Publications

August 1997
Article

Preventable Adverse Drug Events in Hospitalized Patients: A Comparative Study of Intensive Care and General Care Units

By: D. J. Cullen, J. Sweitzer, D. W. Bates, E. Burdick, A. Edmondson and L. L. Leape

Keywords: Health; Information

September 1996
Case

Food and Drug Administration: Business as Unusual at CDER

By: Steven C. Wheelwright and James Leonard

Keywords: Government Administration; Food and Beverage Industry; Pharmaceutical Industry

1996
Chapter

The Determinants of Research Productivity in Ethical Drug Discovery

By: Rebecca M. Henderson and Ian Cockburn

Keywords: Ethics; Health Testing and Trials; Research and Development; Performance Productivity; Pharmaceutical Industry

Article

Scale and Scope in Drug Development: Unpacking the Advantages of Size in Pharmaceutical Research

By: Rebecca M. Henderson and Iain Cockburn

Keywords: Research and Development; Health; Size

spring 1996
Article

Scale, Scope and Spillovers: The Determinants of Research Productifity in Drug Discovery

By: Rebecca M. Henderson and Ian Cockburn

Keywords: Research; Product; Health

January 1996
Case

Biogen, Inc.: rBeta Interferon Manufacturing Process Development

By: Steven C. Wheelwright

Biogen, Inc., a Cambridge, MA-based biotechnology company, is wrapping up a project to develop a new manufacturing process for a new drug product that will reposition the company from a purely research-oriented company to a fully integrated pharmaceutical manufacturing... View Details

Keywords: Learning; Technological Innovation; Management Analysis, Tools, and Techniques; Product Development; Organizational Change and Adaptation; Projects; Research and Development; Corporate Strategy; Biotechnology Industry

fall 1994
Article

Racing to Invest? The Dynamics of Competition in Ethical Drug Discovery

By: Rebecca M. Henderson and Ian Cockburn

Keywords: Investment; Competition; Ethics; Health

Article

Measuring Competence? Exploring Firm Effects in Drug Discovery

By: Rebecca M. Henderson and Ian Cockburn

Keywords: Measurement and Metrics; Competency and Skills; Health

1994
Article

The Evolution of Integrative Capability: Innovation in Cardiovascular Drug Discovery

By: Rebecca M. Henderson

Keywords: Innovation and Invention; Health; Integration

November 1993 (Revised January 2006)
Supplement

Beech-Nut Nutrition Corporation (B)

By: Lynn S. Paine

Officials of the U.S. Food and Drug Administration (FDA) must decide whether to refer the Beech-Nut apple juice case to the Justice Department for criminal prosecution, and if so, whether to recommend prosecution of individual executives or of the company only. View Details

Keywords: Crime and Corruption; Decisions; Cases; Law; Management; Food and Beverage Industry

September 1993
Case

Manufacturing at ALZA: The Right Prescription? (A)

By: Dorothy A. Leonard

ALZA, a company specializing in drug delivery systems such as transdermal patches, considers manufacturing its own products. Until now, the company has conducted research and development on its patented system but has then licensed the technology to client-partner... View Details

Keywords: Business or Company Management; Technological Innovation; Innovation and Management; Growth and Development Strategy; Problems and Challenges; Production; Research and Development; Organizational Change and Adaptation; Pharmaceutical Industry; Medical Devices and Supplies Industry

September 1993
Supplement

Manufacturing at ALZA: The Right Prescription? (B)

By: Dorothy A. Leonard

ALZA, a drug delivery company, must decide what and for whom to manufacture. In the past, it has licensed to pharmaceutical companies its patented system for the slow release of drugs into the human system. Therefore the company has little experience in choice of drug... View Details

Keywords: Experience and Expertise; Decision Choices and Conditions; Patents; Production; Pharmaceutical Industry; Medical Devices and Supplies Industry

September 1993
Supplement

Manufacturing at ALZA: The Right Prescription? (C)

By: Dorothy A. Leonard

ALZA, a drug delivery company, considers marketing its own and other companies' products. The primary issue is whether to build an internal sales force focused on a few niche markets, to finance a sales force through alliances, or to acquire a marketing company. View Details

Keywords: Mergers and Acquisitions; Product Marketing; Alliances; Research and Development; Salesforce Management; Business Strategy; Pharmaceutical Industry

June 1993
Case

Boston Fights Drugs

By: V. Kasturi Rangan

Keywords: Social Issues; Boston

April 1993 (Revised October 1995)
Case

ALZA and Bio-Electro Systems (A): Technological and Financial Innovation

By: Josh Lerner and Peter Tufano

To develop the next generation of risky products, ALZA, a mature and profitable biotechnology firm specializing in drug delivery systems, must raise $40 million. Organizational constraints and competitive concerns demand that the work be done inside the firm. However,... View Details

Keywords: Risk and Uncertainty; Technological Innovation; Business Subsidiaries; Decision Choices and Conditions; Corporate Finance; Biotechnology Industry; Medical Devices and Supplies Industry

March 1993
Supplement

Burroughs Wellcome and AZT (B)

By: Willis M. Emmons III

Describes Burroughs Wellcome's response to protests over the pricing of its AIDS drug AZT in September 1989. Also presents short-term reactions by government officials, AIDS activists, and investors to Burroughs Wellcome's strategy. View Details

Keywords: Ethics; Health Pandemics; Multinational Firms and Management; Price; Crime and Corruption; Risk and Uncertainty; Business Strategy; Business and Community Relations; Business and Government Relations; Business and Shareholder Relations; Pharmaceutical Industry