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- January 2025
- Case
Negotiating with Data: Analytics FC (A)
By: Jillian Jordan and Livia Alfonsi
Analytics FC was a UK-based sports consultancy that focused on international football (soccer), leveraging cutting-edge data-analytic techniques to support clubs, federations, and players. In 2022, Alex Greenwood, an elite female defender, approached the company for... View Details
- January 2025
- Supplement
Negotiating with Data: Analytics FC (B)
By: Jillian Jordan and Livia Alfonsi
Analytics FC was a UK-based sports consultancy that focused on international football (soccer), leveraging cutting-edge data-analytic techniques to support clubs, federations, and players. In 2022, Alex Greenwood, an elite female defender, approached the company for... View Details
- February 2024
- Supplement
Seeds of Innovation: GALY's Quest to Cultivate the Future of Agriculture in the Lab
By: George Serafeim
In 2023, Luciano Bueno, CEO and founder of plant cell culture agriculture company GALY, was considering the best path forward for his company as he planned to pitch Series B investors. GALY, founded in 2019, aimed to produce cotton and other crops from cells grown in... View Details
Keywords: Business Model; Green Technology; Goods and Commodities; Growth and Development Strategy; Science-Based Business; Entrepreneurship; Plant-Based Agribusiness; Business Startups; Decisions; Technological Innovation; Production; Entrepreneurial Finance; Agriculture and Agribusiness Industry; Technology Industry; Boston; Sao Paulo
- 2025
- Working Paper
Bringing Science to Market: Knowledge Foundations, Inventor-Founders, and Performance
By: Justine Boudou and Maria Roche
In this paper, we examine how a startup’s knowledge foundations—embedded in its
core technology—influence its performance in the exit market. Using a dataset of 1,006
biomedicine startups founded between 2005 and 2015, we focus on two key factors: (1)
the degree of... View Details
- September 2023 (Revised November 2023)
- Case
Seeds of Innovation: GALY's Quest to Cultivate the Future of Agriculture in the Lab
By: George Serafeim and Michael Norris
In 2023, Luciano Bueno, CEO and founder of plant cell culture agriculture company GALY, was considering the best path forward for his company as he planned to pitch Series B investors. GALY, founded in 2019, aimed to produce cotton and other crops from cells grown in... View Details
Keywords: Business Model; Green Technology; Goods and Commodities; Growth and Development Strategy; Science-Based Business; Entrepreneurship; Plant-Based Agribusiness; Business Startups; Decisions; Technological Innovation; Production; Agriculture and Agribusiness Industry; Technology Industry; Boston; Sao Paulo
- November 22, 2022
- Article
Is Novel Research Worth Doing? Evidence from Peer Review at 49 Journals
By: Misha Teplitskiy, Hao Peng, Andrea Blasco and Karim R. Lakhani
There are long-standing concerns that peer review, which is foundational to scientific institutions like journals and funding agencies, favors conservative ideas over novel ones. We investigate the association between novelty and the acceptance of manuscripts submitted... View Details
- Article
Core Earnings: New Data and Evidence
By: Ethan Rouen, Eric C. So and Charles C.Y. Wang
Using a novel dataset, we show that components of firms' GAAP earnings stemming from ancillary business activities or transitory shocks are significant in frequency and magnitude. These components have grown over time and are dispersed across various sections of the... View Details
- March 2019
- Case
Investing in the Future: Corning Inc. and the Alternative School for Math and Science
By: Derek van Bever and Miho Kubagawa
In early 2017, Kim Frock (MBA 1987), founder and administrative head of school for the Alternative School for Math and Science (ASMS) in Corning, New York, is beginning to think through the issue of leadership succession at the school. Founded in close partnership with... View Details
- 2018
- Article
Insight into Gender Differences in STEM: Evidence from Peer Reviews in an Engineering Class
By: Jacqueline N. Lane, Bruce Ankenman and Seyed Iravani
As the service industry moves toward self-service, peer feedback serves a critical role in this shift for educational services. Peer feedback is a process by which students provide feedback to each other. One of its major benefits is that it enables students to become... View Details
Keywords: Peer Review; Peer Feedback; STEM Education; Anonymity; Education; Gender; Education Industry
- October 2018 (Revised August 2023)
- Case
Safecast: Bootstrapping Human Capital to Big Data
By: Ethan Bernstein and Stephanie Marton
On March 11, 2011, at 2:46pm, a 9.1-on-the-Richter-scale, six-minute long earthquake unleashed a tsunami that ravaged the Tohoku region of Japan, damaging the Fukushima Daiichi Nuclear Power facility and releasing sufficient radioactive material into the air and ocean... View Details
