Publications

April 2006
Case

Adrian Ivinson at the Harvard Center for Neurodegeneration and Repair

By: Robert Steven Kaplan and Ayesha Kanji

Adrian Ivinson is the director of Harvard Center for Neurodegeneration and Repair (HCNR), a not-for-profit research center at the Harvard Medical School (HMS). The center was started in late 2000 with a gift of $37.5 million from an anonymous donor. Its mandate was to... View Details

Keywords: Leadership Style; Power and Influence; Organizational Culture; Research and Development; Nonprofit Organizations; Motivation and Incentives; Change Management; Alignment; Collaborative Innovation and Invention; Health Industry; Massachusetts

January–February 2022
Article

Mobilizing the U.S. Military’s TRICARE Program for Value-Based Care: A Report From the Defense Health Board

By: Robert S. Kaplan, Paul R. Schaettle, Vivian S. Lee, Michael D. Parkinson, Gregory H. Gorman and Michael-Anne Browne

The U.S. Military Health System spends about $50 billion annually through its TRICARE health plans to provide care to 9.6 million active duty service members, retirees, and their families. TRICARE, historically, has used the predominant U.S. fee-for-service payment... View Details

Keywords: Military Health System; Value-based Healthcare; Health Care and Treatment; United States

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Web

Health & Safety Protocols

What to Expect When Coming to Campus Last updated: 13 APR 2023 The health, safety, and well-being of our entire HBS community remain our top priority. We continue to monitor health and safety protocols as provided by the U.S. Centers for View Details

2023
Article

Benchmarking Large Language Models on CMExam—A Comprehensive Chinese Medical Exam Dataset

By: Junling Liu, Peilin Zhou, Yining Hua, Dading Chong, Zhongyu Tian, Andrew Liu, Helin Wang, Chenyu You, Zhenhua Guo, Lei Zhu and Michael Lingzhi Li

Recent advancements in large language models (LLMs) have transformed the field of question answering (QA). However, evaluating LLMs in the medical field is challenging due to the lack of standardized and comprehensive datasets. To address this gap, we introduce CMExam,... View Details

Keywords: Large Language Model; AI and Machine Learning; Analytics and Data Science; Health Industry

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August 2016 (Revised August 2016)
Teaching Note

Intrapreneurship at DaVita Healthcare Partners

By: Joseph B. Fuller and Matthew Preble

DaVita Healthcare Partners Inc. (DaVita) is one of the U.S.'s leading dialysis providers, a process whereby persons with end-stage renal disease (ESRD) are connected to a machine that performs the functions of a healthy kidney. Kent Thiry, DaVita's CEO, has expanded... View Details

Keywords: Intrapreneurship; Entrepreneurial Organizations; Startup Management; Startup; Strategic Positioning; Corporate Entrepreneurship; Corporate Strategy; Business Startups; Strategic Planning; Competitive Strategy; Health Industry; United States

07 Feb 2012
First Look

First Look: February 7

efforts all around GE. But will this focus enable GE to achieve and maintain market leadership across a healthcare market that is being buffeted by strong currents, including cost pressures, changes in chronic disease patterns, and... View Details

Keywords: Sean Silverthorne

March 2023 (Revised March 2025)
Case

Close Concerns: Diabetes Research and Advocacy

By: Regina Herzlinger and Brian L. Walker

Diagnosed with diabetes at the age of 18, Kelly Close understood the importance of balancing consistency and iteration. This principle had also informed her professional work, which started with a rapid promotion from financial analyst at Goldman Sachs to an analyst... View Details

Keywords: Diabetes; Health; Health Care; Health Care And Treatment; Health Care Outcomes; Health Care Industry; Knowledge Dissemination; Outcome or Result; Equality and Inequality; Business Model; Entrepreneurship

Professor Lodge had been a member of the Harvard Business School faculty since 1963. Before his retirement in 1997, he taught a number of courses in the MBA Master's Program and in various HBS executive programs. in the MBA program these included: Business,... View Details

10 Oct 2007
First Look

First Look: First Look: October 10

Working PapersTesting Limits to Policy Reversal: Evidence from Indian Privatizations Authors:Siddhartha G. Dastidar, Raymond Fisman, and Tarun Khanna Abstract We examine the effect of regime change on privatization using the 2004 election surprise in India. The... View Details

Keywords: Martha Lagace

2018
Chapter

The Orphan Drug Act at 35: Observations and an Outlook for the Twenty-First Century

By: Nicholas Bagley, Benjamin Berger, Amitabh Chandra, Craig Garthwaite and Ariel Dora Stern

On the 35th anniversary of the adoption of the Orphan Drug Act (ODA), we describe the enormous changes in the markets for therapies for rare diseases that have emerged over recent decades. The most prominent example is the fact that the profit-maximizing price of new... View Details

