and Machine Learning; Refugees; Employment
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Bansak, Kirk, Elisabeth Paulson, and Dominik Rothenhäusler. "Learning Under Random Distributional Shifts." Proceedings of the International Conference on Artificial Intelligence and Statistics (AISTATS) 27th (2024).
  • 2023
  • Article

On the Impact of Actionable Explanations on Social Segregation

By: Ruijiang Gao and Himabindu Lakkaraju
As predictive models seep into several real-world applications, it has become critical to ensure that individuals who are negatively impacted by the outcomes of these models are provided with a means for recourse. To this end, there has been a growing body of research... View Details
Keywords: Forecasting and Prediction; AI and Machine Learning; Outcome or Result
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Gao, Ruijiang, and Himabindu Lakkaraju. "On the Impact of Actionable Explanations on Social Segregation." Proceedings of the International Conference on Machine Learning (ICML) 40th (2023): 10727–10743.
  • August 2016
  • Article

Cooperation Can Emerge in Prisoner’s Dilemma from a Multi-species Predator Prey Replicator Dynamic

By: Elisabeth Paulson and Christopher Griffin
In this paper we study a generalized variation of the replicator dynamic that involves several species and sub-species that may interact. We show how this dynamic comes about from a specific finite-population model, but also show that one must take into consideration... View Details
Keywords: Prisoner's Dilemma; Replicator Dynamic; Zero-sum Game; Cooperation; Behavior; Balance and Stability
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Paulson, Elisabeth, and Christopher Griffin. "Cooperation Can Emerge in Prisoner’s Dilemma from a Multi-species Predator Prey Replicator Dynamic." Mathematical Biosciences 278 (August 2016): 56–62.
  • 2020
  • Working Paper

Designing, Not Checking, for Policy Robustness: An Example with Optimal Taxation

By: Benjami Lockwood, Afras Y. Sial and Matthew C. Weinzierl
Economists typically check the robustness of their results by comparing them across plausible ranges of parameter values and model structures. A preferable approach to robustness—for the purposes of policymaking and evaluation—is to design policy that takes these... View Details
Keywords: Optimal Taxation; Robust Optimization; Taxation; Income; Policy; Design
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Lockwood, Benjami, Afras Y. Sial, and Matthew C. Weinzierl. "Designing, Not Checking, for Policy Robustness: An Example with Optimal Taxation." NBER Working Paper Series, No. 28098, November 2020.
  • Research Summary

Social Networks and Unraveling in Labor Markets

This paper develops a model of local unraveling (or early hiring) in entry-level labor markets. Information about workers' productivity is revealed over time and transmitted credibly via a two-sided network connecting firms and workers. While employment starts only... View Details
  • March–April 2023
  • Article

Market Segmentation Trees

By: Ali Aouad, Adam Elmachtoub, Kris J. Ferreira and Ryan McNellis
Problem definition: We seek to provide an interpretable framework for segmenting users in a population for personalized decision making. Methodology/results: We propose a general methodology, market segmentation trees (MSTs), for learning market... View Details
Keywords: Decision Trees; Computational Advertising; Market Segmentation; Analytics and Data Science; E-commerce; Consumer Behavior; Marketplace Matching; Marketing Channels; Digital Marketing
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Aouad, Ali, Adam Elmachtoub, Kris J. Ferreira, and Ryan McNellis. "Market Segmentation Trees." Manufacturing & Service Operations Management 25, no. 2 (March–April 2023): 648–667.
  • Forthcoming
  • Article

Comparing the Value of Perceived Human Versus AI-Generated Empathy

By: Matan Rubin, Joanna Z. Li, Federico Zimmerman, Desmond C. Ong, Amit Goldenberg and Anat Perry
Artificial intelligence (AI) and specifically large language models demonstrate remarkable social–emotional abilities, which may improve human–AI interactions and AI’s emotional support capabilities. However, it remains unclear whether empathy, encompassing... View Details
Keywords: AI and Machine Learning; Emotions; Perception; Interpersonal Communication
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Rubin, Matan, Joanna Z. Li, Federico Zimmerman, Desmond C. Ong, Amit Goldenberg, and Anat Perry. "Comparing the Value of Perceived Human Versus AI-Generated Empathy." Nature Human Behaviour (forthcoming). (Pre-published online June 30, 2025.)
  • February 2021
  • Case

