Publications

January–February 2023
Article

Data-Driven COVID-19 Vaccine Development for Janssen

By: Dimitris Bertsimas, Michael Lingzhi Li, Xinggang Liu, Jennings Xu and Najat Khan

The COVID-19 pandemic has spurred extensive vaccine research worldwide. One crucial part of vaccine development is the phase III clinical trial that assesses the vaccine for safety and efficacy in the prevention of COVID-19. In this work, we enumerate the first... View Details

Keywords: COVID-19; Health Testing and Trials; Forecasting and Prediction; AI and Machine Learning; Research; Pharmaceutical Industry

25 Apr 2014
Research & Ideas

To Pay or Not to Pay: Argentina and the International Debt Market

Editor's note. Argentina is in the midst of a continuing saga regarding its 2002 default on its sovereign debt, a case that the US Supreme Court will decide soon. HBS finance professor Laura Alfaro, who served from 2010 to 2012 as... View Details

Keywords: by Laura Alfaro

2012
Other Unpublished Work

Lost in the Clouds: The Impact of Copyright Scope on Investment in Cloud Computing Ventures

By: Josh Lerner and Greg Rafert

Our analysis seeks to understand the impact of changes in copyright scope on investment in new firms. We begin by analyzing the investment effects of the Cartoon Network, et al. v. Cablevision decision in the U.S. and court rulings in France and Germany on venture... View Details

Keywords: Technological Innovation; Venture Capital; Internet and the Web; Investment; Business Startups; Copyright; France; Germany; United States; European Union

Read Now

26 Sep 2017
First Look

First Look at New Research and Ideas, September 26, 2017

infringement lawsuits in U.S. district courts. The results of this review would be nonbinding but admissible in later court proceedings. Whether conducted by an independent Patent Litigation Review Board or a division of the U.S. Patent... View Details

Keywords: Sean Silverthorne

20 Nov 2019
Video

Zia Mody

Zia Mody, founder of AZB & Partners, a leading corporate law firm in India, describes the changing relationship... View Details

Rare Disease Day – Small Numbers, Big Challenges… and Big Opportunities - Blog: Health Supplement

tag Biotech/pharma Care Delivery Clinical Trials Health Care Innovation Public Health Hereditary Hemorrhagic Telangiectasia (HHT) . Not only a mouthful, but also very hard to spell and remember - a fitting... View Details

28 Oct 2024
Op-Ed

Latino Voters Have Grown More Politically Divided. That’s Not Surprising.

vehicles—political parties fight for votes where they can get them. If a group of voters starts to grow, then both parties will court that group with campaign effort, messaging, and policy change. And, in... View Details

Keywords: by Richard Calvo, Vincent Pons, and Jesse M. Shapiro

12 Aug 2019
Working Paper Summaries

Case Histories of Significant Medical Advances

Keywords: by Amar Bhidé, Srikant M. Datar, and Katherine Stebbins

2010
Chapter

From Visible Harm to Relative Risk: Centralization and Fragmentation of Pharmacovigilance

By: Arthur A. Daemmrich

Adverse drug reactions pose distinct but potentially catastrophic risks to patients, physicians, pharmaceutical firms, and regulators. Between the early 1960s and the present, national systems were built to collect, standardize, and respond to individual reports of... View Details

Keywords: Governing Rules, Regulations, and Reforms; Health Testing and Trials; Business and Government Relations; Risk and Uncertainty; Safety; Pharmaceutical Industry; United States

09 Sep 2024
HBS Case

McDonald’s and the Post #MeToo Rules of Sex in the Workplace

boardroom in 2019, moved to the Delaware Court of Chancery in 2021, and ultimately led to a Securities and Exchange Commission sanction in 2023, which attracted HBS Baker... View Details

Keywords: by Avery Forman; Food & Beverage

November 2024
Supplement

Epic Games: Nineteen Eighty-Fortnite (B)

By: Andy Wu and Ronald Wang

In a significant ruling on April 24, 2023, the U.S. Court of Appeals for the Ninth Circuit upheld portions of the district court’s decision against Epic Games back in September 2021. However, Apple’s anti-steering provisions, which restricted app developers from... View Details

Keywords: Lawsuits and Litigation; Market Transactions; Applications and Software; Technology Industry; Video Game Industry

Buy Now, Pay Later: Credit and the Market Economy: The Rise of Credit Reporting

the Courts Credit and Information Technology Credit in a Consumer Society Research Links Credits “Credit is the vital air of the system of modern commerce. It has done more — a thousand times more — to... View Details

July 2005
Background Note

Guth v. Loft: Synopsis

By: Lynn S. Paine and Christopher Bruner

Provides a brief overview of the Supreme Court of Delaware's opinion in the 1939 case of Guth v. Loft, a widely cited application of the "corporate opportunity doctrine." Explores the corporate law principles regulating when a corporate manager can or cannot take... View Details

Keywords: Courts and Trials; Lawfulness; Management; Opportunities

Educators

2021
Working Paper

Venture Capital's 'Me Too' Moment

By: Sophie Calder-Wang, Paul A. Gompers and Patrick Sweeney

In this paper, we document the historically low rate of hiring of women in the venture capital sector. We find that the high-profile Ellen Pao v. Kleiner Perkins gender discrimination trial had dramatic treatment effects. In difference-in-differences regressions, we... View Details

Keywords: Gender Discrimination; Founders; Venture Capital; Selection and Staffing; Gender; Lawsuits and Litigation

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March 2020
Case

Aereo

By: Thomas R. Eisenmann and Jacey Taft

Aereo aimed to disrupt television program distribution by providing consumers access to local broadcast TV programming using offsite antennas, cloud-based DVRs, and an Internet connection. With Aereo, consumers could “cut the cord” and avoid the high cost of a cable TV... View Details

Keywords: Entrepreneurship; Failure; Lawsuits and Litigation; Internet and the Web; Media; Entertainment and Recreation Industry; United States

Educators

July 2006 (Revised July 2007)
Case

C.K. Coolidge, Inc. (Abridged)

Coolidge (CKC), a chemical manufacturer, is being sued for patent infringement. The plaintiffs are the patent holder and its sole licensee, who is also a CKC competitor. An analyst at CKC has done a breakeven decision analysis from CKC's perspective, balancing going to... View Details

Keywords: Negotiation Preparation; Courts and Trials; Patents; Analysis; Decision Choices and Conditions; Lawsuits and Litigation; Chemical Industry

Educators

June 1984
Case

Federal Trade Commission and the Shared Monopoly Case against the Ready-to-Eat Cereal Manufacturers

By: Thomas K. McCraw and Richard S. Tedlow

Keywords: Business and Government Relations; Monopoly; Courts and Trials; Food and Beverage Industry; United States

July 2024
Article

Buying the Verdict

By: Lauren Cohen and Umit Gurun

We document evidence that firms systematically increase specialized, locally targeted advertising following the firm being taken to trial in that given location, precisely following initiation of the suit. In particular, we use legal actions brought against publicly... View Details

Keywords: Lawsuits and Litigation; Advertising; Marketing Strategy

November 2020
Teaching Note

DayTwo: Going to Market with Gut Microbiome

By: Ayelet Israeli

Teaching Note for HBS Case No. 519-010. DayTwo is a young Israeli startup that applies research on the gut microbiome and machine learning algorithms to deliver personalized nutritional recommendations to its users in order to minimize blood sugar spikes after meals.... View Details