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Article

Dying Is Unexpectedly Positive

By: Amelia Goranson, Ryan S. Ritter, Adam Waytz, Michael I. Norton and Kurt Gray

In people’s imagination, dying seems dreadful; however, these perceptions may not reflect reality. In two studies, we compared the affective experience of people facing imminent death with that of people imagining imminent death. Study 1 revealed that blog posts of... View Details

Keywords: Death; Language; LIWC; Positivity; Affective Forecasting; Open Materials; Perspective; Attitudes

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April 2003 (Revised October 2004)
Case

Novartis: The Challenge of Success (A)

By: Sandra J. Sucher and Stacy McManus

Preliminary results from Phase 1 clinical trials of a newly developed compound, STI571, showed that 31 out of 31 patients with chronic myelogenous leukemia (CML) had their blood counts return to normal. In the world of oncology, this was unheard of. This was the... View Details

Keywords: Decision Making; Health Testing and Trials; Innovation and Invention; Markets; Distribution; Product Development; Production; Problems and Challenges; Research; Research and Development; Complexity; Biotechnology Industry; Pharmaceutical Industry

May 2009 (Revised August 2013)
Case

The DiagnoFirst Opportunity

By: Robert C. Pozen and Rukmini Balu

John Mason, a principle at Oldwell Partners, was facing a decision of whether or not to invest in DiagnoFirst, a molecular diagnostics firm. DiagnoFirst's key product was a genetic test that identified a subset of prostate cancer patients with a high risk of clinical... View Details

Keywords: Genetic Engineering; Genetically Modified; Genomics; Venture Capital; Patents; Genetics; Decision Choices and Conditions; Laws and Statutes; Investment; Science-Based Business; Biotechnology Industry

Article

Defining the Value Framework for Prostate Brachytherapy Using Patient-Centered Outcome Metrics and Time-Driven Activity-Based Costing

By: N.G. Thaker, T.J. Pugh, U. Mahmood, S. Choi, T.E. Spinks, N.E. Martin, T.T. Sio, R.J. Kudchadker, R. S. Kaplan, D.A. Kuban, D.A. Swanson, P.F. Orio, M.J. Zelefsky, B.W. Cox, L. Potters, T.A. Buchholz, T.W. Feeley and S.J. Frank

PURPOSE: Value, defined as outcomes over costs, has been proposed as a measure to evaluate prostate cancer (PCa) treatments. We analyzed standardized outcomes and time-driven activity-based costing (TDABC) for prostate brachytherapy (PBT) to define a value... View Details

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August 2001 (Revised August 2012)
Case

BestDoctors, Inc.

By: Regina E. Herzlinger and Seth Bokser

Upon learning the news of a critical illness, patients and their families are shocked, saddened, fearful, and angry all at once. And just as soon as they catch their collective breath, they all ask the same question—a question that has the potential to infuse hope into... View Details

Keywords: Business Model; Entrepreneurship; Health Care and Treatment; Medical Specialties; Knowledge Sharing; Demand and Consumers; Health Industry

Satish Tadikonda is a Senior Lecturer in the Entrepreneurial Management Unit at Harvard Business School. In the MBA program, Satish teaches The Entrepreneurial Manager, a required first-year MBA course, and Entrepreneurship in Life Sciences, an elective course for... View Details

September 2011
Supplement

Expansion at Narayana Hrudayalaya

By: Tarun Khanna and Tanya Bijlani

Narayana Hrudayalaya has expanded into a multi-specialty health city in Bangalore, with a 25-acre campus that offers complex tertiary care procedures ranging from orthopedics to cancer care. In 2008, NH raised private equity from JP Morgan and Pinebridge Investments to... View Details

Keywords: Investment; Price; Health Care and Treatment; Emerging Markets; Social Enterprise; Expansion; Health Industry; Bangalore; Cayman Islands; Miami

2022
Case

Marathon Petroleum and Southwest Detroit: The Intersection of Community and Environment

By: Andrew J. Hoffman

Environmental racism describes the unequal burden of environmental hazards placed on disadvantaged communities through systems, policies, and practices. In such a situation, these people disproportionately live close to sources of toxic waste-what are referred to as... View Details

Keywords: Environmental Regulation; Pollutants; Pollution; Equality and Inequality; Social Issues; Poverty; Race; Health Disorders; Ethics

Malcolm Salter has been a member of the Harvard Business School faculty since 1967. His teaching and research focus on issues of corporate strategy, organization, and governance.

