Publications

January 2025
Case

DMC Biotechnologies: Using Techno-Economic Modeling to Guide Production Strategy

By: Joshua Lev Krieger, Chris Burk and Jim Matheson

January 2025
Technical Note

Launching Tough Tech Ventures

By: Joshua Lev Krieger and Jim Matheson

December 2024
Case

Xtalic

By: Joshua Lev Krieger and Jim Matheson

This case study examines the commercialization efforts of Xtalic, a startup founded by MIT scientists based on their discovery of a novel material science method to protect metal substrates. The case focuses on the strategic decisions involved in bringing this... View Details

Keywords: Innovation ＆ Entrepreneurship; Innovation and Management; Entrepreneurial Finance; Entrepreneurship; Business Model; Business Startups; Agreements and Arrangements; Science-Based Business; Commercialization

August 2024 (Revised November 2024)
Case

Commonwealth Fusion Systems: Born at Scale

By: Joshua Lev Krieger, Jim Matheson, Kyle Myers, Gunnar Trumbull and Richard Vietor

This case study chronicles the journey of Commonwealth Fusion Systems (CFS) on its ambitious mission to commercialize fusion energy and become the world’s leading provider of fusion power plants. Emerging from a “special arrangement” with MIT's Plasma Science and... View Details

Keywords: Nuclear Energy; Innovation; Entrepreneurship; Entrepreneurial Finance; Energy Generation; Commercialization; Science-Based Business; Technological Innovation; Market Entry and Exit; Energy Industry

July 2024
Technical Note

Intellectual Property in Tough Tech Ventures

By: Joshua Lev Krieger, Jim Matheson, Russ Wilcox and Mel Martin

This note explains the crucial role of intellectual property rights (IPR), particularly patents, in the success of tough tech ventures (TTVs). It outlines the patent system's mechanics, emphasizing utility patents and their requirements for novelty, non-obviousness,... View Details

Keywords: Intellectual Property

April 2024 (Revised August 2024)
Case

The Engine

By: Joshua Lev Krieger, Jim Matheson, Fiona Murray and Nicholas Christman

The Engine, a venture capital firm founded by MIT to fill a gap in the technology funding landscape by commercializing breakthrough science and technology. Led by managing partner and CEO Katie Rae, the Engine's unique approach involved an unusually longer fund life,... View Details

Keywords: Growth and Development Strategy; Mission and Purpose; Venture Capital; Business Startups; Entrepreneurial Finance; Financial Services Industry

February 2024
Teaching Note

Fusion Industry Association: Igniting the Future of Clean Energy

By: Kyle Myers, Joshua Lev Krieger, Walter Frick and Jim Matheson

Teaching Note for HBS Case No. 624-064. This Teaching Note explores the Fusion Industry Association's efforts to advance commercial fusion energy, highlighting challenges in innovation, regulation, market structure, and financing within the emerging technology sector... View Details

Keywords: Financing and Loans; Governing Rules, Regulations, and Reforms; Technological Innovation; Industry Growth; Energy Industry