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  • June 2021
  • Case

uBiome

By: Thomas R. Eisenmann and Olivia Graham
uBiome provided clinical tests that sequenced the DNA of human microbiome samples, providing data on health conditions directly to consumers or to prescribing physicians. Founded in 2012, the San Francisco-based startup raised $105 million from top-tier venture capital... View Details
Keywords: Business Startups; Crime and Corruption; Insolvency and Bankruptcy
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Eisenmann, Thomas R., and Olivia Graham. "uBiome." Harvard Business School Case 821-076, June 2021.
  • January 2017
  • Case

Kada Orthopedics: A Bone of Contention

By: Kevin Schulman and Matt Strickland
Kada Orthopedics is a small implantable orthopedic device manufacturer founded by industry veterans trying to sell stable-technology products to an increasingly cost-conscious healthcare market. Although they have marginally successful product in early 2016, the... View Details
Keywords: Market Design; Growth And Development Strategy; Health Care; Business Startup; Growth and Development; Health Care and Treatment; Medical Specialties; Business Startups; Supply and Industry; Medical Devices and Supplies Industry; United States
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Schulman, Kevin, and Matt Strickland. "Kada Orthopedics: A Bone of Contention." Harvard Business School Case 317-091, January 2017.
  • 16 Nov 2021
  • Cold Call Podcast

Can Mass General Brigham Diversify Its Community of Innovators?

Keywords: Re: Katherine B. Coffman; Health
  • January 2018 (Revised May 2019)
  • Case

Adeo Health Science: Turning a Product into a Brand

By: Elizabeth A. Keenan and Jill Avery
For decades, American parents were warned to avoid introducing potential allergens to their babies prior to their first birthday. But two influential clinical studies caused the medical establishment to radically reverse its position. Parents were now warned that... View Details
Keywords: Startup; Health Care; Consumer; Consumer Products; Branding; Distribution; Retailing; Go To Market Strategy; Marketing; Marketing Channels; Marketing Communications; Brands and Branding; Marketing Strategy; Entrepreneurship; Health Care and Treatment; Consumer Products Industry; Health Industry; United States; North America
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Keenan, Elizabeth A., and Jill Avery. "Adeo Health Science: Turning a Product into a Brand." Harvard Business School Case 518-065, January 2018. (Revised May 2019.)
  • 12 Mar 2019
  • First Look

New Research and Ideas, March 12, 2019

Abstract—Objectives: To apply time-driven activity-based costing (TDABC) methodology to determine emergency medicine physician documentation costs with and without scribes. Methods: Two research assistants shadowed attending View Details
Keywords: Dina Gerdeman
  • May 2021
  • Case

Inclusive Innovation at Mass General Brigham

By: Katherine Baldiga Coffman and Olivia Hull
Massachusetts General Brigham (MGB) Chief Innovation Officer Christopher Coburn had overseen a period of exciting transformation and growth in healthcare innovation at MGB. In November 2019, the health system was the largest recipient of National Institutes of Health... View Details
Keywords: Inclusion; Innovation; Invention; Gender; Business Startups; Investment Funds; Private Equity; Health Care and Treatment; Innovation Strategy; Technological Innovation; Intellectual Property; Copyright; Patents; Research; Research and Development; Diversification; Technology; Health Industry; Massachusetts; Boston
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Coffman, Katherine Baldiga, and Olivia Hull. "Inclusive Innovation at Mass General Brigham." Harvard Business School Case 921-006, May 2021.
  • Article

The CMS New Rule on Ambulatory Surgical Centers Earns Only Partial Credit

By: Junaid Nabi and Robert S. Kaplan
The Centers of Medicare and Medicaid Services (CMS) recently announced that it will be removing more... View Details
Keywords: Ambulatory Care; Payment Policy; Health Care and Treatment; Governing Rules, Regulations, and Reforms
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Nabi, Junaid, and Robert S. Kaplan. "The CMS New Rule on Ambulatory Surgical Centers Earns Only Partial Credit." Health Affairs Blog (June 2, 2021).
  • November 2016 (Revised April 2017)
  • Case

Hygeia Group: Delivering Quality Care in Nigeria

By: Robert F. Higgins and Ifedayo O. Kuye
Fola Laoye is the Group Managing Director of Hygeia Group, a Nigerian healthcare insurer and provider, and she is deciding on the optimal strategy to grow the provider arm of her business. Hygeia Group was founded in the 1980s by her physician parents, and although... View Details
Keywords: Healthcare; Healthcare Industry; Hospitals; Nigeria; Health Care and Treatment; Growth and Development Strategy; Health Industry; Nigeria
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Higgins, Robert F., and Ifedayo O. Kuye. "Hygeia Group: Delivering Quality Care in Nigeria." Harvard Business School Case 817-088, November 2016. (Revised April 2017.)
  • March 2017
  • Article

