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  • All HBS Web  (9,674)
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  • March 2002 (Revised May 2002)
  • Case

Genzyme: Engineering the Market for Orphan Drugs

Genzyme has made money with external technology in orphan drug markets generally considered to be too small to be attractive to other drug companies. Now competition is entering these same markets, placing Genzyme's business model under new pressures. View Details
Keywords: Business Model; Information Technology; Market Entry and Exit; Biotechnology Industry; Pharmaceutical Industry
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Chesbrough, Henry W., and Clarissa Ceruti. "Genzyme: Engineering the Market for Orphan Drugs." Harvard Business School Case 602-147, March 2002. (Revised May 2002.)
  • 2010
  • Article

Competing against Online Sharing

By: Ramon Casadesus-Masanell and Andres Hervas-Drane
This paper aims to explore online sharing of copyrighted content over peer-to-peer (p2p) file sharing networks and its impact on the music industry and to assess the viable business models for the industry in the future. View Details
Keywords: Consumers; Computer Networks; Resource Sharing; Online Operations; Internet and the Web; Copyright; Networks; Business Model; Music Industry
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Casadesus-Masanell, Ramon, and Andres Hervas-Drane. "Competing against Online Sharing." Management Decision 48, no. 8 (2010): 1247–1260.
  • June 2024
  • Teaching Note

Numenta in 2020: The Future of AI

By: David B. Yoffie
In 2020, Numenta’s co-founder, Jeff Hawkins, completed his pathbreaking research on artificial intelligence. His co-founder and CEO, Donna Dubinsky, had to find a business model to monetize the technology. This teaching note explores the challenges of building a... View Details
Keywords: Artificial Intelligence; Monetization; Strategy; Intellectual Property; AI and Machine Learning; Business Model; Entrepreneurship; Technology Industry
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Yoffie, David B. "Numenta in 2020: The Future of AI." Harvard Business School Teaching Note 724-496, June 2024.

    Producing Prosperity: Why America Needs a Manufacturing Renaissance

    For years—even decades—in response to intensifying global competition, American companies decided to outsource their manufacturing operations in order to reduce costs. But we are now seeing the alarming long-term effect of those choices: in... View Details

    • 08 Dec 2006
    • Working Paper Summaries

    The Industry R&D Survey: Patent Database Link Project

    Keywords: by William R. Kerr & Shihe Fu; Technology
    • January 2024 (Revised March 2024)
    • Case

    Tesla Motors in 2024--Turbulence Ahead?

    By: Felix Oberholzer-Gee and Kate Stoppiello
    Over its 20 years in existence, Tesla had become nearly synonymous with electric vehicles, and the company assumed an enviable market position. By 2023, however, Tesla faced intense competition. Traditional carmakers and EV upstarts were expected to introduce close to... View Details
    Keywords: Competitive Strategy; Product Positioning; Competition; Industry Growth; Auto Industry; North America; Europe; China; Australia
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    Oberholzer-Gee, Felix, and Kate Stoppiello. "Tesla Motors in 2024--Turbulence Ahead?" Harvard Business School Case 724-446, January 2024. (Revised March 2024.)
    • November 2024
    • Case

    Polish Agro: Where Do We Grow From Here?

    By: Willy C. Shih, Lena Duchene and Daniela Beyersdorfer
    By July 2024, Polish Agro had grown into one of Poland’s fastest-growing agribusinesses, with €230 million in revenue, 82 employees, and operations across Northern Poland. The company supported farmers with essential agricultural inputs like fertilizers and seeds,... View Details
    Keywords: Plant-Based Agribusiness; Distribution; Volatility; Customer Focus and Relationships; Customer Value and Value Chain; Climate Change; Environmental Regulation; Profit; Trade; Digital Strategy; Innovation Strategy; Crisis Management; Growth and Development Strategy; Resource Allocation; Advertising; Brands and Branding; E-commerce; Business and Community Relations; Networks; Adaptation; Adoption; Competitive Advantage; Business Model; Health Pandemics; War; Agriculture and Agribusiness Industry; Europe; Poland
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    Shih, Willy C., Lena Duchene, and Daniela Beyersdorfer. "Polish Agro: Where Do We Grow from Here?" Harvard Business School Case 625-061, November 2024.
    • 07 Feb 2019
    • Book

    How Big Companies Can Outrun Disruption

    scale might actually be an advantage for innovation motivated me to write this book. Lagace: As you say, innovation is a broad term. What does it mean to you? Pisano: View Details
    Keywords: by Martha Lagace
    • 15 Jul 2014
    • First Look

