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  • All HBS Web  (1,022)
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  • All HBS Web  (1,022)
    • News  (154)
    • Research  (697)
    • Events  (23)
    • Multimedia  (1)
  • Faculty Publications  (441)
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  • 04 Dec 2018
  • First Look

New Research and Ideas, December 4, 2018

or Co-locate? Autonomy versus Learning Effects at the United States Patent Office By: Choudhury, Prithwiraj, Cirrus Foroughi, and Barbara Larson Abstract—While employees might prefer work arrangements that offer greater autonomy, such as... View Details
Keywords: Dina Gerdeman
  • January 2010
  • Article

Breakthrough Inventions and Migrating Clusters of Innovation

By: William R. Kerr
We investigate the speed at which clusters of invention for a technology migrate spatially following breakthrough inventions. We identify breakthrough inventions as the top one percent of U.S. inventions for a technology during 1975-1984 in terms of subsequent... View Details
Keywords: History; Technological Innovation; Patents; Labor; Immigration; United States
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Kerr, William R. "Breakthrough Inventions and Migrating Clusters of Innovation." Journal of Urban Economics 67, no. 1 (January 2010): 46–60.
  • 2025
  • Working Paper

Trade and Industrial Policy in Supply Chains: Directed Technological Change in Rare Earths

By: Laura Alfaro, Harald Fadinger, Jay Schymik and Gede Virananda
Trade and industrial policies, while primarily intended to support domestic industries, may unintentionally stimulate technological progress abroad. We document this mechanism in the case of rare earth elements (REEs)—critical inputs for manufacturing at the knowledge... View Details
Keywords: Industrial Policy; Global Value Chains; Directed Technological Change; Input-output Linkages; Innovation; Trade; Metals and Minerals; Technological Innovation; Supply Chain; Technology Industry
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Alfaro, Laura, Harald Fadinger, Jay Schymik, and Gede Virananda. "Trade and Industrial Policy in Supply Chains: Directed Technological Change in Rare Earths." Harvard Business School Working Paper, No. 25-059, May 2025.
  • 05 Nov 2007
  • Research & Ideas

The Changing Face of American Innovation

science and engineering workforce and nearly 50 percent of those with science and engineering doctorates. And at the Ph.D. level, ethnic researchers make an exceptional contribution to science as measured by Nobel Prizes, election to the National Academy of Sciences,... View Details
Keywords: by Sarah Jane Gilbert; Technology
  • Article

Big Names or Big Ideas: Do Peer-Review Panels Select the Best Science Proposals?

By: Danielle Li and Leila Agha
This paper examines the success of peer-review panels in predicting the future quality of proposed research. We construct new data to track publication, citation, and patenting outcomes associated with more than 130,000 research project (R01) grants funded by the U.S.... View Details
Keywords: Patents; Research; Entrepreneurship; Forecasting and Prediction; Innovation and Invention; Business and Government Relations; United States
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Li, Danielle, and Leila Agha. "Big Names or Big Ideas: Do Peer-Review Panels Select the Best Science Proposals?" Science 348, no. 6233 (April 24, 2015): 434–438.
  • July 2023 (Revised July 2025)
  • Case

Miracle Therapeutics: Negotiating an IP License (A)

By: Satish Tadikonda, Michael Singer, William Marks and Wendi Yajnik
(General Experience Case) Beth Sharp and Jennifer Brilliant founded Miracle Therapeutics based on intellectual property developed by Brilliant and her post-doctoral student, John Supreme, in Brilliant’s lab at Elite University (EU). Miracle will have to obtain a... View Details
Keywords: Business Startups; Entrepreneurship; Patents; Negotiation Process
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Tadikonda, Satish, Michael Singer, William Marks, and Wendi Yajnik. "Miracle Therapeutics: Negotiating an IP License (A)." Harvard Business School Case 824-020, July 2023. (Revised July 2025.)
  • November 2012
  • Teaching Plan

The Langer Lab: Commercializing Science (TP)

By: Vicki L. Sato and Annelena Lobb
The Langer Lab at the Massachusetts Institute of Technology (MIT) was a unique operation. Its head, Robert Langer, had always focused on selecting ideas to research that would have the greatest positive impact for humanity, and he encouraged an unusual... View Details
Keywords: Computers; Industry Evolution; Entrepreneurship; Intellectual Capital; R&D; Technology Transfer; Patents; Research and Development; Massachusetts
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Sato, Vicki L., and Annelena Lobb. "The Langer Lab: Commercializing Science (TP)." Harvard Business School Teaching Plan 613-014, November 2012.
  • March 2023
  • Article

