Publications

January 2025
Case

Moderna: Democratizing Artificial Intelligence

By: Iavor I. Bojinov, Karim R. Lakhani, Annika Hildebrandt and James Weber

The case study examines Moderna's journey in democratizing artificial intelligence (AI), particularly generative AI, across its workforce. It details the company's "digital-first, AI-focused" approach, including the rollout of OpenAI's ChatGPT Enterprise to all... View Details

Keywords: AI and Machine Learning; Technology Adoption; Innovation Strategy; Governance Controls; Biotechnology Industry

March 2020 (Revised June 2020)
Case

Social Salary Setting at Spiber

By: Ashley Whillans and John Beshears

Can a “set your own salary” system boost employee happiness and motivation? Spiber made synthetic silk built from proteins mimicking the proteins found in spider silk, the world’s toughest known material by weight. Kazuhide Sekiyama and Junichi Sugahara established... View Details

Keywords: Compensation and Benefits; Motivation and Incentives; Happiness; Negotiation Tactics; Cross-Cultural and Cross-Border Issues; Biotechnology Industry; Japan; United States

September 2019 (Revised August 2020)
Case

Engineering an Inclusive Bioeconomy

By: Tarun Khanna, Raffaella Sadun and Susie L. Ma

In 2019, entrepreneur Juan Carlos Castilla-Rubio was developing a project he hoped could generate and share wealth from the natural resources of the Amazon without destroying those resources. His idea, called Earth Bank of Codes (EBC), would create a library of the... View Details

November 2017
Case

Passion and Strategy: Novozymes' Embrace of the UN Sustainable Development Goals

By: Andy Zelleke and Emilie Billaud

This case explores the sustainability efforts at Novozymes, the world's largest and oldest producer of industrial enzymes. In 2015, the Danish company became the world’s first company known to have crafted a new corporate strategy based on the United Nations... View Details

Keywords: Corporate Governance; Transformation; Environmental Sustainability; Corporate Social Responsibility and Impact; Mission and Purpose; Business and Shareholder Relations; Business and Stakeholder Relations; Business Strategy; Organizational Culture; Organizational Change and Adaptation; Biotechnology Industry; Europe; Denmark

September 2011
Teaching Note

Tengion: Bringing Regenerative Medicine to Life (TN)

By: Elie Ofek and Natalie Kindred

Teaching Note for 510031. View Details

Keywords: Partners and Partnerships; Production; Marketing; Cash; Health Care and Treatment; Medical Specialties; Research and Development; Biotechnology Industry

September 2009
Teaching Note

iZumi (TN)

By: Robert F. Higgins

Teaching Note for [809105]. View Details

Keywords: Perspective; Intellectual Property; Venture Capital; Innovation and Invention; Investment; Financing and Loans; Information Technology; Mergers and Acquisitions; Commercialization; Biotechnology Industry

December 2004 (Revised July 2005)
Case

Extend Fertility

By: Myra M. Hart and Sylvia Sensiper

Focuses on the search for opportunity, the generation and evaluation of business concepts, creation of a business plan, and the start-up process. Follows experienced entrepreneur Christy Jones as she combines her business skills and personal experience to generate new... View Details

Keywords: Opportunities; Business Plan; Entrepreneurship; Personal Development and Career; Social Issues; Gender; Business Startups; Biotechnology Industry

June 2003 (Revised October 2003)
Case

Institut Pasteur

The Pasteur Institut is implementing a proactive commercialization strategy under the direction of Christian Policard. Highlights the government's innovation policy and the role that the Pasteur Institut can play in shaping it. Also addresses issues relating to higher... View Details

Keywords: Commercialization; Research and Development; Biotechnology Industry; France

October 2001 (Revised March 2008)
Case

Anagene, Inc.

By: Robert S. Kaplan and Christina L. Darwall

An entrepreneurial, publicly traded biotech company has begun production and sales of its core product--cartridges that permit DNA samples to be analyzed on a microchip. In the early quarters, sales are difficult to forecast and the company has experienced fluctuating... View Details

Keywords: Cost Accounting; Financial Reporting; Production; Performance Capacity; Risk and Uncertainty; Genetics; Governing and Advisory Boards; Biotechnology Industry; California

February 1994
Case

Alpha-Beta Technology, Inc.: Pioneering Carbohydrate Technology

Alpha-Beta was founded in 1988 by two scientist-entrepreneurs with ten patents on carbohydrate technology. In 1991, the company faces critical questions about how to focus its product definition from among several promising, but risky, choices. How should they analyze... View Details

Keywords: Technological Innovation; Product Design; Entrepreneurship; Product Development; Biotechnology Industry

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November 1978 (Revised October 1989)
Case

Amicon Corp. (A)

Amicon holds a patent on a new process for the separation of blood plasma from whole blood. It has to decide whether to pursue a direct entry, joint venture, or licensing strategy. If it chooses licensing, there are many sub-issues to consider. View Details

Keywords: Technology; Patents; Commercialization; Health Care and Treatment; Biotechnology Industry

October 1987
Case

T Cell Sciences, Inc.

By: Francis Aguilar

Keywords: Biotechnology Industry

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27 Aug 2008
Research & Ideas

Creating Leaders for Science-Based Businesses

It's been said that in this century, carbohydrates will replace hydrocarbons, and biology will supplant physics as the innovation-producing science. As science fiction becomes science fact, and with science-based firms presenting unique challenges for managers, HBS is... View Details

Keywords: by Garry Emmons; Biotechnology; Biotechnology

May 1999
Teaching Note

Genset Initial Public Offering (A) & (B) TN

By: Paul A. Gompers

Teaching Note for (9-297-096) and (9-297-097). View Details

Keywords: Biotechnology Industry; United States; France

December 2023 (Revised March 2024)
Case

Manufacturing Moderna's Future

By: Satish Tadikonda and William Marks

In 2019, Moderna faced long odds of survival having failed to develop a successful clinical program out of the vast platform technology they had built around mRNA. Nearly overnight, the company skyrocketed to success with a vaccine for COVID-19, leading to an extremely... View Details

Keywords: Health Pandemics; Health Testing and Trials; Technological Innovation; Product Development; Production; Science-Based Business; Biotechnology Industry

January 2023
Case

Vertex and the Cure for Type 1 Diabetes

By: Amitabh Chandra, William J Anderson and Silvia Mare

Keywords: Biotechnology Industry

2016
Working Paper

Patent Publication and the Market for Ideas

By: Deepak Hegde and Hong Luo

In this paper, we study the effect of invention disclosure through patent publication on the market for ideas. We do so by analyzing the effects of the American Inventor's Protection Act of 1999 (AIPA)—which required US patent applications to be published 18 months... View Details

Keywords: Patents; Biotechnology Industry

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January 2011 (Revised March 2011)
Case

Predictive Biosciences

By: Thomas R. Eisenmann, Jeffrey J. Bussgang and David Kiron

A small cancer diagnostics start-up is deciding whether to acquire a laboratory to make and sell its bladder cancer test or build its own manufacturing and sales team. View Details

Keywords: Mergers and Acquisitions; Factories, Labs, and Plants; Business Startups; Entrepreneurship; Health Testing and Trials; Growth and Development Strategy; Product Development; Biotechnology Industry