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- 17 Oct 2012
- Research & Ideas
America Needs a Manufacturing Renaissance
Erosion Of The Industrial Commons From, Producing Prosperity: Why America Needs a Manufacturing Renaissance By Gary P. Pisano and Willy C. Shih In times past, farmers and local townspeople would bring their livestock to the commons—a... View Details
- September 2024
- Case
Myeloma Investment Fund
By: Kyle Myers and Scott Sawaya
This case explores a critical decision facing the Myeloma Investment Fund (MIF) as it evaluates two investment opportunities aimed at accelerating a cure for multiple myeloma.
The MIF, a venture philanthropy fund, must choose between two distinct paths. One... View Details
The MIF, a venture philanthropy fund, must choose between two distinct paths. One... View Details
Keywords: Venture Philanthropy; Biomedical Research; Investing For Impact; Innovation ＆ Entrepreneurship; Venture Capital; Science-Based Business; Philanthropy and Charitable Giving; Decision Making; Health Care and Treatment; Biotechnology Industry; Biotechnology Industry
Myers, Kyle, and Scott Sawaya. "Myeloma Investment Fund." Harvard Business School Case 625-047, September 2024.
- November 2014
- Teaching Note
Claritas Genomics
By: Robert F. Higgins and Matthew G. Preble
Dr. Patrice Milos is the first CEO of Claritas Genomics (Claritas) and she faces a number of challenges in scaling the young company. Claritas was formed around a lab spun out from Boston Children's Hospital (BCH) which had performed genomic tests for the hospital. Now... View Details
- September 2014
- Case
Pfizer's Centers for Therapeutic Innovation (CTI)
By: Gary Pisano, James Weber and Kait Szydlowski
In 2010, Pfizer established four small research units in New York, Boston, San Francisco, and San Diego located close to several premier Academic Medical Centers (AMCs), or hospitals with adjoining medical schools. The goal of these units was to redesign collaboration... View Details
Keywords: Drug Development; Academic Collaboration; Research And Development; Innovation; Translational Research; Management; Operations; Problems and Challenges; Research; Science; Information Technology; Strategy; Biotechnology Industry; Biotechnology Industry; North and Central America; Europe; Asia
Pisano, Gary, James Weber, and Kait Szydlowski. "Pfizer's Centers for Therapeutic Innovation (CTI)." Harvard Business School Case 615-024, September 2014.
- December 2010
- Teaching Note
Roche's Acquisition of Genentech (TN)
By: Bo Becker and Carliss Y. Baldwin
Teaching Note for 210-040. View Details
- November 2009
- Case
The Explosion of Genetic Testing: Opportunities and Challenges
By: Richard G. Hamermesh, Mara G. Aspinall and Rachel Gordon
This case study invites the reader to consider genetic testing in several different lights. First, can the business of genetic testing be considered a disruptive innovation to the current drug therapy model as defined by Harvard Business School Professor Clay... View Details
- October 2009 (Revised July 2013)
- Case
Gilead Sciences, Inc.: Access Program
By: V. Kasturi Rangan and Katharine Lee
Gilead Sciences, the U.S. leader in HIV/AIDS medicines, with global sales of $5.4 billion in 2009, had undertaken several innovative actions to make its anti-viral products available to over 100 low- and middle-income countries. Having reached nearly 680,000 patients... View Details
Keywords: Health Care and Treatment; Emerging Markets; Product; Sales; Competitive Strategy; Biotechnology Industry; Biotechnology Industry
Rangan, V. Kasturi, and Katharine Lee. "Gilead Sciences, Inc.: Access Program." Harvard Business School Case 510-029, October 2009. (Revised July 2013.)
- June 2008
- Case
Gordon Williams: Clinical Research at Brigham and Women's Hospital
By: H. Kent Bowen and Courtney Purrington
Clinical research is a critical element of biomedical research and development. This case describes the challenges of clinical research, and its role in bringing breakthroughs to patients. Dr. Williams leads through his own research and special programs to train... View Details
Keywords: Training; Health Care and Treatment; Success; Programs; Research and Development; Biotechnology Industry; Biotechnology Industry
Bowen, H. Kent, and Courtney Purrington. "Gordon Williams: Clinical Research at Brigham and Women's Hospital." Harvard Business School Case 608-168, June 2008.
- June 2003 (Revised October 2004)
- Case
Novartis: The Challenge of Success (D)
By: Sandra J. Sucher and Stacy McManus
Supplements the (A) and (B) cases. View Details
Sucher, Sandra J., and Stacy McManus. "Novartis: The Challenge of Success (D)." Harvard Business School Case 603-046, June 2003. (Revised October 2004.)