Keywords: Citizen Science; Creative Commons; Open Data; Open Architecture; Volunteer-based Organization; Fukushima Daiichi Nuclear Power Facility; 311; Nuclear; Radiation; Crowdsourcing; Bgeigie; Geiger Counters; Kickstarter; Sustainability; Sustainable Business And Innovation; Design; Energy Generation; Social Entrepreneurship; Human Capital; Innovation and Invention; Crisis Management; Organizational Structure; Organizational Design; Information Technology; Business Model; Energy Industry; Technology Industry; Japan; North and Central America; Europe
- October 2016 (Revised September 2017)
- Case
The CRISPR-Cas9 Quarrel
By: Richard G. Hamermesh and Matthew G. Preble
In mid-2016, the Broad Institute and the University of California, Berkeley were in the middle of a contentious patent dispute over which entity controlled a breakthrough gene editing technology called CRISPR-Cas9. With CRISPR-Cas9, scientists might soon be able to... View Details
- January 2013
- Case
Cabot Corporation: The Fuel Cell Decision (A)
By: Willy Shih and Ying Zhou
Managers at Cabot Corporation are faced with deciding the future of its fuel cell program. The (A) case recounts the view of the business manager and the technical project lead, and the (B) case describes the perspective of a senior manager who is the head of the New... View Details
Keywords: Technical Decision-making; Decision-making Process; Fuel Cells; Decision Choices and Conditions; Decisions; Judgments; Business Plan; Business Exit or Shutdown; Energy Generation; Energy Sources; Innovation and Management; Innovation Strategy; Technological Innovation; Research and Development; Science-Based Business; Commercialization; Technology Industry; Manufacturing Industry; Massachusetts; United States
- January 2013
- Supplement
Cabot Corporation: The Fuel Cell Decision (B)
By: Willy Shih and Ying Zhou
Managers at Cabot Corporation are faced with deciding the future of its fuel cell program. The (A) case recounts the view of the business manager and the technical project lead, and the (B) case describes the perspective of a senior manager who is the head of the New... View Details
Keywords: Technical Decision-making; Decision Making Process; Fuel Cells; Decision Choices and Conditions; Decisions; Judgments; Business Plan; Business Exit or Shutdown; Energy Generation; Energy Sources; Innovation and Management; Innovation Strategy; Technological Innovation; Research and Development; Science-Based Business; Commercialization; Technology Industry; Manufacturing Industry; United States; Massachusetts
- June 2010 (Revised May 2017)
- Teaching Note
Sydney IVF: Stem Cell Research
By: Robert Simons and Kathryn Rosenberg
Teaching Note for 109017. View Details
Keywords: Strategy And Execution; Management Control Systems; Levers Of Control; Strategy; Risk Management; Decisions; Cooperative Ownership; Product Development; Moral Sensibility; Governing Rules, Regulations, and Reforms; Expansion; Science-Based Business; Research; Management Practices and Processes; Business Subsidiaries; Biotechnology Industry; Sydney
- January 2009 (Revised February 2009)
- Case
Sydney IVF: Stem Cell Research
By: Robert L. Simons, Kathryn Rosenberg and Natalie Kindred
This case examines the strategy implementation and risk management decisions at Sydney IVF, a research-based in vitro fertilization and stem cell company based in Australia. Drs. Robert Jansen and Jock Anderson, who co-founded Sydney IVF in 1986, developed novel... View Details
- 2007
- Article
Selling Stem Cell Science: How Markets Drive Law along the Technological Frontier
By: Debora Spar and Anna Harrington
- November 2006 (Revised March 2008)
- Case
The Harvard Stem Cell Institute
Describes a set of issues confronting the leaders of the Harvard Stem Cell Institute, an innovative cross-university effort to accelerate scientific discovery and translation in the domain of stem cells. Covers a wide range of topics, including understanding how... View Details
- 2006
- Book
Science Business: The Promise, the Reality, and the Future of Biotech
By: Gary P. Pisano
Why has the biotechnology industry failed to perform up to expectations—despite all its promise? In Science Business, Gary P. Pisano answers this question by providing an incisive critique of the industry. Pisano not only reveals the underlying causes of... View Details
- May 2006
- Case
A123Systems
By: H. Kent Bowen, Kenneth P Morse and Douglass Cannon
A 123Systems was a young company that was founded on basic materials science research at the Massachusetts Institute of Technology. A co-founder of the company, Yet-Ming Chiang, was a full professor at MIT and served as scientific adviser. Intellectual property based... View Details
- February 2004 (Revised March 2004)
- Case
Fuel Cells: The Hydrogen Revolution?
By: Thomas R. Eisenmann and Ryland Matthew Willis
The challenges faced in establishing hydrogen fuel cell-powered transportation in the United States, which promises to reduce greenhouse gas emissions and dependence on imported oil is examined. Foremost among these challenges is a "chicken-and-egg" dynamic: consumers... View Details