Attracting the Sharks: Corporate Innovation and Securities Class Action Lawsuits

By: Elisabeth Kempf and Oliver Spalt
This paper provides novel evidence suggesting that securities class action lawsuits, a central pillar of the U.S. litigation and corporate governance system, can constitute an obstacle to valuable corporate innovation. We first establish that valuable innovation output... View Details
Keywords: Class-action Litigation; Turnover; Lawsuits and Litigation; Innovation and Invention; Risk and Uncertainty
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Kempf, Elisabeth, and Oliver Spalt. "Attracting the Sharks: Corporate Innovation and Securities Class Action Lawsuits." Management Science 69, no. 3 (March 2023): 1323–1934.
  • 2023
  • Working Paper

Learning by Investing: Entrepreneurial Spillovers from Venture Capital

By: Josh Lerner, Jinlin Li and Tong Liu
This paper studies how investing in venture capital (VC) affects the entrepreneurial outcomes of individual limited partners (LPs). Using comprehensive administrative data on entrepreneurial activities and VC fundraising and investments in China, we first document that... View Details
Keywords: Partners and Partnerships; Entrepreneurship; Venture Capital; Investment; China
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Lerner, Josh, Jinlin Li, and Tong Liu. "Learning by Investing: Entrepreneurial Spillovers from Venture Capital." Harvard Business School Working Paper, No. 24-029, November 2023. (Revise and resubmit, Review of Financial Studies.)
  • July 2013
  • Article

Ethnic Innovation and U.S. Multinational Firm Activity

By: C. Fritz Foley and William R. Kerr
This paper studies the impact that immigrant innovators have on the global activities of U.S. firms by analyzing detailed data on patent applications and on the operations of the foreign affiliates of U.S. multinational firms. The results indicate that increases in the... View Details
Keywords: Technology Transfer; Innovation; Ethnic Networks; Patents; Diasporas; Ethnicity; Multinational Firms and Management; Competitive Advantage; Research and Development; Foreign Direct Investment; Innovation and Invention; United States
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Foley, C. Fritz, and William R. Kerr. "Ethnic Innovation and U.S. Multinational Firm Activity." Management Science 59, no. 7 (July 2013): 1529–1544.
  • 2023
  • Working Paper

Market Exclusivity and Innovation: Evidence From Antibiotics

By: Edward Kong and Olivia Zhao
The US incentivizes drug innovation via patents as well as market exclusivity periods awarded by the US Food and Drug Administration. We estimate the causal effects of extending market exclusivity for an important drug class: antibiotics. Using a... View Details
Keywords: Health Testing and Trials; Innovation and Invention; Motivation and Incentives; Government Administration; Government Legislation; Pharmaceutical Industry; United States
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Kong, Edward, and Olivia Zhao. "Market Exclusivity and Innovation: Evidence From Antibiotics." Working Paper, December 2023.
  • 30 Sep 2009
  • Working Paper Summaries

Breakthrough Inventions and Migrating Clusters of Innovation

Keywords: by William R. Kerr; Technology
  • May 2021
  • Article

Risk-Mitigating Technologies: The Case of Radiation Diagnostic Devices

By: Alberto Galasso and Hong Luo
We study the impact of consumers’ risk perception on firm innovation. Our analysis exploits a major surge in the perceived risk of radiation diagnostic devices following extensive media coverage of a set of over-radiation accidents involving CT scanners in late 2009.... View Details
Keywords: Risk Perception; Innovation; Medical Devices; Liability Risk; Risk and Uncertainty; Perception; Technological Innovation
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Galasso, Alberto, and Hong Luo. "Risk-Mitigating Technologies: The Case of Radiation Diagnostic Devices." Management Science 67, no. 5 (May 2021): 3022–3040.
  • March 1993 (Revised April 1995)
  • Case

Signalling Costs

NutraSweet's worldwide patent-protected monopoly on aspartame, the low-calorie high-intensity sweetener, ended with the 1987 entry of the Holland Sweetener Co. (HSC) into the European market. Following the arrival of a challenger, NutraSweet acted to reduce sharply the... View Details
Keywords: Patents; Competition; Price; Market Entry and Exit; Food and Beverage Industry; United States; Europe
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Brandenburger, Adam M. "Signalling Costs." Harvard Business School Case 793-125, March 1993. (Revised April 1995.)
  • March 2010 (Revised January 2011)
  • Case

