Joshua Lev Krieger - Publications - Faculty & Research - Harvard Business School

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February 2025
Case

Fly, Fix, Fly at True Anomaly

By: Joshua Lev Krieger, Jim Matheson, Fiona Murray and David Allen

How should companies learn from failure? Founded by four U.S. Space Force warfighters, the tough tech startup True Anomaly wanted to compete with major defense contractors to supply the U.S. Department of Defense with satellites and software that could help protect... View Details

Keywords: Business Startups; Engineering; National Security; Digital Platforms; Failure; Problems and Challenges; Business and Government Relations; Entrepreneurship; Aerospace Industry; United States; Colorado

January 2025
Case

DMC Biotechnologies: Using Techno-Economic Modeling to Guide Production Strategy

By: Joshua Lev Krieger, Chris Burk and Jim Matheson

January 2025
Technical Note

Launching Tough Tech Ventures

By: Joshua Lev Krieger and Jim Matheson

December 2024
Case

Xtalic

By: Joshua Lev Krieger and Jim Matheson

This case study examines the commercialization efforts of Xtalic, a startup founded by MIT scientists based on their discovery of a novel material science method to protect metal substrates. The case focuses on the strategic decisions involved in bringing this... View Details

Keywords: Innovation ＆ Entrepreneurship; Innovation and Management; Entrepreneurial Finance; Entrepreneurship; Business Model; Business Startups; Agreements and Arrangements; Science-Based Business; Commercialization

2024
Working Paper

Charting (and Updating) the Path: A Bayesian Perspective on Entrepreneurial Learning

By: Joshua L. Krieger

This chapter explores two distinct modes of entrepreneurial learning: assessing venture viability and choosing between alternative development paths. It introduces a framework for decomposing venture viability into technological feasibility, commercial potential and... View Details

Keywords: Decision Making; Entrepreneurship; Growth and Development Strategy; Learning

September 2024
Article

Standing on the Shoulders of Science

By: Joshua Lev Krieger, Monika Schnitzer and Martin Watzinger

Today’s innovations rely on scientific discoveries of the past, yet only some corporate R&D builds directly on scientific output. In this paper, we analyze U.S. patents to investigate how firms generate value by building on prior art “closer” to science. We show... View Details

Keywords: Patent Novelty; Value Capture; Science; Patents; Valuation; Research and Development

August 2024 (Revised November 2024)
Case

Commonwealth Fusion Systems: Born at Scale

By: Joshua Lev Krieger, Jim Matheson, Kyle Myers, Gunnar Trumbull and Richard Vietor

This case study chronicles the journey of Commonwealth Fusion Systems (CFS) on its ambitious mission to commercialize fusion energy and become the world’s leading provider of fusion power plants. Emerging from a “special arrangement” with MIT's Plasma Science and... View Details

Keywords: Nuclear Energy; Innovation; Entrepreneurship; Entrepreneurial Finance; Energy Generation; Commercialization; Science-Based Business; Technological Innovation; Market Entry and Exit; Energy Industry

July 2024
Technical Note

Intellectual Property in Tough Tech Ventures

By: Joshua Lev Krieger, Jim Matheson, Russ Wilcox and Mel Martin

This note explains the crucial role of intellectual property rights (IPR), particularly patents, in the success of tough tech ventures (TTVs). It outlines the patent system's mechanics, emphasizing utility patents and their requirements for novelty, non-obviousness,... View Details

Keywords: Intellectual Property

June 2024
Article

Valuing the Societal Impact of Medicines and Other Health Technologies: A User Guide to Current Best Practices

By: Jason Shafrin, Jaehong Kim, Joshua T. Cohen, Louis P. Garrison, Dana A. Goldman, Jalpa A. Doshi, Joshua Krieger, Darius N. Lakdawalla, Peter J. Neumann, Charles E. Phelps, Melanie D. Whittington and Richard Willke

This study argues that value assessment conducted from a societal perspective should rely on the Generalized Cost-Effectiveness Analysis (GCEA) framework proposed herein. Recently developed value assessment inventories—such as the Second Panel on Cost-Effectiveness’s... View Details

Keywords: Health Care and Treatment; Valuation; Cost vs Benefits; Society

2024
Working Paper

Old Moats for New Models: Openness, Control, and Competition in Generative AI

By: Pierre Azoulay, Joshua L. Krieger and Abhishek Nagaraj

Drawing insights from the field of innovation economics, we discuss the likely competitive environment shaping generative AI advances. Central to our analysis are the concepts of appropriability—whether firms in the industry are able to control the knowledge generated... View Details