    First Look: July 15

      Publications August 2013 Strategic Entrepreneurship Journal Business Model Evaluation: Quantifying Walmart's Sources of Advantage By: Brea-Solís, Humberto, Ramon Casadesus-Masanell, and Emili Grifell-Tatjé... View Details
    Keywords: Carmen Nobel

      Paul Hamilton

      Paul studies the economic complements needed for firms to realize productivity gains from machine learning and artificial intelligence. These complements include data, human capital & skills, organizational processes, and business models. 
      View Details
      • July 2008 (Revised September 2009)
      • Case

      Betfair vs. UK Bookmakers

      By: Ramon Casadesus-Masanell and Neil Campbell
      Betting exchanges provide an electronic platform that allows ordinary consumers to not only back teams to win, but also to lay odds for other punters to back. This business model allows punters to cut out the middleman of the bookmaker and leads to a much more... View Details
      Keywords: Business Model; Decision Choices and Conditions; Two-Sided Platforms; Market Transactions; Competition; Entertainment and Recreation Industry
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      Casadesus-Masanell, Ramon, and Neil Campbell. "Betfair vs. UK Bookmakers." Harvard Business School Case 709-417, July 2008. (Revised September 2009.)
      • 22 Aug 2011
      • Research & Ideas

      Getting to Eureka!: How Companies Can Promote Creativity

      Innovation Lab. Upon his appointment last year, Harvard Business School Dean Nitin Nohria named innovation, along with globalization and business ethics, as one of the most... View Details
      Keywords: by Michael Blanding
      • November 2012 (Revised July 2014)
      • Supplement

      Andrew Sullivan and Faraway Ltd (B): Sam Cartwright of Mothercare

      By: Frank V. Cespedes and Alex Godden
      The "Andrew Sullivan and Faraway Ltd" case series focuses on entrepreneurial selling, and is based on an older case study, "Deaver Brown and Cross River Inc." (9-394-042). It concerns two entrepreneurs, Andrew Sullivan and Hope Abasi, who have designed an innovative... View Details
      Keywords: Entrepreneurship; Sales; Marketing; Management; Consumer Products Industry; United Kingdom
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      Cespedes, Frank V., and Alex Godden. "Andrew Sullivan and Faraway Ltd (B): Sam Cartwright of Mothercare." Harvard Business School Supplement 813-105, November 2012. (Revised July 2014.)
      • 10 Sep 2007
      • Research & Ideas

      High Note: Managing the Medici String Quartet

      professional and professor. Reliable innovation is "a weird concept," Austin admits. "Reliability in business is about things aimed at consistency of outcome. Reliable View Details
      Keywords: by Martha Lagace; Music
      • 2014
      • Working Paper

      The Decoupling Effect of Digital Disruptors

      By: Thales S. Teixeira and Peter Jamieson
      While the Internet's first wave of disruption was marked by the unbundling of digital content, the second wave, decoupling, promises to generate more casualties in an even broader array of industries. Digital start-ups are disrupting traditional businesses by inserting... View Details
      Keywords: Disruptive Innovation; Information Technology
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      Teixeira, Thales S., and Peter Jamieson. "The Decoupling Effect of Digital Disruptors." Harvard Business School Working Paper, No. 15-031, October 2014.
      • September 2000 (Revised July 2001)
      • Case

      Chapters.ca

      By: Michael J. Roberts, Rajiv Lal and Walter J. Salmon
      Describes the challenges facing the online site associated with Canada's largest bricks-and-mortar bookseller. Presents a variety of lenses for examining the economic model of the online versus traditional book-selling business, and asks students to identify the... View Details
      Keywords: Marketing Strategy; Internet and the Web; Business Model; Entrepreneurship; Product Marketing; Business Strategy; Technological Innovation; Canada
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      Roberts, Michael J., Rajiv Lal, and Walter J. Salmon. "Chapters.ca." Harvard Business School Case 801-158, September 2000. (Revised July 2001.)
      • 08 Feb 2017
      • Video

      Francesca Ioffreda, MBA 2017

      • 21 Nov 2017
      • News

      6 Ways to Create a Competitive Work Culture That's Team First (And Not Me First)

      • 11 Jan 2011
      • First Look

      First Look: Jan. 11

      E. Ricart Publication:Harvard Business Review 89 Abstract Most executives believe that competing through business models is critical for success, but few have come to grips... View Details
      Keywords: Sean Silverthorne
      • 02 May 2012
      • News

      How outsiders solve problems that stump experts

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