Digital Manufacturing at Amgen

By: Shane Greenstein, Kyle R. Myers and Sarah Mehta
This case discusses efforts made by biotechnology (biotech) company Amgen to introduce digital technologies into its manufacturing processes. Doing so is complicated by the fact that the process for manufacturing biologics—or therapeutics made from living cells—is... View Details
Keywords: Digital Technologies; Change; Change Management; Decision Making; Cost vs Benefits; Decisions; Information; Analytics and Data Science; Innovation and Invention; Innovation and Management; Innovation Leadership; Innovation Strategy; Technological Innovation; Jobs and Positions; Knowledge; Leadership; Organizational Culture; Science; Strategy; Information Technology; Technology Adoption; Biotechnology Industry; Pharmaceutical Industry; United States; California; Puerto Rico; Rhode Island
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Greenstein, Shane, Kyle R. Myers, and Sarah Mehta. "Digital Manufacturing at Amgen." Harvard Business School Case 621-008, February 2021.
  • 2010
  • Working Paper

Do Bonuses Enhance Sales Productivity? A Dynamic Structural Analysis of Bonus-Based Compensation Plans

By: Doug J. Chung, Thomas J. Steenburgh and K. Sudhir
We estimate a dynamic structural model of sales force response to a bonus based compensation plan. The paper has two main methodological innovations: First, we implement empirically the method proposed by Arcidiacono and Miller (2010) to accommodate unobserved latent... View Details
Keywords: Compensation and Benefits; Performance Productivity; Mathematical Methods; Salesforce Management; Motivation and Incentives
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Chung, Doug J., Thomas J. Steenburgh, and K. Sudhir. "Do Bonuses Enhance Sales Productivity? A Dynamic Structural Analysis of Bonus-Based Compensation Plans." Harvard Business School Working Paper, No. 11-041, October 2010.
  • 2023
  • Working Paper

Evaluation and Learning in R&D Investment

By: Alexander P. Frankel, Joshua L. Krieger, Danielle Li and Dimitris Papanikolaou
We examine the role of spillover learning in shaping the value of exploratory versus incremental R&D. Using data from drug development, we show that novel drug candidates generate more knowledge spillovers than incremental ones. Despite being less likely to reach... View Details
Keywords: Research and Development; Forecasting and Prediction; Valuation; Pharmaceutical Industry
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Frankel, Alexander P., Joshua L. Krieger, Danielle Li, and Dimitris Papanikolaou. "Evaluation and Learning in R&D Investment." Harvard Business School Working Paper, No. 23-074, May 2023. (NBER Working Paper Series, No. 31290, May 2023.)
  • 2023
  • Working Paper

Competition and Speculation in Cryptocurrencies

By: Alex A. Wu and Justin Katz
We examine how mutual fund managers' performance incentives generated speculative demand during the 2020-2022 cryptocurrency boom and bust. Managers with strong relative performance incentives began investing in crypto after their competitors began investing in it,... View Details
Keywords: Cryptocurrency; Mutual Funds; Competition; Investment; Decision Making
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Wu, Alex A., and Justin Katz. "Competition and Speculation in Cryptocurrencies." Working Paper, April 2023.
  • Article

Competition for Scarce Resources

By: Peter Eso, Volker Nocke and Lucy White
We model a downstream industry where firms compete to buy capacity in an upstream market that allocates capacity efficiently. Although downstream firms have symmetric production technologies, we show that industry structure is symmetric only if capacity is sufficiently... View Details
Keywords: Competitive Strategy; Natural Environment; Technology; Production; Business Cycles; Forecasting and Prediction; Cost; Demand and Consumers; Industry Structures; Performance Capacity
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Eso, Peter, Volker Nocke, and Lucy White. "Competition for Scarce Resources." RAND Journal of Economics 41, no. 3 (Fall 2010): 524–548.
  • 2009
  • Working Paper

Patent Policy, Patent Pools, and the Accumulation of Claims in Sequential Innovation

By: Gaston Llanes and Stefano Trento
We present a dynamic model where the accumulation of patents generates an increasing number of claims on sequential innovation. We study the equilibrium innovation activity under three regimes: patents, no-patents and patent pools. Patent pools increase the probability... View Details
Keywords: Innovation and Invention; Patents; Rights; Mathematical Methods
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Llanes, Gaston, and Stefano Trento. "Patent Policy, Patent Pools, and the Accumulation of Claims in Sequential Innovation." Harvard Business School Working Paper, No. 10-005, July 2009.
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