In addition to teaching at HBS, he has held faculty positions at the Harvard... View Details

Keywords: arts; automobiles; energy; investment banking industry; retailing; venture capital industry

Web

Capstone | MBA

medicine, microbiomes, opioid use disorder, organoid systems for drug development, oncology, psychedelics, women’s health, and many more. Recent Capstone Projects iPSC-Derived NK Cells – Changing Cancer’s Fate Richard Nixon declared a war on View Details

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Faculty & Advisors | MBA

she started her career as an analyst at MPM. She currently serves on the Harvard Medical School Board of Fellows and is a Trustee of the American Association for Cancer Research Foundation. Enke Bashllari MBA, Harvard University; PhD,... View Details

May 2025 (Revised May 2025)
Case

Daiichi Sankyo: Steering a Global Organization

By: Tiona Zuzul, Amy C. Edmondson and Cat Huang

In the spring of 2023, Sunao Manabe, CEO of Daiichi Sankyo, reflected on a pivotal decision. A large Western pharmaceutical company had made a bid to partner with Daiichi Sankyo to develop the next three products in its oncology pipeline. Daiichi Sankyo, a 125-year old... View Details

Keywords: Strategy; Culture Change; Decision-making; Leadership; Culture; Innovation; Psychological Safety

05 Sep 2023
Book

Failing Well: How Your ‘Intelligent Failure’ Unlocks Your Full Potential

In the 1990s, after drugmaker Eli Lilly spent more than a decade and millions of dollars developing the new drug Alimta to treat lung cancer, the medication came up short in effectively treating cancer in expanded trials. While the... View Details

Keywords: by Michael Blanding

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Value-Based Health Care - Institute For Strategy And Competitiveness

and then costs are based on the people involved in providing care for specific events.... See All Publications Cases & Teaching Notes Martini Klinik Prostate Cancer Care 2019 June 2019 HBS Case Collection Since its establishment in 2005,... View Details

August 2023
Case

Constellation Pharmaceuticals: Corporate Development at a Novel Therapeutic Company

By: Satish Tadikonda and Brad Prosek

Constellation Pharmaceuticals was a company focused on epigenetic therapies for cancer patients. Despite a promising start and an early deal with a leading biopharma company, the company weathered twin setbacks in the end of a major research collaboration and the... View Details

Keywords: Mergers and Acquisitions; Health Care and Treatment; Organizational Change and Adaptation; Research and Development; Business Strategy; Partners and Partnerships; Goals and Objectives; Pharmaceutical Industry; United States

2022
Article

Improving Efficiency and Reducing Costs of MRI-Guided Prostate Brachytherapy Using Time-Driven Activity-Based Costing

By: Nikhil G. Thaker, Rajat J. Kudchadker, James R. Incalcaterra, Tharakeswara K. Bathala, Robert S. Kaplan, Ankit Agarwal, Deborah A. Kuban, Benjamin D. Frank, Prajnan Das, Thomas W. Feeley and Steven J. Frank

Integrated quality improvement (QI) and cost reduction strategies can help increase value in cancer care. We applied standard QI and TDABC methods to improve workflow efficiency and reduce costs for MRI-guided prostate brachytherapy. We constructed process maps,... View Details

Keywords: Brachytherapy; Quality Improvement; Prostate; Time-Driven Activity-Based Costing; Cost Accounting; Health Care and Treatment; Performance Efficiency; Health Industry