Keywords: Technological Innovation; AI and Machine Learning; Open Source Distribution; Policy

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2024
Working Paper

Dusting Off the Old Ones: Drug Licensing to Startups, Innovation Success and Efficiency

By: Mosab Hammoudeh, Joshua Lev Krieger and Jiajie Xu

This paper investigates whether moving R&D from incumbents to startups can increase innovation. Using comprehensive drug development data, we examine the outcomes of drug projects licensed from large firms to startups. We find that these projects licensed to startups... View Details

Keywords: Product Development; Innovation and Invention; Business Startups; Research and Development; Performance Efficiency; Pharmaceutical Industry

April 2024 (Revised August 2024)
Case

The Engine

By: Joshua Lev Krieger, Jim Matheson, Fiona Murray and Nicholas Christman

The Engine, a venture capital firm founded by MIT to fill a gap in the technology funding landscape by commercializing breakthrough science and technology. Led by managing partner and CEO Katie Rae, the Engine's unique approach involved an unusually longer fund life,... View Details

Keywords: Growth and Development Strategy; Mission and Purpose; Venture Capital; Business Startups; Entrepreneurial Finance; Financial Services Industry

February 2024
Supplement

Fusion Industry Association: Igniting the Future of Clean Energy

By: Kyle Myers and Joshua Lev Krieger

February 2024
Teaching Note

Fusion Industry Association: Igniting the Future of Clean Energy

By: Kyle Myers, Joshua Lev Krieger, Walter Frick and Jim Matheson

Teaching Note for HBS Case No. 624-064. This Teaching Note explores the Fusion Industry Association's efforts to advance commercial fusion energy, highlighting challenges in innovation, regulation, market structure, and financing within the emerging technology sector... View Details

Keywords: Financing and Loans; Governing Rules, Regulations, and Reforms; Technological Innovation; Industry Growth; Energy Industry

January 2024
Case

Fusion Industry Association: Igniting the Future of Clean Energy

By: Joshua Lev Krieger, Jim Matheson, Kyle R. Myers and Henry Tao

Fusion energy is evolving from a scientific idea to a commercial possibility, drawing large investments and regulatory discussions; how should the FIA navigate this evolution?

The Fusion Industry Association (FIA) is at the forefront of transforming fusion... View Details

Keywords: Science-Based Business; Engineering; Venture Capital; Entrepreneurship; Government and Politics; Government Legislation; Industry Clusters; Industry Growth; Industry Structures; Technological Innovation; Energy Industry; United States

2023
Working Paper

Evaluation and Learning in R&D Investment

By: Alexander P. Frankel, Joshua L. Krieger, Danielle Li and Dimitris Papanikolaou

We examine the role of spillover learning in shaping the value of exploratory versus incremental R&D. Using data from drug development, we show that novel drug candidates generate more knowledge spillovers than incremental ones. Despite being less likely to reach... View Details

Keywords: Research and Development; Forecasting and Prediction; Valuation; Pharmaceutical Industry

September 2022
Article

Find and Replace: R&D Investment Following the Erosion of Existing Products

By: Joshua L. Krieger, Xuelin Li and Richard T. Thakor

How do innovative firms react when existing products experience negative shocks? We explore this question with detailed project-level data from drug development firms. Using FDA Public Health Advisories as idiosyncratic negative shocks to approved drugs, we first... View Details

Keywords: R＆D Investments; Drug Development; Product Shocks; M＆A; Biopharmaceutical Industry; FDA; System Shocks; Research and Development; Investment; Decision Making; Pharmaceutical Industry

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2023
Working Paper

Scoring and Funding Breakthrough Ideas: Evidence from a Global Pharmaceutical Company

By: Joshua Krieger, Ramana Nanda, Ian Hunt, Aimee Reynolds and Peter Tarsa

We study resource allocation to early-stage ideas at an internal startup program of one the largest pharmaceutical firms in the world. Our research design enables us to elicit every evaluator’s scores across five different attributes, before seeing how they would... View Details

Keywords: Project Selection; Pharmaceuticals; Financing Innovation; Resource Allocation; Innovation and Invention; Research and Development

August 2022
Teaching Note

AppHarvest: Rebuilding the Appalachian Economy Through Agriculture

By: Joshua Lev Krieger, William R. Kerr and Bailey McAfee

Keywords: Agriculture; Entrepreneurship; Agriculture and Agribusiness Industry

August 2022
Teaching Note

In-Q-Tel: Innovation On A Mission

By: Josh Lerner and Joshua Lev Krieger

Teaching Note for HBS Case No. 823-031. View Details

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