Variation in the Cost of Care for Primary Total Knee Arthroplasties

By: Derek A. Haas and Robert S. Kaplan
The study examined the cost variation across 29 high-volume U.S. hospitals for delivering a primary total knee arthroplasty without major complicating conditions. Hospital and physician personnel costs were calculated using time-driven activity-based costing.... View Details
Keywords: Cost Management; Performance Productivity; Health Care and Treatment; Health Industry
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Haas, Derek A., and Robert S. Kaplan. "Variation in the Cost of Care for Primary Total Knee Arthroplasties." Arthroplasty Today 3, no. 1 (March 2017): 33–37.
  • September 2013 (Revised August 2014)
  • Case

Claritas Genomics

By: Robert F. Higgins and Matthew Preble
Claritas Genomics was formed in January 2013 when BCH spun out its Genetics Diagnostic Lab into a fully commercial entity. Claritas offered over 100 genomic tests to detect a range of conditions, including autism and intellectual disabilities, and was developing new... View Details
Keywords: Boston Children's Hospital; Genetic Engineering; Genetically Modified; Genetics Diagnostics; Health Care Industry; Healthcare IT; Healthcare Technology; Healthcare Ventures; Biomedical Research; Patrice Milos; Genomics; Genomic Testing; Life Technologies; Health Care and Treatment; Information Technology; Information Management; Genetics; Biotechnology Industry; Information Technology Industry; Health Industry; Boston; Massachusetts; United States
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Higgins, Robert F., and Matthew Preble. "Claritas Genomics." Harvard Business School Case 814-032, September 2013. (Revised August 2014.)
  • December 2009 (Revised March 2025)
  • Case

Phreesia: The Patient Intake Company

By: Regina E. Herzlinger, Sunaina Yarlagadda and Brian L. Walker
How should the co-founders of an organization that provides patient sign-in and billing services scale their company after five years of successfully targeting small private physician practices? Phreesia had deployed a direct mail and sales force strategy that resulted... View Details
Keywords: Advertising; Social Entrepreneurship; Revenue; Health Care and Treatment; Health Industry
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Herzlinger, Regina E., Sunaina Yarlagadda, and Brian L. Walker. "Phreesia: The Patient Intake Company." Harvard Business School Case 310-066, December 2009. (Revised March 2025.)
  • Article

A Cost Comparison of Cataract Surgeries in Three Countries—United States, India, and Nepal

By: Jiayin Xue, John Hinkle, Mary-Grace Reeves, Luo Luo Zheng, Vengadesan Natarajan, Shyam Vyas, Radhika Upreti Oli, Matt Oliva, Robert S. Kaplan, Arnold Milstein, Geoff Tabin, Jeffrey L. Goldberg and Kevin Schulman
U.S.-based cataract surgeries are costly compared with those performed in high-quality Indian and Nepalese eye centers. The authors used time-driven activity-based costing to evaluate phacoemulsification surgery across four sites: a U.S.-based academic hospital... View Details
Keywords: Time-Driven Activity-Based Costing; Cost Accounting; Health Care and Treatment; Health Industry; India; Nepal; United States
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Xue, Jiayin, John Hinkle, Mary-Grace Reeves, Luo Luo Zheng, Vengadesan Natarajan, Shyam Vyas, Radhika Upreti Oli, Matt Oliva, Robert S. Kaplan, Arnold Milstein, Geoff Tabin, Jeffrey L. Goldberg, and Kevin Schulman. "A Cost Comparison of Cataract Surgeries in Three Countries—United States, India, and Nepal." NEJM Catalyst Innovations in Care Delivery 2, no. 9 (September 2021).
  • 2019
  • Chapter

Characterizing the Drug Development Pipeline for Precision Medicines

By: Amitabh Chandra, Craig Garthwaite and Ariel Dora Stern
BOOK ABSTRACT: Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement... View Details
Keywords: Healthcare; Precision Medicine
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Chandra, Amitabh, Craig Garthwaite, and Ariel Dora Stern. "Characterizing the Drug Development Pipeline for Precision Medicines." Chap. 5 in Economic Dimensions of Personalized and Precision Medicine, edited by Ernest R. Berndt, Dana P. Goldman, and John W. Rowe, 115–158. University of Chicago Press, 2019.
  • Article

Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting

By: Raymond H. Mak, Michael G. Endres, Jin Hyun Paik, Rinat A. Sergeev, Hugo Aerts, Christopher L. Williams, Karim R. Lakhani and Eva C. Guinan
Importance: Radiation therapy (RT) is a critical cancer treatment, but the existing radiation oncologist work force does not meet growing global demand. One key physician task in RT planning involves tumor segmentation for targeting, which requires substantial... View Details
Keywords: Crowdsourcing; AI Algorithms; Health Care and Treatment; Collaborative Innovation and Invention; AI and Machine Learning
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Mak, Raymond H., Michael G. Endres, Jin Hyun Paik, Rinat A. Sergeev, Hugo Aerts, Christopher L. Williams, Karim R. Lakhani, and Eva C. Guinan. "Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting." JAMA Oncology 5, no. 5 (May 2019): 654–661.
  • 09 Apr 2013
  • First Look

First Look: April 9

  Cases & Course Materials Harvard Business School Case 612-016 Lowell General Physician Hospital Organization This case focuses on the Alternative Quality Contract (AQC), a novel payment program designed to incentivize providers to... View Details
Keywords: Sean Silverthorne
  • March 2013
  • Other Article

Redesigning Primary Care: A Strategic Vision to Improve Value by Organizing Around Patients' Needs

By: Michael E. Porter, Erika A. Pabo and Thomas H. Lee
Primary care in the United States currently struggles to attract new physicians and to garner investments in infrastructure required to meet patients' needs. We believe that the absence of a robust overall strategy for the entire spectrum of primary care is a... View Details
Keywords: Health
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Porter, Michael E., Erika A. Pabo, and Thomas H. Lee. "Redesigning Primary Care: A Strategic Vision to Improve Value by Organizing Around Patients' Needs." Health Affairs 32, no. 3 (March 2013): 516–525.
  • July 2000 (Revised November 2001)
  • Case

Catalyst Medical Solutions

By: Amy C. Edmondson, Richard M.J. Bohmer and Naomi Atkins
Faced with a drop in the NASDAQ, four eHealth entrepreneurs must decide between two distribution strategies for their new company's technology. The team, comprised of three full-time resident physicians and an MBA, has developed software to enable electronic... View Details
Keywords: Product Development; Health Care and Treatment; Distribution; Strategy; Venture Capital; Applications and Software; Partners and Partnerships; Borrowing and Debt; Information Technology Industry; Service Industry
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Edmondson, Amy C., Richard M.J. Bohmer, and Naomi Atkins. "Catalyst Medical Solutions." Harvard Business School Case 601-014, July 2000. (Revised November 2001.)
  • 2016
  • Article

Integrated Care from the Patient's Perspective and its Relationship to Medical Group Attributes.

By: Michaela Kerrissey, Jonathan Clark, Ashley-Kay Fryer, Wei Jiang, Maryaline Catillon, Patricia Ramsay, Stephen Shortell, Lawrence Casalino, Mark Friedberg and Sara J. Singer
Integrating care for patients with multiple chronic conditions is essential to improving quality. Yet little is known about care integration from the patient’s perspective and how it relates to medical group characteristics. We created a nationally representative... View Details
Keywords: Care Coordination; Integrated Care; Health; Health Care and Treatment; Quality; Perspective; Health Industry
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Kerrissey, Michaela, Jonathan Clark, Ashley-Kay Fryer, Wei Jiang, Maryaline Catillon, Patricia Ramsay, Stephen Shortell, Lawrence Casalino, Mark Friedberg, and Sara J. Singer. "Integrated Care from the Patient's Perspective and its Relationship to Medical Group Attributes." Academy of Management Proceedings (2016).
  • July 1996 (Revised August 2024)
  • Case

Innovative Opportunities to Manage Health Care Delivery

By: Regina E. Herzlinger and D. Scott Lurding
The purpose of this case is: To familiarize the students with the changing landscape of health care delivery, through chains of retail medical centers and those offering value-based care (VBC).

To discuss fundamental managerial decisions about their... View Details
Keywords: Managed Care; Capitation; Strategy
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Herzlinger, Regina E., and D. Scott Lurding. "Innovative Opportunities to Manage Health Care Delivery." Harvard Business School Case 197-011, July 1996. (Revised August 2024.)
  • 22 Sep 2009
  • First Look

First Look: September 22

  Working PapersMixed Source Authors:Ramon Casadesus-Masanell and Gastón Llanes Abstract We study competitive interaction between profit-maximizing firms that sell software and complementary goods or services. In addition to tactical price competition, we allow firms... View Details
Keywords: Martha Lagace
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