- 12 Oct 1999
- Research & Ideas
Porter’s Perspective: Competing in the Global Economy
you decide to put together this collection of articles? Porter: In retrospect, my work divides into three major areas. The first has to do with how firms compete in industries and gain competitive advantage. The next focuses on locations... View Details
Keywords: Re: Michael E. Porter
- April 1995
- Teaching Note
Genzyme Corporation: A Financing History (TN)
By: Timothy A. Luehrman
Teaching Note for (9-294-005). View Details
Keywords: Biotechnology Industry
- March 2024
- Case
Biomanufacturing Decentralization by Stämm
By: Paul A. Gompers, Jenyfeer Martínez Buitrago and Mariana Cal
In Buenos Aires, Argentina, cousins Llamazares and D’Alvia founded Stämm, a startup based on the idea of decentralizing biomanufacturing processes and downsizing biotech facilities. After raising its seed and series A rounds, and while finalizing its series B round in... View Details
Keywords: Business Model; Business Startups; Entrepreneurship; Venture Capital; Selection and Staffing; Technological Innovation; Science-Based Business; Business Strategy; Commercialization; Growth and Development Strategy; Product Launch; Research and Development; Biotechnology Industry; Latin America; South America; Argentina; Buenos Aires
Gompers, Paul A., Jenyfeer Martínez Buitrago, and Mariana Cal. "Biomanufacturing Decentralization by Stämm." Harvard Business School Case 824-190, March 2024.
- October 2023 (Revised July 2025)
- Case
Thermo Fisher Scientific: Foray into Contract Research
By: Satish Tadikonda, William Marks and Kevin Emancipator
After publicly declaring that they would not enter the contract research organization (CRO) business in 2017, Thermo Fisher purchased Pharmaceutical Product Development (PPD), one of the biggest players in the CRO space, in 2021. Much had changed in the intervening... View Details
Keywords: Mergers and Acquisitions; Customer Focus and Relationships; Corporate Strategy; Organizational Change and Adaptation; Biotechnology Industry
Tadikonda, Satish, William Marks, and Kevin Emancipator. "Thermo Fisher Scientific: Foray into Contract Research." Harvard Business School Case 824-073, October 2023. (Revised July 2025.)
- November 2016 (Revised December 2016)
- Supplement
Anthony Starks at InSiL Therapeutics (B)
By: Vicki Sato and Gary Pisano
This case accompanies the (A) case from Anthony Starks's perspective. View Details
Keywords: Biotech; Management Challenges; R＆D; R＆D Project Management; Management; Biotechnology Industry; California
Sato, Vicki, and Gary Pisano. "Anthony Starks at InSiL Therapeutics (B)." Harvard Business School Supplement 617-030, November 2016. (Revised December 2016.)
- September 2008 (Revised April 2009)
- Supplement
Kevin Sharer at Amgen: Sustaining the High-Growth Company (B)
By: William W. George
Kevin Sharer, CEO of Amgen, is assessing the challenges he has faced as a major product came under regulatory scrutiny. View Details
Keywords: Governing Rules, Regulations, and Reforms; Leadership; Product Development; Biotechnology Industry
George, William W. "Kevin Sharer at Amgen: Sustaining the High-Growth Company (B)." Harvard Business School Supplement 409-037, September 2008. (Revised April 2009.)
- 2009
- Working Paper
Social Influence Given (Partially) Deliberate Matching: Career Imprints in the Creation of Academic Entrepreneurs
By: Pierre Azoulay, Christopher C. Liu and Toby E. Stuart
Actors often match with associates on a small set of dimensions that matter most for the particular relationship at hand. In so doing, they are exposed to unanticipated social influences because counterparts have more interests, attitudes, and preferences than would-be... View Details
Keywords: Entrepreneurship; Patents; Marketplace Matching; Mathematical Methods; Science-Based Business; Power and Influence; Social and Collaborative Networks; Biotechnology Industry
Azoulay, Pierre, Christopher C. Liu, and Toby E. Stuart. "Social Influence Given (Partially) Deliberate Matching: Career Imprints in the Creation of Academic Entrepreneurs." Harvard Business School Working Paper, No. 09-136, May 2009.
- April 2002
- Teaching Note
Anagene, Inc. TN
By: Robert S. Kaplan
Teaching Note for (9-102-030). View Details
- October 2001 (Revised March 2002)
- Case
Perlegen Sciences
By: Linda A. Hill and Nicole Tempest
As a biotech start-up company involved in studying human genomes, Perlegen needed to develop an organization that fostered innovation and teamwork among a group of highly trained professionals from both the science and technology fields. Perlegen's CEO, Brad Margus,... View Details
Keywords: Innovation Leadership; Groups and Teams; Management Teams; Problems and Challenges; Business Startups; Genetics; Talent and Talent Management; Innovation Strategy; Biotechnology Industry
Hill, Linda A., and Nicole Tempest. "Perlegen Sciences." Harvard Business School Case 402-026, October 2001. (Revised March 2002.)
- August 1985 (Revised May 1986)
- Case
BioTechnica International
By: Ray A. Goldberg
Keywords: Biotechnology Industry
Goldberg, Ray A. "BioTechnica International." Harvard Business School Case 586-014, August 1985. (Revised May 1986.)
- November 1995 (Revised March 1996)
- Case
Ares-Serono (Abridged)
By: Michael Y. Yoshino, Jean-Pierre Jeannet and Carin-Isabel Knoop
Keywords: Biotechnology Industry
Yoshino, Michael Y., Jean-Pierre Jeannet, and Carin-Isabel Knoop. "Ares-Serono (Abridged)." Harvard Business School Case 396-104, November 1995. (Revised March 1996.)