Carrot or Stick? Getting Paid for Innovation at Tessera Technologies

By: Willy C. Shih
Tessera Technologies has been very successful developing technologies for the semiconductor and mobile device industry, and then licensing them broadly to manufacturers. In addition to licensing patents, it also supplies know-how to help manufacturers move into... View Details
Keywords: Business Model; Innovation Strategy; Patents; Courts and Trials; Rights; Mobile Technology; Semiconductor Industry; California
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Shih, Willy C. "Carrot or Stick? Getting Paid for Innovation at Tessera Technologies." Harvard Business School Case 610-085, March 2010. (Revised January 2011.)
  • February 2011 (Revised August 2011)
  • Case

Brazil: Leading the BRICs?

By: Arthur A. Daemmrich and Aldo Musacchio
Brazil's new president, Dilma Rousseff, had announced plans to sustain GDP growth above 5% annually and continue the country's leadership role among emerging economies. Between 2003 and 2010, Brazil benefited from strong economic growth and stable policies under the... View Details
Keywords: Developing Countries and Economies; Intellectual Property; Infrastructure; Economic Growth; Trade; International Relations; Economic Systems; Globalization; Corporate Strategy; Brazil; Russia; India; China; United States
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Daemmrich, Arthur A., and Aldo Musacchio. "Brazil: Leading the BRICs?" Harvard Business School Case 711-024, February 2011. (Revised August 2011.)
  • August 2018
  • Article

Growth Through Heterogeneous Innovations

By: Ufuk Akcigit and William R. Kerr
We build a tractable growth model where multi-product incumbents invest in internal innovations to improve their existing products, while new entrants and incumbents invest in external innovations to acquire new product lines. External and internal innovations generate... View Details
Keywords: Endogenous Growth; Innovation; Citations; Scientists; Entrepreneurs; External; Internal; Patents; Innovation Strategy; Entrepreneurship; Economic Growth; Research and Development; Science
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Akcigit, Ufuk, and William R. Kerr. "Growth Through Heterogeneous Innovations." Journal of Political Economy 126, no. 4 (August 2018): 1374–1443.
  • September 2005
  • Article

Managerial Foresight and Attempted Rent Appropriation: Insider Trading on Knowledge of Imminent Breakthroughs

By: Gautam Ahuja, Russell W. Coff and Peggy M. Lee
In order to establish a competitive advantage, firms must acquire or create resources at a price below their value in use. Absent pure luck, this requires managers to exercise foresight about a resource's future value and/or complementarities with pre-existing... View Details
Keywords: Strategy; Knowledge Use and Leverage
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Ahuja, Gautam, Russell W. Coff, and Peggy M. Lee. "Managerial Foresight and Attempted Rent Appropriation: Insider Trading on Knowledge of Imminent Breakthroughs." Strategic Management Journal 26, no. 9 (September 2005): 791–808.
  • August 2001
  • Case

Pharmaceutical Industry and the AIDS Crisis in Developing Countries, The

Explores the controversy over the pricing of AIDS drugs in poor countries. This issue has received wide publicity due to two events: 1) a court case in South Africa that seeks to force drug companies to license their patents and 2) the announcement by the Indian... View Details
Keywords: Competition; Developing Countries and Economies; Business and Government Relations; Pharmaceutical Industry; South Africa; India
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Kennedy, Robert E. "Pharmaceutical Industry and the AIDS Crisis in Developing Countries, The." Harvard Business School Case 702-010, August 2001.
  • March 1992 (Revised June 1995)
  • Case

Introduction of FM Radio (A): Finally, A ""Staticless"" Radio

Describes the evolution of radio technology and business from the initial days of wireless telegraphy to the advent, growth, and establishment of amplitude-modulated (AM) radio manufacturing and broadcasting. Begins and ends with a description of a decision the Radio... View Details
Keywords: Technological Innovation; Leading Change; Product Design; Product Development; Media and Broadcasting Industry; United States
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Dhebar, Anirudh S. Introduction of FM Radio (A): Finally, A ""Staticless"" Radio. Harvard Business School Case 592-092, March 1992. (Revised June 1995.)
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