Keywords: Health Care and Treatment; Laws and Statutes; Research and Development; Investment; Markets; Monopoly

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January 2017
Supplement

Intrapreneurship at DaVita HealthCare Partners: Cash Flow Tool

By: Joseph B. Fuller and Christopher Payton

DaVita Healthcare Partners Inc. (DaVita) is one of the U.S.'s leading dialysis providers, a process whereby persons with end-stage renal disease (ESRD) are connected to a machine that performs the functions of a healthy kidney. Kent Thiry, DaVita's CEO, has expanded... View Details

Keywords: Intrapreneurship; Entrepreneurial Organizations; Startup Management; Startup; Strategic Positioning; Corporate Entrepreneurship; Corporate Strategy; Business Startups; Strategic Planning; Competitive Strategy; Health Industry; United States

09 Nov 2016
HBS Seminar

Robert A. Miller, Tepper School of Business, Carnegie Mellon University

Web

MBA Experience - Health Care

of the Centers for Disease Control and Prevention (2021-2023) and current Executive Fellow at Harvard Business School and Harvard Kennedy School. Moderated by Robert Huckman, Howard Cox Health Care Initiative, Faculty Chair Feb 06 06 Feb... View Details

November 2023 (Revised April 2024)
Case

BiomX: Bringing Phage Back to the Stage

By: Paul A. Gompers, Elie Ofek, Orna Dan and Emilie Billaud

In the spring of 2023, and following the favorable results of a trial involving its phage cocktail for treating lung infections among cystic fibrosis (CF) patients, the leadership of BiomX had several critical issues to wrestle with. First, given its precarious... View Details

Keywords: Working Capital; Financing and Loans; Health Testing and Trials; Product Development; Research and Development; Science-Based Business; Commercialization; Biotechnology Industry; Pharmaceutical Industry

June 2021
Article

From Predictions to Prescriptions: A Data-driven Response to COVID-19

By: Dimitris Bertsimas, Léonard Boussioux, Ryan Cory-Wright, Arthur Delarue, Vassilis Digalakis Jr, Alexander Jacquillat, Driss Lahlou Kitane, Galit Lukin, Michael Lingzhi Li, Luca Mingardi, Omid Nohadani, Agni Orfanoudaki, Theodore Papalexopoulos, Ivan Paskov, Jean Pauphilet, Omar Skali Lami, Bartolomeo Stellato, Hamza Tazi Bouardi, Kimberly Villalobos Carballo, Holly Wiberg and Cynthia Zeng

The COVID-19 pandemic has created unprecedented challenges worldwide. Strained healthcare providers make difficult decisions on patient triage, treatment and care management on a daily basis. Policy makers have imposed social distancing measures to slow the disease, at... View Details

Keywords: COVID-19; Health Pandemics; AI and Machine Learning; Forecasting and Prediction; Analytics and Data Science

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2011
Article

Scalable Detection of Anomalous Patterns With Connectivity Constraints

By: Skyler Speakman, Edward McFowland III and Daniel B. Neill

We present GraphScan, a novel method for detecting arbitrarily shaped connected clusters in graph or network data. Given a graph structure, data observed at each node, and a score function defining the anomalousness of a set of nodes, GraphScan can efficiently and... View Details

Keywords: Biosurveillance; Event Detection; Graph Mining; Scan Statistics; Spatial Scan Statistic

26 May 2015
First Look

First Look: May 26

widespread dissemination of its sole product, Twine. Twine was a cloud-based platform that enabled patients to create and manage chronic disease treatment plans in conjunction with their primary care providers and specialized coaches.... View Details

Keywords: Sean Silverthorne

May 2023 (Revised June 2023)
Supplement

Novartis (C): Reimagining Medicine

By: Ramon Casadesus-Masanell, Claudio Feser, Karolin Frankenberger and David Redaschi

This case unfolds around the first-ever approved personalized cancer treatment, how Novartis wrapped it into a new business model design, and how Novartis scaled it. Novartis — one of the largest pharmaceutical companies in the world — is, among other ventures,... View Details

Keywords: Health Testing and Trials; Health Care and Treatment; Business Model; Problems and Challenges; Pharmaceutical Industry; Switzerland

2015
Article

Scalable Detection of Anomalous Patterns With Connectivity Constraints

By: Skyler Speakman, Edward McFowland III and Daniel B. Neill

We present GraphScan, a novel method for detecting arbitrarily shaped connected clusters in graph or network data. Given a graph structure, data observed at each node, and a score function defining the anomalousness of a set of nodes, GraphScan can efficiently and... View Details

Keywords: Biosurveillance; Event Detection; Graph Mining; Scan Statistics; Spatial Scan Statistic

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